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Povidone iodine (ophthalmic): Drug information

Povidone iodine (ophthalmic): Drug information
(For additional information see "Povidone iodine (ophthalmic): Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Betadine Ophthalmic Prep
Pharmacologic Category
  • Antiseptic, Ophthalmic
Dosing: Adult
Antiseptic

Antiseptic: Ophthalmic solution:

Eyelids: Apply to area with a sterile cotton-tipped applicator; repeat once

Periocular region: Apply in a circular expanding pattern until the entire field is covered; repeat 3 times

Ocular irrigation: Irrigate the cornea, conjunctiva, and palpebral fornices; leave for 2 minutes, then rinse with sterile saline

Dosing: Older Adult

Refer to adult dosing.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Frequency not defined: Local: Local ocular hypersensitivity reaction

Contraindications

Hypersensitivity to iodine or any component of the formulation

Warnings/Precautions

Disease-related concerns:

• Thyroid dysfunction: Use with caution in patients with thyroid disorders.

Other warnings/precautions:

• Appropriate use: For external use only; not for intraocular injection or irrigation.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Ophthalmic:

Betadine Ophthalmic Prep: 5% (30 mL)

Generic Equivalent Available: US

No

Pricing: US

Solution (Betadine Ophthalmic Prep Ophthalmic)

5% (per mL): $0.64

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Ophthalmic:

Eyelids: Saturate sterile cotton-tipped applicator to prep lashes and lid margins.

Periocular region: Saturate sterile prep sponge for periocular region and use circular motions to cover area.

Ocular surface irrigation: Use a sterile bulb syringe. Separate the lids and irrigate the cornea, conjunctiva, and palpebral fornices. Leave on for 2 minutes, then flush with sterile saline solution.

Use: Labeled Indications

Ophthalmic preoperative prep: Used prior to eye surgery to prep the periocular region (lids, brow, and cheek) and irrigate the ocular surface (cornea, conjunctiva, and palpebral fornices).

Medication Safety Issues
Sound-alike/look-alike issues:

Betadine may be confused with Betagan, betaine

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Animal reproduction studies have not been conducted. Transient hypothyroidism in the newborn has been reported following topical or vaginal use prior to delivery (refer to Iodine monograph for additional information). The amount absorbed following ophthalmic administration is not known.

Breastfeeding Considerations

The amount absorbed following ophthalmic administration is not known. Also refer to Iodine monograph.

Mechanism of Action

Povidone-iodine is known to be a powerful broad spectrum germicidal agent effective against a wide range of bacteria, viruses, fungi, protozoa, and spores.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AR) Argentina: Clivasol | Iodoasept | Iodomed;
  • (AU) Australia: O/n antiseptic;
  • (BD) Bangladesh: Povin;
  • (CO) Colombia: Oq septic | Oq-septic;
  • (IN) India: Ocudone;
  • (KE) Kenya: Artear | Povisep;
  • (KR) Korea, Republic of: Eyevidon | Isoclean;
  • (KW) Kuwait: Betadine;
  • (LB) Lebanon: Betadine;
  • (PT) Portugal: Betadine;
  • (PY) Paraguay: Iodofon oftalmico debil | Iodofon oftalmico forte | Iop otico;
  • (QA) Qatar: Minims Povidone Iodine;
  • (UY) Uruguay: Beyonas lagrimas | Iodofon Oftalmico | Iodomed
  1. Betadine 5% [povidone/iodine] sterile ophthalmic solution [prescribing information]. Fort Worth, TX: Alcon Laboratories; June 2018.
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