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Metoprolol in Critically Ill Patients With COVID-19
AgustínClemente-MoragónBSca?JuanMartínez-MillaMD, PhDab?EduardoOliverPhDacArnoldoSantosMD, PhDdeJavierFlandesMD, PhDfIkerFernándezMDfLorenaRodríguez-GonzálezTechghCristinaSerrano del CastilloMDiAna-MaríaIoanMDdMaríaLópez-ÁlvarezRNbcSandraGómez-TalaveraMDabcCarlosGalán-ArriolaDVM, PhDacValentínFusterMD, PhDajCésarPérez-CalvoMD, PhDdBorjaIbáñezMD, PhDabc
doi : 10.1016/j.jacc.2021.07.003
Volume 78, Issue 10, 7 September 2021, Pages 1001-1011
Severe coronavirus disease-2019 (COVID-19) can progress to an acute respiratory distress syndrome (ARDS), which involves alveolar infiltration by activated neutrophils. The beta-blocker metoprolol has been shown to ameliorate exacerbated inflammation in the myocardial infarction setting.
Beta-Blockers in the Critically Ill: Friend or Foe??
Mourad H.SenussiMD, MS
doi : 10.1016/j.jacc.2021.07.006
Volume 78, Issue 10, 7 September 2021, Pages 1012-1014
Risk of Cardiovascular Hospital Admission After Exposure to Fine Particulate Pollution
YiZhangMPHaRunmeiMaMScaJieBanMDaFengLuPhDbMoningGuoMDbYuZhongMScaNingJiangBSMedaChenChenMScaTiantianLiPhDaXiaomingShiMDa
doi : 10.1016/j.jacc.2021.06.043
Volume 78, Issue 10, 7 September 2021, Pages 1015-1024
Heavy fine particulate matter with an aerodynamic diameter ?2.5 ?m (PM2.5) pollution events continue to occur frequently in developing countries.
How Tweets Can Cause a Revolution?
SanjayRajagopalanMDabRobert D.BrookMDcSadeerAl-KindiMDab
doi : 10.1016/j.jacc.2021.07.009
Volume 78, Issue 10, 7 September 2021, Pages 1025-1027
Effect of Heart Rate on the Outcome of Renal Denervation in Patients With Uncontrolled Hypertension
MichaelBöhmMDaKonstantinosTsioufisMDbDavid E.KandzariMDcKazuomiKarioMD, PhDdMichael A.WeberMDeRoland E.SchmiederMDfRaymond R.TownsendMDgSaarraakenKulenthiranMDaChristianUkenaMDaStuartPocockPhDhSebastianEwenMDaJoachimWeilMDiMartinFahyMSjFelixMahfoudMDa
doi : 10.1016/j.jacc.2021.06.044
Volume 78, Issue 10, 7 September 2021, Pages 1028-1038
Sham-controlled trials demonstrated safety and efficacy of renal denervation (RDN) to lower blood pressure (BP). Association of baseline heart rate with BP reduction after RDN is incompletely understood.
Baseline Heart Rate Predicts the Blood Pressure Response to Renal Denervation in Untreated Hypertension?
Brent M.EganMD
doi : 10.1016/j.jacc.2021.07.019
Volume 78, Issue 10, 7 September 2021, Pages 1039-1041
Compression-Only Versus Rescue-Breathing Cardiopulmonary Resuscitation After Pediatric Out-of-Hospital Cardiac Arrest
Maryam Y.NaimMD, MSCEabHeather M.GriffisPhDcRobert A.BergMDbRichard N.BradleyMDdRita V.BurkePhD, MPHeDavidMarkensonMDfBryan F.McNallyMD, MPHgVinay M.NadkarniMD, MSbLihaiSongMScKimberlyVellanoMPHgVictoriaVetterMD, MPHaJoseph W.RossanoMD, MSah
doi : 10.1016/j.jacc.2021.06.042
Volume 78, Issue 10, 7 September 2021, Pages 1042-1052
There are conflicting data regarding the benefit of compression-only bystander cardiopulmonary resuscitation (CO-CPR) compared with CPR with rescue breathing (RB-CPR) after pediatric out-of-hospital cardiac arrest (OHCA).
Chest Compression-Only Cardiopulmonary Resuscitation in Pediatric Out-of-Hospital Cardiac Arrest: (Don’t) Take My Breath Away?
Gene Yong-KwangOngMBBS
doi : 10.1016/j.jacc.2021.07.029
Volume 78, Issue 10, 7 September 2021, Pages 1053-1055
Chronic Fatigue Syndrome and Cardiovascular Disease: JACC State-of-the-Art Review
Benjamin H.NatelsonMDaDanielle L.BrunjesPhDbDonnaManciniMDb
doi : 10.1016/j.jacc.2021.06.045
Volume 78, Issue 10, 7 September 2021, Pages 1056-1067
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a medically unexplained illness characterized by severe fatigue limiting normal daily activities for at least 6 months accompanied by problems with unrefreshing sleep, exacerbation of symptoms following physical or mental efforts (postexertional malaise [PEM]), and either cognitive reports or physiological evidence of orthostatic intolerance in the form of either orthostatic tachycardia and/or hypocapnia. Although rarely considered to have cardiac dysfunction, ME/CFS patients frequently have reduced stroke volume with a significant inverse relation between cardiac output and PEM severity. Magnetic resonance imaging of ME/CFS patients compared with normal control subjects found significantly reduced stroke, end-systolic, and end-diastolic volumes together with reduced end-diastolic wall mass. Another cardiovascular abnormality is reduced nocturnal blood pressure assessed by 24-hour monitoring. Autonomic dysfunction is also frequently observed with postural orthostatic tachycardia and/or hypocapnia. Two consecutive cardiopulmonary stress tests may provide metabolic data substantiating PEM.
Myocardial Viability Assessment Before Surgical Revascularization in Ischemic Cardiomyopathy: JACC Review Topic of the Week
Julio A.PanzaMDabLukaszChrzanowskiMDcRobert O.BonowMDd
doi : 10.1016/j.jacc.2021.07.004
Volume 78, Issue 10, 7 September 2021, Pages 1068-1077
Ischemic cardiomyopathy results from the combination of scar with fibrosis replacement and areas of dysfunctional but viable myocardium that may improve contractile function with revascularization. Observational studies reported that only patients with substantial amounts of myocardial viability had better outcomes following surgical revascularization. Accordingly, dedicated noninvasive techniques have evolved to quantify viable myocardium with the objective of selecting patients for this form of therapeutic intervention. However, prospective trials have not confirmed the interaction between myocardial viability and the treatment effect of revascularization. Furthermore, recent observations indicate that recovery of left ventricular function is not the principal mechanism by which surgical revascularization improves prognosis. In this paper, the authors describe a more contemporary application of viability testing that is founded on the alternative concept that the main goal of surgical revascularization is to prevent further damage by protecting the residual viable myocardium from subsequent acute coronary events.
Cardiovascular Disease Fellowship Interviews 2021: An Evolution in Process
Lisa J.Rose-JonesMDaMustafa M.AhmedMDbBenjamin H.FreedMDcAndrew M.KatesMDdMeeraKondapaneniMDeJonathan R.SalikMDfVictorSoukoulisMD, PhDgHelgaVan HerleMD, MS, MHAhGabyWeissmanMDi
doi : 10.1016/j.jacc.2021.07.005
Volume 78, Issue 10, 7 September 2021, Pages 1078-1081
Sudden Death: Thinking Beyond the Heart
Susan K.KeenMD, MSCRRoss J.SimpsonJr.MD, PhD
doi : 10.1016/j.jacc.2021.06.046
Volume 78, Issue 10, 7 September 2021, Page e61
Reply: Sudden Death: Thinking Beyond the Heart
Zian H.TsengMD, MASSantoRicceriMDJames W.SalazarMD, MAS
doi : 10.1016/j.jacc.2021.07.007
Volume 78, Issue 10, 7 September 2021, Page e63
