Effects of dose increase and prolonged infusion on beta-lactam exposure

Effect on fT > MIC of (a) doubling the antibiotic dose, (b) shortening the dosing interval, (c) prolonging the infusion time from 0.5 h to 3 h and (d) a combination of increasing the dose and prolonging the infusion time. fT > MIC, percentage of the dosing interval that free drug concentrations remain above the MIC; q8h, every 8 h; MIC, minimum inhibitory concentration; q6h, every 6 h.