NCI CTCAE v5.0 left ventricular systolic dysfunction

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Left ventricular systolic dysfunction			Symptomatic due to drop in ejection fraction responsive to intervention	Refractory or poorly controlled heart failure due to drop in ejection fraction; intervention such as ventricular assist device, intravenous vasopressor support, or heart transplant indicated	Death

Left ventricular systolic dysfunction is a disorder characterized by failure of the left ventricle to produce adequate output despite an increase in distending pressure and in end-diastolic volume. Clinical manifestations may include dyspnea, orthopnea, and other signs and symptoms of pulmonary congestion and edema.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

Graphic 99985 Version 5.0

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NCI CTCAE v5.0 left ventricular systolic dysfunction