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Selenium sulfide: Drug information

Selenium sulfide: Drug information
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For additional information see "Selenium sulfide: Patient drug information" and "Selenium sulfide: Pediatric drug information"

For abbreviations, symbols, and age group definitions show table
Brand Names: US
  • Anti-Dandruff [OTC];
  • GoodSense Dandruff Shampoo [OTC];
  • SelRx [DSC]
Pharmacologic Category
  • Antiseborrheic Agent, Topical;
  • Topical Skin Product
Dosing: Adult
Dandruff, scalp seborrhea

Dandruff, scalp seborrhea: Topical:

Lotion 2.5%, shampoo (2.25%, 2.3%): Massage ~5 to 10 mL into wet scalp; leave on scalp for 2 to 3 minutes, then rinse scalp thoroughly. Repeat application and rinse thoroughly. Usually 2 applications each week for 2 weeks will provide control. After this, may repeat at less frequent intervals (eg, once weekly, every 2 to 4 weeks).

Shampoo (OTC 1%): Massage shampoo into wet scalp then rinse thoroughly. Use at least twice weekly for best results.

Tinea versicolor

Tinea versicolor (pityriasis versicolor): Topical:

Lotion 2.5%, shampoo (2.25%, 2.3%): Apply to affected area(s) and lather with small amounts of water; leave on skin for 10 minutes, then rinse thoroughly. Repeat once daily for 7 days (Ref).

Dosing: Kidney Impairment: Adult

There are no dosage adjustments in the manufacturer's labeling.

Dosing: Liver Impairment: Adult

There are no dosage adjustments in the manufacturer's labeling.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Selenium sulfide: Pediatric drug information")

Dandruff, scalp seborrhea

Dandruff, scalp seborrhea:

Lotion (2.5%): Children and Adolescents: Topical: Massage 5 to 10 mL into wet scalp, leave on scalp 2 to 3 minutes, and rinse thoroughly. Repeat application and rinse thoroughly. Usually, 2 applications each week for 2 weeks will provide control; after this, may repeat at less frequent intervals (eg, once weekly, every 2 to 4 weeks).

Shampoo (1%, 2.25%, 2.3%): Children and Adolescents: Limited data available in Children <12 years: Topical: Massage shampoo into wet scalp and rinse thoroughly. Use at least twice weekly for 2 weeks, followed by less frequent application (eg, once weekly); use only as frequently as necessary to maintain control (Ref).

Tinea capitis, adjunctive therapy

Tinea capitis (scalp ringworm), adjunctive therapy: Limited data available: Note: Tinea capitis requires systemic therapy to reach hair follicles; topical therapy may be added as adjunctive therapy to reduce shedding and prevent recurrence (Ref).

Children and Adolescents: Lotion (2.5%), Shampoo (1%, 2.25%, 2.3%): Topical: Apply to the scalp and hair for 5 to 10 minutes two to three times weekly; use in combination with a systemic agent for at least 2 weeks; some continue topical therapy throughout duration of systemic therapy (Ref).

Tinea versicolor

Tinea versicolor (pityriasis versicolor):

Lotion (2.5%): Children and Adolescents: Topical: Apply to affected area and lather with a small amount of water; leave on skin for 10 minutes, then rinse thoroughly; apply once daily for 7 days. Once control is achieved, may apply weekly or monthly to prevent recurrence (Ref).

Shampoo (2.25%, 2.3%): Limited data available: Children and Adolescents: Topical: Apply to affected area and let sit for 5 to 10 minutes, then rinse off. Apply once daily for 3 to 7 days. Once control is achieved, may apply weekly or monthly to prevent recurrence (Ref).

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments in the manufacturer's labeling.

Dosing: Liver Impairment: Pediatric

There are no dosage adjustments in the manufacturer's labeling.

Adverse Reactions

The following adverse drug reactions are derived from product labeling unless otherwise specified.

Postmarketing:

Dermatologic: Hair discoloration, skin discoloration (scalp) (Gilbertson 2012), thinning hair

Local: Application-site irritation

Contraindications

Hypersensitivity to selenium sulfide or any component of the formulation.

Warnings/Precautions

Concerns related to adverse effects:

• Local effects: Skin irritation or sensitization may occur; discontinue use if irritation or sensitivity occurs.

Other warnings/precautions:

• Appropriate use: For external use only; not for ophthalmic, oral, anal or intravaginal use. Due to the risk of systemic toxicity, do not use when acute inflammation or exudation is present or on damaged skin or mucous membranes.

• Self-medication (OTC use): Shampoo: When used for self-medication, contact a health care provider before use if the seborrheic dermatitis is in other areas other than the scalp. Discontinue use and contact a healthcare provider if condition worsens or does not improve after regular use.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Lotion, External:

GoodSense Dandruff Shampoo: 1% (325 mL) [contains fd&c blue #1 (brilliant blue), menthol]

Generic: 2.5% (118 mL, 120 mL)

Shampoo, External:

Anti-Dandruff: 1% (207 mL) [contains fd&c blue #1 (brilliant blue), menthol]

SelRx: 2.3% (180 mL [DSC]) [contains fd&c red #40 (allura red ac dye), methylparaben, propylene glycol, propylparaben]

Generic: 2.25% (180 mL); 2.3% (180 mL)

Generic Equivalent Available: US

Yes

Pricing: US

Lotion (Selenium Sulfide External)

2.5% (per mL): $0.17

Shampoo (Selenium Sulfide External)

2.25% (per mL): $0.88 - $0.91

2.3% (per mL): $3.10 - $3.11

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Topical: Shake well before using. For external use only; not for ophthalmic, oral, anal or intravaginal use. Do not use when acute inflammation or exudation is present or on damaged skin or mucous membranes. For color treated or permed hair, it is especially important to rinse hair thoroughly after treatment. May damage jewelry; remove before treatment.

Administration: Pediatric

Topical: For external topical use only; not for ophthalmic, oral, anal, or intravaginal use. May damage jewelry; remove before treatment.

Lotion: Shake products well prior to use. Do not apply to acutely inflamed or broken skin or on mucous membranes.

Shampoo: Shake well before use. Do not apply to acutely inflamed or broken skin or on mucous membranes. Apply to wet scalp and hair for appropriate duration of time (based on indication), then rinse thoroughly; for color-treated or permed hair, it is especially important to rinse hair thoroughly after treatment.

Hazardous Drugs Handling Considerations

Hazardous agent; use appropriate precautions for handling and disposal (EPA, U-listed).

Use: Labeled Indications

Dandruff, scalp seborrhea: Treatment of dandruff and seborrheic dermatitis of the scalp

Tinea versicolor (pityriasis versicolor): Treatment of tinea versicolor

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Animal reproduction studies have not been conducted. The manufacturer's labeling for some products recommend against using selenium sulfide in pregnant women.

Breastfeeding Considerations

It is not known if selenium sulfide is present in breast milk following topical application. The manufacturer recommends that caution be exercised when administering selenium sulfide to breastfeeding women.

Mechanism of Action

May block the enzymes involved in growth of epithelial tissue

Pharmacokinetics (Adult Data Unless Noted)

Absorption: Topical: None through intact skin, but can be absorbed through damaged skin

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Selsun;
  • (AR) Argentina: Selegel | Selsun azul;
  • (AT) Austria: Selsun | Selukos;
  • (AU) Australia: Selsun | Selsun blue;
  • (BE) Belgium: Selsun;
  • (BG) Bulgaria: Sebomax | Selsun;
  • (BR) Brazil: Caspacil | Selen hair ouro;
  • (CL) Chile: Selsun blue;
  • (CN) China: Xi er sheng;
  • (DE) Germany: Dermasence selensiv | Selukos;
  • (DO) Dominican Republic: Bioselenium | Selsun | Selsun azul | Selsun gold for women;
  • (EC) Ecuador: Selsun | Selsun blu;
  • (EG) Egypt: Selsun blue | Sulfiselen;
  • (FI) Finland: Sebusan | Selsorin | Selsun | Selukos;
  • (GB) United Kingdom: Selsun;
  • (GR) Greece: Selsun;
  • (HK) Hong Kong: Sellon | Selsun | Selsun blue | Selsun gold | Selsun super;
  • (ID) Indonesia: Selsun | Selsun blue | Selsun blue five | Selsun gold | Topisel;
  • (IE) Ireland: Selsun;
  • (IL) Israel: Selsun | Selsun blue;
  • (IT) Italy: Selsun blu;
  • (JO) Jordan: Selsun;
  • (JP) Japan: Micalon;
  • (KR) Korea, Republic of: Selson;
  • (KW) Kuwait: Scalpine | Selsun blue;
  • (LB) Lebanon: Selsun;
  • (LU) Luxembourg: Selsun;
  • (MX) Mexico: Selsun azul | Selsun azul plus | Selsun gold women | Selsun Oro;
  • (MY) Malaysia: Selfide | Sellon | Selsun | Selsun blue | Selsun Blue 2 in 1 Treatment Anti-Dandruff | Selsun Blue Medicated Dandruff Treatment | Selsun Blue Moisturizing Treatment Anti-Dand.;
  • (NL) Netherlands: Selsun;
  • (NO) Norway: Selsun blue | Selukos;
  • (NZ) New Zealand: Selsun gold;
  • (PH) Philippines: Selsun blue;
  • (PK) Pakistan: Medisel | Selsun | Selsun blue;
  • (PL) Poland: Selsun | Selsun blue;
  • (PR) Puerto Rico: Exsel | Selenium | Selseb | Selsun | Selsun blue;
  • (PT) Portugal: Selsun;
  • (PY) Paraguay: Selsun | Selsun azul;
  • (QA) Qatar: Selsun | Selsun Blue;
  • (RU) Russian Federation: Sulsen | Sulsena;
  • (SA) Saudi Arabia: Selsun blue;
  • (SE) Sweden: Selsun blue | Selukos;
  • (SG) Singapore: Sebosel;
  • (SK) Slovakia: Selsun | Selsun blue;
  • (TH) Thailand: Sebosel | Selfide | Sellon | Selsun blue;
  • (TW) Taiwan: Selsun blue;
  • (UY) Uruguay: Selsun azul;
  • (VE) Venezuela, Bolivarian Republic of: Selsun blue;
  • (VN) Viet Nam: Azasun extra;
  • (ZA) South Africa: Selsun
  1. American Academy of Pediatrics (AAP). In: Kimberlin DW, Banerjee R, Barnett ED, Lynfield R, Sawyer MH, eds. Red Book: 2024-2027 Report of the Committee on Infectious Diseases. 33rd ed. American Academy of Pediatrics; 2024.
  2. Bender NR, Chiu YE. Seborrheic dermatitis. In: Kliegman RM, St. Geme J, eds. Nelson Textbook of Pediatrics. 21st ed. Saunders Elsevier; 2020.
  3. Borda LJ, Wikramanayake TC. Seborrheic dermatitis and dandruff: a comprehensive review. J Clin Investig Dermatol. 2015;3(2):10.13188/2373-1044.1000019. doi:10.13188/2373-1044.1000019 [PubMed 27148560]
  4. Bradley JS, Nelson JD, Barnett ED, et al, eds. Nelson's Pediatric Antimicrobial Therapy. 30th ed. American Academy of Pediatrics; 2024.
  5. Chen C, Koch LH, Dice JE, et al. A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Pediatr Dermatol. 2010;27(5):459-462. doi:10.1111/j.1525-1470.2010.01093.x [PubMed 20735804]
  6. Dandruff shampoo 1% (selenium sulfide) [prescribing information]. San Antonio, TX: H-E-B; January 2023.
  7. Ely JW, Rosenfeld S, Seabury Stone M. Diagnosis and management of tinea infections. Am Fam Physician. 2014;90(10):702-710. [PubMed 25403034]
  8. Fuller LC, Barton RC, Mohd Mustapa MF, Proudfoot LE, Punjabi SP, Higgins EM. British Association of Dermatologists' guidelines for the management of tinea capitis 2014. Br J Dermatol. 2014;171(3):454-463. doi:10.1111/bjd.13196 [PubMed 25234064]
  9. Fuller LC, Smith CH, Cerio R, et al. A randomized comparison of 4 weeks of terbinafine vs. 8 weeks of griseofulvin for the treatment of tinea capitis. Br J Dermatol. 2001;144(2):321-327. doi:10.1046/j.1365-2133.2001.04022.x [PubMed 11251566]
  10. Gilbertson K, Jarrett R, Bayliss SJ, Berk DR. Scalp discoloration from selenium sulfide shampoo: a case series and review of the literature. Pediatr Dermatol. 2012;29(1):84-88. doi:10.1111/j.1525-1470.2011.01410.x [PubMed 21453309]
  11. Givens TG, Murray MM, Baker RC. Comparison of 1% and 2.5% selenium sulfide in the treatment of tinea capitis. Arch Pediatr Adolesc Med. 1995;149(7):808-811. [PubMed 7795774]
  12. Gupta AK, Cooper EA. Update in antifungal therapy of dermatophytosis. Mycopathologia. 2008;166(5-6):353-367. doi:10.1007/s11046-008-9109-0 [PubMed 18478357]
  13. Healthcare Environmental Resource Center (HERC). Pharmaceuticals—Hazardous Waste. http://www.hercenter.org/hazmat/pharma.cfm#listed. Published 2015. Accessed October 23, 2016.
  14. Maranich AM. Malassezia. In: Kliegman RM, St. Geme J, Blum NJ, et al, eds. Nelson Textbook of Pediatrics. 22nd ed. Saunders Elsevier; 2024: chap. 282.
  15. Medicated selenium sulfide dandruff shampoo (selenium sulfide) [prescribing information]. Grand Rapids, MI: Meijer; January 2023.
  16. Refer to manufacturer's labeling.
  17. Sánchez JL, Torres VM. Double-blind efficacy study of selenium sulfide in tinea versicolor. J Am Acad Dermatol. 1984;11(2, pt 1):235-238. doi:10.1016/s0190-9622(84)70155-1 [PubMed 6384285]
  18. Selenium sulfide lotion, USP 2.5% [prescribing information]. Allegan, MI: Perrigo; June 2018.
  19. Selenium sulfide shampoo 1% [prescribing information]. Bentonville, AR: Wal-Mart Stores Inc; January 2022.
  20. Selenium sulfide shampoo 2.25% [prescribing information]. Doylestown, PA: Rochester Pharmaceuticals; August 2017.
  21. Selenium sulfide shampoo 2.3% [prescribing information]. Austin, TX: Bowyn Labs, LLC; April 2018.
  22. Selenium sulfide shampoo 2.3% [prescribing information]. Fort Worth, TX: Method Pharmaceuticals, LLC; February 2018.
  23. Selenium sulfide shampoo 2.3% [prescribing information]. Frankfort, KY: Cameron Pharmaceuticals, LLC; August 2015.
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