Edoxaban: Patient drug information
For additional information see "Edoxaban: Drug information"
You must carefully read the "Consumer Information Use and Disclaimer" below in order to understand and correctly use this information.
Warning
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Your doctor will check how well your kidneys work. Based on how well your kidneys work, your dose may need to be changed or you may need to take a different blood thinner. For atrial fibrillation, this drug may not work as well to prevent stroke in people whose kidneys work well. If you have questions, talk with your doctor.
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People who have any type of spinal or epidural procedure are more likely to have bleeding problems around the spine when already on this drug. This bleeding rarely happens, but can lead to not being able to move body (paralysis) long-term or paralysis that will not go away. The risk is raised in people who have problems with their spine, a certain type of epidural catheter, or have had spinal surgery. The risk is also raised in people who take any other drugs that may affect blood clotting, like blood-thinner drugs (like warfarin), aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.
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Tell your doctor you use this drug before you have a spinal or epidural procedure. Call your doctor right away if you have any signs of nerve problems like back pain, numbness or tingling, muscle weakness, paralysis, or loss of bladder or bowel control.
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Talk with your doctor if you have recently had or will be having a spinal or epidural procedure. Some time may need to pass between the use of this drug and your procedure. Talk with your doctor.
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Do not stop taking this drug without talking to the doctor who ordered it for you. Stopping this drug when you are not supposed to may raise the chance of blood clots. This includes stroke in certain people. You may need to stop this drug before certain types of dental or health care. Your doctor will tell you when to start taking it again. Follow what your doctor tells you closely.
What is this drug used for?
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It is used to treat blood clots.
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It is used to lower the risk of stroke and blood clots in certain people with atrial fibrillation.
What do I need to tell my doctor BEFORE I take this drug?
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If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
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If you have active bleeding.
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If you have heart valve problems.
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If you have had or plan to have a heart valve replaced.
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If you have any of these health problems: Kidney disease or liver disease.
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If you have antiphospholipid syndrome (APS).
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If you are taking rifampin.
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If you are breast-feeding. Do not breast-feed while you take this drug.
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This is not a list of all drugs or health problems that interact with this drug.
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Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take this drug?
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Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists. This drug may need to be stopped before certain types of surgery as your doctor has told you. If this drug is stopped, your doctor will tell you when to start taking this drug again after your surgery or procedure.
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Have blood work checked as you have been told by the doctor. Talk with the doctor.
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You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor. Rarely, some bleeding problems have been deadly.
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If you fall or hurt yourself, or if you hit your head, call your doctor right away. Talk with your doctor even if you feel fine.
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Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
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If you used this drug when you were pregnant, tell your baby's doctor.
What are some side effects that I need to call my doctor about right away?
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WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
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Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
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Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
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Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
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Pale skin.
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Very bad headache.
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Feeling tired or weak.
What are some other side effects of this drug?
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All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.
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These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
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You may report side effects to your national health agency.
How is this drug best taken?
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Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
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Take with or without food.
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Keep taking this drug as you have been told by your doctor or other health care provider, even if you feel well.
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Do not run out of this drug.
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If you are not able to swallow tablets, the tablets can be crushed and mixed in 2 to 3 ounces (60 to 90 mL) of water. You may also mix crushed tablets into applesauce. Take right away after mixing.
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Those who have feeding tubes may use this drug. Use as you have been told. Flush the feeding tube after this drug is given.
What do I do if I miss a dose?
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Take a missed dose as soon as you think about it on the same day you missed the dose.
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If you do not think about the missed dose until the next day, skip the missed dose and go back to your normal time.
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Do not take 2 doses at the same time or extra doses.
How do I store and/or throw out this drug?
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Store at room temperature in a dry place. Do not store in a bathroom.
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Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
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Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
General drug facts
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If your symptoms or health problems do not get better or if they become worse, call your doctor.
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Do not share your drugs with others and do not take anyone else's drugs.
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Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
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If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Last Reviewed Date2024-05-10
Consumer Information Use and Disclaimer
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This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patient's specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.
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