Version July 2025
Tinea infection:
Tinea corporis/tinea cruris : Topical: Cream 1%, solution 1%: Apply to affected and surrounding area(s) 1 to 2 times daily until clinical resolution, typically 1 to 3 weeks (Ref).
Tinea pedis (labeled use)/tinea manuum (off-label use): Topical: Cream 1%: Apply to affected and surrounding area(s) twice daily until 1 week after clinical resolution, typically for 4 weeks total (Ref).
Tinea versicolor (pityriasis versicolor): Topical: Cream 1%, solution 1%: Apply a small amount to affected area(s) and surrounding skin once or twice daily for 3 weeks (Ref).
Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
Refer to adult dosing.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
1% to 10%: Dermatologic: Burning sensation of skin (≤3%), erythema of skin (1%), pruritus (1% to 3%), stinging of the skin (≤3%)
Hypersensitivity to sulconazole or any component of the formulation
Concerns related to adverse effects:
• Irritation: Discontinue if sensitivity or irritation occurs.
Other warnings/precautions:
• Appropriate use: For topical use only; avoid contact with eyes.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Cream, External, as nitrate:
Exelderm: 1% (60 g) [contains cetyl alcohol, propylene glycol]
Generic: 1% (60 g)
Solution, External, as nitrate:
Exelderm: 1% (30 mL) [contains propylene glycol]
Generic: 1% (30 mL)
Yes
Cream (Exelderm External)
1% (per gram): $14.74
Cream (Sulconazole Nitrate External)
1% (per gram): $10.65
Solution (Exelderm External)
1% (per mL): $19.22
Solution (Sulconazole Nitrate External)
1% (per mL): $13.89
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
For external use only; avoid contact with the eyes. Apply a small amount and gently massage into affected and surrounding skin areas.
Fungal infections:
Cream: Treatment of tinea pedis (athlete's foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis; treatment of tinea versicolor (pityriasis versicolor).
Solution: Treatment of tinea cruris and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis; treatment of tinea versicolor.
Limitations of use: Effectiveness has not been proven in tinea pedis (athlete's foot).
Tinea manuum
None known.
There are no known significant interactions.
Adverse events have been observed in animal reproduction studies with large doses administered orally. Systemic absorption is limited following topical administration.
It is not known if sulconazole is present in breast milk. The manufacturer recommends that caution be exercised when administering sulconazole to breastfeeding women.
Substituted imidazole derivative which inhibits metabolic reactions necessary for the synthesis of ergosterol, an essential membrane component. The end result is usually fungistatic; however, sulconazole may act as a fungicide in Candida albicans and Candida parapsilosis during certain growth phases.
Absorption: Topical: ~8.7% to 11% percutaneously (Franz 1988)
Excretion: Primarily urine
