دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Impact of disconnected pancreatic duct on recurrence of fluid collections and new-onset diabetes: do we finally have an answer?
Jahangeer Basha, Sundeep Lakhtakia, Zaheer Nabi, Partha Pal, Radhika Chavan, Rupjyoti Talukdar, Mohan Ramchandani, Rajesh Gupta, Rakesh Kalapala, G Venkat Rao, D Nageshwar Reddy
Number of reflux episodes on pH-impedance monitoring associates with improved symptom outcome and treatment satisfaction in gastro-oesophageal reflux disease (GERD) patients with regurgitation
Benjamin D Rogers, Luis R Valdovinos, Michael D Crowell, Reginald Bell, Marcelo F Vela, C Prakash Gyawali
doi : http://dx.doi.org/10.1136/gutjnl-2020-321395
Objective Number of reflux episodes, an adjunctive metric on pH-impedance monitoring, is incompletely studied. We aimed to determine if number of reflux episodes associates with therapeutic outcome in regurgitation predominant gastro-oesophageal reflux disease (GERD).
Global prevalence of Barrett’s oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis
Leonardo Henry Eusebi, Giovanna Grazia Cirota, Rocco Maurizio Zagari, Alexander Charles Ford
doi : http://dx.doi.org/10.1136/gutjnl-2020-321365
Objectives Chronic gastro-oesophageal reflux might lead to the development of Barrett’s oesophagus (BO) or even oesophageal adenocarcinoma. There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of BO or oesophageal adenocarcinoma in individuals with gastro-oesophageal reflux.
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing
Min Zhang, Shuofeng Hu, Min Min, Yanli Ni, Zheng Lu, Xiaotian Sun, Jiaqi Wu, Bing Liu, Xiaomin Ying, Yan Liu
doi : http://dx.doi.org/10.1136/gutjnl-2019-320368
Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular and cellular heterogeneity in GA using single-cell RNA sequencing (scRNA-seq).
Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score
Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Naomi Kakushima, Shu Hoteya, Hisashi Doyama, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tomoyuki Koike, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribasyashi, Shu Kiyotoki, Katsuhiro Mabe, Tomohiro Nakamura, Naoki Nakaya, Mitsuhiro Fujishiro, Atsushi Masamune
doi : http://dx.doi.org/10.1136/gutjnl-2019-319926
Objective Bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is a frequent adverse event after ESD. We aimed to develop and externally validate a clinically useful prediction model (BEST-J score: Bleeding after ESD Trend from Japan) for bleeding after ESD for EGC.
SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation
Lea Ju?ni?, Kenneth Peuker, Anne Strigli, Mario Brosch, Alexander Herrmann, Robert H?sler, Michael Koch, Liz Matthiesen, Yvonne Zeissig, Britt-Sabina L?scher, Alexander Nuber, Gunnar Schotta, Volker Neumeister, Triantafyllos Chavakis, Thomas Kurth, Mathias Lesche, Andreas Dahl, Anne von M?ssenhausen, Andreas Linkermann, Stefan Schreiber, Konrad Aden, Philip C Rosenstiel, Andre Franke, Jochen Hampe, Sebastian Zeissig
doi : http://dx.doi.org/10.1136/gutjnl-2020-321339
Objective The intestinal epithelium is a rapidly renewing tissue which plays central roles in nutrient uptake, barrier function and the prevention of intestinal inflammation. Control of epithelial differentiation is essential to these processes and is dependent on cell type-specific activity of transcription factors which bind to accessible chromatin. Here, we studied the role of SET Domain Bifurcated Histone Lysine Methyltransferase 1, also known as ESET (SETDB1), a histone H3K9 methyltransferase, in intestinal epithelial homeostasis and IBD.
Ranking microbiome variance in inflammatory bowel disease: a large longitudinal intercontinental study
Adam G Clooney, Julia Eckenberger, Emilio Laserna-Mendieta, Kathryn A Sexton, Matthew T Bernstein, Kathy Vagianos, Michael Sargent, Feargal J Ryan, Carthage Moran, Donal Sheehan, Roy D Sleator, Laura E Targownik, Charles N Bernstein, Fergus Shanahan, Marcus J Claesson
doi : http://dx.doi.org/10.1136/gutjnl-2020-321106
Objective The microbiome contributes to the pathogenesis of inflammatory bowel disease (IBD) but the relative contribution of different lifestyle and environmental factors to the compositional variability of the gut microbiota is unclear.
Very early-life exposure to microbiota-induced TNF drives the maturation of neonatal pre-cDC1
Arnaud K?hler, Sandrine Delbauve, Justine Smout, David Torres, Véronique Flamand
doi : http://dx.doi.org/10.1136/gutjnl-2019-319700
Objective Induction of immune protection against pathogens is particularly crucial during the neonatal period dominated by anti-inflammatory and tolerance immunity. The preclinical study was carried out to determine whether environmental factors such as microbiota may influence early life immunity by impacting the development and the functional maturation of precursors of type 1 conventional dendritic cells (pre-cDC1), endowed with regulatory properties.
Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function
Fabian Frost, Tim Kacprowski, Malte Rühlemann, Maik Pietzner, Corinna Bang, Andre Franke, Matthias Nauck, Uwe V?lker, Henry V?lzke, Marcus D?rr, Jan Baumbach, Matthias Sendler, Christian Schulz, Julia Mayerle, Frank U Weiss, Georg Homuth, Markus M Lerch
doi : http://dx.doi.org/10.1136/gutjnl-2020-322753
Objective The intestinal microbiome affects the prevalence and pathophysiology of a variety of diseases ranging from inflammation to cancer. A reduced taxonomic or functional diversity of the microbiome was often observed in association with poorer health outcomes or disease in general. Conversely, factors or manifest diseases that determine the long-term stability or instability of the microbiome are largely unknown. We aimed to identify disease-relevant phenotypes associated with faecal microbiota (in-)stability.
Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort
Jasmohan S Bajaj, Guadalupe Garcia-Tsao, Scott W Biggins, Patrick S Kamath, Florence Wong, Sara McGeorge, Jawaid Shaw, Meredith Pearson, Micheal Chew, Andrew Fagan, Randolph de la Rosa Rodriguez, Janelle Worthington, Amy Olofson, Vanessa Weir, Calvin Trisolini, Sarah Dwyer, K Rajender Reddy
doi : http://dx.doi.org/10.1136/gutjnl-2020-322118
Objective Comorbid conditions are associated with poor prognosis in COVID-19. Registry data show that patients with cirrhosis may be at high risk. However, outcome comparisons among patients with cirrhosis+COVID-19 versus patients with COVID-19 alone and cirrhosis alone are lacking. The aim of this study was to perform these comparisons.
Impact of the COVID-19 pandemic on UK endoscopic activity and cancer detection: a National Endoscopy Database Analysis
Matthew D Rutter, Matthew Brookes, Thomas J Lee, Peter Rogers, Linda Sharp
doi : http://dx.doi.org/10.1136/gutjnl-2020-322179
Objective The COVID-19 pandemic has had a major global impact on endoscopic services. This reduced capacity, along with public reluctance to undergo endoscopy during the pandemic, might result in excess mortality from delayed cancer diagnosis. Using the UK’s National Endoscopy Database (NED), we performed the first national analysis of the impact of the pandemic on endoscopy services and endoscopic cancer diagnosis.
Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning
Korsuk Sirinukunwattana, Enric Domingo, Susan D Richman, Keara L Redmond, Andrew Blake, Clare Verrill, Simon J Leedham, Aikaterini Chatzipli, Claire Hardy, Celina M Whalley, Chieh-hsi Wu, Andrew D Beggs, Ultan McDermott, Philip D Dunne, Angela Meade, Steven M Walker, Graeme I Murray, Leslie Samuel, Matthew Seymour, Ian Tomlinson, Phil Quirke, Timothy Maughan, Jens Rittscher, Viktor H Koelzer
doi : http://dx.doi.org/10.1136/gutjnl-2019-319866
Objective Complex phenotypes captured on histological slides represent the biological processes at play in individual cancers, but the link to underlying molecular classification has not been clarified or systematised. In colorectal cancer (CRC), histological grading is a poor predictor of disease progression, and consensus molecular subtypes (CMSs) cannot be distinguished without gene expression profiling. We hypothesise that image analysis is a cost-effective tool to associate complex features of tissue organisation with molecular and outcome data and to resolve unclassifiable or heterogeneous cases. In this study, we present an image-based approach to predict CRC CMS from standard H&E sections using deep learning.
Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa
Laura Reyes-Uribe, Wenhui Wu, Ozkan Gelincik, Prashant V Bommi, Alejandro Francisco-Cruz, Luisa M Solis, Patrick M Lynch, Ramona Lim, Elena M Stoffel, Priyanka Kanth, N Jewel Samadder, Maureen E Mork, Melissa W Taggart, Ginger L Milne, Lawrence J Marnett, Lana Vornik, Diane D Liu, Maria Revuelta, Kyle Chang, Y Nancy You, Levy Kopelovich, Ignacio I Wistuba, J Jack Lee, Shizuko Sei, Robert H Shoemaker, Eva Szabo, Ellen Richmond, Asad Umar, Marjorie Perloff, Powel H Brown, Steven M Lipkin, Eduardo Vilar
doi : http://dx.doi.org/10.1136/gutjnl-2020-320946
Objective Patients with Lynch syndrome (LS) are at markedly increased risk for colorectal cancer. It is being increasingly recognised that the immune system plays an essential role in LS tumour development, thus making an ideal target for cancer prevention. Our objective was to evaluate the safety, assess the activity and discover novel molecular pathways involved in the activity of naproxen as primary and secondary chemoprevention in patients with LS.
Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure
Huayu Yang, Lejia Sun, Yuan Pang, Dandan Hu, Haifeng Xu, Shuangshuang Mao, Wenbo Peng, Yanan Wang, Yiyao Xu, Yong-Chang Zheng, Shunda Du, Haitao Zhao, Tianyi Chi, Xin Lu, Xinting Sang, Shouxian Zhong, Xin Wang, Hongbing Zhang, Pengyu Huang, Wei Sun, Yilei Mao
doi : http://dx.doi.org/10.1136/gutjnl-2019-319960
Objective Shortage of organ donors, a critical challenge for treatment of end-stage organ failure, has motivated the development of alternative strategies to generate organs in vitro. Here, we aim to describe the hepatorganoids, which is a liver tissue model generated by three-dimensional (3D) bioprinting of HepaRG cells and investigate its liver functions in vitro and in vivo.
Naturally occurring 5? preS1 deletions markedly enhance replication and infectivity of HBV genotype B and genotype C
Jing Li, Jisu Li, Shiqi Chen, Quan Yuan, Jing Zhang, Jingwen Wu, Qirong Jiang, Qianru Wang, Ning-Shao Xia, Jiming Zhang, Shuping Tong
doi : http://dx.doi.org/10.1136/gutjnl-2019-320096
Background and aims Deletion of 15-nucleotide or 18-nucleotide (nt) covering preS1 ATG frequently arises during chronic infection with HBV genotypes B and C. Since the second ATG is 33nt downstream, they truncate large (L) envelope protein by 11 residues like wild-type genotype D. This study characterised their functional consequences.
Alpha-1 antitrypsin governs alcohol-related liver disease in mice and humans
Christoph Grander, Benedikt Schaefer, Julian Schw?rzler, Felix Grabherr, Dennis M de Graaf, Barbara Enrich, Georg Oberhuber, Lisa Mayr, Moris Sangineto, Nikolai Jaschke, Timon E Adolph, Maria Effenberger, Alexander R Moschen, Charles A Dinarello, Heinz Zoller, Herbert Tilg
doi : http://dx.doi.org/10.1136/gutjnl-2020-321375
Objective Alcohol-related liver disease (ALD) is a global healthcare problem with limited treatment options. Alpha-1 antitrypsin (AAT, encoded by SERPINA1) shows potent anti-inflammatory activities in many preclinical and clinical trials. In our study, we aimed to explore the role of AAT in ALD.
Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health
Marina Fassarella, Ellen E Blaak, John Penders, Arjen Nauta, Hauke Smidt, Erwin G Zoetendal
doi : http://dx.doi.org/10.1136/gutjnl-2020-321747
The human gut microbiome is a complex ecosystem, densely colonised by thousands of microbial species. It varies among individuals and depends on host genotype and environmental factors, such as diet and antibiotics. In this review, we focus on stability and resilience as essential ecological characteristics of the gut microbiome and its relevance for human health. Microbial diversity, metabolic flexibility, functional redundancy, microbe–microbe and host–microbe interactions seem to be critical for maintaining resilience.
DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives
Lukas Perkhofer, Johann Gout, Elodie Roger, Fernando Kude de Almeida, Carolina Baptista Sim?es, Lisa Wiesmüller, Thomas Seufferlein, Alexander Kleger
doi : http://dx.doi.org/10.1136/gutjnl-2019-319984
Complex rearrangement patterns and mitotic errors are hallmarks of most pancreatic ductal adenocarcinomas (PDAC), a disease with dismal prognosis despite some therapeutic advances in recent years. DNA double-strand breaks (DSB) bear the greatest risk of provoking genomic instability, and DNA damage repair (DDR) pathways are crucial in preserving genomic integrity following a plethora of damage types. Two major repair pathways dominate DSB repair for safeguarding the genome integrity: non-homologous end joining and homologous recombination (HR).
Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study
Chun-Han Lo, Sohee Kwon, Liang Wang, Georgios Polychronidis, Markus D Knudsen, Rong Zhong, Yin Cao, Kana Wu, Shuji Ogino, Edward L Giovannucci, Andrew T Chan, Mingyang Song
Primed circulating monocytes are a source of IL-1? in patients with cirrhosis and ascites
Sven Stengel, Arndt Steube, Nilay K?se-Vogel, Tatiana Kirchberger-Tolstik, Sachin Deshmukh, Tony Bruns
Infliximab for severe ulcerative colitis and subsequent SARS-CoV-2 pneumonia: a stone for two birds
Cristina Bezzio, Gianpiero Manes, Francesco Bini, Lucienne Pellegrini, Simone Saibeni
Management strategies for the colonoscopic surveillance of people with Lynch syndrome during the COVID-19 pandemic
Kevin J Monahan, Anne Lincoln, James E East, Sally Benton, John Burn, Bianca DeSouza, Helen Hanson, Fiona Lalloo, Terri McVeigh, Matthew D Rutter, Katie Snape, Huw J W Thomas, Peter Sasieni
Response to: ‘Unified definition of relapse-free survival should be used for evaluating survival benefit in oesophageal adenocarcinoma’ by Li
Anita Lavery, Jaine K Blayney, Richard C Turkington
FMT in IBS: how cautious should we be?
Magdy El-Salhy
Risk factors in patients with COVID-19 developing severe liver injury during hospitalisation
Ke Zhan, Shengtao Liao, Jinfang Li, Yang Bai, Lin Lv, Keqi Yu, Liewang Qiu, Chuanfei Li, Guodan Yuan, An Zhang, Zhechuan Mei
Risk stratification in chronic hepatitis B patients for hepatocellular carcinoma surveillance: management in migrant sub-Saharan African populations
Zillah Cargill, Sarah E Brown, Geoff Dusheiko, Kosh Agarwal
‘Blast from the past’ colonoscopy complication treated with a novel approach
Mohamed Shiha, Stuart Laidlaw, Lesley Hunt, Andrew D Hopper
Correction: Gastroenterology department operational reorganisation at the time of COVID-19 outbreak: an Italian and Chinese experience
