Common organisms responsible for gastrointestinal infections among patients with different types of inborn errors of immunity

Disease	Organism
Predominantly antibody deficiencies
Common variable immunodeficiency	Bacteria – Campylobacter jejuni, Salmonella, Helicobacter pylori Viruses – CMV, norovirus Fungal – Candida Parasites – Cryptosporidium, Giardia lamblia
X-linked agammaglobulinemia	Bacteria – Salmonella, Campylobacter Parasites – Cryptosporidium, Giardia lamblia Viruses – Rotavirus
X-linked hyperimmunoglobulin M syndrome	Bacteria – Salmonella Parasites – Cryptosporidium, Giardia lamblia, Entamoeba histolytica
Selective IgA deficiency	Parasites – Giardia lamblia
Combined immunodeficiencies
Severe combined immunodeficiency	Bacteria – Salmonella, Escherichia coli Viruses – Rotavirus, picornavirus, parvovirus, adenovirus, CMV Fungal – Candida Parasites – Cryptosporidium, Giardia lamblia
DiGeorge syndrome	Fungal – Candida
MHC class II deficiency	Bacteria – Shigella, Salmonella, Staphylococcus aureus, Escherichia coli, Campylobacter Viruses – Adenovirus, enterovirus
Well-defined syndromes with immunodeficiency
Hyperimmunoglobulin E syndrome	Fungal – Candida
Phagocytic defects
Chronic granulomatous disease	Bacteria – Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia cepacia, Serratia, Mycobacteria, Escherichia coli Fungal – Candida, Aspergillus
Defects in innate immunity
Chronic mucocutaneous candidiasis	Fungal – Candida
NEMO deficiency	Bacteria – Mycobacteria Viruses – CMV

CMV: cytomegalovirus; IgA: immunoglobulin A; MHC: major histocompatibility complex; NEMO: NF-kappa-B essential modifier.

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