دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19A Randomized Clinical Trial
Christoph D. Spinner, MD; Robert L. Gottlieb, MD, PhD; Gerard J. Criner, MD; et al.
doi : 10.1001/jama.2020.16349
JAMA. 2020;324(11):1048-1057.
This open-label randomized trial compares the effect of remdesivir (5 or 10 days) vs standard care on clinical status 11 days after treatment initiation among patients with confirmed SARS-CoV-2 infection hospitalized with moderate pneumonia (room air oxygen saturation >94%).
Association of Intra-arrest Transport vs Continued On-Scene Resuscitation With Survival to Hospital Discharge Among Patients With Out-of-Hospital Cardiac Arrest
Brian Grunau, MD, MHSc; Noah Kime, BS; Brian Leroux, PhD; et al.
doi : 10.1001/jama.2020.14185
JAMA. 2020;324(11):1058-1067.
This study of adult patients with out-of-hospital cardiac arrest compares rates of survival to hospital discharge for those receiving EMS transport vs continued on-scene resuscitation .
Association of Routine Infant Vaccinations With Antibody Levels Among Preterm Infants
Elsbeth D. M. Rouers, MD; Patricia C. J. Bruijning-Verhagen, MD, PhD; Pieter G. M. van Gageldonk, BSc; et al.
doi : 10.1001/jama.2020.12316
JAMA. 2020;324(11):1068-1077.
This cohort study evaluates IgG antibody concentrations in preterm infants after administration of combination diphtheria–tetanus toxoids–acellular pertussis–inactivated poliomyelitis–Haemophilus influenza type b–and hepatitis B (DTaP-IPV-Hib-HepB) and pneumococcal conjugate vaccines.
Point Prevalence Testing of Residents for SARS-CoV-2 in a Subset of Connecticut Nursing Homes
Sunil Parikh, MD, MPH; Kevin O’Laughlin, MD; Hanna Y. Ehrlich, MPhil; et al.
doi : 10.1001/jama.2020.14984
JAMA. 2020;324(11):1101-1103.
This study describes the point prevalence of polymerase chain reaction tests positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among residents of a sample of Connecticut nursing homes in the first half of May 2020.
Association of Nursing Home Ratings on Health Inspections, Quality of Care, and Nurse Staffing With COVID-19 Cases
Jose F. Figueroa, MD, MPH; Rishi K. Wadhera, MD, MPP; Irene Papanicolas, PhD; et al.
doi : 10.1001/jama.2020.14709
JAMA. 2020;324(11):1103-1105.
This study evaluates COVID-19 case rates between high- and low-performing nursing homes based on CMS quality measures.
Policies Among US Pediatricians for Dismissing Patients for Delaying or Refusing Vaccination
Sean T. O’Leary, MD, MPH; Jessica R. Cataldi, MD, MSCS; Megan C. Lindley, MPH; et al.
doi : 10.1001/jama.2020.10658
JAMA. 2020;324(11):1105-1107.
This survey study assesses US pediatrician practices and office policies in response to parents who either refuse primary vaccinations or request to spread out individual vaccines in the primary series.
Determination of Brain Death/Death by Neurologic CriteriaThe World Brain Death Project
David M. Greer, MD, MA; Sam D. Shemie, MD; Ariane Lewis, MD; et al.
doi : 10.1001/jama.2020.11586
JAMA. 2020;324(11):1078-1097.
This Special Communication summarizes consensus recommendations from the World Brain Death project, an international collaborative created to establish minimum standards for diagnosing brain death/death by neurologic criteria (BD/DNC) in children and adults across a broad range of settings and clinical circumstances.
Recognition of Research Participants’ Need for AutonomyRemembering the Legacy of Henrietta Lacks
Carrie D. Wolinetz, PhD; Francis S. Collins, MD, PhD
doi : 10.1001/jama.2020.15936
JAMA. 2020;324(11):1027-1028.
In this Viewpoint, the NIH director and acting chief of staff discuss how Henrietta Lacks’ cervical cancer cells (HeLa) were used without her consent to create an immortal cell line used widely in modern medical research, and argue for development of policies to prevent unauthorized use of biological specimens to prevent the same thing from happening again.
Addressing Influenza Vaccination Disparities During the COVID-19 Pandemic
Lisa A. Grohskopf, MD, MPH; Leandris C. Liburd, PhD, MPH; Robert R. Redfield, MD
doi : 10.1001/jama.2020.15845
JAMA. 2020;324(11):1029-1030.
In this Viewpoint, CDC scientists discuss the public health urgency of increasing influenza vaccination uptake early in the 2020-2021 season to ameliorate the threat to patients and hospitals of overlapping outbreaks, and urges clinicians to strongly recommend the vaccine and administer it to patients whenever and wherever possible.
Ethical Considerations for COVID-19 Vaccine Trials in Correctional Facilities
Emily A. Wang, MD, MAS; Jonathan Zenilman, MD, PhD; Lauren Brinkley-Rubinstein, PhD
doi : 10.1001/jama.2020.15589
JAMA. 2020;324(11):1031-1032.
This Viewpoint discusses the importance of studying coronavirus disease 2019 (COVID-19) vaccine candidates in prisoners, and proposes a framework for considering how to include them safely, ethically, and without coercion in future phase 3 vaccine trials.
Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19A Randomized Clinical Trial
Christoph D. Spinner, MD; Robert L. Gottlieb, MD, PhD; Gerard J. Criner, MD; et al.
doi : 10.1001/jama.2020.16349
JAMA. 2020;324(11):1048-1057.
This open-label randomized trial compares the effect of remdesivir (5 or 10 days) vs standard care on clinical status 11 days after treatment initiation among patients with confirmed SARS-CoV-2 infection hospitalized with moderate pneumonia (room air oxygen saturation >94%).
Association of Intra-arrest Transport vs Continued On-Scene Resuscitation With Survival to Hospital Discharge Among Patients With Out-of-Hospital Cardiac Arrest
Brian Grunau, MD, MHSc; Noah Kime, BS; Brian Leroux, PhD; et al.
doi : 10.1001/jama.2020.14185
JAMA. 2020;324(11):1058-1067.
This study of adult patients with out-of-hospital cardiac arrest compares rates of survival to hospital discharge for those receiving EMS transport vs continued on-scene resuscitation .
Association of Routine Infant Vaccinations With Antibody Levels Among Preterm Infants
Elsbeth D. M. Rouers, MD; Patricia C. J. Bruijning-Verhagen, MD, PhD; Pieter G. M. van Gageldonk, BSc; et al.
doi : 10.1001/jama.2020.12316
JAMA. 2020;324(11):1068-1077.
This cohort study evaluates IgG antibody concentrations in preterm infants after administration of combination diphtheria–tetanus toxoids–acellular pertussis–inactivated poliomyelitis–Haemophilus influenza type b–and hepatitis B (DTaP-IPV-Hib-HepB) and pneumococcal conjugate vaccines.
Point Prevalence Testing of Residents for SARS-CoV-2 in a Subset of Connecticut Nursing Homes
Sunil Parikh, MD, MPH; Kevin O’Laughlin, MD; Hanna Y. Ehrlich, MPhil; et al.
doi : 10.1001/jama.2020.14984
JAMA. 2020;324(11):1101-1103.
This study describes the point prevalence of polymerase chain reaction tests positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among residents of a sample of Connecticut nursing homes in the first half of May 2020.
Association of Nursing Home Ratings on Health Inspections, Quality of Care, and Nurse Staffing With COVID-19 Cases
Jose F. Figueroa, MD, MPH; Rishi K. Wadhera, MD, MPP; Irene Papanicolas, PhD; et al.
doi : 10.1001/jama.2020.14709
JAMA. 2020;324(11):1103-1105.
This study evaluates COVID-19 case rates between high- and low-performing nursing homes based on CMS quality measures.
Policies Among US Pediatricians for Dismissing Patients for Delaying or Refusing Vaccination
Sean T. O’Leary, MD, MPH; Jessica R. Cataldi, MD, MSCS; Megan C. Lindley, MPH; et al.
doi : 10.1001/jama.2020.10658
JAMA. 2020;324(11):1105-1107.
This survey study assesses US pediatrician practices and office policies in response to parents who either refuse primary vaccinations or request to spread out individual vaccines in the primary series.
Determination of Brain Death/Death by Neurologic CriteriaThe World Brain Death Project
David M. Greer, MD, MA; Sam D. Shemie, MD; Ariane Lewis, MD; et al.
doi : 10.1001/jama.2020.11586
JAMA. 2020;324(11):1078-1097.
This Special Communication summarizes consensus recommendations from the World Brain Death project, an international collaborative created to establish minimum standards for diagnosing brain death/death by neurologic criteria (BD/DNC) in children and adults across a broad range of settings and clinical circumstances.
Recognition of Research Participants’ Need for AutonomyRemembering the Legacy of Henrietta Lacks
Carrie D. Wolinetz, PhD; Francis S. Collins, MD, PhD
doi : 10.1001/jama.2020.15936
JAMA. 2020;324(11):1027-1028.
In this Viewpoint, the NIH director and acting chief of staff discuss how Henrietta Lacks’ cervical cancer cells (HeLa) were used without her consent to create an immortal cell line used widely in modern medical research, and argue for development of policies to prevent unauthorized use of biological specimens to prevent the same thing from happening again.
Addressing Influenza Vaccination Disparities During the COVID-19 Pandemic
Lisa A. Grohskopf, MD, MPH; Leandris C. Liburd, PhD, MPH; Robert R. Redfield, MD
doi : 10.1001/jama.2020.15845
JAMA. 2020;324(11):1029-1030.
In this Viewpoint, CDC scientists discuss the public health urgency of increasing influenza vaccination uptake early in the 2020-2021 season to ameliorate the threat to patients and hospitals of overlapping outbreaks, and urges clinicians to strongly recommend the vaccine and administer it to patients whenever and wherever possible.
Ethical Considerations for COVID-19 Vaccine Trials in Correctional Facilities
Emily A. Wang, MD, MAS; Jonathan Zenilman, MD, PhD; Lauren Brinkley-Rubinstein, PhD
doi : 10.1001/jama.2020.15589
JAMA. 2020;324(11):1031-1032.
This Viewpoint discusses the importance of studying coronavirus disease 2019 (COVID-19) vaccine candidates in prisoners, and proposes a framework for considering how to include them safely, ethically, and without coercion in future phase 3 vaccine trials.
The Transformational Effects of COVID-19 on Medical Education
Catherine R. Lucey, MD; S. Claiborne Johnston, MD, PhD
doi : 10.1001/jama.2020.14136
AMA. 2020;324(11):1033-1034.
This Viewpoint discusses the ways medical schools adapted to the coronavirus disease 2019 (COVID-19) pandemic, allowing students to be part of the public health response, adapting curricula to educational opportunities, and modernizing means of instruction without losing time or compromising standards.
Moving the Financing of Graduate Medical Education Into the 21st Century
Justin A. Grischkan, MD; Ari B. Friedman, MD, PhD; Amitabh Chandra, PhD
doi : 10.1001/jama.2020.15480
JAMA. 2020;324(11):1035-1036.
This Viewpoint challenges US hospital claims that government funding to train physicians is necessary to offset costs, maintain physician supply, and keep costs low for other payers, and proposes reforms to use the monies to target known problems, such as geographic disparities in physician workforce and inadequate primary care and public health physician supply.
Legal Interventions to Address US Reductions in Life Expectancy
Lawrence O. Gostin, JD; James G. Hodge Jr, JD, LLM; Donna E. Levin, JD
doi : 10.1001/jama.2020.7715
JAMA. 2020;324(11):1037-1038.
This Viewpoint discusses ways that evidence-based laws can address health disparities and halt the documented reduction of life expectancy across socioeconomic groups in the US, including through regulation of hazardous products, behavioral economic incentives, wage increases, and provision of public benefits.
Finding His Voice
A. Rani Elwy, PhD
doi : 10.1001/jama.2020.16334
JAMA. 2020;324(11):1039-1040.
In this narrative medicine essay, a psychologist recounts how she found her voice through writing and in patient care advocacy and research and how she helped her son, who has Schwartz-Jampel syndrome, find his voice when young, but now he is taking over his own narrative as a young adult.
Efficacy of Remdesivir in COVID-19
Erin K. McCreary, PharmD; Derek C. Angus, MD, MPH
doi : 10.1001/jama.2020.16337
JAMA. 2020;324(11):1041-1042.
Challenging the “Scoop and Run” Model for Management of Out-of-Hospital Cardiac Arrest
Alexander X. Lo, MD, PhD
doi : 10.1001/jama.2020.9245
JAMA. 2020;324(11):1043-1044.
Brain Death—Moving Beyond Consistency in the Diagnostic Criteria
Robert D. Truog, MD, MA; Kandamaran Krishnamurthy, MBBS, DM; Robert C. Tasker, MA, MD, MBBS
doi : 10.1001/jama.2020.11665
JAMA. 2020;324(11):1045-1047.
Estimating Risk Ratios and Risk DifferencesAlternatives to Odds Ratios
Mathias J. Holmberg, MD, MPH, PhD; Lars W. Andersen, MD, MPH, PhD, DMSc
doi : 10.1001/jama.2020.12698
JAMA. 2020;324(11):1098-1099.
This JAMA Guide to Statistics and Methods explains the differences between risk ratios and odds ratios and when each is the more appropriate statistic to estimate measures of effect or association in research findings.
Telehealth Success Spurs a Call for Greater Post–COVID-19 License Portability
Anita Slomski, MA
doi : 10.1001/jama.2020.9142
JAMA. 2020;324(11):1021-1022.
This Medical News article examines the pros and cons of national medical licensure as physicians have grappled with seeing out-of-state patients via telemedicine during the coronavirus disease 2019 pandemic.
CBD Drug Is Approved for a Third Form of Epilepsy
Mary Chris Jaklevic, MSJ
doi : 10.1001/jama.2020.16782
JAMA. 2020;324(11):1026.
Phasing Out Potentially Hazardous Food Packaging
Mary Chris Jaklevic, MSJ
doi : 10.1001/jama.2020.16505
JAMA. 2020;324(11):1026.
Oral Drug Approved for Spinal Muscular Atrophy
Mary Chris Jaklevic, MSJ
doi : 10.1001/jama.2020.16783
JAMA. 2020;324(11):1026.
New Rules for the Pandemic Era
David Cutler, PhD
doi : 10.1001/jama.2020.15526
JAMA. 2020;324(11):1023-1024.
Nearly Half of Dementia Cases Could Be Prevented or Delayed
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2020.16210
JAMA. 2020;324(11):1025.
Interest in Global COVID-19 Vaccine Alliance Grows
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2020.16966
JAMA. 2020;324(11):1025.
Routine Vaccinations Decline During Pandemic
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2020.16968
JAMA. 2020;324(11):1025.
Brain Death
Kristin Walter, MD, MS
doi : 10.1001/jama.2020.15898
JAMA. 2020;324(11):1116.
This JAMA Patient Page explains the current definition of brain death, characteristic causes, and the conditions under which the diagnosis can be made.
Preemptive Therapy vs Antiviral Prophylaxis in Cytomegalovirus-Seronegative Liver Transplant Recipients With Seropositive Donors
Matthew B. Roberts, MBBS; Ronak G. Gandhi, PharmD; Camille N. Kotton, MD
doi : 10.1001/jama.2020.11862
JAMA. 2020;324(11):1107-1108.
Preemptive Therapy vs Antiviral Prophylaxis in Cytomegalovirus-Seronegative Liver Transplant Recipients With Seropositive Donors—Reply
Nina Singh, MD; Ajit P. Limaye, MD
doi : 10.1001/jama.2020.11865
JAMA. 2020;324(11):1108-1109.
Pharmacological Treatments for Tinnitus
Gregory M. Asnis, MD
doi : 10.1001/jama.2020.11851
JAMA. 2020;324(11):1109.
Pharmacological Treatments for Tinnitus—Reply
Jay F. Piccirillo, MD; Thomas L. Rodebaugh, PhD; Eric J. Lenze, MD
doi : 10.1001/jama.2020.11868
JAMA. 2020;324(11):1109-1110.
Benefits of Treating Obstructive Sleep Apnea
Mahadevappa Hunasikatti, MD
doi : 10.1001/jama.2020.11848
JAMA. 2020;324(11):1110.
Benefits of Treating Obstructive Sleep Apnea—Reply
Daniel J. Gottlieb, MD, MPH; Naresh M. Punjabi, MD, PhD
doi : 10.1001/jama.2020.11856
JAMA. 2020;324(11):1110-1111.
