دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Of Occlusions, Inclusions, and Exclusions: Time to Reclassify Infarctions?
Mullasari Ajit Sankardas, Venkatakrishnan Ramakumar, Faraz Ahmed Farooqui
doi : 10.1161/CIRCULATIONAHA.121.055827
Circulation. 2021;144:333–335
Impact of High-Deductible Health Plans on Emergency Department Patients With Nonspecific Chest Pain and Their Subsequent Care
Shih-Chuan Chou, Arthur S. Hong, Scott G. Weiner, J. Frank Wharam
doi : 10.1161/CIRCULATIONAHA.120.052501
Circulation. 2021;144:336–349
Timely evaluation of acute chest pain is necessary, although most evaluations will not find significant coronary disease. With employers increasingly adopting high-deductible health plans (HDHP), how HDHPs impact subsequent care after an emergency department (ED) diagnosis of nonspecific chest pain is unclear.
High-Deductible Health Plans and Emergency Care for Chest Pain: To Go or Not to Go
Neil M. Kalwani, Alexander T. Sandhu
doi : 10.1161/CIRCULATIONAHA.121.055368
Circulation. 2021;144:350–352
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease
Michael G. Levin, Verena Zuber, Venexia M. Walker, Derek Klarin, Julie Lynch, Rainer Malik, Aaron W. Aday, Leonardo Bottolo, Aruna D. Pradhan, Martin Dichgans, Kyong-Mi Chang, Daniel J. Rader, Philip S. Tsao, Benjamin F. Voight, Dipender Gill, Stephen Burgess, Scott M. Damrauer, on behalf of the VA Million Veteran Program
doi : 10.1161/CIRCULATIONAHA.121.053797
Circulation. 2021;144:353–364
Lipoprotein-related traits have been consistently identified as risk factors for atherosclerotic cardiovascular disease, largely on the basis of studies of coronary artery disease (CAD). The relative contributions of specific lipoproteins to the risk of peripheral artery disease (PAD) have not been well defined. We leveraged large-scale genetic association data to investigate the effects of circulating lipoprotein-related traits on PAD risk.
In Vivo Function of Flow-Responsive Cis-DNA Elements of eNOS Gene: A Role for Chromatin-Based Mechanisms
Kyung Ha Ku, Michelle K. Dubinsky, Aravin N. Sukumar, Noeline Subramaniam, Manon Y.M. Feasson, Ranju Nair, Eileen Tran, Brent M. Steer, Britta J. Knight, Philip A. Marsden
doi : 10.1161/CIRCULATIONAHA.120.051078
Circulation. 2021;144:365–381
eNOS (endothelial nitric oxide synthase) is an endothelial cell (EC)–specific gene predominantly expressed in medium- to large-sized arteries where ECs experience atheroprotective laminar flow with high shear stress. Disturbed flow with lower average shear stress decreases eNOS transcription, which leads to the development of atherosclerosis, especially at bifurcations and curvatures of arteries. This prototypic arterial EC gene contains 2 distinct flow-responsive cis-DNA elements in the promoter, the shear stress response element (SSRE) and the KLF (Krüppel-like factor) element. Previous in vitro studies suggested their positive regulatory functions on flow-induced transcription of EC genes including eNOS. However, the in vivo function of these cis-DNA elements remains unknown.
Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy
Dries A.M. Feyen, Isaac Perea-Gil, Renee G.C. Maas, Magdalena Harakalova, Alexandra A. Gavidia, Jennifer Arthur Ataam, Ting-Hsuan Wu, Aryan Vink, Jiayi Pei, Nirmal Vadgama, Albert J. Suurmeijer, Wouter P. te Rijdt, Michelle Vu, Prashila L. Amatya, Maricela Prado, Yuan Zhang, Logan Dunkenberger, Joost P.G. Sluijter, Karim Sallam, Folkert W. Asselbergs, Mark Mercola, Ioannis Karakikes
doi : 10.1161/CIRCULATIONAHA.120.049844
Circulation. 2021;144:382–392
Phospholamban (PLN) is a critical regulator of calcium cycling and contractility in the heart. The loss of arginine at position 14 in PLN (R14del) is associated with dilated cardiomyopathy with a high prevalence of ventricular arrhythmias. How the R14 deletion causes dilated cardiomyopathy is poorly understood, and there are no disease-specific therapies.
Vegan Diets That Are Culturally Aligned With Traditional Soul Food Gain Popularity Among Black Individuals
Bridget M. Kuehn
doi : 10.1161/CIRCULATIONAHA.121.056354
Circulation. 2021;144:393–394
Platypnea-Orthodeoxia Syndrome: A Case of Persistent Hypoxemia in an Elderly Patient
Renata Ribeiro, Inês Fialho, Leonor Boavida
doi : 10.1161/CIRCULATIONAHA.121.054424
Circulation. 2021;144:395–398
Diffuse ST-Segment Elevation With Idiopathic Malignant Ventricular Arrhythmia
Stefanie Cheang, Paul LeLorier, Kelly Gajewski
doi : 10.1161/CIRCULATIONAHA.121.054910
Circulation. 2021;144:399–402
PTPMT1 Is Required for Embryonic Cardiac Cardiolipin Biosynthesis to Regulate Mitochondrial Morphogenesis and Heart Development
Ze’e Chen, Siting Zhu, Hong Wang, Li Wang, Jianlin Zhang, Yusu Gu, Changming Tan, Mehul Dhanani, Eric Wever, Xinru Wang, Boyu Xie, Shijia Wang, Lei Huang, Antoine H.C. van Kampen, Jie Liu, Zhen Han, Hemal H. Patel, Frédéric M. Vaz, Xi Fang, Ju Chen, Kunfu Ouyang
doi : 10.1161/CIRCULATIONAHA.121.054768
Circulation. 2021;144:403–406
Letter by Wang et al Regarding Article, “Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart”
Ti Wang, Yuxue Yang, Daxin Wang
doi : 10.1161/CIRCULATIONAHA.121.055114
Circulation. 2021;144:e92–e93
Response by Forte and Sattler to Letter Regarding Article, “Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart”
Elvira Forte, Susanne Sattler
doi : 10.1161/CIRCULATIONAHA.121.055584
Circulation. 2021;144:e94–e95
Lay Stakeholders in Science and Research Initiative: A Science Advisory From the American Heart Association
William H. Roach Jr, James M. Bischoff, Bernie Dennis, Marvis Donalson, Sandra B. Dunbar, Debbie Hill, Jacqueline Ng-Osorio, Sally Powers, Loren E. Wold, on behalf of the American Heart Association Research Committee
doi : 10.1161/CIR.0000000000000999
Circulation. 2021;144:e96–e106
The American Heart Association (AHA) is the largest not-for-profit funder of cardiovascular and cerebrovascular disease research in the United States. It has supported research of independent scientists for 7 decades with the goal of finding novel discoveries that will reduce death and disability from these diseases and ultimately improve overall health. In 2014, the AHA approved a pilot initiative to include lay stakeholders (patients, caregivers, and passionate advocates) in its research and science operations. The initiative was based on the premise that lay stakeholders would add a unique and necessary perspective that would improve decisions concerning research funding, research direction, and scientific guidelines. The AHA developed a framework for the initiative that defined lay stakeholder, created a volunteer recruitment and training program, established policies for incorporating lay stakeholders into science operations, and set metrics for evaluating the initiative over time. It has instituted creative ways to engage lay volunteers and to foster lay and scientist cooperation. Program assessments have been consistently positive and have identified needed future improvements. The benefits of lay/scientist collaboration have far exceeded the AHA’s expectations. The AHA will continue to strengthen lay volunteer engagement throughout its science and research operations; to focus on developing a larger, diverse group of qualified lay stakeholders; to educate scientists on how to communicate research effectively to the public and donors; and to retain the respect of donors for the rigors of its research funding, scientific statements, and clinical guidelines.
Evidence-Based Practices in the Cardiac Catheterization Laboratory: A Scientific Statement From the American Heart Association
Sripal Bangalore, Gregory W. Barsness, George D. Dangas, Morton J. Kern, Sunil V. Rao, Linda Shore-Lesserson, Jacqueline E. Tamis-Holland, on behalf of the American Heart Association Interventional Cardiovascular Care Committee of the Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Surgery and Anesthesia; and Council on Lifestyle and Cardiometabolic Health
doi : 10.1161/CIR.0000000000000996
Circulation. 2021;144:e107–e119
Cardiac catheterization procedures have rapidly evolved and expanded in scope and techniques over the past few decades. However, although some practices have emerged based on evidence, many traditions have persisted based on beliefs and theoretical concerns. The aim of this review is to highlight common preprocedure, intraprocedure, and postprocedure catheterization laboratory practices where evidence has accumulated over the past few decades to support or discount traditionally held practices.
