Medication classes and specific medications | Combined hormonal contraceptive | Progesterone-only pill | DMPA |
Immunosuppressive |
Mycophenolate | - Not recommended
- May decrease efficacy of combined hormonal contraceptive
| | |
Cyclosporine | - Use with careful follow-up
- May increase cyclosporine level
| | |
Glucocorticoid | - Use with careful follow-up
- May increase glucocorticoid level
| | |
Anticoagulant |
Warfarin | - Avoid or use with careful follow-up
- Reduces effect of warfarin
| - Use with careful follow-up
- Unknown
| - Use with careful follow-up
- Unknown
|
Antiseizure medications |
Barbiturates | - Not recommended
- Decreases efficacy of combined hormonal contraceptive
| | |
Carbamazepine | - Not recommended
- Decreases efficacy of combined hormonal contraceptive
| | |
Oxcarbazepine | - Not recommended
- Decreases efficacy of combined hormonal contraceptive
| | |
Topiramate | - Not recommended
- Decreases efficacy of combined hormonal contraception
| | |
Phenytoin | - Not recommended
- Increases phenytoin concentration and decreases efficacy of combined hormonal contraceptive
| | |
Lamotrigine | - Not recommended
- Decreases lamotrigine concentration
| | |
Other medications |
Modafinil | - Not recommended
- Decreases efficacy of combined hormonal contraceptive
| | |
Potassium-sparing diuretics | - Use with careful follow-up
- Hyperkalemia risk with drospirenone-containing combined hormonal contraceptive
| | |