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Associate Editorial Board
doi : 10.1016/S0007-0912(21)00467-0
Volume 127, Issue 3, September 2021, Page ii
Preoperative opioid use: a modifiable risk factor for poor postoperative outcomes
JaneQuinlan1NicholasLevy2Dileep N.Lobo34Pamela E.Macintyre5
doi : 10.1016/j.bja.2021.04.017
Volume 127, Issue 3, September 2021, Pages 327-331
Current multidisciplinary approaches to preventing chronic postoperative pain
ManoukAdmiraalJeroenHermanidesSoe L.MeinsmaHans C.H.WartenbergMartin V.H.RuttenVivian M.C.Ward-van der StamMarkus W.HollmannHenningHermanns
doi : 10.1016/j.bja.2021.04.018
Volume 127, Issue 3, September 2021, Pages 331-335
Implications for perioperative practice of changes in guidelines on the management of hypertension: challenges and opportunities
PierreFoëxJohn W.Sear
doi : 10.1016/j.bja.2021.05.006
Volume 127, Issue 3, September 2021, Pages 335-340
Sex, drugs, and anaesthesia research
Olivia A.Moody12Kathleen F.Vincent12KenSolt12
doi : 10.1016/j.bja.2021.06.025
Volume 127, Issue 3, September 2021, Pages 340-343
Long-term evidence of neonatal anaesthesia neurotoxicity linked to behavioural phenotypes in monkeys: where do we go from here?
JessicaRaper12Harold K.Simon234Pradip P.Kamat24
doi : 10.1016/j.bja.2021.06.005
Volume 127, Issue 3, September 2021, Pages 343-345
The evolution of methods to estimate the rate of medication error in anaesthesia
Craig S.Webster
doi : 10.1016/j.bja.2021.06.008
Volume 127, Issue 3, September 2021, Pages 346-349
Communication and team function affect patient outcomes in anaesthesia: getting the message across
Alan F.Merry12Jennifer M.Weller23
doi : 10.1016/j.bja.2021.06.033
Volume 127, Issue 3, September 2021, Pages 349-352
Noninvasive respiratory support and patient self-inflicted lung injury in COVID-19: a narrative review
DeniseBattaglini12ChiaraRobba13LorenzoBall13Pedro L.Silva45Fernanda F.Cruz45PaoloPelosi13Patricia R.M.Rocco45
doi : 10.1016/j.bja.2021.05.024
Volume 127, Issue 3, September 2021, Pages 353-364
Activation of the innate immune response and organ injury after cardiac surgery: a systematic review and meta-analysis of randomised trials and analysis of individual patient data from randomised and non-randomised studies
Riccardo G.Abbasciano1†Florence Y.Lai1†Marius A.Roman1AngelicaRizzello1SurajPathak1JoussiRamzi2CarlaLucarelli3Georgia R.Layton4TracyKumar1Marcin J.Wozniak1BryonyEagle-Hemming1EnochAkowuah5Chris A.Rogers6Gianni D.Angelini7Gavin J.Murphy1
doi : 10.1016/j.bja.2021.04.032
Volume 127, Issue 3, September 2021, Pages 365-375
It is unclear whether the innate immune response represents a therapeutic target for organ protection strategies in cardiac surgery.
Adherence to the European Society of Cardiology/European Society of Anaesthesiology recommendations on preoperative cardiac testing and association with positive results and cardiac events: a cohort study
Giovanna A.L.Lurati Buse1ChristianPuelacher2Danielle MenosiGualandro23DeryaKilinc2NoemiGlarner2RekaHidvegi24DanielBolliger4KetinaArslani2AndreasLampart4Luzius A.Steiner4ChristophKindler5ThomasWolff6EdinMujagic6LorenzGuerke6ChristianMueller2
doi : 10.1016/j.bja.2021.06.027
Volume 127, Issue 3, September 2021, Pages 376-385
European Society of Cardiology/European Society of Anaesthesiology (ESC/ESA) guidelines inform cardiac workup before noncardiac surgery based on an algorithm. Our primary hypotheses were that there would be associations between (i) the groups stratified according to the algorithms and major adverse cardiac events (MACE), and (ii) over- and underuse of cardiac testing and MACE.
Effect of electroencephalogram-guided anaesthesia administration on 1-yr mortality: follow-up of a randomised clinical trial
Bradley A.Fritz1†Christopher R.King1†Angela M.Mickle1Troy S.Wildes1Thaddeus P.Budelier1JordanOberhaus1DanielPark1Hannah R.Maybrier1ArbiBen Abdallah1AlexKronzer1Sherry L.McKinnon1Brian A.Torres1Thomas J.Graetz1Daniel A.Emmert1Ben J.Palanca1Tracey W.Stevens1Susan L.Stark2Eric J.Lenze3Michael S.Avidan1for the
doi : 10.1016/j.bja.2021.04.036
Volume 127, Issue 3, September 2021, Pages 386-395
Intraoperative EEG suppression duration has been associated with postoperative delirium and mortality. In a clinical trial testing anaesthesia titration to avoid EEG suppression, the intervention did not decrease the incidence of postoperative delirium, but was associated with reduced 30-day mortality. The present study evaluated whether the EEG-guided anaesthesia intervention was also associated with reduced 1-yr mortality.
Association of the intraoperative peripheral perfusion index with postoperative morbidity and mortality in acute surgical patients: a retrospective observational multicentre cohort study
MarianneAgerskov1Anna N.W.Thusholdt1HenrikHolm-S?rensen2SebastianWiberg1Christian S.Meyhoff3JakobH?jlund1Niels H.Secher4Nicolai B.Foss1
doi : 10.1016/j.bja.2021.06.004
Volume 127, Issue 3, September 2021, Pages 396-404
We hypothesised that in acute high-risk surgical patients, a lower intraoperative peripheral perfusion index (PPI) would indicate a higher risk of postoperative complications and mortality.
Association between perioperative allogeneic red blood cell transfusion and infection after clean-contaminated surgery: a retrospective cohort study
XiaohanXu1†YuelunZhang2†JiaGan3XiangyangYe4XuerongYu1YuguangHuang1
doi : 10.1016/j.bja.2021.05.031
Volume 127, Issue 3, September 2021, Pages 405-414
Allogeneic red blood cell (RBC) transfusion can induce immunosuppression, which can then increase the susceptibility to postoperative infection. However, studies in different types of surgery show conflicting results regarding this effect.
Pharmacokinetic properties of remimazolam in subjects with hepatic or renal impairment
ThomasSt?hr1Pieter J.Colin2JoachimOssig1†MarijaPesic1KeithBorkett3PeterWinkle4Michel M.R.F.Struys2FrankSchippers1
doi : 10.1016/j.bja.2021.05.027
Volume 127, Issue 3, September 2021, Pages 415-423
Remimazolam is a new benzodiazepine for procedural sedation and general anaesthesia. The aim of this study was to characterise its pharmacokinetic properties and safety in renally and hepatically impaired subjects.
Preoperative inflammatory mediators and postoperative delirium: systematic review and meta-analysis
Abiodun M.NoahDalalAlmghairbi†RachelEvleyIain K.Moppett
doi : 10.1016/j.bja.2021.04.033
Volume 127, Issue 3, September 2021, Pages 424-434
Postoperative delirium has eluded attempts to define its complex aetiology and describe specific risk factors. The role of neuroinflammation as a risk factor, determined by measuring blood levels of preoperative ‘innate’ inflammatory mediator levels, has been investigated. However, results have been conflicting. We conducted a systematic review and meta-analysis of the evidence on associations between preoperative blood levels of inflammatory mediators and postoperative delirium in the older person. Influence of type of surgery was also assessed.
Differential effects of the novel neurosteroid hypnotic (3?,5?,17?)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats
Srdjan M.Joksimovic1DayalanSampath2KathiresanKrishnan3Douglas F.Covey34VesnaJevtovic-Todorovic1Yogendra H.Raol5Slobodan M.Todorovic16
doi : 10.1016/j.bja.2021.03.029
Volume 127, Issue 3, September 2021, Pages 435-446
We recently showed that a neurosteroid analogue, (3?,5?,17?)-3-hydroxyandrostane-17-carbonitrile (3?-OH), induced hypnosis in rats. The aim of the present study was to evaluate the hypnotic and anaesthetic potential of 3?-OH further using electroencephalography.
Astrogliosis in juvenile non-human primates 2 years after infant anaesthesia exposure
ViolaNeudecker1†Jose F.Perez-Zoghbi1†Lauren D.Martin2Gregory A.Dissen2Marjorie R.Grafe3Ansgar M.Brambrink1
doi : 10.1016/j.bja.2021.04.034
Volume 127, Issue 3, September 2021, Pages 447-457
Infant anaesthesia causes acute brain cell apoptosis, and later in life cognitive deficits and behavioural alterations, in non-human primates (NHPs). Various brain injuries and neurodegenerative conditions are characterised by chronic astrocyte activation (astrogliosis). Glial fibrillary acidic protein (GFAP), an astrocyte-specific protein, increases during astrogliosis and remains elevated after an injury. Whether infant anaesthesia is associated with a sustained increase in GFAP is unknown. We hypothesised that GFAP is increased in specific brain areas of NHPs 2 yr after infant anaesthesia, consistent with prior injury.
An integrative review of method types used in the study of medication error during anaesthesia: implications for estimating incidence
RavinderBratch1Jaideep J.Pandit2
doi : 10.1016/j.bja.2021.05.023
Volume 127, Issue 3, September 2021, Pages 458-469
To meet the WHO vision of reducing medication errors by 50%, it is essential to know the current error rate. We undertook an integrative review of the literature, using a systematic search strategy. We included studies that provided an estimate of error rate (i.e. both numerator and denominator data), regardless of type of study (e.g. RCT or observational study). Under each method type, we categorised the error rate by type, by classification used by the primary studies (e.g. wrong drug, wrong dose, wrong time), and then pooled numerator and denominator data across studies to obtain an aggregate error rate for each method type. We included a total of 30 studies in this review. Of these, two studies were national audit projects containing relevant data, and for 28 studies we identified five discrete method types: retrospective recall (6), self-reporting (7), observational (5), large databases (7), and observing for drug calculation errors (3). Of these 28 studies we included 22 for a numerical analysis and used six to inform a narrative review. Drug error is recalled by ~1 in 5 anaesthetists as something that happened over their career; in self-reports there is an admitted rate of ~1 in 200 anaesthetics. In observed practice, error is seen in almost every anaesthetic. In large databases, drug error constitutes ~10% of anaesthesia incidents reported. Wrong drug or dose form the most common type of error across all five study method types (especially dosing error in paediatric studies). We conclude that medication error is common in anaesthetic practice, although we were uncertain of the precise frequency or extent of harm. Studies concerning medication error are very heterogenous, and we recommend consideration of standardised reporting as in other research domains.
Communication failures contributing to patient injury in anaesthesia malpractice claims??,
Rachel N.Douglas1Linda S.Stephens1Karen L.Posner1Joanna M.Davies1Shawn L.Mincer1Amanda R.Burden2Karen B.Domino1
doi : 10.1016/j.bja.2021.05.030
Volume 127, Issue 3, September 2021, Pages 470-478
Communication amongst team members is critical to providing safe, effective medical care. We investigated the role of communication failures in patient injury using the Anesthesia Closed Claims Project database.
Dimensional compatibility of currently available equipment for cricothyroidotomy and adult airway anatomy: an in vitro analysis
MichaelKemper12MarenKleine-Brueggeney1BertholdMoser3Christian P.Both1MarkusWeiss1
doi : 10.1016/j.bja.2021.05.022
Volume 127, Issue 3, September 2021, Pages 479-486
There are scant data on the dimensional compatibility of cricothyroidotomy equipment and related airway anatomy. We compared the dimensional design of devices for cricothyroidotomy with anatomical airway data for adult patients.
A Bayesian analysis of mortality outcomes in multicentre clinical trials in critical care
DavidSidebotham12IvorPopovich2ThomasLumley3
doi : 10.1016/j.bja.2021.06.026
Volume 127, Issue 3, September 2021, Pages 487-494
Multicentre RCTs are widely used by critical care researchers to answer important clinical questions. However, few trials evaluating mortality outcomes report statistically significant results. We hypothesised that the low proportion of trials reporting statistically significant differences for mortality outcomes is plausibly explained by lower-than-expected effect sizes combined with a low proportion of participants who could realistically benefit from studied interventions.
Venous congestion is more accurate than hypotension in predicting acute kidney injury after cardiac surgery. Comment on Br J Anaesth 2021; 126: 599–607
MatthiasJacquet-Lagrèze123ChristelleBerthod4RémiSchweizer1FaustineBredèche1ClaireLouyot1MartinRuste1Jean-LucFellahi123
doi : 10.1016/j.bja.2021.05.028
Volume 127, Issue 3, September 2021, Pages e81-e82
Intraoperative ketorolac may interact with patient-specific tumour genomics to modify recurrence risk in lung adenocarcinoma: an exploratory analysis
James G.Connolly1†Joseph R.Scarpa2†Hersh V.Gupta3†Kay SeeTan4BrookeMastrogiacomo5JosephDycoco1RaulCaso1Gregory D.Jones1FranciscoSanchez-Vega5Prasad S.Adusumilli16GaetanoRocco16James M.Isbell16Matthew J.Bott16TakeshiIrie27Patrick J.McCormick27Gregory W.Fischer27David R.Jones16Joshua S.Mincer27
doi : 10.1016/j.bja.2021.05.032
Volume 127, Issue 3, September 2021, Pages e82-e85
Gastric fluid volume in adults after implementation of a liberal fasting policy: a prospective cohort study
MarijeMarsman1NielsPouw1Leon M.G.Moons2Wilton A.van Klei1Teus H.Kappen1
doi : 10.1016/j.bja.2021.06.006
Volume 127, Issue 3, September 2021, Pages e85-e87
Association of surgery type and duration of hospitalisation with the ability to live independently after surgery
Felix C.Linhardt12Luca J.Wachtendorf12KarunaWongtangman13OmidAzimaraghi12Maximilian S.Schaefer14MatthiasEikermann25SamirKendale1
doi : 10.1016/j.bja.2021.06.007
Volume 127, Issue 3, September 2021, Pages e87-e90
Comparing high-flow nasal oxygenation or standard oxygenation for gastrointestinal endoscopy with sedation. Comment on Br J Anaesth 2021; 127: 133-42
Fu S.XueLiu J.Z.ShaoShao H.Liu
doi : 10.1016/j.bja.2021.06.017
Volume 127, Issue 3, September 2021, Pages e90-e92
Comparing high-flow nasal oxygenation or standard oxygenation for gastrointestinal endoscopy with sedation. Response to Br J Anaesth 2021; 127, e90–e91
Mai-AnhNayThierryBoulain
doi : 10.1016/j.bja.2021.06.013
Volume 127, Issue 3, September 2021, Page e92
Physiologically variable ventilation and severe asthma. Response to Br J Anaesth 2020; 126, e214
AndréDos Santos Rocha1RobertaSüdy1FerencPet?k2WalidHabre1
doi : 10.1016/j.bja.2021.05.029
Volume 127, Issue 3, September 2021, Pages e93-e94
Socioeconomic status and perioperative risk. Comment on Br J Anaesth 2021; 126:642-51
HelenWilliams1IainMoppett23
doi : 10.1016/j.bja.2021.06.015
Volume 127, Issue 3, September 2021, Pages e94-e95
Team factors influence emotions and stress in a non-operating room anaesthetising location
HedwigSchroeck12Andreas H.Taenzer123Karen E.Schifferdecker3
doi : 10.1016/j.bja.2021.06.018
Volume 127, Issue 3, September 2021, Pages e95-e98
Association between postoperative delirium and cerebral oxygen desaturation in older patients undergoing cardiac surgery. Comment on Br J Anaesth 2020; 124: 146-53
Fu S.XueShao H.LiuHai J.Hou
doi : 10.1016/j.bja.2021.06.019
Volume 127, Issue 3, September 2021, Pages e98-e99
Comparison of fascial plane blocks on quality of recovery for minimally invasive thoracic surgery. Response to Br J Anaesth 2021; 127: e14–5
Dylan T.Finnerty123Donal J.Buggy1245
doi : 10.1016/j.bja.2021.06.020
Volume 127, Issue 3, September 2021, Pages e99-e100
Perioperative fluid balance and its relationship with patient outcomes. Comment on Br J Anaesth 2021; 126: 720–9
CatherineYarr1UshaGurunathan23
doi : 10.1016/j.bja.2021.06.021
Volume 127, Issue 3, September 2021, Pages e101-e102
Association between intraoperative mean arterial pressure and postoperative complications is independent of cardiac index in patients undergoing noncardiac surgery
KamalMaheshwari12XuanPu23EvaRivas2BerndSaugel24AlparslanTuran12Marc T.Schmidt2KurtRuetzler12ChristianReiterer5BarbaraKabon5AndreaKurz126Daniel I.Sessler2
doi : 10.1016/j.bja.2021.06.024
Volume 127, Issue 3, September 2021, Pages e102-e104
Environmental impact of medical oxygen production in Australia. Comment on Br J Anaesth 2020; 125: 773–8
RichardSeglenieks12ScottMcAlister2ForbesMcGain123
doi : 10.1016/j.bja.2021.06.028
Volume 127, Issue 3, September 2021, Pages e104-e105
Under-recognised burden of postoperative anaemia in patients undergoing emergency abdominal surgery in the UK
KateKanga1EdwardDickson2HansVan Huellen1RuthDe Las Casas1MatthewCadd1Simon J.Stanworth45JohnGrant-Casey3AnitaSugavanam1
doi : 10.1016/j.bja.2021.06.029
Volume 127, Issue 3, September 2021, Pages e105-e108
Humidification via high-flow nasal cannula oxygen therapy does not generate aerosols
SatoshiHamada1NaoyaTanabe2ToyohiroHirai2
doi : 10.1016/j.bja.2021.06.001
Volume 127, Issue 3, September 2021, Pages e109-e110
Improved oxygenation with inhaled milrinone in mechanically ventilated patients with severe COVID-19
Dominik J.Vogel1AimeeBrame1FraserHanks12ChrisRemmington12NataliChung3LuigiCamporota14
doi : 10.1016/j.bja.2021.06.002
Volume 127, Issue 3, September 2021, Pages e111-e113
COVID-19: a novel risk factor for perioperative neurocognitive disorders
PenghuiWei1†WenyuanLyu1†TiantianWan2QiangZheng1WenxiTang1JianjunLi1Jian-junYang3
doi : 10.1016/j.bja.2021.06.016
Volume 127, Issue 3, September 2021, Pages e113-e115
Emergencies in Anaesthesia, 3rdedition Alastair Martin, Keith Allman, and Andrew McIndoe, editors Oxford University Press, Oxford, UK, 592 pp., £29.99, ISBN 9780198758143
George M.Francké1David W.Hewson2
doi : 10.1016/j.bja.2021.04.030
Volume 127, Issue 3, September 2021, Page 495
Immunomodulation of innate immunity by brachial plexus blockade: a crossover study
Shaun M.May12EricChiang1AnnaReyes2GladysMartir2AmourPatel1ShamirKarmali1SanjivPatel2SimeonWest2Ana G.del Arroyo1Alexander V.Gourine3Gareth L.Ackland14
doi : 10.1016/j.bja.2021.06.010
Volume 127, Issue 3, September 2021, Pages e116-e118
Distribution of in-line fluid injection pressure measurements during 40 MHz microultrasound targeted nerve injection in anaesthetised pigs
AlistairCowie1AmySadler2MalachyColumb3GraemeMcLeod12
doi : 10.1016/j.bja.2021.06.011
Volume 127, Issue 3, September 2021, Pages e118-e119
Recovery of motor function in ambulatory hand trauma using chloroprocaine 2%
A.AbdelhadiR.VanstoneM.Oldman
doi : 10.1016/j.bja.2021.06.012
Volume 127, Issue 3, September 2021, Page e119
