Early-onset dementia systemic features

Systemic features	Range of diseases
Splenomegaly	Niemann-Pick type C, Gaucher
Tendon xanthomas	CTX
Paget disease of bone	FTD
Renal impairment	Fabry disease, Lesch-Nyhan, mitochondrial disease
Liver dysfunction	Wilson disease, Gaucher disease, mitochondrial disease
Respiratory failure	FTD with MND, mitochondrial disease, anti-NMDAR encephalitis
Gastrointestinal dysfunction	Whipple disease
Anemia	Vitamin B12 deficiency, neuroacanthocytosis, Wilson disease, alcohol
Urinary incontinence	NPH
Skin lesions	Systemic vasculitides, Fabry disease
Hyponatremia	Limbic encephalitis
Amenorrhea	VWM

CTX: cerebrotendinous xanthomatosis; FTD: frontotemporal dementia; MND: motor neuron disease; NMDAR: N-methyl-D-aspartate receptor; NPH: normal pressure hydrocephalus; VWM: vanishing white matter disease.

Adapted from:

Rossor MN, Fox NC, Mummery CJ, et al. The diagnosis of young-onset dementia. Lancet Neurol 2010; 9:793.

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Early-onset dementia systemic features