دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Selective digestive decontamination, a seemingly effective regimen with individual benefit or a flawed concept with population harm?
James C. Hurley
doi : 10.1186/s13054-021-03744-w
Critical Care volume 25, Article number: 323 (2021)
Selective digestive decontamination (SDD) regimens, variously constituted with topical antibiotic prophylaxis (TAP) and protocolized parenteral antibiotic prophylaxis (PPAP), appear highly effective for preventing ICU-acquired infections but only within randomized concurrent control trials (RCCT’s). Confusingly, SDD is also a concept which, if true, implies population benefit. The SDD concept can finally be reified in humans using the broad accumulated evidence base, including studies of TAP and PPAP that used non-concurrent controls (NCC), as a natural experiment. However, this test implicates overall population harm with higher event rates associated with SDD use within the ICU context.
Ten strategies to optimize early mobilization and rehabilitation in intensive care
Carol L. Hodgson, Stefan J. Schaller, Peter Nydahl, Karina Tavares Timenetsky & Dale M. Needham
doi : 10.1186/s13054-021-03741-z
Critical Care volume 25, Article number: 324 (2021)
Seasonal trends of incidence and outcomes of cardiogenic shock : findings from a large, nationwide inpatients sample with 441,696 cases
Peter Moritz Becher, Benedikt Schrage, Alina Go?ling, Nina Fluschnik, Moritz Seiffert, Alexander M. Bernhardt, Hermann Reichenspurner, Paulus Kirchhof, Stefan Blankenberg, Dirk Westermann & Collaboration Study Group
doi : 10.1186/s13054-021-03656-9
Critical Care volume 25, Article number: 325 (2021)
Isn’t it time to abandon ARDS? The COVID-19 lesson
L. Gattinoni & J. J. Marini
doi : 10.1186/s13054-021-03748-6
Critical Care volume 25, Article number: 326 (2021)
The use of head helmets to deliver noninvasive ventilatory support: a comprehensive review of technical aspects and clinical findings
Andrea Coppadoro, Elisabetta Zago, Fabio Pavan, Giuseppe Foti & Giacomo Bellani
doi : 10.1186/s13054-021-03746-8
Critical Care volume 25, Article number: 327 (2021)
A helmet, comprising a transparent hood and a soft collar, surrounding the patient’s head can be used to deliver noninvasive ventilatory support, both as continuous positive airway pressure and noninvasive positive pressure ventilation (NPPV), the latter providing active support for inspiration. In this review, we summarize the technical aspects relevant to this device, particularly how to prevent CO2 rebreathing and improve patient–ventilator synchrony during NPPV. Clinical studies describe the application of helmets in cardiogenic pulmonary oedema, pneumonia, COVID-19, postextubation and immune suppression. A section is dedicated to paediatric use. In summary, helmet therapy can be used safely and effectively to provide NIV during hypoxemic respiratory failure, improving oxygenation and possibly leading to better patient-centred outcomes than other interfaces.
Machine-learning-based COVID-19 mortality prediction model and identification of patients at low and high risk of dying
Mohammad M. Banoei, Roshan Dinparastisaleh, Ali Vaeli Zadeh & Mehdi Mirsaeidi
doi : 10.1186/s13054-021-03749-5
Critical Care volume 25, Article number: 328 (2021)
The coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-Cov2 virus has become the greatest health and controversial issue for worldwide nations. It is associated with different clinical manifestations and a high mortality rate. Predicting mortality and identifying outcome predictors are crucial for COVID patients who are critically ill. Multivariate and machine learning methods may be used for developing prediction models and reduce the complexity of clinical phenotypes.
Between-centre differences in care for in-hospital cardiac arrest: a prospective cohort study
B. Y. Gravesteijn, M. Schluep, H. F. Lingsma, R. J. Stolker, H. Endeman, S. E. Hoeks on behalf of the ROUTINE-study consortium
doi : 10.1186/s13054-021-03754-8
Critical Care volume 25, Article number: 329 (2021)
Survival after in-hospital cardiac arrest is poor, but current literature shows substantial heterogeneity in reported survival rates. This study aims to evaluate care for patients suffering in-hospital cardiac arrest (IHCA) in the Netherlands by assessing between-hospital heterogeneity in outcomes and to explain this heterogeneity stemming from differences in case-mix or differences in quality of care.
The management of multi-morbidity in elderly patients: Ready yet for precision medicine in intensive care?
Michael Beil, Hans Flaatten, Bertrand Guidet, Sigal Sviri, Christian Jung, Dylan de Lange, Susannah Leaver, Jesper Fj?lner, Wojciech Szczeklik & Peter Vernon van Heerden
doi : 10.1186/s13054-021-03750-y
Critical Care volume 25, Article number: 330 (2021)
There is ongoing demographic ageing and increasing longevity of the population, with previously devastating and often-fatal diseases now transformed into chronic conditions. This is turning multi-morbidity into a major challenge in the world of critical care. After many years of research and innovation, mainly in geriatric care, the concept of multi-morbidity now requires fine-tuning to support decision-making for patients along their whole trajectory in healthcare, including in the intensive care unit (ICU). This article will discuss current challenges and present approaches to adapt critical care services to the needs of these patients.
The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients
Antoni Torres, Anna Motos, Jordi Riera, Laia Fern?ndez-Barat, Adri?n Ceccato, Raquel Pérez-Arnal, Dario Garc?a-Gasulla, Oscar Pe?uelas, José Angel Lorente, Alejandro Rodriguez, David de Gonzalo-Calvo, Raquel Almansa, Albert Gabarr?s, Rosario Menéndez, Jes?s F. Bermejo-Martin, Ricard Ferrer, Rosario Amaya Villar, José M. A??n, Carme Barberà, José Barber?n, Aaron Blandino Ortiz, Elena Bustamante-Munguira, Jes?s Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catal?n-Gonz?lez, Crist?bal Galb?n, V?ctor D. Gumucio-Sanguino, Maria del Carmen de la Torre, Emili D?az, ?ngel Estella, Elena Gallego, José Luis Garc?a Garmendia, José Garnacho-Montero, José M. G?mez, Arturo Huerta, Ruth Noem? Jorge Garc?a, Ana Loza-V?zquez, Judith Marin-Corral, Amalia Mart?nez de la G?ndara, Ignacio Mart?nez Varela, Juan L?pez Messa, Guillermo M. Albaiceta, Mariana Andrea Novo, Yhivian Pe?asco, Juan Carlos Pozo-Laderas, Pilar Ricart, Inmaculada Salvador-Adell, Angel S?nchez-Miralles, Susana Sancho Chinesta, Lorenzo Socias, Jordi Solé-Violan, Fernando Suares Sipmann, Luis Tamayo Lomas, José Trenado, Ferran Barbé on behalf of CIBERESUCICOVID Project (COV20/00110, ISCIII)-Show fewer authors
doi : 10.1186/s13054-021-03727-x
Critical Care volume 25, Article number: 331 (2021)
Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission.
Concern with reproducibility of rehabilitation after critical illness and hospital discharge
Kota Yamauchi, Shunsuke Kina & Shunsuke Taito
doi : 10.1186/s13054-021-03745-9
Critical Care volume 25, Article number: 332 (2021)
Bedside estimates of dead space using end-tidal CO2 are independently associated with mortality in ARDS
Paola Lecompte-Osorio, Steven D. Pearson, Cole H. Pieroni, Matthew R. Stutz, Anne S. Pohlman, Julie Lin, Jesse B. Hall, Yu M. Htwe, Patrick G. Belvitch, Steven M. Dudek, Krysta Wolfe, Bhakti K. Patel & John P. Kress
doi : 10.1186/s13054-021-03751-x
Critical Care volume 25, Article number: 333 (2021)
In acute respiratory distress syndrome (ARDS), dead space fraction has been independently associated with mortality. We hypothesized that early measurement of the difference between arterial and end-tidal CO2 (arterial-ET difference), a surrogate for dead space fraction, would predict mortality in mechanically ventilated patients with ARDS.
Phenotypes and subphenotypes of delirium: a review of current categorisations and suggestions for progression
Emily M. L. Bowman, Emma L. Cunningham, Valerie J. Page & Daniel F. McAuley
doi : 10.1186/s13054-021-03752-w
Critical Care volume 25, Article number: 334 (2021)
Delirium is a clinical syndrome occurring in heterogeneous patient populations. It affects 45–87% of critical care patients and is often associated with adverse outcomes including acquired dementia, institutionalisation, and death. Despite an exponential increase in delirium research in recent years, the pathophysiological mechanisms resulting in the clinical presentation of delirium are still hypotheses. Efforts have been made to categorise the delirium spectrum into clinically meaningful subgroups (subphenotypes), using psychomotor subtypes such as hypoactive, hyperactive, and mixed, for example, and also inflammatory and non-inflammatory delirium. Delirium remains, however, a constellation of symptoms resulting from a variety of risk factors and precipitants with currently no successful targeted pharmacological treatment. Identifying specific clinical and biological subphenotypes will greatly improve understanding of the relationship between the clinical symptoms and the putative pathways and thus risk factors, precipitants, natural history, and biological mechanism. This will facilitate risk factor mitigation, identification of potential methods for interventional studies, and informed patient and family counselling. Here, we review evidence to date and propose a framework to identify subphenotypes. Endotype identification may be done by clustering symptoms with their biological mechanism, which will facilitate research of targeted treatments. In order to achieve identification of delirium subphenotypes, the following steps must be taken: (1) robust records of symptoms must be kept at a clinical level. (2) Global collaboration must facilitate large, heterogeneous research cohorts. (3) Patients must be clustered for identification, validation, and mapping of subphenotype stability.
Antifungal prophylaxis for prevention of COVID-19-associated pulmonary aspergillosis in critically ill patients: an observational study
Stefan Hatzl, Alexander C. Reisinger, Florian Posch, Juergen Prattes, Martin Stradner, Stefan Pilz, Philipp Eller, Michael Schoerghuber, Wolfgang Toller, Gregor Gorkiewicz, Philipp Metnitz, Martin Rief, Florian Prüller, Alexander R. Rosenkranz, Thomas Valentin, Robert Krause, Martin Hoenigl & Gernot Schilcher
doi : 10.1186/s13054-021-03753-9
Critical Care volume 25, Article number: 335 (2021)
Coronavirus disease 19 (COVID-19)-associated pulmonary aspergillosis (CAPA) emerged as important fungal complications in patients with COVID-19-associated severe acute respiratory failure (ARF). Whether mould active antifungal prophylaxis (MAFP) can prevent CAPA remains elusive so far.
Identification of persistent and resolving subphenotypes of acute hypoxemic respiratory failure in two independent cohorts
Neha A. Sathe, Leila R. Zelnick, Carmen Mikacenic, Eric D. Morrell, Pavan K. Bhatraju, J. Brennan McNeil, Susanna Kosamo, Catherine L. Hough, W. Conrad Liles, Lorraine B. Ware & Mark M. Wurfel
doi : 10.1186/s13054-021-03755-7
Critical Care volume 25, Article number: 336 (2021)
Acute hypoxemic respiratory failure (HRF) is associated with high morbidity and mortality, but its heterogeneity challenges the identification of effective therapies. Defining subphenotypes with distinct prognoses or biologic features can improve therapeutic trials, but prior work has focused on ARDS, which excludes many acute HRF patients. We aimed to characterize persistent and resolving subphenotypes in the broader HRF population.
Short and long-term outcomes of patients with COVID-19-associated acute respiratory distress syndrome and difficult veno-venous-ECMO weaning
Paul Masi, Samuel Tuffet, Laurent Boyer, Thierry Folliguet, Armand Mekontso Dessap & Nicolas de Prost
doi : 10.1186/s13054-021-03758-4
Critical Care volume 25, Article number: 337 (2021)
Trends in the incidence and outcome of sepsis using data from a Japanese nationwide medical claims database-the Japan Sepsis Alliance (JaSA) study group-
Taro Imaeda, Taka-aki Nakada, Nozomi Takahashi, Yasuo Yamao, Satoshi Nakagawa, Hiroshi Ogura, Nobuaki Shime, Yutaka Umemura, Asako Matsushima & Kiyohide Fushimi
doi : 10.1186/s13054-021-03762-8
Critical Care volume 25, Article number: 338 (2021)
Trends in the incidence and outcomes of sepsis using a Japanese nationwide database were investigated.
Lung ultrasound in a tertiary intensive care unit population: a diagnostic accuracy study
Jasper M. Smit, Mark E. Haaksma, Michiel H. Winkler, Micah L. A. Heldeweg, Luca Arts, Erik J. Lust, Paul W. G. Elbers, Lilian J. Meijboom, Armand R. J. Girbes, Leo M. A. Heunks & Pieter R. Tuinman
doi : 10.1186/s13054-021-03759-3
Critical Care volume 25, Article number: 339 (2021)
Evidence from previous studies comparing lung ultrasound to thoracic computed tomography (CT) in intensive care unit (ICU) patients is limited due to multiple methodologic weaknesses. While addressing methodologic weaknesses of previous studies, the primary aim of this study is to investigate the diagnostic accuracy of lung ultrasound in a tertiary ICU population.
Early versus late awake prone positioning in non-intubated patients with COVID-19
Ramandeep Kaur, David L. Vines, Sara Mirza, Ahmad Elshafei, Julie A. Jackson, Lauren J. Harnois, Tyler Weiss, J. Brady Scott, Matthew W. Trump, Idrees Mogri, Flor Cerda, Amnah A. Alolaiwat, Amanda R. Miller, Andrew M. Klein, Trevor W. Oetting, Lindsey Morris, Scott Heckart, Lindsay Capouch, Hangyong He & Jie Li
doi : 10.1186/s13054-021-03761-9
Critical Care volume 25, Article number: 340 (2021)
Awake prone positioning (APP) is widely used in the management of patients with coronavirus disease (COVID-19). The primary objective of this study was to compare the outcome of COVID-19 patients who received early versus late APP.
A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes
Faheem W. Guirgis, Lauren Page Black, Morgan Henson, Guillaume Labilloy, Carmen Smotherman, Charlotte Hopson, Ian Tfirn, Elizabeth L. DeVos, Christiaan Leeuwenburgh, Lyle Moldawer, Susmita Datta, Todd M. Brusko, Alexis Hester, Andrew Bertrand, Victor Grijalva, Alexander Arango-Esterhay, Frederick A. Moore & Srinivasa T. Reddy
doi : 10.1186/s13054-021-03757-5
Critical Care volume 25, Article number: 341 (2021)
Approximately one-third of sepsis patients experience poor outcomes including chronic critical illness (CCI, intensive care unit (ICU) stay?>?14 days) or early death (in-hospital death within 14 days). We sought to characterize lipoprotein predictive ability for poor outcomes and contribution to sepsis heterogeneity.
The lonely glutamine tree in the middle of the infinite critically ill forest
Panagiotis Briassoulis, Stavroula Ilia, Efrossini Briassouli, Marianna Miliaraki & George Briassoulis
doi : 10.1186/s13054-021-03743-x
Critical Care volume 25, Article number: 342 (2021)
Does inspiration of exhaled CO2 explain improved oxygenation with a face mask plus high-flow nasal cannula oxygen in severe COVID-19 infection?
Erik R. Swenson
doi : 10.1186/s13054-021-03771-7
Critical Care volume 25, Article number: 343 (2021)
Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe
Christian Jung, Jesper Fj?lner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Finn H. Andersen, Rui Moreno, Susannah Leaver, Ariane Boumendil, Dylan W. De Lange, Bertrand Guidet, Hans Flaatten & , COVIP Study Group
doi : 10.1186/s13054-021-03739-7
Critical Care volume 25, Article number: 344 (2021)
The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe.
Feasibility of machine integrated point of care lung ultrasound automatic B-lines tool in the Corona-virus 2019 critical care unit
Gal Tsaban, Ori Galante, Yaniv Almog, Yuval Ullman & Lior Fuchs
doi : 10.1186/s13054-021-03770-8
Critical Care volume 25, Article number: 345 (2021)
Acute cor pulmonale in Covid-19 related acute respiratory distress syndrome
Pedro Cavaleiro, Paul Masi, François Bagate, Thomas d’Humières & Armand Mekontso Dessap
doi : 10.1186/s13054-021-03756-6
Critical Care volume 25, Article number: 346 (2021)
Restricted visitation policies in acute care settings during the COVID-19 pandemic: a scoping review
Stephana J. Moss, Karla D. Krewulak, Henry T. Stelfox, Sofia B. Ahmed, Melanie C. Anglin, Sean M. Bagshaw, Karen E. A. Burns, Deborah J. Cook, Christopher J. Doig, Alison Fox-Robichaud, Robert Fowler, Laura Hern?ndez, Michelle E. Kho, Maia Kredentser, Kira Makuk, Srinivas Murthy, Daniel J. Niven, Kendiss Olafson, Ken Kuljit S. Parhar, Scott B. Patten, Oleksa G. Rewa, Bram Rochwerg, Bonnie Sept, Andrea Soo, Krista Spence, Sean Spence, Sharon Straus, Andrew West, Jeanna Parsons Leigh & Kirsten M. Fiest -Show fewer authors
doi : 10.1186/s13054-021-03763-7
Critical Care volume 25, Article number: 347 (2021)
Restricted visitation policies in acute care settings because of the COVID-19 pandemic have negative consequences. The objective of this scoping review is to identify impacts of restricted visitation policies in acute care settings, and describe perspectives and mitigation approaches among patients, families, and healthcare professionals.
Pneumocystis pneumonia risk among viral acute respiratory distress syndrome related or not to COVID 19
Keyvan Razazi, Romain Arrestier, Anne Fleur Haudebourg, Francoise Botterel, Armand Mekontso Dessap & and the COVID PCP group
doi : 10.1186/s13054-021-03767-3
Critical Care volume 25, Article number: 348 (2021)
Effectiveness of anisodamine for the treatment of critically ill patients with septic shock: a multicentre randomized controlled trial
Yuetian Yu, Cheng Zhu, Yucai Hong, Lin Chen, Zhiping Huang, Jiancang Zhou, Xin Tian, Dadong Liu, Bo Ren, Cao Zhang, Caibao Hu, Xinan Wang, Rui Yin, Yuan Gao & Zhongheng Zhang
doi : 10.1186/s13054-021-03774-4
Critical Care volume 25, Article number: 349 (2021)
Septic shock is characterized by an uncontrolled inflammatory response and microcirculatory dysfunction. There is currently no specific agent for treating septic shock. Anisodamine is an agent extracted from traditional Chinese medicine with potent anti-inflammatory effects. However, its clinical effectiveness remains largely unknown.
Association of deranged cerebrovascular reactivity with brain injury following cardiac arrest: a post-hoc analysis of the COMACARE trial
Johanna Laurikkala, Anders Aneman, Alexander Peng, Matti Reinikainen, Paul Pham, Pekka Jakkula, Johanna H?stbacka, Erika Wilkman, Pekka Loisa, Jussi Toppila, Thomas Birkelund, Kaj Blennow, Henrik Zetterberg & Markus B. Skrifvars
doi : 10.1186/s13054-021-03764-6
Critical Care volume 25, Article number: 350 (2021)
Impaired cerebrovascular reactivity (CVR) is one feature of post cardiac arrest encephalopathy. We studied the incidence and features of CVR by near infrared spectroscopy (NIRS) and associations with outcome and biomarkers of brain injury.
The impact of wearable continuous vital sign monitoring on deterioration detection and clinical outcomes in hospitalised patients: a systematic review and meta-analysis
Carlos Areia, Christopher Biggs, Mauro Santos, Neal Thurley, Stephen Gerry, Lionel Tarassenko, Peter Watkinson & Sarah Vollam
doi : 10.1186/s13054-021-03766-4
Critical Care volume 25, Article number: 351 (2021)
Timely recognition of the deteriorating inpatient remains challenging. Wearable monitoring systems (WMS) may augment current monitoring practices. However, there are many barriers to implementation in the hospital environment, and evidence describing the clinical impact of WMS on deterioration detection and patient outcome remains unclear.
The knowns and unknowns of perfusion disturbances in COVID-19 pneumonia
Mattia Busana & Lorenzo Giosa
doi : 10.1186/s13054-021-03742-y
Critical Care volume 25, Article number: 352 (2021)
