Common organisms responsible for gastrointestinal infections among patients with different types of primary immunodeficiencies

Disease	Organism
Predominantly antibody deficiencies
Common variable immunodeficiency	Bacteria: Campylobacter jejuni, Salmonella, Helicobacter pylori Viruses: CMV, norovirus Fungal: Candida Parasites: Cryptosporidium, Giardia lamblia
X-linked agammaglobulinemia	Bacteria: Salmonella, Campylobacter Parasites: Cryptosporidium, Giardia lamblia Viruses: Rotavirus
X-linked hyperimmunoglobulin M syndrome	Bacteria: Salmonella Parasites: Cryptosporidium, Giardia lamblia, Entamoeba histolytica
Selective IgA deficiency	Parasites: Giardia lamblia
Combined immunodeficiencies
Severe combined immunodeficiency	Bacteria: Salmonella, Escherichia coli Viruses: Rotavirus, picornavirus, parvovirus, adenovirus, CMV Fungal: Candida Parasites: Cryptosporidium, Giardia lamblia
DiGeorge syndrome	Fungal: Candida
MHC class II deficiency	Bacteria: Shigella, Salmonella, Staphylococcus aureus, Escherichia coli, Campylobacter Viruses: Adenovirus, enterovirus
Well-defined syndromes with immunodeficiency
Hyperimmunoglobulin E syndrome	Fungal: Candida
Phagocytic defects
Chronic granulomatous disease	Bacteria: Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia cepacia, Serratia, Mycobacteria, Escherichia coli Fungal: Candida, Aspergillus
Defects in innate immunity
Chronic mucocutaneous candidiasis	Fungal: Candida
NEMO deficiency	Bacteria: Mycobacteria Viruses: CMV

CMV: cytomegalovirus; IgA: immunoglobulin A; MHC: major histocompatibility complex; NEMO: NF-kappa-B essential modifier.

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