Pochapin, Mark B.
doi : 10.14309/ajg.0000000000001119
February 2021 - Volume 116 - Issue 2 - p 225-226
Stollman, Neil; Kefalas, Costas H.
doi : 10.14309/ajg.0000000000001066
February 2021 - Volume 116 - Issue 2 - p 227-228
Bhalla, Sean; Sonnenday, Christopher J.; Schulman, Allison R.
doi : 10.14309/ajg.0000000000001081
February 2021 - Volume 116 - Issue 2 - p 229-233
Miranda, Estefan?a; Meza, Rodrigo; Kolbach, Marianne; Torres, Javiera; Harris, Paul R.
doi : 10.14309/ajg.0000000000000645
February 2021 - Volume 116 - Issue 2 - p 234
Hoogenes, Neil; Daams, Freek; Britstra, Rieneke; Nielsen, Karin; de Boer, Nanne K; Hendrickx, Jan Jaap
doi : 10.14309/ajg.0000000000000674
February 2021 - Volume 116 - Issue 2 - p 235
Shen, Xiao-Chun; Zhou, Yin-Bin; Zhu, Yang-Jie; Chen, Dong-Feng; Lan, Chun-Hui
doi : 10.14309/ajg.0000000000000699
February 2021 - Volume 116 - Issue 2 - p 236
Sakai, Norihiro; Kamimura, Kenya; Terai, Shuji
doi : 10.14309/ajg.0000000000000703
February 2021 - Volume 116 - Issue 2 - p 237
Liu, Wen; Wang, Sheng; Guo, Jintao; Liu, Xiang; Ge, Nan; Wang, Guoxin; Sun, Siyu
doi : 10.14309/ajg.0000000000000938
February 2021 - Volume 116 - Issue 2 - p 238
doi : 10.14309/ajg.0000000000001123
February 2021 - Volume 116 - Issue 2 - p 239-240
Shafi, Mehnaz A.
doi : 10.14309/ajg.0000000000001155
February 2021 - Volume 116 - Issue 2 - p 241
Article Title: Hypercontractile Esophagus From Pathophysiology to Management: Proceedings of the PISA Symposium
Carpenter, Steven L.
doi : 10.14309/ajg.0000000000001156
February 2021 - Volume 116 - Issue 2 - p 242
Article Title: The Role of Noninvasive Tests in Clinical Gastroenterology Practices to Identify Patients With Non-Alcoholic Steatohepatitis at High Risk for Adverse Outcomes: Expert Panel Recommendations
Gubatan, John; Nielsen, Ole Haagen; Levitte, Steven; Juhl, Carsten Bogh; Maxwell, Cynthia; Streett, Sarah E.; Habtezion, Aida
doi : 10.14309/ajg.0000000000000910
February 2021 - Volume 116 - Issue 2 - p 243-253
Biologics, such as tumor necrosis factor inhibitors, anti-integrins and anticytokines, are therapies for inflammatory bowel disease (IBD) that may increase the risk of infection. Most biologics undergo placental transfer during pregnancy and persist at detectable concentrations in exposed infants. Whether this is associated with an increased risk of infantile infections is controversial. We performed a systematic review and meta-analysis evaluating the risk of infantile infections after in utero exposure to biologics used to treat IBD.
Younossi, Zobair M.; Noureddin, Mazen; Bernstein, David; Kwo, Paul; Russo, Mark; Shiffman, Mitchell L.; Younes, Ziad; Abdelmalek, Manal
doi : 10.14309/ajg.0000000000001054
February 2021 - Volume 116 - Issue 2 - p 254-262
Nonalcoholic fatty liver disease (NAFLD) is generally considered a silent and potentially reversible condition. The subtype of NAFLD that can be classified as nonalcoholic steatohepatitis (NASH) can progress to advanced fibrosis and cirrhosis. Because of the metabolic nature of the pathogenic mechanism underlying NAFLD and NASH, it is often accompanied by common comorbidities such as obesity, insulin resistance, and type 2 diabetes mellitus. The increase in the prevalence of these comorbidities has resulted in a parallel increase in the prevalence of NAFLD and NASH, globally, nationally, and even in children.
de Bortoli, Nicola; Gyawali, Prakash Chandra; Roman, Sabine; Tolone, Salvatore; Sifrim, Daniel; Tutuian, Radu; Penagini, Roberto; Pandolfino, John Erik; Savarino, Edoardo Vincenzo
doi : 10.14309/ajg.0000000000001061
February 2021 - Volume 116 - Issue 2 - p 263-273
Hypercontractile esophagus (HE) is a heterogeneous major motility disorder diagnosed when ?20% hypercontractile peristaltic sequences (distal contractile integral >8,000 mm Hg*s*cm) are present within the context of normal lower esophageal sphincter (LES) relaxation (integrated relaxation pressure < upper limit of normal) on esophageal high-resolution manometry (HRM). HE can manifest with dysphagia and chest pain, with unclear mechanisms of symptom generation.
Tack, Jan; Schol, Jolien; Van den Houte, Karen; Huang, I-Hsuan; Carbone, Florencia
doi : 10.14309/ajg.0000000000001077
February 2021 - Volume 116 - Issue 2 - p 274-275
For up to 2 decades, pathophysiological research in functional dyspepsia focused on gastric sensorimotor dysfunction underlying symptom generation. Recent pathophysiological research has focused on low-grade inflammation in the duodenal mucosa. Emerging evidence confirms a loss of mucosal integrity in the duodenum in functional dyspepsia, and this is confirmed in a confocal laser endomicroscopy study demonstrating altered mucosal barrier function and pyroptosis. This technique may help to establish underlying mechanisms and evaluate novel therapeutic approaches to functional dyspepsia.
Pohl, Heiko
doi : 10.14309/ajg.0000000000001088
February 2021 - Volume 116 - Issue 2 - p 276-277
Clip closure is effective for large (? 20 mm) nonpedunculated polyps in the proximal colon. The cost-effectiveness analysis by Albeniz et al. found that selective clipping of polyps at a minimum risk (>13% in the United States, >10% in Spain) is worthwhile clipping. Although such model is theoretically sound, clinical practice should be primarily guided by efficacy data. Moreover, the analysis is very sensitive to the high price of clips, which is likely to reduce in the foreseeable future.
Lam, Angela Y.; Lee, Jeffrey K.
doi : 10.14309/ajg.0000000000001087
February 2021 - Volume 116 - Issue 2 - p 278-279
Although screening reduces colorectal cancer (CRC) incidence and related mortality, national CRC screening rates remain suboptimal. Identifying strategies to improve screening rates remains an area of intense focus, and previous literature supports an association between the perceived risk of CRC and a likelihood or intent to complete screening. However, risk estimation alone through the validated National Cancer Institute Colorectal Cancer Risk Assessment Tool does not improve screening uptake compared with general education. Future studies should couple risk estimation with patient navigation and decision support aids to build upon our existing armamentarium of effective interventions.
Sanagapalli, Santosh; McGuire, Joshua; Leong, Rupert W.; Patel, Kalp; Raeburn, Amanda; Abdul-Razakq, Humayra; Plumb, Andrew; Banks, Matthew; Haidry, Rehan; Lovat, Laurence; Sehgal, Vinay; Graham, David; Sami, Sarmed S.; Sweis, Rami
doi : 10.14309/ajg.0000000000000988
February 2021 - Volume 116 - Issue 2 - p 280-288
Esophagogastric junction outflow obstruction (EGJOO) defined on high-resolution esophageal manometry (HRM) poses a management dilemma given marked variability in clinical manifestations. We hypothesized that findings from provocative testing (rapid drink challenge and solid swallows) could determine the clinical relevance of EGJOO.
Zagari, Rocco Maurizio; Marasco, Giovanni; Tassi, Valentina; Ferretti, Stefano; Lugaresi, Marialuisa; Fortunato, Francesca; Bazzoli, Franco; Mattioli, Sandro
doi : 10.14309/ajg.0000000000000955
February 2021 - Volume 116 - Issue 2 - p 289-295
Epidemiological studies assessing relative risk and incidence rate of esophageal cancer in patients with achalasia are scarce. We performed a long-term prospective cohort study to evaluate the risk of both squamous cell carcinoma and adenocarcinoma of the esophagus in these patients.
Guo, Howard; Lam, Angela Y.; Shaheen, Abdel Aziz; Forbes, Nauzer; Kaplan, Gilaad G.; Andrews, Christopher N.; Laffin, Michael; Singh, Siddharth; Jairath, Vipul; Teriaky, Anouar; Lee, Jeffrey K.; Ma, Christopher
doi : 10.14309/ajg.0000000000000997
February 2021 - Volume 116 - Issue 2 - p 296-305
The incidence of peptic ulcer disease (PUD) has been decreasing over time with Helicobacter pylori eradication and use of acid-suppressing therapies. However, PUD remains a common cause of hospitalization in the United States. We aimed to evaluate contemporary national trends in the incidence, treatment patterns, and outcomes for PUD-related hospitalizations and compare care delivery by hospital rurality.
Schettino, Mario; Pellegrini, Lucienne; Picascia, Desiree; Saibeni, Simone; Bezzio, Cristina; Bini, Francesco; Omazzi, Barbara F.; Devani, Massimo; Arena, Ilaria; Bongiovanni, Marco; Manes, Gianpiero; Della Corte, Cristina Maria Rita
doi : 10.14309/ajg.0000000000000965
February 2021 - Volume 116 - Issue 2 - p 306-310
The most typical presentation of COVID-19 is an acute respiratory syndrome whose most common symptoms include fever, cough, and dyspnea. However, gastrointestinal symptoms, such as diarrhea and nausea/vomiting, are increasingly reported in patients affected by COVID-19. This study aimed to describe the prevalence and time of onset of gastrointestinal symptoms in patients affected by COVID-19 and to find potential associations between gastrointestinal symptoms and clinical outcomes.
Albéniz, Eduardo; Enguita-Germ?n, M?nica; Gimeno-Garc?a, Antonio Zebenzuy; Herreros de Tejada, Alberto; Nogales, Oscar; Espin?s, Jorge C.; Rodr?guez S?nchez, Joaqu?n; Ros?n, Pedro; Guarner, Carlos; Mar?n, José Carlos; Bhandari, Pradeep; Spadaccini, Marco; Repici, Alessandro; Hassan, Cesare; ?lvarez-Gonz?lez, Marco Antonio; Ib??ez Beroiz, Berta
doi : 10.14309/ajg.0000000000000943
February 2021 - Volume 116 - Issue 2 - p 311-318
Delayed bleeding (DB) is the most common major complication of endoscopic mucosal resection (EMR). Two randomized clinical trials recently demonstrated that clip closure after EMR of large nonpedunculated colorectal polyps (LNPCPs) reduces the risk of DB. We analyzed the cost-effectiveness of this prophylactic measure.
Di Palma, Jack A.; Bhandari, Raj; Cleveland, Mark vB.; Mishkin, Daniel S.; Tesoriero, Jessica; Hall, Sue; McGowan, John
doi : 10.14309/ajg.0000000000001020
February 2021 - Volume 116 - Issue 2 - p 319-328
A new tablet-based bowel prep for colonoscopy has been developed containing poorly absorbed sulfate salts which act to retain water within the intestinal lumen resulting in a copious diarrhea, thereby cleansing the bowel. This study evaluated the safety and efficacy of these oral sulfate tablets (OST) compared with a US FDA–approved bowel prep solution containing PEG3350, electrolytes, and ascorbate (polyethylene glycol and ascorbate [PEG-EA]).
Sinn, Dong Hyun; Kang, Danbee; Guallar, Eliseo; Chang, Yoosoo; Ryu, Seungho; Zhao, Di; Hong, Yun Soo; Cho, Juhee; Gwak, Geum-Youn
doi : 10.14309/ajg.0000000000000966
February 2021 - Volume 116 - Issue 2 - p 329-335
We evaluated the association between alcohol intake and all-cause and cause-specific mortality in subjects with chronic viral hepatitis, using nationwide population-based cohort study.
Hu, Chang; Anjur, Vikram; Saboo, Krishnakant; Reddy, K. Rajender; O'Leary, Jacqueline; Tandon, Puneeta; Wong, Florence; Garcia-Tsao, Guadalupe; Kamath, Patrick S.; Lai, Jennifer C.; Biggins, Scott W.; Fallon, Michael B.; Thuluvath, Paul; Subramanian, Ram M.; Maliakkal, Benedict; Vargas, Hugo; Thacker, Leroy R.; Iyer, Ravishankar K.; Bajaj, Jasmohan S.
doi : 10.14309/ajg.0000000000000971
February 2021 - Volume 116 - Issue 2 - p 336-346
Readmission and death in cirrhosis are common, expensive, and difficult to predict. Our aim was to evaluate the abilities of multiple artificial intelligence (AI) techniques to predict clinical outcomes based on variables collected at admission, during hospitalization, and at discharge.
Elten, Michael; Benchimol, Eric I.; Fell, Deshayne B.; Kuenzig, M. Ellen; Smith, Glenys; Kaplan, Gilaad G.; Chen, Hong; Crouse, Dan; Lavigne, Eric
doi : 10.14309/ajg.0000000000000990
February 2021 - Volume 116 - Issue 2 - p 347-353
Environmental factors related to urbanization and industrialization are believed to be involved in inflammatory bowel disease (IBD) development, but no study has looked at the association between greenspace and IBD.
Chey, William D.; Sayuk, Gregory S.; Bartolini, Wilmin; Reasner, David S.; Fox, Susan M.; Bochenek, Wieslaw; Boinpally, Ramesh; Shea, Elizabeth; Tripp, Kenneth; Borgstein, Niels
doi : 10.14309/ajg.0000000000000967
February 2021 - Volume 116 - Issue 2 - p 354-361
Immediate-release (IR) formulation of linaclotide 290 ?g improves abdominal pain and constipation (APC) in patients with irritable bowel syndrome (IBS) with constipation. Delayed-release (DR) formulations were developed on the premise that targeting the ileum (delayed-release formulation 1 [DR1]) or ileocecal junction and cecum (MD-7246, formerly DR2) would modulate linaclotide's secretory effects while preserving pain relief effects.
Barberio, Brigida; Houghton, Lesley A.; Yiannakou, Yan; Savarino, Edoardo V.; Black, Christopher J.; Ford, Alexander C.
doi : 10.14309/ajg.0000000000000946
February 2021 - Volume 116 - Issue 2 - p 362-371
Irritable bowel syndrome (IBS) is a chronic functional bowel disorder, which follows a relapsing and remitting course. Little is known about how evolving definitions of IBS or treatment for the condition affect symptom stability. We conducted a 12-month longitudinal follow-up study of individuals who self-identified as having IBS to examine these issues.
Black, Christopher J.; Yiannakou, Yan; Guthrie, Elspeth A.; West, Robert; Houghton, Lesley A.; Ford, Alexander C.
doi : 10.14309/ajg.0000000000000975
February 2021 - Volume 116 - Issue 2 - p 372-381
Conventionally, patients with irritable bowel syndrome (IBS) are subgrouped based on their predominant bowel habit. Given the relevance of psychological comorbidity to IBS symptoms, our aim was to explore an alternative approach to subgrouping by incorporating factors beyond stool form and frequency.
Song, Mingyang; Emilsson, Louise; Hultcrantz, Rolf; Roelstraete, Bjorn; Ludvigsson, Jonas F.
doi : 10.14309/ajg.0000000000001018
February 2021 - Volume 116 - Issue 2 - p 382-390
Endoscopic screening reduces colorectal cancer (CRC) incidence and mortality. Individuals with a negative result are recommended to undergo rescreening within a 10-year interval, but evidence supporting this advice is limited.
Yen, Timothy; Qin, FeiFei; Sundaram, Vandana; Asiimwe, Edgar; Storage, Tina; Ladabaum, Uri
doi : 10.14309/ajg.0000000000000963
February 2021 - Volume 116 - Issue 2 - p 391-400
Risk stratification has been proposed as a strategy to improve participation in colorectal cancer (CRC) screening, but evidence is lacking. We performed a randomized controlled trial of risk stratification using the National Cancer Institute's Colorectal Cancer Risk Assessment Tool (CCRAT) on screening intent and completion.
Wong, Robert J.; Saab, Sammy; Konyn, Peter; Sundaram, Vinay; Khalili, Mandana
doi : 10.14309/ajg.0000000000000948
February 2021 - Volume 116 - Issue 2 - p 401-406
To evaluate impact of urbanicity and household income on hepatocellular carcinoma (HCC) incidence among US adults.
McGrath, Brian; Calderon, Lucie F.; Xie, Mengdan; Messallam, Ahmed; Masuda, Hikaru; Chen, Huimin; Keilin, Steven; Cai, Qiang
doi : 10.14309/ajg.0000000000000998
February 2021 - Volume 116 - Issue 2 - p 407-410
Per-oral endoscopic myotomy (POEM) is an effective modality for the management of achalasia. Tension pneumoperitoneum is a significant complication that causes hemodynamic instability, generally within the periprocedural period.
Kim, Nicole J.; Jacob, David A.; Ioannou, George N.; John, Binu V.; Rogal, Shari; Rozenberg-Ben-Dror, Karine
doi : 10.14309/ajg.0000000000001000
February 2021 - Volume 116 - Issue 2 - p 411-415
We aimed to assess rates and predictors of hepatocellular carcinoma (HCC) screening among patients with cirrhosis.
King, Dominic; Thomas, Tom; Chandan, Joht Singh; Bhala, Nij; Adderley, Nicola J.; Nirantharakumar, Krishnarajah; Trudgill, Nigel
doi : 10.14309/ajg.0000000000001006
February 2021 - Volume 116 - Issue 2 - p 416-419
Case reports describe individuals with achalasia features subsequently diagnosed with eosinophilic esophagitis (an atopic disorder). We have examined associations between achalasia and atopic and autoimmune conditions.
He, Qing; Zhang, Guo; Gu, Ye; Wang, Jitao; Tang, Qiyuan; Jiang, Zicheng; Shao, Chuxiao; Zhang, Hongguang; Chen, Zhenhuai; Ma, Baoyi; Liu, Dengxiang; Xie, Guanghang; Xu, Dan; Huang, Yifei; Zhang, Haijun; Liang, Mingkai; Huang, Huihong; Wang, Yan; Liu, Hongyan; Yang, Jie; Pan, Hongqiu; Zou, Shengqiang; Li, Fujian; Wang, Fang; Liu, Chuan; Wang, Wenjuan; Xiong, Bin; Li, Xun; Liu, Lei; Yang, Jianrong; Qi, Xiaolong
doi : 10.14309/ajg.0000000000000924
February 2021 - Volume 116 - Issue 2 - p 420-421
Bisseling, Tanya M.; van Laarhoven, Arjan; Huijbers, Angelique; Brink, Monique; Roverts, Rona; Wagner, Bart; Nagtegaal, Iris D.; van der Post, Rachel S.
doi : 10.14309/ajg.0000000000000927
February 2021 - Volume 116 - Issue 2 - p 421-424
Kumar, Karan; Kulkarni, Anand
doi : 10.14309/ajg.0000000000000914
February 2021 - Volume 116 - Issue 2 - p 424
Hao, Shaorui; Yang, Yida
doi : 10.14309/ajg.0000000000001067
February 2021 - Volume 116 - Issue 2 - p 424-425
Sterpetti, Antonio V.
doi : 10.14309/ajg.0000000000000929
February 2021 - Volume 116 - Issue 2 - p 425-426
DeMeester, Steven; Dunst, Christy; Davila Bradley, Daniel; Reavis, Kevin; Swanstrom, Lee
doi : 10.14309/ajg.0000000000000923
February 2021 - Volume 116 - Issue 2 - p 426
Brewer Gutierrez, Olaya I.; Khashab, Mouen A.; Benias, Petro C.
doi : 10.14309/ajg.0000000000001065
February 2021 - Volume 116 - Issue 2 - p 427
Chu, Jacqueline N.; Yarze, Joseph C.
doi : 10.14309/ajg.0000000000000922
February 2021 - Volume 116 - Issue 2 - p 427-428
Black, Christopher J.; Ford, Alexander C.
doi : 10.14309/ajg.0000000000000932
February 2021 - Volume 116 - Issue 2 - p 428-429
Plasse, Terry F.
doi : 10.14309/ajg.0000000000001009
February 2021 - Volume 116 - Issue 2 - p 429
Doukas, Sotirios G.; Charilaou, Paris; Velpari, Sugirdhana
doi : 10.14309/ajg.0000000000000951
February 2021 - Volume 116 - Issue 2 - p 429-431
Kochar, Bharati; Ufere, Nneka N.; Nipp, Ryan; Gustafson, Jenna L.; Carolan, Peter; Ritchie, Christine S.
doi : 10.14309/ajg.0000000000000961
February 2021 - Volume 116 - Issue 2 - p 431-432
Patel, Shreya; Issaka, Rachel B.; Chen, Ellen; Somsouk, Ma
doi : 10.14309/ajg.0000000000000970
February 2021 - Volume 116 - Issue 2 - p 433-434
Omidvari, Amir-Houshang; Roumans, Carlijn A.M.; Naber, Steffie K.; Kroep, Sonja; Wijnhoven, Bas P.L.; van der Gaast, Ate; de Jonge, Pieter-Jan; Spaander, Manon C.W.; Lansdorp-Vogelaar, Iris
doi : 10.14309/ajg.0000000000001027
February 2021 - Volume 116 - Issue 2 - p 435-439
doi : 10.14309/ajg.0000000000001137
February 2021 - Volume 116 - Issue 2 - p 440
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