Cynthia A. Stuenkel, M.D., and JoAnn E. Manson, M.D., Dr.P.H.
doi : 10.1056/NEJMp2105292
N Engl J Med 2021; 384:2073-2076
Alyssa M. Newman, Ph.D.
doi : 10.1056/NEJMp2103063
N Engl J Med 2021; 384:2076-2078
Richard P. Whitlock, M.D., Ph.D., Emilie P. Belley-Cote, M.D., Ph.D., Domenico Paparella, M.D., Jeff S. Healey, M.D., et al., for the LAAOS III Investigators*
doi : 10.1056/NEJMoa2101897
N Engl J Med 2021; 384:2081-2091
Surgical occlusion of the left atrial appendage has been hypothesized to prevent ischemic stroke in patients with atrial fibrillation, but this has not been proved. The procedure can be performed during cardiac surgery undertaken for other reasons.
Andreas Greinacher, M.D., Thomas Thiele, M.D., Theodore E. Warkentin, M.D., Karin Weisser, Ph.D., et al.
doi : 10.1056/NEJMoa2104840
N Engl J Med 2021; 384:2092-2101
Several cases of unusual thrombotic events and thrombocytopenia have developed after vaccination with the recombinant adenoviral vector encoding the spike protein antigen of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (ChAdOx1 nCov-19, AstraZeneca). More data were needed on the pathogenesis of this unusual clotting disorder.
Dean F. Bajorin, M.D., J. Alfred Witjes, M.D., Jürgen E. Gschwend, M.D., Michael Schenker, M.D., et al.
doi : 10.1056/NEJMoa2034442
N Engl J Med 2021; 384:2102-2114
The role of adjuvant treatment in high-risk muscle-invasive urothelial carcinoma after radical surgery is not clear.
Milagritos D. Tapia, M.D., Samba O. Sow, M.D., Abdi Naficy, M.D., Fatoumata Diallo, M.D., et al.
doi : 10.1056/NEJMoa2013615
N Engl J Med 2021; 384:2115-2123
Neisseria meningitidis serogroups A, B, C, W, X, and Y cause outbreaks of meningococcal disease. Quadrivalent conjugate vaccines targeting the A, C, W, and Y serogroups are available. A pentavalent vaccine that also includes serogroup X (NmCV-5) is under development.
Nina H. Schultz, M.D., Ph.D., Ingvild H. S?rvoll, M.D., Annika E. Michelsen, Ph.D., Ludvig A. Munthe, M.D., Ph.D., et al.
doi : 10.1056/NEJMoa2104882
N Engl J Med 2021; 384:2124-2130
Michael S. Saag, M.D.
doi : 10.1056/NEJMcp1915826
N Engl J Med 2021; 384:2131-2143
Shinji Izuka, M.D., and Hiroyuki Yamashita, M.D., Ph.D.
doi : 10.1056/NEJMicm2034179
N Engl J Med 2021; 384:2144
André Zimerman, M.D., and Andre d’Avila, M.D., Ph.D.
doi : 10.1056/NEJMicm2030596
N Engl J Med 2021; 384:e83
Emily S. Lau, M.D., Benjamin Scirica, M.D., M.P.H., Inga-Marie Schaefer, M.D., Amy L. Miller, M.D., Ph.D., et al.
doi : 10.1056/NEJMcps2018493
N Engl J Med 2021; 384:2145-2152
Richard L. Page, M.D.
doi : 10.1056/NEJMe2106069
N Engl J Med 2021; 384:2154-2155
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2109334
N Engl J Med 2021; 384:e103
Marc E. Rothenberg, M.D., Ph.D.
doi : 10.1056/NEJMcibr2104146
N Engl J Med 2021; 384:2156-2158
doi : 10.1056/NEJMc2100365
N Engl J Med 2021; 384:2159-2161
doi : 10.1056/NEJMc2104192
N Engl J Med 2021; 384:2161-2163
doi : 10.1056/NEJMc2102124
N Engl J Med 2021; 384:2163-2165
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