The Long and Winding Road to an Effective Left Ventricular Assist Device: The Demise of Medtronic’s HVAD

Josef Stehlik, James K. Kirklin

doi : 10.1161/CIRCULATIONAHA.121.056027

Circulation. 2021;144:509–511

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International Observational Analysis of Evolution and Outcomes of Chronic Stable Angina: The Multinational CLARIFY Study

Jules Mesnier, Gregory Ducrocq, Nicolas Danchin, Roberto Ferrari, Ian Ford, Jean-Claude Tardif, Michal Tendera, Kim M. Fox, Philippe Gabriel Steg, and for the CLARIFY Investigators

doi : 10.1161/CIRCULATIONAHA.121.054567

Circulation. 2021;144:512–523

Although angina is common in patients with stable coronary artery disease, limited data are available on its prevalence, natural evolution, and outcomes in the era of effective cardiovascular drugs and widespread use of coronary revascularization.

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Usefulness of Angina to Guide Revascularization Decisions

David D. Waters, Gregg W. Stone

doi : 10.1161/CIRCULATIONAHA.121.055065

Circulation. 2021;144:524–527

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Cardiac Troponin Thresholds and Kinetics to Differentiate Myocardial Injury and Myocardial Infarction

Ryan Wereski, Dorien M. Kimenai, Caelan Taggart, Dimitrios Doudesis, Kuan Ken Lee, Matthew T.H. Lowry, Anda Bularga, David J. Lowe, Takeshi Fujisawa, Fred S. Apple, Paul O. Collinson, Atul Anand, Andrew R. Chapman, Nicholas L. Mills

doi : 10.1161/CIRCULATIONAHA.121.054302

Circulation. 2021;144:528–538

Although the 99th percentile is the recommended diagnostic threshold for myocardial infarction, some guidelines also advocate the use of higher troponin thresholds to rule in myocardial infarction at presentation. It is unclear whether the magnitude or change in troponin concentration can differentiate causes of myocardial injury and infarction in practice.

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Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia

Fei Sun, Guolun Wang, Arun Pradhan, Kui Xu, Jose Gomez-Arroyo, Yufang Zhang, Gregory T. Kalin, Zicheng Deng, Ronald J. Vagnozzi, Hua He, Andrew W. Dunn, Yuhua Wang, Allen J. York, Rashmi S. Hegde, Jason C. Woods, Tanya V. Kalin, Jeffery D. Molkentin, Vladimir V. Kalinichenko

doi : 10.1161/CIRCULATIONAHA.121.053980

Circulation. 2021;144:539–555

Pulmonary hypertension (PH) is a common complication in patients with alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), a severe congenital disorder associated with mutations in the FOXF1 gene. Although the loss of alveolar microvasculature causes PH in patients with ACDMPV, it is unknown whether increasing neonatal lung angiogenesis could prevent PH and right ventricular (RV) hypertrophy.

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Nanoparticle-Facilitated Gene Delivery in Congenital Pulmonary Vascular Disease: Roadmap for Other Forms of Pulmonary Hypertension

Jane A. Leopold

doi : 10.1161/CIRCULATIONAHA.121.055345

Circulation. 2021;144:556–558

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Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging

Gabor Czibik, Zaineb Mezdari, Dogus Murat Altintas, Juliette Bréhat, Maria Pini, Thomas d’Humières, Thaïs Delmont, Costin Radu, Marielle Breau, Hao Liang, Cecile Martel, Azania Abatan, Rizwan Sarwar, Ophélie Marion, Suzain Naushad, Yanyan Zhang, Maissa Halfaoui, Nadine Suffee, Didier Morin, Serge Adnot, Stéphane Hatem, Arash Yavari, Daigo Sawaki, Geneviève Derumeaux

doi : 10.1161/CIRCULATIONAHA.121.054204

Circulation. 2021;144:559–574

Aging myocardium undergoes progressive cardiac hypertrophy and interstitial fibrosis with diastolic and systolic dysfunction. Recent metabolomics studies shed light on amino acids in aging. The present study aimed to dissect how aging leads to elevated plasma levels of the essential amino acid phenylalanine and how it may promote age-related cardiac dysfunction.

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Studies Detail Heart Risks for Firefighters

Bridget M. Kuehn

doi : 10.1161/CIRCULATIONAHA.121.056119

Circulation. 2021;144:575–576

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A Patient With Acute Shortness of Breath and Inferior ST-Segment Elevation: A Diagnostic Trap

Zhuo-Yu An, Ding Peng, Ya-Juan Shi

doi : 10.1161/CIRCULATIONAHA.121.055085

Circulation. 2021;144:577–579

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Catheter-Based Adrenal Ablation Remits Primary Aldosteronism: A Randomized Medication-Controlled Trial

Zhigang Zhao, Xiaoli Liu, Hexuan Zhang, Qiang Li, Hongbo He, Zhencheng Yan, Fang Sun, Yingsha Li, Xunmei Zhou, Xiaona Bu, Hao Wu, Rufei Shen, Hongting Zheng, Gangyi Yang, Zhiming Zhu, and for the Chongqing Endocrine Hypertension Collaborative Team

doi : 10.1161/CIRCULATIONAHA.121.054318

Circulation. 2021;144:580–582

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Clinician Well-Being—Addressing Global Needs for Improvements in the Health Care Field: A Joint Opinion From the American College of Cardiology, American Heart Association, European Society of Cardiology, and the World Heart Federation

Laxmi S. Mehta, Mitchell S.V. Elkind, Stephan Achenbach, Fausto J. Pinto, Athena Poppas

doi : 10.1161/CIRCULATIONAHA.121.055748

Circulation. 2021;144:e151–e155

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Letter by Wong and Siu Regarding Article, “Microthrombi as a Major Cause of Cardiac Injury in COVID-19: A Pathologic Study”

Chun-Ka Wong, Chung-Wah Siu

doi : 10.1161/CIRCULATIONAHA.121.054509

Circulation. 2021;144:e156–e157

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Response by Pellegrini et al to Letter Regarding Article, “Microthrombi as a Major Cause of Cardiac Injury in COVID-19: A Pathologic Study”

Dario Pellegrini, Giulio Guagliumi, Aloke V. Finn

doi : 10.1161/CIRCULATIONAHA.121.055585

Circulation. 2021;144:e158–e159

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