Neurosurgery




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سفارش

A Review of Cortical and Subcortical Stimulation Mapping for Language 

Jacob S Young, MD, Anthony T Lee, MD, PhD, Edward F Chang, MD 

doi : 10.1093/neuros/nyaa436

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 331–342

Since the early descriptions of language function based on observations of patients with language deficits by Broca and Wernicke, neurosurgeons have been focused on characterizing the anatomic regions necessary for language perception and production, and preserving these structures during surgery to minimize patient deficits post operatively. In this supplementary issue on awake intraoperative mapping, we review language processing across multiple domains, highlighting key advances in direct electrical stimulation of different cortical and subcortical regions involved in naming, repetition, reading, writing, and syntax. We then discuss different intraoperative tasks for assessing the function of a given area and avoiding injury to critical, eloquent regions.

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Pathological Features of Tumors of the Nervous System in Hereditary Cancer Predisposition Syndromes: A Review 

Saber Tadros, MD, Aleksei Kondrashov, MD, Sriya Namagiri, BA, Ashis Chowdhury, BHMS, Yeshavanth Kumar Banasavadi-Siddegowda, PhD, Abhik Ray-Chaudhury, MD

doi : 10.1093/neuros/nyab019

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 343–363

Hereditary cancer predisposition syndromes (HCS) become more recognizable as the knowledge about them expands, and genetic testing becomes more affordable. In this review, we discussed the known HCS that predispose to central and peripheral nervous system tumors. Different genetic phenomena were highlighted, and the important cellular biological alterations were summarized. Genetic mosaicism and germline mutations are features of HCS, and recently, they were described in normal population and as modifiers for the genetic landscape of sporadic tumors. Description of the tumors arising in these conditions was augmented by representative cases explaining the main pathological findings. Clinical spectrum of the syndromes and diagnostic criteria were tabled to outline their role in defining these disorders. Interestingly, precision medicine has found its way to help these groups of patients by offering targeted preventive measures. Understanding the signaling pathway alteration of mammalian target of rapamycin (mTOR) in tuberous sclerosis helped introducing mTOR inhibitors as a prophylactic treatment in these patients. More research to define the germline genetic alterations and resulting cellular signaling perturbations is needed for effective risk-reducing interventions beyond prophylactic surgeries.

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United States Medicolegal Progress and Innovation in Telemedicine in the Age of COVID-19: A Primer for Neurosurgeons 

Michael J Cruz, BA, Edwin Nieblas-Bedolla, MPH, Christopher C Young, MD, PhD, Abdullah H Feroze, MD, John R Williams, MD, Richard G Ellenbogen, MD, Michael R Levitt, MD

doi : 10.1093/neuros/nyab185

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 364–371

Telemedicine has received increased attention in recent years as a potential solution to expand clinical capability and patient access to care in many fields, including neurosurgery. Although patient and physician attitudes are rapidly shifting toward greater telemedicine use in light of the COVID-19 pandemic, there remains uncertainty about telemedicine's regulatory future. Despite growing evidence of telemedicine's utility, there remain a number of significant medicolegal barriers to its mass adoption and wider implementation. Herein, we examine recent progress in state and federal regulations in the United States governing telemedicine's implementation in quality of care, finance and billing, privacy and confidentiality, risk and liability, and geography and interstate licensure, with special attention to how these concern teleneurosurgical practice. We also review contemporary topics germane to the future of teleneurosurgery, including the continued expansion of reciprocity in interstate licensure, expanded coverage for homecare services for chronic conditions, expansion of Center for Medicare and Medicaid Services reimbursements, and protections of store-and-forward technologies. Additionally, we discuss recent successes in teleneurosurgery, stroke care, and rehabilitation as models for teleneurosurgical best practices. As telemedicine technology continues to mature and its expanse grows, neurosurgeons’ familiarity with its benefits, limitations, and controversies will best allow for its successful adoption in our field to maximize patient care and outcomes.

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Ultrasound in Traumatic Spinal Cord Injury: A Wide-Open Field 

Brian Y Hwang, MD, 18D, David Mampre, BS, MD, A Karim Ahmed, MD, Ian Suk, BSc, BMC, William S Anderson, PhD, MD, Amir Manbachi, PhD, Nicholas Theodore, MD 

doi : 10.1093/neuros/nyab177

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 372–382

Traumatic spinal cord injury (SCI) is a common and devastating condition. In the absence of effective validated therapies, there is an urgent need for novel methods to achieve injury stabilization, regeneration, and functional restoration in SCI patients. Ultrasound is a versatile platform technology that can provide a foundation for viable diagnostic and therapeutic interventions in SCI. In particular, real-time perfusion and inflammatory biomarker monitoring, focal pharmaceutical delivery, and neuromodulation are capabilities that can be harnessed to advance our knowledge of SCI pathophysiology and to develop novel management and treatment options. Our review suggests that studies that evaluate the benefits and risks of ultrasound in SCI are severely lacking and our understanding of the technology's potential impact remains poorly understood. Although the complex anatomy and physiology of the spine and the spinal cord remain significant challenges, continued technological advances will help the field overcome the current barriers and bring ultrasound to the forefront of SCI research and development.

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Complications of Cranioplasty in Relation to Material: Systematic Review, Network Meta-Analysis and Meta-Regression

Jack Henry, BSc, Michael Amoo, MB, MCh, MRCS, Joseph Taylor, MSc, David P O’Brien, MB, MCh, MMedSc, MBA, LLM, FRCSI, FRCS(SN)

doi : 10.1093/neuros/nyab180

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 383–394

Cranioplasty is a ubiquitous neurosurgical procedure consisting of reconstruction of a pre-existing calvarial defect. Many materials are available, including polymethylmethacrylate in hand-moulded (hPMMA) and prefabricated (pPMMA) form, hydroxyapatite (HA), polyetheretherketone (PEEK) and titanium (Ti).

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Commentary: Complications of Cranioplasty in Relation to Material: Systematic Review, Network Meta-Analysis and Meta-Regression 

Philip B Ostrov, MS, Ankit I Mehta, MD

doi : 10.1093/neuros/nyab216

Neurosurgery, Volume 89, Issue 3, September 2021, Page E144

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External Lumbar Drainage following Traumatic Intracranial Hypertension: A Systematic Review and Meta-Analysis

Jetan Badhiwala, MD, PhD, Angela Lumba-Brown, MD, Gregory W J Hawryluk, MD, PhD, Jamshid Ghajar, MD, PhD

doi : 10.1093/neuros/nyab181

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 395–405

Traumatic brain injury (TBI) often results in elevations in intracranial pressure (ICP) that are refractory to standard therapies. Several studies have investigated the utility of external lumbar drainage (ELD) in this setting.

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Analysis of Deep Brain Stimulation Lead Targeting in the Stimulation of Anterior Nucleus of the Thalamus for Epilepsy Clinical Trial 

Robert E Gross, MD, PhD, Robert S Fisher, MD, PhD, Michael R Sperling, MD, Jonathon E Giftakis, PhD, Paul H Stypulkowski, PhD on behalf of the SANTÉ Study Group

doi : 10.1093/neuros/nyab186

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 406–412

Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is an effective therapy for patients with drug-resistant focal epilepsy. Best practices for surgical targeting of the ANT can be refined as new information becomes available regarding effective stimulation sites.

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Comparison Between Flow-Regulated and Gravitational Shunt Valves in the Treatment of Normal Pressure Hydrocephalus: Flow-Grav Study

Pierre Scheffler, MD, Markus Florian Oertel, MD, Lennart Henning Stieglitz, MD

doi : 10.1093/neuros/nyab176

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 413–419

Normal pressure hydrocephalus (NPH) is frequently treated with ventriculoperitoneal shunt (VPS) surgery. However, VPS implantation can lead to overdrainage and complications such as headaches, hygroma, and subdural hematoma due to a siphon effect in an upright position. Gravitational valves prevent overdrainage through position-dependent adjustment of valve resistance. Flow-regulated valves that increase resistance in presence of high cerebrospinal fluid flow may provide similar protection against overdrainage and present an alternative to gravitational valves.

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Correlation of Aneurysmal Wall Enhancement of Unruptured Intracranial Aneurysms on High-Resolution Vessel-Wall Imaging With Clinical Indices and Surgical Findings

Heejin Bae, MD, Sang-il Suh, MD, PhD, Won Ki Yoon, MD, PhD, Haewon Roh, MD, Chungyeul Kim, MD, PhD, Taek-Hyun Kwon, MD, PhD

doi : 10.1093/neuros/nyab178

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 420–427

Many physicians consider aneurysmal wall enhancement (AWE) on high resolution-vessel wall imaging (HR-VWI) as an imaging biomarker of unstable unruptured intracranial aneurysms (UIAs).

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Load-Sharing Classification Score as Supplemental Grading System in the Decision-Making Process for Patients With Thoracolumbar Injury Classification and Severity 4

Nima Alan, MD, Joseph Donohue, BS, Alp Ozpinar, MD, Nitin Agarwal, MD, Adam S Kanter, MD, David O Okonkwo, MD, PhD, D Kojo Hamilton, MD

doi : 10.1093/neuros/nyab179

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 428–434

Patients with Thoracolumbar Injury Classification and Severity (TLICS) score of 4 fall into a gray zone between surgical and conservative management. The integrity of posterior ligamentous complex (PLC) evaluated by magnetic resonance imaging (MRI) contributes to surgical decision-making. Load-sharing classification (LSC) may provide a modifier to further guide decision-making in these patients.

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Genome-Wide Association Study Identifies Genetic Risk Factors for Spastic Cerebral Palsy

Andrew T Hale, PhD, Oluwatoyin Akinnusotu, BA, Jing He, MS, Janey Wang, MS, Natalie Hibshman, BA, Chevis N Shannon, DrPH, MPH, MBA, Robert P Naftel, MD

doi : 10.1093/neuros/nyab184

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 435–442

Although many clinical risk factors of spastic cerebral palsy (CP) have been identified, the genetic basis of spastic CP is largely unknown. Here, using whole-genome genetic information linked to a deidentified electronic health record (BioVU) with replication in the UK Biobank and FinnGen, we perform the first genome-wide association study (GWAS) for spastic CP.

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Commentary: Genome-Wide Association Study Identifies Genetic Risk Factors for Spastic Cerebral Palsy

Kevin K Kumar, MD, PhD, Gerald A Grant, MD

doi : 10.1093/neuros/nyab201

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E145–E146

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Pipeline Embolization Devices for the Treatment of Intracranial Aneurysms, Single-Center Registry: Long-Term Angiographic and Clinical Outcomes from 1000 Aneurysms 

Ivan Lylyk, MD, Esteban Scrivano, MD, Javier Lundquist, MD, Angel Ferrario, MD, Carlos Bleise, MD, Nicolas Perez, MD, Pedro Nicolas Lylyk, MD, Rene Viso, MD, Rodolfo Nella-Castro, MD, Pedro Lylyk, MD

doi : 10.1093/neuros/nyab183

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 443–449

Prospective studies have established the safety and efficacy of the PipelineTM Embolization Device (PED; Medtronic) for treatment of intracranial aneurysms (IA).

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Fields of Forel Brain Stimulation Improves Levodopa-Unresponsive Gait and Balance Disorders in Parkinson's Disease

Maria Sheila Guimarães Rocha, MD, PhD, Julian Leticia de Freitas, MD, Carlos Daniel Miranda Costa, MD, Maira Okada de Oliveira, MSc, Paulo Roberto Terzian, MD, João Welberthon Matos Queiroz, MD, Jamana Barbosa Ferraz, BSc, João Fellipe Santos Tatsch, MD, Diogo Coutinho Soriano, PhD, Clement Hamani, MD, PhD, Fabio Godinho, MD, PhD

doi : 10.1093/neuros/nyab195

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 450–459

Gait and balance disturbance are challenging symptoms in advanced Parkinson's disease (PD). Anatomic and clinical data suggest that the fields of Forel may be a potential surgical target to treat these symptoms.

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Impact of Opioid Prescribing Guidelines on Postoperative Opioid Prescriptions Following Elective Spine Surgery: Results From an Institutional Quality Improvement Initiative

William E Krauss, MD, Elizabeth B Habermann, MPH, PhD, Anshit Goyal, MBBS, MS, Daniel S Ubl, MPH, Mohammed Ali Alvi, MBBS, MS, Daniel C Whipple, MS, Amy E Glasgow, MHA, Halena M Gazelka, MD, Mohamad Bydon, MD

doi : 10.1093/neuros/nyab196

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 460–470

With a dramatic rise in prescription opioid use, it is imperative to review postsurgical prescribing patterns given their contributions to the opioid epidemic.

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Commentary: Impact of Opioid Prescribing Guidelines on Postoperative Opioid Prescriptions Following Elective Spine Surgery: Results From an Institutional Quality Improvement Initiative

Seokchun Lim, MD, Victor Chang, MD

doi : 10.1093/neuros/nyab202

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E147–E148

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Commentary: Impact of Opioid Prescribing Guidelines on Postoperative Opioid Prescriptions Following Elective Spine Surgery: Results From an Institutional Quality Improvement Initiative

Dean Chou, MD

doi : 10.1093/neuros/nyab211

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E149–E150

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A Novel Protocol for Reducing Intensive Care Utilization After Craniotomy

Arjun V Pendharkar, MD, Maryam N Shahin, MD, Sohun S Awsare, BA, Allen L Ho, MD, Christine Wachira, DNP, RN, Johnathan Clevinger, MSN, RN, Sveinn Sigurdsson, MS, Yohan Lee, MS, Alicia Wilson, RN, Amy C Lu, MD, Melanie Hayden Gephart, MD

doi : 10.1093/neuros/nyab187

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 471–477

There is a growing body of evidence suggesting not all craniotomy patients require postoperative intensive care.

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Predictors of Academic Neurosurgical Career Trajectory among International Medical Graduates Training Within the United States

Adham M Khalafallah, MD, Adrian E Jimenez, BS, Samantha Camp, Melanie A Horowitz, Ian Chiu, David Ryu, Natasha Charewycz, Lauren Vera, Myan Bhoopalam, MS, James Feghali, MD, Mayur Sharma, MD, MCh, Daniel Lubelski, MD, Alan R Cohen, MD, Rafael J Tamargo, MD, Timothy Witham, MD, Judy Huang, MD, Henry Brem, MD, Debraj Mukherjee, MD, MPH

doi : 10.1093/neuros/nyab194

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 478–485

Within the literature, there has been limited research tracking the career trajectories of international medical graduates (IMGs) following residency training.

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Commentary: Predictors of Academic Neurosurgical Career Trajectory Among International Medical Graduates Training Within the United States

Krystal L Tomei, MD, MPH

doi : 10.1093/neuros/nyab197

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E151–E152

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Middle Meningeal Artery Embolization Versus Conventional Treatment of Chronic Subdural Hematomas

Alejandro Enriquez-Marulanda, MD, Santiago Gomez-Paz, MD, Mohamed M Salem, MD, MPH, Akashleena Mallick, MD, Rouzbeh Motiei-Langroudi, MD, J E Arle, MD, PhD, Martina Stippler, MD, Efstathios Papavassiliou, MD, Ron L Alterman, MD, Christopher S Ogilvy, MD, Justin M* Moore, MD, PhD, Ajith J Thomas, MD

doi : 10.1093/neuros/nyab192

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 486–495

Middle meningeal artery (MMA) embolization is an emerging minimally invasive endovascular technique for chronic subdural hematoma (cSDH). Currently, limited literature exists on its safety and efficacy compared with conventional treatment (open-surgical-evacuation-only).

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A Cohort Study on Prognostic Factors for Laser Interstitial Thermal Therapy Success in Newly Diagnosed Glioblastoma

Long Di, BS, Christopher P Wang, BS, Ashish H Shah, MD, Daniel G Eichberg, MD, Alexa M Semonche, MD, Alexander D Sanjurjo, BS, Evan M Luther, MD, Walter J Jermakowicz, MD, PhD, Ricardo J Komotar, MD, Michael E Ivan, MBS, MD

doi : 10.1093/neuros/nyab193

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 496–503

Laser interstitial thermal therapy (LITT) is a promising approach for cytoreduction of deep-seated gliomas. However, parameters contributing to treatment success remain unclear.

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The Role of Gender in Neurosurgical Residency Applicants’ Letters of Recommendation

Nicholas C Field, MD, Julie G Pilitsis, MD, PhD, Alexandra R Paul, MD

doi : 10.1093/neuros/nyab223

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 504–508

Letters of recommendation (LORs) are one of the most important components of the neurosurgical residency application. Studies in other fields and surgical subspecialties have found gender bias.

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Commentary: The Role of Gender in Neurosurgical Residency Applicants’ Letters of Recommendation

Krystal L Tomei, MD, MPH, Warren R Selman, MD

doi : 10.1093/neuros/nyab234

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E153–E154

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Commentary: The Role of Gender in Neurosurgical Residency Applicants’ Letters of Recommendation

Catherine A Mazzola, MD

doi : 10.1093/neuros/nyab235

Neurosurgery, Volume 89, Issue 3, September 2021, Page E155

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Machine-Learning Approach to Differentiation of Benign and Malignant Peripheral Nerve Sheath Tumors: A Multicenter Study

Michael Zhang, MD, Elizabeth Tong, MD, Forrest Hamrick, BS, Edward H Lee, PhD, Lydia T Tam, BS, Courtney Pendleton, MD, Brandon W Smith, MD, Nicholas F Hug, BA, Sandip Biswal, MD, Jayne Seekins, DO, Sarah A Mattonen, PhD, Sandy Napel, PhD, Cynthia J Campen, MD, Robert J Spinner, MD, Kristen W Yeom, MD, Thomas J Wilson, MD, Mark A Mahan, MD

doi : 10.1093/neuros/nyab212

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 509–517

Clinicoradiologic differentiation between benign and malignant peripheral nerve sheath tumors (PNSTs) has important management implications.

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Commentary: Machine-Learning Approach to Differentiation of Benign and Malignant Peripheral Nerve Sheath Tumors: A Multicenter Study

Vikram C Prabhu, MD, Suguna Pappu, MD, PhD, Ewa Borys, MD, Leighanne Ormston, MS, CGC, Laurie M Lomasney, MD

doi : 10.1093/neuros/nyab224

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E156–E157

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First Report of a Multicenter Prospective Registry of Cranioplasty in the United Kingdom and Ireland

Daniel M Fountain, MRCS, Jack Henry, BSc, Susan Honeyman, BMBCh, Paul O’Connor, MBChB, Priya Sekhon, MBBS, Rory J Piper, MRCS, Ellie Edlmann, PhD, Michael Martin, BA, Gemma Whiting, BA, Carole Turner, MSc, Harry Mee, MRCP, Alexis J Joannides, FRCS(SN), Angelos G Kolias, FRCS(SN), Peter J Hutchinson, FMedSci, UK Cranial Reconstruction Registry (UKCRR) Collaborative , British Neurosurgical Trainee Research Collaborative (BNTRC)

doi : 10.1093/neuros/nyab220

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 518–526

There are many questions that remain unanswered regarding outcomes following cranioplasty including the timing of cranioplasty following craniectomy as well as the material used.

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Comparison of the Safety of Prophylactic Anticoagulants After Intracranial Surgery

Joseph S Bell, MD, PhD, T J Florence, MD, PhD, H Westley Phillips, MD, Kunal Patel, MD, Nicholas J Macaluso, BS, Paulina G Villanueva, BS, Priyanka K Naik, BS, Won Kim, MD

doi : 10.1093/neuros/nyab221

Neurosurgery, Volume 89, Issue 3, September 2021, Pages 527–536

Venous thromboembolism (VTE) represents a rare but preventable postoperative complication. Unfractionated heparin (UH) and low-molecular-weight heparin (LMWH) are used to prevent VTE, but comparative studies of their safety and efficacy in the neurosurgical context are limited.

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Commentary: Comparison of the Safety of Prophylactic Anticoagulants After Intracranial Surgery

Mohamed Macki, MD, MPH, Victor Chang, MD

doi : 10.1093/neuros/nyab230

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E158–E159

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Commentary: Neuroform Atlas Stent for Treatment of Middle Cerebral Artery Aneurysms: 1-Year Outcomes From Neuroform Atlas Stent Pivotal Trial

Mohamed Abouelleil, MD, Leah Lyons, PA-C, Andres Restrepo, MD, Justin Singer, MD

doi : 10.1093/neuros/nyab190

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E160–E161

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Commentary: External Validation of the R2eD AVM Score to Predict the Likelihood of Rupture Presentation of Brain Arteriovenous Malformations

Visish M Srinivasan, MD, Michael T Lawton, MD

doi : 10.1093/neuros/nyab225

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E162–E164

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Commentary: Predicting Spinal Surgery Candidacy From Imaging Data Using Machine Learning

Timothy C Gooldy, MD, Laura A Snyder, MD

doi : 10.1093/neuros/nyab227

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E165–E166

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Letter: Prognostic Factors for Adjacent Segment Disease After L4-L5 Lumbar Fusion 

Ding-Jun Hao, MD, Jia-Nan Zhang, MD

doi : 10.1093/neuros/nyab189

Neurosurgery, Volume 89, Issue 3, September 2021, Page E167

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Letter: Length of Stay Beyond Medical Readiness in a Neurosurgical Patient Population and Associated Healthcare Costs 

Naci Balak, MD

doi : 10.1093/neuros/nyab198

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E168–E169

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In Reply: Length of Stay Beyond Medical Readiness in a Neurosurgical Patient Population and Associated Healthcare Costs 

Joseph R Linzey, MD, MS, Aditya S Pandey, MD

doi : 10.1093/neuros/nyab200

Neurosurgery, Volume 89, Issue 3, September 2021, Page E170

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Letter: Operationalizing Global Neurosurgery Research in Neurosurgical Journals 

Andre E Boyke, MS, Nathan A Shlobin, BA, Vaishnavi Sharma, BS, Donald K E Detchou, BA, Myron Rolle, MD

doi : 10.1093/neuros/nyab199

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E171–E172

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Letter: Low-Profile Visualized Intraluminal Support Jr Braided Stent Versus Atlas Self-Expandable Stent for Treatment of Intracranial Aneurysms: A Single Center Experience 

Sirinkaanta Pongprasert, PhD

doi : 10.1093/neuros/nyab205

Neurosurgery, Volume 89, Issue 3, September 2021, Page E173

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Letter: Commentary: Adjuvant Radiotherapy Versus Watchful Waiting for World Health Organization Grade II Atypical Meningioma: A Single-Institution Experience 

David P Bray, MD, Joseph W Quillin, MD, Robert H Press, MD, Yilin Yang, BS, Zhengjia Chen, PhD, Bree R Eaton, MD, Jeffrey J Olson, MD

doi : 10.1093/neuros/nyab204

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E174–E175

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In Reply: Commentary: Adjuvant Radiotherapy Versus Watchful Waiting for World Health Organization Grade II Atypical Meningioma: A Single-Institution Experience 

Michael R Chicoine, MD, Albert H Kim, MD, PhD

doi : 10.1093/neuros/nyab207

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E176–E177

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Letter: A Scoping Review of Registered Clinical Studies on Mild Traumatic Brain Injury and Concussion (2000-2019) 

Laura Ganau, Gianfranco K I Ligarotti, MD, Lara Prisco, MD, MSc, Mario Ganau, MD, PhD, MBA, FEBNS

doi : 10.1093/neuros/nyab188

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E178–E179

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In Reply: A Scoping Review of Registered Clinical Studies on Mild Traumatic Brain Injury and Concussion (2000-2019) 

Julio C Furlan, MD, LLB, MBA, MSc, PhD, FRCPC, Charles H Tator, MD, PhD, FRCSC

doi : 10.1093/neuros/nyab191

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E180–E181

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Letter: Spinal Neurovascular Malformations in Klippel-Trenaunay Syndrome: A Single Center Study 

Zeferino Demartini, Jr, MD, Adriano Keijiro Maeda, MD, MSc, Gelson Luis Koppe, MD, L A M Gatto, MD, MSc, Adriane Cardoso-Demartini, MD, PhD

doi : 10.1093/neuros/nyab206

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E182–E183

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In Reply: Spinal Neurovascular Malformations in Klippel-Trenaunay Syndrome: A Single Center Study 

Anthony Larson, BS, Megha Tollefson, MD, Waleed Brinjikji, MD

doi : 10.1093/neuros/nyab208

Neurosurgery, Volume 89, Issue 3, September 2021, Page E184

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Letter: Frailty and Outcomes of Traumatic Spinal Cord Injury 

Syed Faraz Kazim, MD, PhD, Christian A Bowers, MD, Robert A Lloyd, BS, Chad D Cole, MD, MS, Meic H Schmidt, MD, MBA

doi : 10.1093/neuros/nyab210

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E185–E186

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Letter: Functional Outcomes and Health-Related Quality of Life Following Glioma Surgery 

Mervyn Jun Rui Lim, MBBS, MPH

doi : 10.1093/neuros/nyab214

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E187–E188

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In Reply: Functional Outcomes and Health-Related Quality of Life Following Glioma Surgery 

Philip C De Witt Hamer, MD, PhD, Martin Klein, PhD, Shawn L Hervey-Jumper, MD, Jeffrey S Wefel, PhD, Mitchel S Berger, MD

doi : 10.1093/neuros/nyab218

Neurosurgery, Volume 89, Issue 3, September 2021, Page E189

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Letter: A Scoping Review of Burnout in Neurosurgery 

Grazia Menna, MD, Ismail Zaed, MD, Giuseppe Maria Della Pepa, MD

doi : 10.1093/neuros/nyab217

Neurosurgery, Volume 89, Issue 3, September 2021, Page E190

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Letter: Telemedicine in Neurosurgery: Lessons Learned From a Systematic Review of the Literature for the COVID-19 Era and Beyond 

Borislav D Kitov, MD, PhD, Atanas N Davarski, MD, PhD, Tanya T Kitova, MD, PhD, DMSc, Kristina P Kilova, MEng, MHM, PhD

doi : 10.1093/neuros/nyab215

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E191–E192

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In Reply: Telemedicine in Neurosurgery: Lessons Learned From a Systematic Review of the Literature for the COVID-19 Era and Beyond 

Daniel G Eichberg, MD, Gregory W Basil, MD, Long Di, BS, Ashish H Shah, MD, Evan M Luther, MD, Victor M Lu, MD, PhD, Maggy Perez-Dickens, MBA, Ricardo J Komotar, MD, Allan D Levi, MD, PhD, Michael E Ivan, MD, MBS

doi : 10.1093/neuros/nyab226

Neurosurgery, Volume 89, Issue 3, September 2021, Page E193

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Letter: Neurosurgery Resident Interviews: The Prevalence and Impact of Inappropriate and Potentially Illegal Questions 

Sandra Marcela Mass-Ramirez, MS, Ivan David Lozada-Martínez, MS, Amit Agrawal, MCh, Luis Rafael Moscote-Salazar, MD, Pedro Jose Cabarcas-Sabbag, MD, William Florez-Perdomo, MD

doi : 10.1093/neuros/nyab213

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E194–E195

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In Reply: Neurosurgery Resident Interviews: The Prevalence and Impact of Inappropriate and Potentially Illegal Questions 

Natalie Limoges, DO, Scott L Zuckerman, MD, MPH, Lola B Chambless, MD, Deborah L Benzil, MD, Aurora Cruz, MD, MBA, Susan Durham, MD, MS

doi : 10.1093/neuros/nyab219

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E196–E197

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Letter: Lesion Shape and Size in MRgFUS Thalamotomy: Predictors and Implications 

Andrew I Yang, MD, MS, Opeyemi O Alabi, PhD, Frederick L Hitti, MD, PhD, Lenora Henry, MS, Ryan Clanton, PhD, Gordon H Baltuch, MD, PhD

doi : 10.1093/neuros/nyab233

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E198–E200

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Letter: Impact of Sub-Internship Cancellations in Neurosurgery During COVID-19 

Chidinma M Wilson, BA, BS, Nolan J Brown, BS, Donald K E Detchou, BA

doi : 10.1093/neuros/nyab232

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E201–E202

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In Reply: Randomized Trial of Unilateral Focused Ultrasound Subthalamotomy for Parkinson Disease 

Raúl Martínez-Fernández, MD, PhD, Jorge U Máñez-Miró, MD, Rafael Rodríguez-Rojas, PhD, Marta del Álamo, MD, José A Obeso, MD, PhD

doi : 10.1093/neuros/nyab236

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E203–E204

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Letter: Traumatic Encephalopathy Syndrome [TES] Is Not Chronic Traumatic Encephalopathy [CTE]: CTE Is Only a Subtype of TES 

Bennet Omalu, MD, MBA, MPH, Jennifer Hammers, DO

doi : 10.1093/neuros/nyab231

Neurosurgery, Volume 89, Issue 3, September 2021, Pages E205–E206

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Corrigendum to “Postmarket American Experience With Woven EndoBridge Device: Adjudicated Multicenter Case Series” by Jacob Cherian, MD, Stephen R Chen, MD, Ajit Puri, MD, Kunal Vakharia, MD, Elad Levy, MD, Sheila Eshraghi, MD, Brian M Howard, MD, Frank C Tong, MD, C Michael Cawley, MD, Bradley Gross, MD, Matthew D Alexander, MD, Ramesh Grandhi, MD, Visish M Srinivasan, MD, Jan-Karl Burkhardt, MD, Jeremiah N Johnson, MD, Peter Kan, MD. Neurosurgery, nyab158, 10.1093/neuros/nyab158 

doi : 10.1093/neuros/nyab270

Neurosurgery, Volume 89, Issue 3, September 2021, Page 537

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