JAMA - Journal of the American Medical Association




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سفارش

Effect of Out-of-Hospital Tranexamic Acid vs Placebo on 6-Month Functional Neurologic Outcomes in Patients With Moderate or Severe Traumatic Brain Injury

Susan E. Rowell, MD, MBA; Eric N. Meier, MS; Barbara McKnight, PhD; et al.

doi : 10.1001/jama.2020.8958

JAMA. 2020;324(10):961-974. 

This randomized clinical trial compares the effects of an out-of-hospital tranexamic acid bolus vs placebo within 2 hours of traumatic brain injury (TBI) on 6-month functional neurologic outcome (Glasgow Coma Scale-Extended score >4) in patients with moderate or severe TBI.

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Association Between Patient Social Risk and Physician Performance Scores in the First Year of the Merit-based Incentive Payment System

Dhruv Khullar, MD, MPP; William L. Schpero, PhD; Amelia M. Bond, PhD; et al.

doi : 10.1001/jama.2020.13129

JAMA. 2020;324(10):975-983.

This study uses data from the Medicare Physician Compare database to assess associations between patient social risk, defined as dual eligibility for Medicare and Medicaid, and physicians’ Merit-based Incentive Payment System (MIPS) data scores, a proxy for patient outcomes and care value.

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Association of Clinician Health System Affiliation With Outpatient Performance Ratings in the Medicare Merit-based Incentive Payment System

Kenton J. Johnston, PhD; Timothy L. Wiemken, PhD; Jason M. Hockenberry, PhD; et al.

doi : 10.1001/jama.2020.13136

JAMA. 2020;324(10):984-992.

This study uses data from the Medicare Physician Compare database to assess associations between clinician affiliation with health systems and performance scores and value-based reimbursement under the 2019 Merit-based Incentive Payment System (MIPS).

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Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity OutcomesInterim Analysis of 2 Randomized Clinical Trials

Shengli Xia, BS; Kai Duan, PhD; Yuntao Zhang, PhD; et al.

doi : 10.1001/jama.2020.15543

JAMA. 2020;324(10):951-960.

This interim analysis of 2 randomized trials compares adverse reactions and neutralizing antibody responses to inactivated coronavirus disease 2019 (COVID-19) vs adjuvant-only control vaccination, and compares the outcomes at varying vaccine doses among healthy adults in China.

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Characteristics and Outcomes of COVID-19 Patients During Initial Peak and Resurgence in the Houston Metropolitan Area

Farhaan S. Vahidy, PhD, MBBS, MPH; Ashley L. Drews, MD; Faisal N. Masud, MD; et al.

doi : 10.1001/jama.2020.15301

JAMA. 2020;324(10):998-1000.

This study examined the sociodemographic and clinical characteristics of patients, as well as their clinical outcomes, during a surge in COVID-19 disease in Houston, Texas.

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Allocation of COVID-19 Relief Funding to Disproportionately Black Counties

Pragya Kakani, AB; Amitabh Chandra, PhD; Sendhil Mullainathan, PhD; et al.

doi : 10.1001/jama.2020.14978

JAMA. 2020;324(10):1000-1003. 

This study describes correlations between the dollar amount of relief funding authorized by the US Congress to fund prevention, diagnosis, and treatment of coronavirus disease 2019 (COVID-19) and to reimburse health care entities for lost revenues, and county-level Black population fraction accounting for county COVID-19 burden, comorbidity, and hospital financial health.

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Hepatitis C–Related Hepatocellular Carcinoma Incidence in the Veterans Health Administration After Introduction of Direct-Acting Antivirals

Lauren A. Beste, MD, MSc; Pamela Green, PhD; Kristin Berry, PhD; et al.

doi : 10.1001/jama.2020.10121

JAMA. 2020;324(10):1003-1005

This study describes trends in the incidence of hepatocellular carcinoma within the Veterans Health Administration from 2002 to 2018 before and after widespread direct-acting anti–hepatitis C virus (HCV) treatment.

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Unwavering Regulatory Safeguards for COVID-19 Vaccines

Anand Shah, MD; Peter W. Marks, MD, PhD; Stephen M. Hahn, MD

doi : 10.1001/jama.2020.15725

JAMA. 2020;324(10):931-932. 

This Viewpoint from the FDA reviews the minimum safety and efficacy standards COVID-19 vaccine candidates would need to meet to be considered for approval, and affirms its commitments to evaluating both in diverse populations and to postmarketing surveillance as means to ensure that approval will meet the highest safety and regulatory standards based on science and evidence, not politics.

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Precision Public Health as a Key Tool in the COVID-19 Response

Sonja A. Rasmussen, MD, MS; Muin J. Khoury, MD, PhD; Carlos del Rio, MD

doi : 10.1001/jama.2020.14992

JAMA. 2020;324(10):933-934.

This Viewpoint provides examples of how applying precision public health operations can help curb the COVID-19 pandemic.

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Cascading Risks of COVID-19 Resurgence During an Active 2020 Atlantic Hurricane Season

James M. Shultz, MS, PhD; Craig Fugate; Sandro Galea, MD, DrPH

doi : 10.1001/jama.2020.15398

JAMA. 2020;324(10):935-936.

This Viewpoint discusses the prospects for exacerbation of the coronavirus disease 2019 (COVID-19) pandemic during hurricane season in the US, and proposes reinforcement of public health measures, clear communication, and learning from each experience to reduce the risks of hurricane-related harms and increases in COVID-19 cases.

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Improving Physician Communication About Treatment DecisionsReconsideration of “Risks vs Benefits”

Daniel J. Morgan, MD; Laura D. Scherer, PhD; Deborah Korenstein, MD

doi : 10.1001/jama.2020.0354

JAMA. 2020;324(10):937-938.

This Viewpoint emphasizes the importance of precise language to help patients make evidence-informed decisions in shared decision-making, and argues that references to “chances of harms and benefits” will be more understandable to patients than discussions of “probabilities of risks and benefits.”

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Over-the-Counter Oral Contraceptives to Reduce Unintended Pregnancies

Kunal K. Sindhu, MD; Eli Y. Adashi, MD, MS

doi : 10.1001/jama.2019.21862

JAMA. 2020;324(10):939-940.

This Viewpoint reviews progress and challenges to date in federal and state efforts to transition combination oral contraceptives (COCs) from being prescription only to over-the-counter status in the US.

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The Silence and Sorrow of Miscarriage

Altaf Saadi, MD, MSc

doi : 10.1001/jama.2020.15959

JAMA. 2020;324(10):941-942. 

In this narrative medicine essay, a neurologist relates the story of her miscarriage while touring immigration detention centers in Texas documenting medical care and human rights violations and shares her deep sorrow for the women who lost children either by force or miscarriages while incarcerated.

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An Inactivated Virus Candidate Vaccine to Prevent COVID-19

Mark J. Mulligan, MD

doi : 10.1001/jama.2020.15539

JAMA. 2020;324(10):943-945. 

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Out-of-Hospital Tranexamic Acid for Traumatic Brain Injury

David C. Cone, MD; Daniel W. Spaite, MD; Timothy J. Coats, MBBS

doi : 10.1001/jama.2020.9244

JAMA. 2020;324(10):946-947.

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Potential Adverse Financial Implications of the Merit-based Incentive Payment System for Independent and Safety Net Practices

Carrie H. Colla, PhD; Toyin Ajayi, MD, MPhil; Asaf Bitton, MD, MPH

doi : 10.1001/jama.2020.13093

JAMA. 2020;324(10):948-950. 

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Polymyalgia Rheumatica and Giant Cell Arteritis

Frank Buttgereit, MD; Eric L. Matteson, MD, MPH; Christian Dejaco, MD, PhD

doi : 10.1001/jama.2020.10155

JAMA. 2020;324(10):993-994.

This JAMA Insights Clinical Update reviews the diagnosis and management of polymyalgia rheumatica and giant cell arteritis and provides a suggested treatment algorithm for giant cell arteritis.

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Decreased Exercise Tolerance in a Young Woman

Nicholas A. Oh, MD; John E. Mayer Jr, MD

doi : 10.1001/jama.2020.8415

JAMA. 2020;324(10):995-996.

A 31-year-old woman with a history of childhood heart murmur has exercise intolerance due to dyspnea, no chest pain, a fixed split S2 and a 2/6 systolic murmur at the left upper sternal border, and incomplete right bundle-branch block on ECG. Chest imaging shows increased vascularity, cardiomegaly, and an enlarged right atrium and right ventricle. What is the diagnosis and what would you do next?

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What Happens When COVID-19 Collides With Flu Season?

doi : 10.1001/jama.2020.15260

JAMA. 2020;324(10):923-925.

This Medical News feature examines what might happen when COVID-19 meets seasonal influenza this fall.

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Flu Vaccination Urged During COVID-19 Pandemic

Mary Chris Jaklevic, MSJ

doi : 10.1001/jama.2020.15444

JAMA. 2020;324(10):926-927.

This Medical News article reports on efforts to increase flu vaccinations during the COVID-19 pandemic.

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COVID-19 Precautions Helped Limit Cases Linked to Milwaukee Primary

Bridget M. Kuehn, MSJ

doi : 10.1001/jama.2020.16103

JAMA. 2020;324(10):929.

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TB Control Suffers During Pandemic

Bridget M. Kuehn, MSJ

doi : 10.1001/jama.2020.15886

JAMA. 2020;324(10):929. 

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Antibiotic-Sparing Gonorrhea Diagnostic Wins Federal Funding

Jennifer Abbasi

doi : 10.1001/jama.2020.16465

JAMA. 2020;324(10):928.

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Drug Repurposing Study Pinpoints Potential COVID-19 Antivirals

Jennifer Abbasi

doi : 10.1001/jama.2020.15948

JAMA. 2020;324(10):928.

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New T-Cell Therapy Tested for Multiple Myeloma

Jennifer Abbasi

doi : 10.1001/jama.2020.16467

JAMA. 2020;324(10):928. 

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Dance for Respiratory Patients in Low-Resource Settings

Keir E. J. Philip, MRCP; Winceslaus Katagira, MD; Rupert Jones, MD

doi : 10.1001/jama.2020.15426

JAMA. 2020;324(10):921-922.

This Arts and Medicine feature describes the integration of local dance traditions into pulmonary rehabilitation programs for COPD and tuberculosis patients in low- and middle-income countries.

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Moving Back to the Marriage Bed

Deborah Scaperoth, PhD

doi : 10.1001/jama.2020.7447

JAMA. 2020;324(10):1010. 

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The President Outlines a Program

doi : 10.1001/jama.2019.13609

JAMA. 2020;324(10):1011. 

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Heart Failure

Jayson R. Baman, MD; Faraz S. Ahmad, MD, MS

doi : 10.1001/jama.2020.13310

JAMA. 2020;324(10):1015.

This JAMA Patient Page describes heart failure and its diagnosis, treatment options, and prevention measures.

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Caring for Someone With COVID-19

Lindsey Y. Mortenson, MD; Preeti N. Malani, MD, MSJ; Robert D. Ernst, MD

doi : 10.1001/jama.2020.15061

JAMA. 2020;324(10):1016. 

This JAMA Patient Page reviews the symptoms and signs of COVID-19, at-home management of the infection, and precautions to take while caring for someone with it.

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Reconfiguring Medical Education

Hugh A. Stoddard, MEd, PhD

doi : 10.1001/jama.2020.10899

JAMA. 2020;324(10):1005-1006. 

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Reconfiguring Medical Education

Jennifer M. Connell, BS; Jan A. Niec, BS; Kayvon F. Sharif, BA

doi : 10.1001/jama.2020.10902

JAMA. 2020;324(10):1006.

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Reconfiguring Medical Education

Daniel Yim

doi : 10.1001/jama.2020.10896

JAMA. 2020;324(10):1006-1007.

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Reconfiguring Medical Education

George D. Everett, MD; Michael Muszynski, MD

doi : 10.1001/jama.2020.10905

JAMA. 2020;324(10):1007. 

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Reconfiguring Medical Education—Reply

Ezekiel J. Emanuel, MD, PhD

doi : 10.1001/jama.2020.10908

JAMA. 2020;324(10):1007-1008.

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Chikungunya Virus–Like Particle Vaccine

Nishant Jaiswal, MBBS, PhD; Shreya Singh, MD; Meenu Singh, MD

doi : 10.1001/jama.2020.11845

JAMA. 2020;324(10):1008. 

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Chikungunya Virus–Like Particle Vaccine—Reply

Grace L. Chen, MD, MPH

doi : 10.1001/jama.2020.11859

JAMA. 2020;324(10):1008-1009.

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Correction to Affiliations in Arts and Medicine Feature

doi : 10.1001/jama.2020.15817

JAMA. 2020;324(10):1009.

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