Version October 2024
Antiseptic: Oral: 10 mL gargled up to 4 times daily.
Antiseptic: Topical: Apply to affected area 1 to 3 times daily.
Surgical scrub: Topical: Apply solution to wet skin or hands, scrub for ~5 minutes, rinse; refer to product labeling for specific procedure-related instructions.
Vaginal irritation: Douche: Insert 0.3% solution vaginally once daily for up to 3 days.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
(For additional information see "Povidone iodine external and oral antiseptic (topical): Pediatric drug information")
Antiseptic: Infants, Children, and Adolescents: Topical: Apply to affected area 1 to 3 times daily.
Preoperative skin preparation: Infants, Children, and Adolescents: Topical: Apply solution to wet skin and lather, wash vigorously for at least 15 seconds, and then rinse.
Sore throat: Gargle solution 0.5%: Children ≥12 years and Adolescents: Oral topical: 10 mL gargled for 30 seconds and then expectorated up to 4 times daily.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Also refer to Iodine monograph.
Frequency not defined:
Dermatologic: Localized erythema, severe dermatological reaction (localized; rare)
Hypersensitivity: Local hypersensitivity reaction
Local: Application site pain (persistent or increases), local irritation, local swelling
OTC labeling: When used for self-medication, do not use if hypersensitivity to iodine or any component of the formulation exists, in the eyes, or over large areas of the body. In addition, do not use vaginal formulation to prevent pregnancy, during pregnancy, or if trying to get pregnant; or to treat or prevent sexually transmitted disease or pelvic inflammatory disease. Do not use gargle in children <3 years of age, for >7 days, or in patients with thyroid conditions.
Other warnings/precautions:
• Appropriate use: When used as a topical antiseptic, improper use may lead to product contamination. Although infrequent, product contamination has been associated with reports of localized and systemic infections. To reduce the risk of infection, ensure antiseptic products are used according to the labeled instructions, avoid diluting products after opening, and apply single-use containers only one time to one patient and discard any unused solution (FDA Drug Safety Communication 2013). Topical products are for external use only. Do not use these products in the eyes or over large areas of the body. Avoid spraying the aerosol in the eyes. In preoperative prepping, avoid "pooling" beneath the patient.
• Self-medication (OTC use): Ask health care provider prior to applying topical formulations to deep or puncture wounds, animal bites, or serious burns; discontinue use and notify health care provider if condition persists or gets worse, if need to use product >1 week, or if redness, swelling, irritation, or pain develops, increases, or continues. Notify health care provider promptly if sore throat is severe, persistent, or accompanied by headache, high fever, nausea, or vomiting.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Aerosol Powder, External:
Betadine Antiseptic Dry Powder: 5% (56.7 g)
Cream, External:
Betadine Antiseptic: 5% (15 g [DSC])
Gel, External:
Aplicare Povidone-Iodine: 10% (118 mL [DSC]) [latex free]
Miscellaneous, External:
Generic: 10% (2 ea [DSC], 4 ea [DSC])
Ointment, External:
First Aid Antiseptic: 10% (28.4 g)
Generic: 10% (1 g [DSC], 28.35 g [DSC])
Pad, External:
Generic: 10% (1 ea [DSC], 100 ea, 200 ea [DSC])
Solution, External:
Aplicare Povidone-Iodine: 10% (59 mL [DSC], 118 mL [DSC], 237 mL [DSC], 473 mL [DSC], 946 mL [DSC], 3800 mL [DSC]) [latex free]
Aplicare Povidone-Iodine Scrub: 7.5% (59 mL [DSC], 118 mL [DSC], 473 mL [DSC], 946 mL [DSC], 3800 mL [DSC]) [latex free]
Betadine: 5% (88.7 mL); 10% (14.8 mL, 118 mL, 177 mL, 237 mL, 473 mL, 946 mL [DSC], 3780 mL)
Betadine Surgical Scrub: 7.5% (118 mL, 473 mL, 946 mL, 3780 mL)
PVP Prep: 10% (473 mL [DSC]) [latex free]
PVP Scrub: 7.5% (118 mL [DSC]) [latex free]
Scrub Care Povidone-iodine: 10% (118 mL)
Generic: 10% (30 mL [DSC], 236 mL, 237 mL, 473 mL, 3780 mL)
Solution, Mouth/Throat:
Betadine Antiseptic Gargle: 0.5% (237 mL) [contains propylene glycol, saccharin sodium]
Betadine Antiseptic Rinse: 0.5% (237 mL) [contains propylene glycol, saccharin sodium]
Solution, Vaginal:
Summers Eve Disp Medicated: 0.3% (274 mL) [contains disodium edta, sodium benzoate]
Swab, External:
Betadine Swabsticks: 10% (1 ea, 3 ea)
Clorox Nasal Antiseptic: 10% (4 ea [DSC])
Generic: 7.5% (50 ea [DSC]); 10% (1 ea [DSC], 2 ea [DSC], 3 ea [DSC], 50 ea, 75 ea)
May be product dependent
Aerosol powder (Betadine Antiseptic Dry Powder External)
5% (per gram): $0.13
Pads (Povidone-Iodine External)
10% (per each): $0.05
Solution (Betadine Antiseptic Gargle Mouth/Throat)
0.5% (per mL): $0.03
Solution (Betadine Antiseptic Rinse Mouth/Throat)
0.5% (per mL): $0.03
Solution (Betadine External)
5% (per mL): $0.09
10% (per mL): $0.05
Solution (Betadine Surgical Scrub External)
7.5% (per mL): $0.01
Solution (Povidone-Iodine External)
10% (per mL): $0.02
Solution (Scrub Care Povidone-iodine External)
10% (per mL): $0.02
Solution (Summers Eve Disp Medicated Vaginal)
0.3% (per mL): $0.02
Swab (Betadine Swabsticks External)
10% (per each): $0.24
Swab (Povidone-Iodine External)
10% (per each): $0.13
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Topical, external: For external use only. Avoid contact with eyes, nose, or mouth. Refer to product labeling for additional instructions.
Topical, oral rinse: Gargle in mouth for 30 seconds; do not swallow. Only use dosing cup provided. May stain clothing or dental work. Avoid contact with jewelry, especially silver.
Vaginal: Refer to product labeling for detailed instructions.
Topical, external: For external use only. Do not use on deep puncture wounds, animal bites, or serious burns. Avoid contact with eyes, nose, or mouth. Refer to product labeling for additional instructions.
Topical, oral gargle: Gargle in mouth for 30 seconds; do not swallow. Only use dosing cup provided. May stain clothing or dental work. Avoid contact with jewelry, especially silver.
Antiseptic, external: Antiseptic with broad microbicidal spectrum for the prevention or treatment of topical infections associated with surgery, burns, and minor cuts/scrapes.
Antiseptic, oral: Topical oral antiseptic for temporary relief of occasional sore throat.
Vaginal irritation: Temporary relief of minor vaginal irritation or itching.
Betadine may be confused with Betadine without povidone-iodine, Betagan, betaine
The Institute for Safe Medication Practices (ISMP) includes this medication among its list of drugs (contraindicated in pregnancy [vaginal products]) which have a heightened risk of causing significant patient harm when used in error (High-Alert Medications in Community/Ambulatory Care Settings).
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.
Sodium Iodide I131: Povidone-Iodine (Topical) may diminish the therapeutic effect of Sodium Iodide I131. Management: Discontinue topical povidone-iodine at least 3 weeks before sodium iodide I-131 administration, and avoid concurrent use. Risk X: Avoid combination
Taurolidine: May enhance the adverse/toxic effect of Povidone-Iodine (Topical). Specifically, concomitant use of taurolidine and povidone-iodine may increase the risk of metabolic acidosis. Risk X: Avoid combination
Vaginal products should not be used during pregnancy. Povidine-iodine is absorbed systemically as iodine following topical administration to the vaginal mucosa (Velasco 2009; Vorherr 1980). Following vaginal administration as a douche, iodine concentrations are increased in the maternal urine, amniotic fluid, cord blood and fetal thyroid (Bachrach 1984; Mahillon 1989). Transient hypothyroidism in the newborn has been reported following topical use prior to delivery (Danziger 1987). Refer to Iodine for additional information.
Iodine can be detected in breast milk following topical application of povidone-iodine (Koga 1995).
Povidone-iodine is known to be a powerful broad spectrum germicidal agent effective against a wide range of bacteria, viruses, fungi, protozoa, and spores.
Absorption: Absorbed systemically as iodine; amount depends upon concentration, route of administration, characteristics of skin
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