Blepharoptosis: Ophthalmic: Instill 1 drop in affected eye(s) once daily.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
1% to 10:
Local: Application site pain (1% to 5%)
Nervous system: Headache (1% to 5%)
Ophthalmic: Blurred vision (1% to 5%), conjunctival hyperemia (1% to 5%), dry eye syndrome (1% to 5%), eye irritation (1% to 5%), punctate keratitis (1% to 5%)
Frequency not defined: Nervous system: Transient burning or stinging in the eyes
There are no contraindications listed in the manufacturer's labeling.
Concerns related to adverse effects:
• Ptosis: Ptosis associated with neurologic (eg, cerebral aneurysm, Horner syndrome, myasthenia gravis, stroke) or orbital disease (eg, external ophthalmoplegia, orbital infection, orbital masses) may occur. Evaluate patients who develop ptosis, especially in presence of decreased levator muscle function and/or other neurologic signs.
Disease-related concerns:
• Cardiovascular disease: Use with caution in patients with severe or unstable cardiovascular disease including orthostatic hypotension, uncontrolled hypertension, or uncontrolled hypotension; advise patients to contact health care provider if condition worsens.
• Glaucoma: Use with caution in patients with untreated narrow-angle glaucoma; advise patients to contact health care provider if signs and symptoms occur.
• Vascular disease: Use with caution in patients with cerebral insufficiency, coronary insufficiency, or Sjögren disease; advise patients to contact health care provider if signs and symptoms of vascular insufficiency occur.
Other warnings/precautions:
• Appropriate use: For topical ophthalmic use only. To avoid contamination, do not touch tip of container to any surface.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Ophthalmic, as hydrochloride [preservative free]:
Upneeq: 0.1% (30 ea, 45 ea)
No
Solution (Upneeq Ophthalmic)
0.1% (per each): $8.33
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Ophthalmic: For ophthalmic use only. Remove contact lenses before use; after instilling drops, wait at least 15 minutes before inserting. Instill into lower eyelid immediately after opening container; discard any unused portion. Do not touch tip of container to eye or any surface. Allow 15 minutes between application of other ophthalmic agents.
Blepharoptosis: Treatment of acquired blepharoptosis in adults.
Oxymetazoline may be confused with oxymetholone.
None known.
There are no known significant interactions.
Adverse events were not observed in animal reproduction studies (studies conducted with oral oxymetazoline).
If ophthalmic agents are needed during pregnancy, the minimum effective dose should be used in combination with punctal occlusion to decrease potential exposure to the fetus (Samples 1988).
It is not known if oxymetazoline is present in breast milk following ophthalmic administration.
According to the manufacturer, the decision to breastfeed during therapy should consider the risk of infant exposure, the benefits of breastfeeding to the infant, and the benefits of treatment to the mother.
Stimulates alpha-adrenergic receptors in the Müller's muscle of the eyelid.
Protein binding: ~57%.
Metabolism: Hepatic: Minimally to mono-oxygenated and dehydrogenated products of oxymetazoline.
Half-life elimination: Terminal: 8.3 hours (range: 5.6 to 13.9 hours).
Time to peak: Median: 2 hours (range: 0.5 to 12 hours).
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