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Ranitidine (United States: Withdrawn from market): Drug information

Ranitidine (United States: Withdrawn from market): Drug information
(For additional information see "Ranitidine (United States: Withdrawn from market): Patient drug information" and see "Ranitidine (United States: Withdrawn from market): Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: Canada
  • ACT Ranitidine [DSC];
  • AG-Ranitidine [DSC];
  • APO-Ranitidine [DSC];
  • JAMP-Ranitidine;
  • M-Ranitidine [DSC];
  • MAR-Ranitidine;
  • MED Ranitidine;
  • MINT-Ranitidine;
  • PMS-Ranitidine;
  • RAN-Ranitidine;
  • RIVA-Ranitidine [DSC];
  • SANDOZ Ranitidine [DSC];
  • TEVA-Ranitidine [DSC];
  • Zantac C
Pharmacologic Category
  • Histamine H2 Antagonist
Dosing: Adult

Note : As of April 2020, all prescription (including oral and injectable) and OTC ranitidine formulations have been withdrawn from the US market.

Duodenal ulcer

Duodenal ulcer:

Oral: Treatment: 150 mg twice daily, or 300 mg once daily after the evening meal or at bedtime; maintenance of healing: 150 mg once daily at bedtime.

IM: 50 mg every 6 to 8 hours.

IV:

Intermittent bolus or infusion: 50 mg every 6 to 8 hours (if increased doses are necessary utilize more frequent administration up to a maximum of 400 mg/day).

Continuous IV infusion: 6.25 mg/hour.

Gastric ulcer, benign

Gastric ulcer, benign: Oral: 150 mg twice daily; maintenance of healing: 150 mg once daily at bedtime.

Gastroesophageal reflux disease

Gastroesophageal reflux disease: Oral: 150 mg twice daily.

Heartburn prevention or relief

Heartburn prevention or relief (OTC labeling): Oral:

Prevention: 75 to 150 mg 30 to 60 minutes before eating food or drinking beverages that cause heartburn (maximum: 2 doses/day); do not use for more than 14 days.

Relief of symptoms: 75 mg to 150 mg up to twice daily (maximum: 2 doses/day); do not use for more than 14 days.

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Adult

CrCl ≥50 mL/minute: No dosage adjustment necessary.

CrCl <50 mL/minute:

Oral: 150 mg every 24 hours; adjust dose cautiously if needed (frequency of dosing may be increased to every 12 hours or further with caution).

IV: 50 mg every 18 to 24 hours; adjust dose cautiously if needed

Hemodialysis: Adjust dosing schedule so that dose is scheduled to coincide with the end of hemodialysis.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling; use with caution.

Dosing: Older Adult

Refer to adult dosing (use caution with dose selection).

Dosing: Pediatric

(For additional information see "Ranitidine (United States: Withdrawn from market): Pediatric drug information")

Note : As of April 2020, all prescription (including oral and injectable) and OTC ranitidine formulations have been withdrawn from the US market.

Duodenal or gastric ulcer

Duodenal or gastric ulcer:

Treatment:

Infants, Children, and Adolescents ≤16 years:

Oral: 4 to 8 mg/kg/day divided twice daily; maximum daily dose: 300 mg/day.

IV: 2 to 4 mg/kg/day divided every 6 to 8 hours; maximum dose: 50 mg/dose.

Adolescents >16 years:

Oral:

Duodenal ulcer: 150 mg twice daily or 300 mg once daily after the evening meal or at bedtime.

Gastric ulcer: 150 mg twice daily.

IV, IM: 50 mg every 6 to 8 hours.

Maintenance:

Infants, Children, and Adolescents ≤16 years: Oral: 2 to 4 mg/kg/day once daily; maximum daily dose: 150 mg/day.

Adolescents >16 years: Oral: 150 mg once daily at bedtime.

Erosive esophagitis

Erosive esophagitis:

Infants, Children, and Adolescents ≤16 years: Oral: 5 to 10 mg/kg/day divided twice daily; maximum dose: 150 mg/dose.

Adolescents >16 years: Oral:

Treatment: 150 mg 4 times daily.

Maintenance: 150 mg twice daily.

GI bleed or stress ulcer; prophylaxis

GI bleed or stress ulcer; prophylaxis: Limited data available; dosing regimens variable:

Intermittent IV infusion:

Infants: 2 to 6 mg/kg/day divided every 8 hours (ASHP 1999; Crill 1999).

Children and Adolescents: 2 to 6 mg/kg/day divided every 6 hours; maximum daily dose: 300 mg/day (ASHP 1999; Crill 1999; Yildizdas 2002).

Continuous IV infusion: Infants, Children, and Adolescents: Initial: 0.15 to 0.5 mg/kg/dose for 1 dose, followed by infusion of 0.08 to 0.2 mg/kg/hour (2 to 5 mg/kg/day) (Gal 2007; Lugo 2001; Osteyee 1994).

Gastroesophageal reflux disease

Gastroesophageal reflux disease: Note: Guidelines recommend a 4- to 8-week treatment course; if improvement seen after 4 to 8 weeks, consider possible wean; if no response after 4 to 8 weeks, reevaluate diagnosis and consider referral to pediatric GI specialist (NASPGHAN/ESPGHAN [Rosen 2018]).

Infants, Children, and Adolescents: Oral: 5 to 10 mg/kg/day in 2 to 3 divided doses; maximum daily dose: 300 mg/day (AAP [Lightdale 2013]; NASPGHAN/ESPGHAN [Rosen 2018]).

Heartburn

Heartburn: OTC labeling: Note: Do not use for more than 14 days.

Prevention: Children ≥12 years and Adolescents: Oral: 75 to 150 mg 30 to 60 minutes before eating food or drinking beverages which cause heartburn; maximum daily dose: 2 doses/day.

Relief of symptoms: Children ≥12 years and Adolescents: Oral: 75 to 150 mg twice daily; maximum daily dose: 2 doses/day.

Pathological hypersecretory conditions

Pathological hypersecretory conditions (eg, Zollinger-Ellison): Note: Proton pump inhibitors are the preferred agents (Kliegman 2020).

Adolescents >16 years:

Oral: 150 mg twice daily; adjust dose or frequency as clinically indicated; doses of up to 6 g/day have been used.

Continuous IV infusion: Initial: 1 mg/kg/hour; measure gastric acid output at 4 hours, if >10 mEq/hour or if patient is symptomatic, increase dose in increments of 0.5 mg/kg/hour; doses of up to 2.5 mg/kg/hour (or 220 mg/hour) have been used.

Anaphylaxis, adjunct therapy

Anaphylaxis, adjunct therapy: Note: Should not be used as monotherapy or as first-line therapy (AAAAI/ACAAI [Campbell 2014]; iCAALL [Simons 2014]; WAO [Simons 2015]).

Infants, Children, and Adolescents: IV: 1 mg/kg/dose; maximum dose: 50 mg/dose (AAAAI/ACAAI [Lieberman 2010]; Canadian Paediatric Society [Cheng 2011]).

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Pediatric

Infants, Children, and Adolescents (Aronoff 2007):

Oral: Based on a usual dose of 2 to 6 mg/kg/day divided every 8 to 12 hours.

GFR >50 mL/minute/1.73 m2: No adjustment required.

GFR 30 to 50 mL/minute/1.73 m2: 2 mg/kg/dose every 12 hours.

GFR 10 to 29 mL/minute/1.73 m2: 1 mg/kg/dose every 12 hours.

GFR <10 mL/minute/1.73 m2: 1 mg/kg/dose every 24 hours.

Hemodialysis: 1 mg/kg/dose every 24 hours.

Peritoneal dialysis: 1 mg/kg/dose every 24 hours.

Continuous renal replacement therapy: 2 mg/kg/dose every 12 hours.

Parenteral (IV): Based on a usual dose of 2 to 4 mg/kg/day divided every 6 to 24 hours.

GFR >50 mL/minute/1.73 m2: No adjustment required.

GFR 30 to 50 mL/minute/1.73 m2: 1 mg/kg/dose every 12 hours.

GFR 10 to 29 mL/minute/1.73 m2: 0.5 mg/kg/dose every 12 hours.

GFR <10 mL/minute/1.73 m2: 0.5 mg/kg/dose every 24 hours.

Hemodialysis: 0.5 mg/kg/dose every 24 hours.

Peritoneal dialysis: 0.5 mg/kg/dose every 24 hours.

Continuous renal replacement therapy: 1 mg/kg/dose every 12 hours.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling; use with caution.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Frequency not defined.

Cardiovascular: Asystole, atrioventricular block, bradycardia (with rapid IV administration), tachycardia, vasculitis, ventricular premature contractions

Central nervous system: Agitation, confusion, dizziness, depression, drowsiness, hallucination, headache, insomnia, involuntary motor activity, malaise, vertigo

Dermatologic: Alopecia, erythema multiforme, injection site pruritus (transient), skin rash

Endocrine & metabolic: Acute porphyria, increased serum prolactin

Gastrointestinal: Abdominal distress, abdominal pain, constipation, diarrhea, nausea, necrotizing enterocolitis (very low weight neonates; Guillet 2006), pancreatitis, vomiting

Hematologic & oncologic: Agranulocytosis, aplastic anemia, granulocytopenia, hemolytic anemia (immune; acquired), leukopenia, pancytopenia, thrombocytopenia

Hepatic: Cholestatic hepatitis, hepatic failure, hepatitis, jaundice

Hypersensitivity: Anaphylaxis, angioedema, hypersensitivity reaction (eg, bronchospasm, eosinophilia, fever)

Local: Burning sensation at injection site (transient), pain at injection site (transient)

Neuromuscular & skeletal: Arthralgia, myalgia

Ophthalmic: Blurred vision

Renal: Acute interstitial nephritis, increased serum creatinine

Respiratory: Pneumonia (causal relationship not established)

Contraindications

Hypersensitivity to ranitidine or any component of the formulation

OTC labeling: When used for self-medication (OTC), do not use if trouble or pain when swallowing food, vomiting with blood, or bloody or black stools, allergic to ranitidine or other acid reducers. Do not use with other acid reducers. Do not use 150 mg tablet with kidney disease without medical advice.

Warnings/Precautions

Concerns related to adverse effects:

• Confusion: Rare cases of reversible confusion have been associated with ranitidine; usually elderly or severely ill patients, or in patients with renal or hepatic impairment.

• Hepatic effects: Elevation in ALT levels has occurred with higher doses (≥100 mg) or prolonged IV therapy (≥5 days); monitor ALT levels daily for the remainder of treatment.

• Vitamin B12 deficiency: Prolonged treatment (≥2 years) may lead to vitamin B12 malabsorption and subsequent vitamin B12 deficiency. The magnitude of the deficiency is dose-related and the association is stronger in females and those younger in age (<30 years); prevalence is decreased after discontinuation of therapy (Lam 2013).

Disease-related concerns:

• Gastric malignancy: Relief of symptoms does not preclude the presence of a gastric malignancy.

• Hepatic impairment: Use with caution in patients with hepatic impairment (ranitidine undergoes hepatic metabolism).

• Porphyria: Avoid use in patients with a history of acute porphyria; may precipitate attacks.

• Renal impairment: Ranitidine is primarily excreted renally; dosage adjustment is recommended in patients with renal impairment.

Special populations:

• Children: Use of gastric acid inhibitors, including proton pump inhibitors and H2 blockers, has been associated with an increased risk for development of acute gastroenteritis and community-acquired pneumonia in pediatric patients (Canani 2006).

Dosage form specific issues:

• Injection: Rapid administration has been associated with bradycardia (rare), usually in patients with predisposing risk factors for cardiac rhythm disorders. Do not exceed the recommended IV administration rate(s).

• Syrup: May contain up to 7.5% alcohol.

Other warnings/precautions:

• OTC labeling: When used for self-medication (OTC), notify health care provider before use if any of the following are present: Frequent chest pain; frequent wheezing particularly with heartburn; nausea/vomiting; unexplained weight loss; stomach pain; heartburn longer than 3 months; heartburn with light-headedness, sweating, or dizziness; chest pain or shoulder pain with shortness of breath; sweating or pain that spreads to arms, neck, or shoulders; light-headedness. Stop use and notify health care provider if heartburn continues, worsens, or lasts longer than 14 days.

Warnings: Additional Pediatric Considerations

Use of gastric acid inhibitors, including proton pump inhibitors and H2 blockers, has been associated with an increased risk for development of acute gastroenteritis and community-acquired pneumonia in pediatric patients 4 to 36 months (Canani 2006). A large epidemiological study has suggested an increased risk for developing pneumonia in patients receiving H2 receptor antagonists; however, a causal relationship with ranitidine has not been demonstrated. A cohort analysis including over 11,000 neonates reported an association of H2 blocker use and an increased incidence of necrotizing enterocolitis (NEC) in very low birth weight (VLBW) neonates (Guillet 2006). An approximate six-fold increase in mortality, NEC, and infection (ie, sepsis, pneumonia, urinary tract infection) was reported in patients receiving ranitidine in a cohort analysis of 274 VLBW neonates (Terrin 2012). Routine use in preterm infants is not recommended (AAP [Eichenwald 2018]). Gastric acid suppression medications, including H2 blockers, have also been associated with an increase in Clostridioides difficile infection (CDI) and recurrent CDI in pediatric patients (Nylund 2014).

Product Availability

As of April 2020, all prescription (including oral and injectable) and OTC ranitidine formulations have been withdrawn from the US market.

Generic Equivalent Available: US

No

Pricing: US

Capsules (raNITIdine HCl Oral)

150 mg (per each): $1.52

300 mg (per each): $2.74

Solution (raNITIdine HCl Injection)

50 mg/2 mL (per mL): $7.73

150 mg/6 mL (per mL): $7.74

1000 mg/40 mL (per mL): $7.16

Solution (Zantac Injection)

50 mg/2 mL (per mL): $9.90

Syrup (raNITIdine HCl Oral)

15 mg/mL (per mL): $0.74

Tablets (raNITIdine HCl Oral)

75 mg (per each): $0.07

150 mg (per each): $1.48 - $1.75

300 mg (per each): $2.69 - $3.22

Tablets (Zantac 150 Maximum Strength Oral)

150 mg (per each): $0.34

Tablets (Zantac 75 Oral)

75 mg (per each): $0.30

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule, Oral:

Zantac C: 150 mg, 300 mg [contains soybean lecithin]

Solution, Injection:

Generic: 25 mg/mL ([DSC])

Solution, Oral:

Generic: 15 mg/mL ([DSC])

Tablet, Oral:

Generic: 150 mg, 300 mg

Administration: Adult

Injection may be administered IM or IV:

IM: Injection is administered undiluted

IV: Must be diluted; may be administered intermittent bolus or intermittent IV infusion

Intermittent bolus: Manufacturer recommends a maximum rate of administration of 10 mg/minute (infuse over at least 5 minutes); however, in adults may also be administered at a maximum rate of 25 mg/minute (or over 2 minutes) if necessary (Coursin 1988; Goelzer 1988; Smith 1987).

Intermittent IV infusion: Administer over a maximum rate of 2.5 to 3.5 mg/minute (infuse over at least 15 to 20 minutes)

Administration: Pediatric

Oral: Administer with meals and/or at bedtime.

Parenteral:

IV: Must be diluted prior to administration; may be administered IV push, intermittent IV infusion, or continuous IV infusion.

Intermittent IV infusion: Preferred over IV push to decrease risk of bradycardia; infuse over 15 to 20 minutes.

IV push: Manufacturer recommends administering over a period of at least 5 minutes, not to exceed 10 mg/minute (4 mL/minute).

Continuous IV infusion: Administer at ordered rate; titration may be necessary for some conditions.

IM: Administer undiluted.

Usual Infusion Concentrations: Adult

Intermittent bolus injection: 50 mg diluted in NS or other compatible IV solution to a maximum concentration of 2.5 mg/mL (20 mL).

Intermittent IV infusion: 50 mg diluted in D5W or other compatible IV solution to a maximum concentration of 0.5 mg/mL (100 mL).

Usual Infusion Concentrations: Pediatric

IV infusion: 0.5 mg/mL

Use: Labeled Indications

Oral:

Gastroesophageal reflux disease: Treatment of gastroesophageal reflux disease (GERD).

Heartburn (OTC only): Relief and prevention of heartburn associated with acid indigestion and sour stomach.

Peptic ulcer disease: Treatment of active duodenal or gastric ulcers.

Injection:

Patients not able to take oral medication: As an alternative to the oral ranitidine dosage form for short-term (eg, GERD, peptic ulcer disease) use in patients who are unable to take oral medication.

Medication Safety Issues
Sound-alike/look-alike issues:

RaNITIdine may be confused with amantadine, riMANTAdine

Zantac may be confused with Xanax, Zantac 360 (famotidine), Zarontin, Zofran, ZyrTEC

Metabolism/Transport Effects

Substrate of CYP1A2 (minor), CYP2C19 (minor), CYP2D6 (minor), OCT1, OCT2, P-glycoprotein/ABCB1 (minor); Note: Assignment of Major/Minor substrate status based on clinically relevant drug interaction potential

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Acalabrutinib: Histamine H2 Receptor Antagonists may decrease the serum concentration of Acalabrutinib. Management: Give acalabrutinib capsules 2 hours before a histamine H2 receptor antagonist (H2RA). No action is required if acalabrutinib tablets are coadministered with H2RAs. Risk D: Consider therapy modification

Atazanavir: Histamine H2 Receptor Antagonists may decrease the serum concentration of Atazanavir. Management: Specific dose limitations and administration guidelines exist; consult full interaction monograph or atazanavir prescribing information. Risk D: Consider therapy modification

Belumosudil: Histamine H2 Receptor Antagonists may decrease the serum concentration of Belumosudil. Risk C: Monitor therapy

Bosutinib: Histamine H2 Receptor Antagonists may decrease the serum concentration of Bosutinib. Management: Administer histamine H2 receptor antagonists (H2RAs) more than 2 hours before or after bosutinib. Risk D: Consider therapy modification

Cefditoren: Histamine H2 Receptor Antagonists may decrease the serum concentration of Cefditoren. Risk X: Avoid combination

Cefpodoxime: Histamine H2 Receptor Antagonists may decrease the serum concentration of Cefpodoxime. Risk C: Monitor therapy

Cefuroxime: Histamine H2 Receptor Antagonists may decrease the absorption of Cefuroxime. Risk X: Avoid combination

Cysteamine (Systemic): Histamine H2 Receptor Antagonists may diminish the therapeutic effect of Cysteamine (Systemic). Risk C: Monitor therapy

Dacomitinib: Histamine H2 Receptor Antagonists may decrease the serum concentration of Dacomitinib. Management: Administer dacomitinib at least 6 hours before or 10 hours after an histamine H2-receptor antagonist (H2RA). Risk D: Consider therapy modification

Dasatinib: Histamine H2 Receptor Antagonists may decrease the absorption of Dasatinib. Management: Antacids (taken 2 hours before or after dasatinib administration) can be used in place of H2-antagonists if some acid-reducing therapy is needed. Risk X: Avoid combination

Delavirdine: Histamine H2 Receptor Antagonists may decrease the serum concentration of Delavirdine. Risk X: Avoid combination

Doxofylline: RaNITIdine (Withdrawn from US Market) may increase the serum concentration of Doxofylline. Risk C: Monitor therapy

Enoxacin: Histamine H2 Receptor Antagonists may decrease the absorption of Enoxacin. Risk C: Monitor therapy

Erlotinib: Histamine H2 Receptor Antagonists may decrease the serum concentration of Erlotinib. Management: Avoid H2-antagonists in patients receiving erlotinib when possible. If concomitant treatment cannot be avoided, erlotinib should be dosed once daily, 10 hours after and at least 2 hours before H2-antagonist dosing. Risk D: Consider therapy modification

Fosamprenavir: Histamine H2 Receptor Antagonists may decrease the serum concentration of Fosamprenavir. Cimetidine may also inhibit the metabolism of the active metabolite amprenavir, making its effects on fosamprenavir/amprenavir concentrations difficult to predict. Risk C: Monitor therapy

Gefitinib: Histamine H2 Receptor Antagonists may decrease the serum concentration of Gefitinib. Management: Administer gefitinib at least 6 hours before or 6 hours after administration of a histamine H2 receptor antagonist (H2RA), and closely monitor clinical response to gefitinib. Risk D: Consider therapy modification

GlipiZIDE: RaNITIdine (Withdrawn from US Market) may increase the serum concentration of GlipiZIDE. Risk C: Monitor therapy

GlyBURIDE: RaNITIdine (Withdrawn from US Market) may enhance the hypoglycemic effect of GlyBURIDE. Risk C: Monitor therapy

Indinavir: Histamine H2 Receptor Antagonists may decrease the serum concentration of Indinavir. Risk C: Monitor therapy

Infigratinib: Histamine H2 Receptor Antagonists may decrease serum concentrations of the active metabolite(s) of Infigratinib. Histamine H2 Receptor Antagonists may decrease the serum concentration of Infigratinib. Management: Avoid coadministration of infigratinib with histamine receptor antagonists (H2RAs) or other gastric acid-lowering agents. If H2RAs cannot be avoided, administer infigratinib 2 hours before or 10 hours after administration of H2RAs. Risk D: Consider therapy modification

Itraconazole: Histamine H2 Receptor Antagonists may increase the serum concentration of Itraconazole. Histamine H2 Receptor Antagonists may decrease the serum concentration of Itraconazole. Management: Administer Sporanox brand itraconazole at least 2 hours before or 2 hours after administration of any histamine H2 receptor antagonists (H2RAs). Exposure to Tolsura brand itraconazole may be increased by H2RAs; consider itraconazole dose reduction. Risk D: Consider therapy modification

Ketoconazole (Systemic): Histamine H2 Receptor Antagonists may decrease the serum concentration of Ketoconazole (Systemic). Management: Administer ketoconazole with an acidic beverage (eg, non-diet cola) and monitor for reduced efficacy if concomitant use with a H2RA is required. Increases in ketoconazole dose may be required. Risk D: Consider therapy modification

Ledipasvir: Histamine H2 Receptor Antagonists may decrease the serum concentration of Ledipasvir. Management: Administer H2 receptor antagonist doses less than or comparable to famotidine 40 mg twice daily simultaneously or 12 hours prior to ledipasvir. The effect of administering H2 receptor antagonists at other time intervals is unknown and not recommended. Risk D: Consider therapy modification

Levoketoconazole: Histamine H2 Receptor Antagonists may decrease the absorption of Levoketoconazole. Risk X: Avoid combination

Lomitapide: RaNITIdine (Withdrawn from US Market) may increase the serum concentration of Lomitapide. Management: Patients taking lomitapide 10 mg/day or more should decrease the lomitapide dose by half with concurrent ranitidine; the lomitapide dose may then be increased to a max adult dose of 30 mg/day (patients on lomitapide 5 mg/day may continue that dose). Risk D: Consider therapy modification

Lumacaftor and Ivacaftor: May decrease the serum concentration of RaNITIdine (Withdrawn from US Market). Lumacaftor and Ivacaftor may increase the serum concentration of RaNITIdine (Withdrawn from US Market). Risk C: Monitor therapy

Nelfinavir: Histamine H2 Receptor Antagonists may decrease serum concentrations of the active metabolite(s) of Nelfinavir. Histamine H2 Receptor Antagonists may decrease the serum concentration of Nelfinavir. Concentrations of the active M8 metabolite may also be reduced. Risk C: Monitor therapy

Neratinib: Histamine H2 Receptor Antagonists may decrease the serum concentration of Neratinib. Specifically, histamine H2 receptor antagonists may reduce neratinib absorption. Management: Administer neratinib at least 2 hours before or 10 hours after administration of a histamine H2 receptor antagonist to minimize the impact of this interaction. Risk D: Consider therapy modification

Nilotinib: Histamine H2 Receptor Antagonists may decrease the serum concentration of Nilotinib. Management: The nilotinib dose should be given 10 hours after or 2 hours before the H2 receptor antagonist in order to minimize the risk of a significant interaction. Risk D: Consider therapy modification

Nirogacestat: Histamine H2 Receptor Antagonists may decrease the serum concentration of Nirogacestat. Risk X: Avoid combination

Octreotide: Histamine H2 Receptor Antagonists may decrease the serum concentration of Octreotide. Risk C: Monitor therapy

PAZOPanib: Histamine H2 Receptor Antagonists may decrease the serum concentration of PAZOPanib. Risk X: Avoid combination

Pexidartinib: Histamine H2 Receptor Antagonists may decrease the serum concentration of Pexidartinib. Management: Administer pexidartinib 2 hours before or 10 hours after histamine H2 receptor antagonists. Risk D: Consider therapy modification

Posaconazole: Histamine H2 Receptor Antagonists may decrease the serum concentration of Posaconazole. Risk C: Monitor therapy

Procainamide: RaNITIdine (Withdrawn from US Market) may increase the serum concentration of Procainamide. Ranitidine may also increase the concentration of the active N-acetyl-procainamide (NAPA) metabolite. Risk C: Monitor therapy

Rilpivirine: Histamine H2 Receptor Antagonists may decrease the serum concentration of Rilpivirine. Management: Administer histamine H2 receptor antagonists (H2RAs) at least 12 hours before or 4 hours after oral rilpivirine. Risk D: Consider therapy modification

Risedronate: Histamine H2 Receptor Antagonists may increase the serum concentration of Risedronate. This applies specifically to delayed-release risedronate. Risk X: Avoid combination

Saquinavir: Histamine H2 Receptor Antagonists may increase the serum concentration of Saquinavir. Management: Consider alternatives to this combination for patients taking the Invirase formulation of saquinavir. No action beyond standard clinical care measures is required for patients taking the Fortovase formulation of saquinavir. Risk D: Consider therapy modification

Secretin: Histamine H2 Receptor Antagonists may diminish the diagnostic effect of Secretin. Specifically, use of H2-Antagonists may cause a hyperresponse in gastrin secretion in response to secretin stimulation testing, falsely suggesting gastrinoma. Management: Avoid concomitant use of histamine H2-antagonists (H2RAs) and secretin. Discontinue H2RAs at least 2 days prior to secretin administration. Risk D: Consider therapy modification

Selpercatinib: Histamine H2 Receptor Antagonists may decrease the serum concentration of Selpercatinib. Management: Coadministration of selpercatinib and H2 receptor antagonists should be avoided. If coadministration cannot be avoided, selpercatinib should be administered 2 hours before or 10 hours after H2 receptor antagonists. Risk D: Consider therapy modification

Sotorasib: Histamine H2 Receptor Antagonists may decrease the serum concentration of Sotorasib. Risk X: Avoid combination

Sparsentan: Histamine H2 Receptor Antagonists may decrease the serum concentration of Sparsentan. Risk X: Avoid combination

Triazolam: RaNITIdine (Withdrawn from US Market) may increase the serum concentration of Triazolam. Risk C: Monitor therapy

Velpatasvir: Histamine H2 Receptor Antagonists may decrease the serum concentration of Velpatasvir. Risk C: Monitor therapy

Warfarin: RaNITIdine (Withdrawn from US Market) may increase the serum concentration of Warfarin. Risk C: Monitor therapy

Food Interactions

Prolonged treatment (≥2 years) may lead to malabsorption of dietary vitamin B12 and subsequent vitamin B12 deficiency (Lam 2013).

Pregnancy Considerations

Ranitidine crosses the placenta (Armentano 1989).

Breastfeeding Considerations

Ranitidine is excreted into breast milk (Riley 1982).

Dietary Considerations

Some products may contain phenylalanine and/or sodium. Oral dosage forms may be taken with or without food.

Monitoring Parameters

AST, ALT, serum creatinine; occult blood with GI bleeding, signs/symptoms of peptic ulcer disease; when used to prevent stress-related GI bleeding, measure the intragastric pH and try to maintain pH >4; when used for Zollinger-Ellison syndrome, monitor gastric acid secretion (goal: <10 mEq/hour); signs of confusion

Mechanism of Action

Competitive inhibition of histamine at H2-receptors of the gastric parietal cells, which inhibits gastric acid secretion, gastric volume, and hydrogen ion concentration are reduced. Does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion, or serum gastrin.

Pharmacokinetics (Adult Data Unless Noted)

Absorption: Oral: 50%; IM: Rapid

Distribution: Vd: Minimally penetrates the blood-brain barrier

Infants, Children, and Adolescents: IV, Oral: 1 to 2.3 L/kg

Adults: Normal renal function: ~1.4 L/kg; CrCl 25 to 35 mL/minute: 1.76 L/kg

Protein binding: ~15%

Metabolism: Hepatic (minor) to N-oxide, S-oxide, and N-desmethyl metabolites

Bioavailability: Oral tablets: ~50%; IM: 90% to 100%

Half-life elimination:

Neonates (receiving ECMO): IV: 6.6 hours

Infants, Children, and Adolescents: IV: 1.7 to 2.4 hours

Adults:

Oral: Normal renal function: 2.5 to 3 hours; Elderly: 3 to 4 hours

IV: Normal renal function: 2 to 2.5 hours; CrCl 25 to 35 mL/minute: 4.8 hours; Elderly: 3.1 hours

Time to peak, serum: Oral: 2 to 3 hours; IM: ≤15 minutes

Excretion: Urine (as unchanged drug): Oral: 30%, IV: 70%; feces (as metabolites)

Pharmacokinetics: Additional Considerations (Adult Data Unless Noted)

Altered kidney function: Plasma half-life, clearance, and volume of distribution are all altered in proportion to creatinine clearance.

Hepatic function impairment: Plasma half-life, clearance, and volume of distribution are all altered in proportion to creatinine clearance.

Pediatric: In pediatric cardiac failure, clearance may be reduced. In a prospective population pharmacokinetic study of critically ill pediatric patients (n=78; age range: 15 days to 15.51 years), cardiac failure/surgery was found to reduce clearance by a factor of 0.463 (Hawwa 2013).

Older adult: Total clearance is lowered.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Antagonin | Apo ranitidine | Glotac | Histac | Nadine | Novo-ranidine | Pylorid | Ranacid | Ranid | Ranidine | Ranimax | Ranimed | Ranitcare | Rantag | Ranzin | Zantac;
  • (AR) Argentina: Acidex | Alivian | Dualid | Espaven | Espaven Extra Forte | Faboacid r | Fada ranitidina | Fendibina | Gastrial | Gastrosedol | Gastrozac | Labsidex | Notrab | Pylorid | Ranitic | Ranitidina celtyc | Ranitidina denver farma | Ranitidina ilab | Ranitidina lazar | Ranitidina millet | Ranitidina Pharma | Ranitidina Rigo | Ranitidina unc | Ranitidina vent 3 | Ranitral | Ranitul | Raticina | Reco | Sustac | Taural | Teogrand | Ulcotenk | Vingional | Zantac;
  • (AT) Austria: Pylorisin | Ranic | Raninorm | Ranitidin 1a pharma gmbh | Ranitidin Accord | Ranitidin arcana | Ranitidin genericon pharma | Ranitidin Ranbaxy | Ranitidin ratiopharm | Ranitidin Sandoz | Ranitidin stada arzneihmittel gmbh | Ranityrol | Ulsal | Zantac;
  • (AU) Australia: Acid & heart burn | Amcal heartburn relief | Apo ranitidine | Apohealth ranitidine acid & heartburn relief | Ausran | Biochemie heartburn relief | Cm acid&heartburn | Cm ranitidine | CO Ranitidine | Dbl ranitidine | Gastrogel ranitidine | Gavilast | Gavilast 12 hour action | Heartburn relief | Medix | Mylanta | Mylanta 12 hour | Pharmacy action heartburn & acid indigestion relief | Pharmacy care heartburn relief | Pharmacy health reflux relief | Rani | Ranihexal | Ranital | Ranitidine | Ranitidine an | Ranitidine gh | Ranitidine sandoz | Ranitidine-bc | Ranoxyl | Sbpa ranitidine | Tw acid&h/burn rlf | Tw ranitidine | Ulcaid | Ultac | Zantac | Zantac relief;
  • (BD) Bangladesh: Aceptin R | Acin | Alin | Amuran | Anitid | Antac | Antamin-R | Bentid | Bitack | Centac | Ceptin r | Denitid | Denitine | Detac | Dimeran | Dugal | Duran | Editin-r | Ethidin | Exac | G-ranitidin | H blok | Hi-Tac | Inran | Inseac | Lucin-r | Lumeran | Mystin-r | Neoceptin r | Neodin | Neodin-s | Neofast-s | Neopep | Neosetin R | Neotack | Neotid | Neotidin | Neotin | Norma-H | Normacid | Off h | Ortac | Peotide | Peptidin | Peptil h | Peptosol | Protec-r | Q-ran | Radin | Ranbex | Rani | Ranicare | Ranid | Ranidin | Raniloc | Ranisis | Ranison | Ranit | Ranitab | Ranitack | Ranitec | Ranitid | Ranitidine | Ranitidine-r | Ranitor | Ranix | Rantec | Rantin | Ranul | Recodin | Redin | Reetac-R | Renicon | Rhine | Rn | Rostid | Rotid | Rt | Sutac | Tinadin | Tytac | Ulcar | Ultac | Unitac | Veridin | Wintack | Xantid | Xantid hs | Xardin | Z-ranid | Zactin | Zantac | Zenil | Zodin | Zorep | Zostac;
  • (BE) Belgium: Docraniti | Pylorid | Ranitidine bexal | Ranitidine eurogenerics | Ranitidine merck-generics | Ranitidine Ratiopharm | Ranitidine sandoz | Ranitidine teva | Zantac;
  • (BF) Burkina Faso: Rani denk;
  • (BG) Bulgaria: Histac | Raniberl | Ranitidin | Razidin | Zantac;
  • (BR) Brazil: Antagon | Antak | Antidin | Aziliv | Bloculcer | Cloridrato de ranitidina | Ethenem | Gastak | Genotak | Iquego ranitidina | Label | Lfm ranitidina | Logat | Neosac | Nititom | Pylorid | Ramifabra | Raniclor | Ranidin | Ranidina | Ranidine | Ranidolim | Raniflex | Ranilup | Ranimax | Ranitak | Ranitidil | Ranitidina | Ranitil | Ranitinol | Ranition | Ranitrat | Ranitzen | Ranytisan | Regalil | Rhanitak | Tazepin | Tekadin | Ulcerit | Ulcerocin | Ulcoren | Zadine | Zylium;
  • (CH) Switzerland: Ranimed | Ranisifar | Ranitidin cophar | Ranitidin-mepha | Zantic;
  • (CI) Côte d'Ivoire: Acidac | Rani denk | Ranimat | Zynol;
  • (CL) Chile: Ranicel | Ranitax | Ranitidina | Uldine | Zantac;
  • (CN) China: Dong yi | Ge lai shi | Histac | Jin de le | Lan bai xing | Ou hua da | Pylorid | Qi di | Ranitidine | Ranitidine hydrochloride and sodium chloride | Ranitidine hydrochloride in sodium chloride | Rui bei | Shan de kang | Shang wei | Xi si da | Xi si ta | Yi li shu | Zantac;
  • (CO) Colombia: Azanplus | Clorimed | Gastrelin | Peptiran | Ragastro | Raldin | Rancet | Raniclorh | Ranidin | Ranidox | Ranimed | Raniogas | Ranipep | Raniphar | Ranisul | Raniter | Ranitidina | Ranitidina mk | Ranitil | Regastin | Reycid | Ul-pep | Ulcuran | Uldin | Ulpigas | Ultidin | Zantac;
  • (CZ) Czech Republic: Apo ranitidine | Eradipak | Histac | Ranisan | Ranital | Ranitidine aurovitas | Ulran | Zantac;
  • (DE) Germany: Azantac | Azuranit | Junizac | Milinda rani-nerton | Phamoranit | Ran lich | Rani | Rani biochemie | Rani nerton | Rani sanorania | Raniberl | Ranibeta | Ranibloc | Ranicux | Ranidura | Ranidura t | Raniprotect | Ranitab | Ranitic | Ranitidin | Ranitidin 1a pharma | Ranitidin atid | Ranitidin AWD | Ranitidin axsan | Ranitidin basics | Ranitidin Heumann | Ranitidin Heumann Heunet | Ranitidin ratiopharm | Ranitidin Siga | Ranitidin stada | Ranitidin-Isis | Ranitidin-saar | Ranitidoc | Raniwieb | Sostril | Zantic;
  • (DK) Denmark: Acikure | Ranicodan | Ranitidin ratiopharm;
  • (DO) Dominican Republic: Apoprin | Durak | Fendibina | Pylorid | Ran H2 | Randil | Ranifur | Ranilap | Raniogas | Ranisen | Ranitidina | Ranitidina cinfa | Ranitidina normon | Taural | Tiroran | Ulciflax | Ulgasin | Ulsana | Zantac;
  • (EC) Ecuador: It Ranichem | Libradina | Nitidan | Pylorid | Radinat | Ranicid | Raniogas | Ranitab | Ranitidina | Ranitidina genfar | Ranitidina mk | Ranitidina R | Stomacid | Taural | Tiroran | Zantac;
  • (EE) Estonia: Acidex | Kuracid | Pylorid | Raniberl | Ranideks | Ranigast | Ranisan | Ranitidin | Ranitidin alpharma | Ranitidin ratiopharm | Ranitidine accord | Zantac;
  • (EG) Egypt: Aciloc | Epiran | Gastproct | Gastroprotect | Histac | Osmoran | Pylorid | Ranicap | Ranitak | Ranitidine | Ranitidol | Rantag | Rantiblock | Rantidine | Rantidol | Zantac;
  • (ES) Spain: Arcid | Ardoral | Coralen | Denulcer | Quantor | Ran H2 | Ranidin | Ranitidina aurovitas | Ranitidina bexal | Ranitidina Edigen | Ranitidina grapa | Ranitidina grifols | Ranitidina lareq | Ranitidina mabo | Ranitidina merck | Ranitidina mundogen | Ranitidina normon | Ranitidina Pensa | Ranitidina pharmagenus | Ranitidina Ratiopharm | Ranitidina tarbis | Ranitidina Teva | Ranitidina vir | Ranix | Ranuber | Rubiulcer | Tanidina | Terposen | Toriol | Underacid | Zantac;
  • (ET) Ethiopia: Rani denk | Ranitidine | Ranitol | Rantag | Zantac;
  • (FI) Finland: Esofex | Pylorid | Ranicur | Ranicur gerard | Ranil | Ranimex | Ranisan | Ranitidin alpharma | Ranitidin merck nm | Ranitidin pliva | Ranitidin stada | Ranitidine ranbaxy | Ranitidine sandoz | Ranixal | Zantac;
  • (FR) France: Azantac | Raniplex | Ranitidine | Ranitidine accord | Ranitidine Biogaran | Ranitidine g gam | Ranitidine gnr | Ranitidine ivax | Ranitidine merck | Ranitidine Ratiopharm | Ranitidine RPG | Ranitidine sandoz | Ranitidine teva;
  • (GB) United Kingdom: Dumoran | Galpharm ranitidine | Gavilast | Gavilast-p | Heartbur antacid | Histac | Peach Ethical | Pylorid | Raciran | Ranicalm | Ranitic | Ranitidine | Ranitidine almus | Ranitidine arrow | Ranitidine cox | Ranitidine kent | Ranitidine sandoz | Ranitil | Rantec | Ranzac | Vivatak | Zaedoc | Zantac | Zantac 75;
  • (GR) Greece: Alphadine | Aova | Baroxal | Blumol | Brixoral | Ceftrinal | Ezopta | Galebiron | Gaproxen | Lomadryl | Lumaren | Narigen | Odanet | Ptinolin | Pylorid | Raniclon | Ranitidine | Ranitidine/Generics | Ranitidine/mylan | Semuele | Smaril | Specinor | Synthomanet | Tupast | Zantac | Zoliden | Zurfix;
  • (HK) Hong Kong: Apo ranitidine | Eurotac | Glotac | Hyzan | Kanacid | Karitidine | Kin pak | Lumeran | Neo tac | Pylorid | Quicran | Radin | Ranatec | Randac | Ranicone | Ranidine | Ranital | Ranitid | Ranitidina cinfa | Ranitidine | Ranolta | Rantacid | Rantin | Simetac | Ulticer | Uni-Rantac | Vesyca | Weicotac | Weidos | Zantac | Zanticaine | Zantidon | Zendhin;
  • (HR) Croatia: Bloculcer | Peptoran | Peptoran MAX | Ranital | Ranitidin Europharma | Ranitidin lek | Ranitidin Sandoz | Ranix | Rantin;
  • (HU) Hungary: Histac | Huma-ranidine | Pylorid | Ranitic | Ranitidin 1 A Pharma | Ranitidin-b | Ulceran | Ulcosin | Umaren | Zantac;
  • (ID) Indonesia: Aciblock | Acran | Aldin | Bloxer | Chopintac forte | Conranin | Curadyn | Fordin | Gastridin | Graseric | Harmidin | Hexer | Indoran | Omeramine | Radin | Ranal | Rancus | Ranilex | Ranin | Ranitab | Ranitidin | Ranitidine | Ranivel | Ranoxin | Rantag | Ranticid | Rantin | Ratinal | Renatac | Scanarin | Titan | Tricker-150 | Tyran | Ulceranin | Uldinal | Wiacid | Xeradin | Zantac | Zantadin | Zantifar | Zenti | Zumaran;
  • (IE) Ireland: Gertac | Pylorid | Ranitic | Ranitidine | Ranopine | Xanomel | Zandine | Zantac;
  • (IL) Israel: Apozan | Zanidex | Zantab | Zantac;
  • (IN) India: Aciloc | Aciran | Acirid | Agiloc | Alprodine | Alurin | Antac | Aztec | Dentac | Din | Emeltidine | Emtac | Gertac | Giran | H2loc | Healcer | Helkoss | Histac | Intac | Kamtac | Kaytec | Lydin | Monorin | Natidine | Nicotac | Nit | Peploc | R-loc | Rafilon | Rancafe | Rancer | Randinat | Ranial | Ranibid | Ranicer | Ranicom | Ranicool | Ranilink | Ranimax | Ranin | Ranipep | Ranisun | Ranit | Ranitas | Raniter | Ranitidine | Ranitidine HCL | Ranitin | Ranizac | Ranizen | Ranloc | Ranpep | Rantac | Rantica | Rd | Rdin | Relitin | Renact | Renicret | Renitab | Ridcer | Rintin | Rintric | S.tac | Saintac | Tidac | Tydin | Ulceran | Ulfast | Ultac | Ultidin | Z-ran | Zinetac | Zoran | Zynol | Zytak;
  • (IT) Italy: Dolilux | Elicodil | Pylorid | Raniben | Ranibloc | Ranidil | Ranitidina | Ranitidina Angenerico | Ranitidina D&G | Ranitidina doc | Ranitidina DRM | Ranitidina eg | Ranitidina Hexal | Ranitidina Ibirn | Ranitidina jet | Ranitidina Magis | Ranitidina Merck Generics | Ranitidina new | Ranitidina Pantafarm | Ranitidina Ranbaxy | Ranitidina sandoz | Sensigard | Ulcex | Zantac;
  • (JO) Jordan: Antagonin | Nadine | Peptac | Pylorisin | Ranacid | Ranid | Ranidine | Zantac;
  • (JP) Japan: Braulibera | Hatsker | Lanizac | Lantic | Raden | Raitadin | Ranimerck | Ranitac | Ranitidine | Ranitizane | Ranitizane amel | Seochitozin | Tsurudek | Zamec | Zantac;
  • (KE) Kenya: Aciloc | Neotack | R loc | Rancer | Rani denk | Ranison | Ranitidine agio | Ranitin | Rantac | Rantag | Reducid | Renitab | Rinatadin | Ultac | Zantac | Zerocid;
  • (KR) Korea, Republic of: Alsanon | Anitin | Aprogen ranitidine | Austin ranitidine hcl | Barogrin | Bc ranitidine | Bitidine | Camillan | Camilran | Celtidin | Cudin | Curan | Curitin | Curodine | Dactel | Duractin | Eltidine | Exta f | Gadin | Garantine | Gastidine | Gi-easy | Gl ranitidine | Hunitin | Huran | Hutecs ranitidine | I ran | I ranitidine | Ilyangbio ranitidine | Inotidine | Jan q pro | Jeidin | Jeil maxtidin plus | Jenitin | Jera q | Jinradine | Katiring | Keibitidine | Kms ranitidine | Kwangdong ranitidine | Kyongbo ranitidine | Locid | Luratin | Marutin | Medira | Megatin | Nelson ranitidine | Neotidine | Panstac | Pharmgen ranitidine | Ponaltin | Pylorid | Qutidin | Racidine | Radin q | Radine | Raditine | Radubadine | Ranacid | Randin | Rani s | Ranibic | Ranibig | Ranid | Ranidan | Ranidin | Ranidine | Ranidon | Ranidone | Ranikim | Raniking | Ranil | Ranis | Ranisca | Ranisen | Ranitac | Raniten | Ranitid | Ranitidine | Ranitidine hyosung | Ranitiem | Ranitigen | Ranitina | Ranition | Ranitiran gold | Ranitop | Ranix | Ranizan | Rantin | Rantine | Rantis | Raticon | Ratigen | Ratinnis | Ratudin | Renitine | Restidine | Ribotin | Rp ranitidine hcl | Rtd | Samnam ranitidine | SCD Ranitidine | Scheinedin | Tarana | Tinatin | Tinoq | Tritin | U-rantac | Ulcemed | Unidin | Urantac | Winatac | Wiradin | Wizan | Wontac | Wooritin | Xansiq | Xantas f | Youngpoong ranitidine | Yuhan ranitidine hcl | Zan q 75 | Zanci-Q | Zancid L | Zandark | Zani q | Zanstin | Zantac | Zatidine | Zellatidine | Zenitin | Zenix | Zyniq;
  • (KW) Kuwait: Apo ranitidine | Glotac | Navidine | Pylorid | Ranacid | Ranid | Ranitcare | Rantag | Rantin | Zantac;
  • (LB) Lebanon: Antagonin | Glotac | Nadine | Ptinolin | Pylorid | Ranacid | Ranicux | Ranimat | Raniplex | Ranitidine | Rantag | Ulticer | Zantac;
  • (LT) Lithuania: Acidex | Aciloc e | Apo ranitidine | Histac | Pylorid | Raniberl | Raniday | Ranigast | Ranisan | Ranitab | Ranital | Ranitidin | Ranitidin al | Ranitidin bp | Ranitidina normon | Ranitidine accord | Ranitidine siromed | Rantac | Ulcosan | Ulran | Zantac | Zoran;
  • (LU) Luxembourg: Docraniti | Pylorid | Ranitic | Ranitidine eg | Ranitidine mylan | Zantac;
  • (LV) Latvia: Acidex | Aciloc | Histac | Raniberl | Ranidex | Ranigast | Ranitab | Ranital | Ranitidin | Ranitidina | Ranitidine accord | Ranitidinum | Ranitin | Rantac | Ultak | Zantac | Zoran;
  • (MA) Morocco: Acidac | Azantac | Pylorid | Ranimat | Ranitil | Tanidine | Xanidine;
  • (MX) Mexico: Acloral | Acloral b.i. | Agrisen | Alter h2 | Apodatina | Azanplus | Azantac | Azantac f | Deratin | Dinaxin | Driges | Ducan | Durak | Estoradin | Flatmed | Galidrin | Gastridin | Genotidina | Iqfadina | Katalem | Microtid | Radyn | Ranifur | Raniger | Ranisen | Ranitab | Ranitidina | Ranitidina avivia | Ranitidina gi | Ranitidina gi leme | Ranitidina gi phar | Ranitidina gi serr | Ranitidina Kendrick | Ranitidina Wermar | Ranitinida | Raudil | Redacid | Serranit | Sinhcloran | Solrasol | Syngasy | Terodul | Tianak | Tidibuffin | Ulmodhyl | Ulsaven | Unitin | Vistac;
  • (MY) Malaysia: Apo ranitidine | Gastril | Histac | Hyzan | Ranitic | Ranitidine | Rantac | Rintac | Vesyca | X'tac | Xanomel | Zantac | Zendhin;
  • (NG) Nigeria: Aciloc | Ranivan | Softhealth ranitidine | Timetidine | Topix ranitidine | Zaridex;
  • (NL) Netherlands: Azantac | Pylorid | Ranitidine | Ranitidine A | Ranitidine accord | Ranitidine cf | Ranitidine mdq | Ranitidine teva | Zantac;
  • (NO) Norway: Pylorid | Ranacid | Ranitidin | Ranitidin al | Ranitidin gea | Ranitidine | Ranitidine accord | Ranitidine rosemont | Ranitidine sandoz | Zantac | Zantac euromedica;
  • (NZ) New Zealand: Apo ranitidine | Arrow-ranitidine | Gavilast | Peptisoothe | Ranitidine relief | Zanidin | Zantac | Zantac relief;
  • (OM) Oman: Zantac;
  • (PE) Peru: Aciflux | Atural | Galtidin | Gastriflam | Histac | Ranifur | Ranimek | Ranit | Ranitax | Ranitidina | Ulceran | Ulcip | Zantac;
  • (PH) Philippines: Amloc | Boie ranitidine | Ceranid | Contracid | Cygran | Entac | Eu-ran | Gastrone | Incid | Intac | Mordek | Pep Bloc | Peptica | Pylorid | Radine | Ramadine | Ranae | Ranid | Ranitab | Ranitein | Ranix | Rapidin | Ratidin | Raxide | Renfort | Ritemed Ranitidine | Ulcemed | Ulceragon | Ulceral | Ulcergo | Ulcerix | Ulci bloc | Ulcin | Ulzim | Zantac | Zidaxim | Zilatec;
  • (PK) Pakistan: Adetac | Anzol | Certine | Dart | Degust | Dinetac | Duotec | Glamet | H2 rec | Hitac | Lomadryl | Melfax | Mifotec | Neotack | Nilcer | Nitid | Nulcer | Obatidine | Peptac | Pepticure | Peptinil | Purod | Rakitac | Ramedac | Ranacid | Ranax | Rancer | Ranidin | Ranidol | Raniloc | Ranimax | Ranimed | Ranin | Ranipep | Raniscot | Ranison | Ranizan | Rantid | Rantin | Ranulcid | Ratac | Reliance | Renacid | Renata | Renatil | Reneph | Renera | Ritadine | S cid | Stomacid | Tanidina | Ulcemed | Ulcenor | Ulcer Off | Ulcerid | Ulcetac | Ultec | Ulzan | Xancid | Xetac | Zantac | Zantidon | Zenit;
  • (PL) Poland: Apo ranitidine | Histac | Novo-ranidine | Raniberl | Raniberl max | Ranic | Ranigast | Ranigast max | Ranigast pro | Ranimax | Ranisan | Ranital | Ranitin | Ranitydyna | Ranitydyna aurovitas | Riflux | Zantac;
  • (PR) Puerto Rico: Acid reducer | Gabitidine | Ranitidine | Ranitidine HCL | Tritec | Zantac;
  • (PT) Portugal: Bloculcer | Gastridina | Gastrimuto | Gastrolav | Pep Rani | Peptab | Peptifar | Pylorid | Ran | Ranitidina | Stacer | Ulcecur | Zantac;
  • (PY) Paraguay: Ranitidina genfar | Ranitidina vent 3 | Teogrand;
  • (QA) Qatar: Acicare | Antagonin | Apo-Ranitidine | Glotac | Nadine | Navidine | Peptac | Qranid | Ragasit | Ranacid | Rani-nerton | Ranid | Ranidine | Ranimax AC | Ranitak | Ranitidine Mabo | Rantag | Rolan | Zantac | Zydac;
  • (RO) Romania: Digen | Ranitab | Ranital | Ranitidin | Ranitidin helcor | Ranitidin Ranbaxy | Ranitidina arena | Ranitidina atb | Ranitidina Laropharm | Ranitidina lph | Ranitidina slavia | Ranitin | Ulcoran | Zantac;
  • (RU) Russian Federation: Acidex | Aciloc e | Histac | Novo ranitidine | Pylorid | Raniberl | Ranigast | Ranisan | Ranison | Ranitab | Ranital | Ranitidin | Ranitidin akri | Ranitidin Olainfarm | Ranitidine | Ranitidine akos | Ranitidine ferein | Ranitidine lekt | Ranitin | Rantac | Rantak | Renx | Ulcodin | Zantac | Zantin | Zoran;
  • (SA) Saudi Arabia: Acicare | Antagonin | Apo ranitidine | Glotac | Nadine | Navidine | Novo-ranidine | Peptac | Pms ranitidine | Pylorid | Ranacid | Ranid | Ranidin | Ranidine | Ranimax | Ranimax ac | Rantag | Ranzin | Tanidina | Zydac;
  • (SE) Sweden: Artonil | Inside | Rani-q | Ranitidin actavis | Ranitidin alpharma | Ranitidin apofri | Ranitidin Hexal | Ranitidin medartuum | Ranitidin mylan | Ranitidin nm pharma | Ranitidin pliva | Ranitidin ratiopharm | Ranitidin recip | Ranitidin stada | Ranitidine ranbaxy | Zantac;
  • (SG) Singapore: Aciloc | Apo ranitidine | Histac | Hyzan | Neoceptin r | Pylorid | Radine | Rani denk | Ranidine | Ranitidina | Ranitidine | Sp-gastril | Vesyca | Xanadine | Zantac | Zendhin | Zynol;
  • (SI) Slovenia: Pylorid | Ranital | Ulran | Zantac;
  • (SK) Slovakia: Histac | Ranisan | Ranital | Zantac;
  • (TH) Thailand: Acicare | Aciloc | Apo ranitidine | Histac | Oltak | Pylorid | Radine | Ranicid | Ranid | Ranidine | Ranitidine | Rantac | Ranto | Rantodine | Ratic | Utac | Xanidine | Zanamet | Zantac | Zantidon;
  • (TN) Tunisia: Antagonine | Tanidina;
  • (TR) Turkey: Pylorid | Ranit | Ranobel | Rozon | Ulcuran | Zandid | Zantac;
  • (TW) Taiwan: Apo ranitidine | Curan | Getway | Kiradin | Kowecan | Nicewe | Novo-ranidine | Quicran | Ranidine | Ranitidine | Rannine | Rnd | Sontac | Ulsafe | Vesyca | Weichilin | Weidos | Wintac | Zantac;
  • (UA) Ukraine: Acidex | Aciloc e | Histac | Raniberl | Ranitidin | Ranitidine | Ranitidine forte | Ranitin | Rantac | Rinit | Umetak | Zantac | Zoran;
  • (UG) Uganda: R loc | Rani denk;
  • (UY) Uruguay: Acigastrol | Acitran | Binacil | Binacil-s | Lunadina | Miniac | Nulacid | Ranitidina | Ranitidina lazar | Ranitidina Phs Pharmaservice | Sustac | Taural | Zantac;
  • (VE) Venezuela, Bolivarian Republic of: Aplom | Enteral | Gastac | Pylorid | Ranic | Ranitidina | Ranitidina G.C. | Ranix | Retamin | Ultidine | Vizerul | Zantac | Zoran;
  • (VN) Viet Nam: Kantacid;
  • (ZA) South Africa: Apex ranitidine | Apo ranitidine | Austac | Be-tabs ranitidine | Cpl alliance ranitidine | Garec-Ranitidine | Gi-tak | Gulf ranitidine | Histak | Ranihexal | Ranitidine | Ranitidine biotech | Ranteen | Simayla ranitidine | Ultak | Zantac;
  • (ZM) Zambia: Aciloc | R-loc | Rani denk | Ranitin | Ranloc | Rintid | Ultac;
  • (ZW) Zimbabwe: Ranitin | Zynol
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