Jamal, Mohammad MBChB (Hons)1; AlMahmeed, Husain MBChB2; AlGhanem, Mansour MBChB2; AlMatooq, Maen MBChB2; Sadek, Adnan MBChB2; AlMousawi, Mustafa MBChB3; Al-Sabah, Salman MD1; Vilca Melendez, Hector PhD4; Rela, Mohamed MBBS5; Heaton, Nigel MBBS4; Jassem, Wayel PhD4
doi : 10.1097/TP.0000000000003537
October 2021 - Volume 105 - Issue 10 - p 2125-2127
Adigbli, George MRCS1; Berlin, Claudia MD1; Issa, Fadi DPhil, FRCS(Plast)1
doi : 10.1097/TP.0000000000003937
October 2021 - Volume 105 - Issue 10 - p 2128-2129
Gentilini, María Virginia PhD1,2; Rumbo, Martín PhD3; Gondolesi, Gabriel E. MD1,2
doi : 10.1097/TP.0000000000003833
October 2021 - Volume 105 - Issue 10 - p 2130-2131
Doshi, Mona D. MD1; Gordon, Elisa J. PhD, MPH2; Freedman, Barry I. MD3; Glover, Craig4; Locke, Jayme E. MD, MPH5; Thomas, Christie P. MD6,7
doi : 10.1097/TP.0000000000003641
October 2021 - Volume 105 - Issue 10 - p 2132-2134
Gabardi, Steven PharmD, BCPS1,2,3
doi : 10.1097/TP.0000000000003661
October 2021 - Volume 105 - Issue 10 - p 2135-2136
Calabrese, Daniel R. MD1,2
doi : 10.1097/TP.0000000000003613
October 2021 - Volume 105 - Issue 10 - p 2137-2139
Gallagher, Tom K. MD, FRCSI1
doi : 10.1097/TP.0000000000003492
October 2021 - Volume 105 - Issue 10 - p 2140-2141
Pruett, Timothy L. MD1
doi : 10.1097/TP.0000000000003577
October 2021 - Volume 105 - Issue 10 - p 2142-2143
Panayotova, Guergana G. MD, MHS1; Lunsford, Keri E. MD, PhD1,2; Guarrera, James V. MD1
doi : 10.1097/TP.0000000000003534
October 2021 - Volume 105 - Issue 10 - p 2144-2145
Coll, Elisabeth MD, PhD1; Fernández-Ruiz, Mario MD, PhD2; Padilla, María1; Moreso, Francesc MD, PhD3; Hernández-Vicente, Ana MD4; Yañez, Iñigo MD5; Molina, María MD, PhD6; Vázquez-Sánchez, Teresa MD7; Crespo, Marta MD, PhD8; Facundo, Carme MD9; Rodríguez-Ferrero, María Luisa MD10; Ruiz Fuentes, María Carmen MD, PhD11; Loinaz, Carmelo MD, PhD12; Bernal, Gabriel MD, PhD13; Melilli, Edoardo MD, PhD14; Bravo, Carlos MD, PhD15; Diekmann, Fritz MD, PhD16; Lladó, Laura MD, PhD17; García-Álvarez, Teresa M. MD18; Salcedo, Magdalena MD, PhD19; Beneyto, Isabel MD, PhD20; Castells, Lluis MD, PhD21,22; Alonso, Rodrigo MD, PhD23,24; Rodríguez-Benot, Alberto MD, PhD25; Díaz-Corte, Carmen MD, PhD26; Graus, Javier MD, PhD27; Ortiz-Bautista, Carlos MD, PhD28,29; García-Cosío, María Dolores MD, PhD30; Hinojal, Rosa1; Peña, Lucía1; Domínguez-Gil, Beatriz MD, PhD1; on behalf of the Spanish Group for the Study of COVID-19 in Transplant Recipients.
doi : 10.1097/TP.0000000000003873
October 2021 - Volume 105 - Issue 10 - p 2146-2155
Few studies have analyzed differences in clinical presentation and outcomes in solid organ transplant (SOT) recipients with coronavirus disease 2019 (COVID-19) across different pandemic waves.
Thieme, Constantin J. MD1; Anft, Moritz PhD2; Paniskaki, Krystallenia MD3; Blazquez-Navarro, Arturo PhD1,2; Doevelaar, Adrian MD2; Seibert, Felix S. MD2; Hoelzer, Bodo MD2; Justine Konik, Margarethe MD3; Meister, Toni L. MD3; Pfaender, Stephanie PhD3; Steinmann, Eike PhD3; Moritz Berger, Marc MD4; Brenner, Thorsten MD4; Kölsch, Uwe MD5; Dolff, Sebastian MD3; Roch, Toralf PhD1,2; Witzke, Oliver MD3; Schenker, Peter MD6; Viebahn, Richard MD6; Stervbo, Ulrik MD2; Westhoff, Timm H. MD2; Babel, Nina MD1,2
doi : 10.1097/TP.0000000000003755
October 2021 - Volume 105 - Issue 10 - p 2156-2164
The ability of transplant (Tx) patients to generate a protective antiviral response under immunosuppression is pivotal in COVID-19 infection. However, analysis of immunity against SARS-CoV-2 is currently lacking.
Caillard, Sophie MD, PhD1; Benotmane, Ilies MD1,2; Meidinger, Céline1; Jegou, Vanessa1; Ludwiller, Sandra1; Rihon, Anne1; Desmarquets, Audrey1; Steinmetz, Lucille1; Morvan, Murielle1; Kedjam, Karima1; Bigot, Amandine1; Roy, Danielle1; Schmitt, Dominique1; Marx, David MD1,2; Bassand, Xavier MD1; Perrin, Peggy MD1,2; Gautier Vargas, Gabriela MD1; Cognard, Noelle MD1; Olagne, Jérome MD1; Braun, Laura MD1; Heibel, Francoise MD1; Martzloff, Jonas MD1; Moulin, Bruno MD, PhD1; Fafi Kremer, Samira PharmD, PhD2,3
doi : 10.1097/TP.0000000000003766
October 2021 - Volume 105 - Issue 10 - p 2165-2169
Data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence in kidney transplant recipients (KTRs) remain rare. We sought to shed further light on this issue by conducting a single-center study in a kidney transplant center located in one of the France’s highest risk zone (Grand Est) for coronavirus disease 2019 (Covid-19) during the initial disease outbreak.
Ou, Michael T. BS1; Boyarsky, Brian J. MD1; Motter, Jennifer D. MHS1; Greenberg, Ross S. BS1; Teles, Aura T. BS1; Ruddy, Jake A. BS1; Krach, Michelle R. MS1; Jain, Vedant S. BA1; Werbel, William A. MD2; Avery, Robin K. MD2; Massie, Allan B. PhD1; Segev, Dorry L. MD, PhD1,3; Garonzik-Wang, Jacqueline M. MD, PhD1
doi : 10.1097/TP.0000000000003780
October 2021 - Volume 105 - Issue 10 - p 2170-2174
We studied the safety and reactogenicity SARS-CoV-2 mRNA vaccines in transplant recipients because immunosuppressed patients were excluded from vaccine trials.
Marinelli, Tina MBBS1; Ferreira, Victor H. PhD1; Ierullo, Matthew MSc1; Ku, Terrance MSc1; Lilly, Les MD1; Kim, S. Joseph MD1; Schiff, Jeffrey MD1; Sidhu, Aman MD1; McDonald, Michael MD1; Hosseini-Moghaddam, Seyed M. MD1; Husain, Shahid MD1; Rotstein, Coleman MD1; Majchrzak-Kita, Beata MSc1; Kulasingam, Vathany PhD2; Humar, Atul MD1; Kumar, Deepali MD1
doi : 10.1097/TP.0000000000003860
October 2021 - Volume 105 - Issue 10 - p 2175-2183
Several studies have described the clinical features of COVID-19 in solid-organ transplant recipients. However, many have been retrospective or limited to more severe cases (hospitalized) and have not routinely included serial virological sampling (especially in outpatients) and immunologic assessment.
Bezinover, Dmitri MD, PhD1; Mukhtar, Ahmed MD2; Wagener, Gebhard MD3; Wray, Christopher MD4; Blasi, Annabel MD5; Kronish, Kate MD6; Zerillo, Jeron MD7; Tomescu, Dana MD, PhD8; Pustavoitau, Aliaksei MD9; Gitman, Marina MD10; Singh, Anil MD11; Saner, Fuat H. MD12
doi : 10.1097/TP.0000000000003642
October 2021 - Volume 105 - Issue 10 - p 2184-2200
Hemodynamic instability (HDI) during liver transplantation (LT) can be difficult to manage and increases postoperative morbidity and mortality. In addition to surgical causes of HDI, patient- and graft-related factors are also important. Nitric oxide–mediated vasodilatation is a common denominator associated with end-stage liver disease related to HDI. Despite intense investigation, optimal management strategies remain elusive.
Agarwal, Ankita MD1; Neujahr, David C. MD2
doi : 10.1097/TP.0000000000003671
October 2021 - Volume 105 - Issue 10 - p 2201-2212
The concept of frailty has gained considerable interest in clinical solid-organ transplantation over the past decade. Frailty as a phenotypic construct to describe a patient’s risk from biologic stresses has an impact on posttransplant survival. There is keen interest in characterizing frailty in lung transplantation, both to determine which patients are suitable candidates for listing and also to prepare for their care in the aftermath of lung transplantation. Here, we review the current status of research on frailty in lung transplant candidates and recipients. This review will highlight areas of uncertainty for frailty in clinical lung transplantation that are likely to impact the state-of-the-art in the field for the next decade.
Saritas, Turgay MD1,2; Kramann, Rafael MD, PhD1,2,3
doi : 10.1097/TP.0000000000003678
October 2021 - Volume 105 - Issue 10 - p e114-e130
Interstitial fibrosis with tubule atrophy (IF/TA) is the response to virtually any sustained kidney injury and correlates inversely with kidney function and allograft survival. IF/TA is driven by various pathways that include hypoxia, renin-angiotensin-aldosterone system, transforming growth factor-? signaling, cellular rejection, inflammation, and others. In this review, we will focus on key pathways in the progress of renal fibrosis, diagnosis and therapy of allograft fibrosis. This review discusses the role and origin of myofibroblasts as matrix producing cells and therapeutic targets in renal fibrosis with a particular focus on renal allografts. We summarize current trends to use multiomic approaches to identify new biomarkers for IF/TA detection and to predict allograft survival. Furthermore, we review current imaging strategies that might help to identify and follow-up IF/TA complementary or as alternative to invasive biopsies. We further discuss current clinical trials and therapeutic strategies to treat kidney fibrosis.
Yoon, Jihoon G. MD1,2; Song, Seung Hwan MD3,4; Choi, Sungkyoung PhD5; Oh, Jaeseong MD, PhD6; Jang, In-Jin MD, PhD6; Kim, Young Jin PhD7; Moon, Sanghoon PhD7; Kim, Bong-Jo PhD7; Cho, Yuri BS3; Kim, Hyo Kee MD8; Min, Sangil MD8; Ha, Jongwon MD8,9; Shin, Ho Sik MD10; Yang, Chul Woo MD11; Yoon, Hye Eun MD12; Yang, Jaeseok MD13; Lee, Min Goo MD, PhD1,2; Park, Jae Berm MD, PhD14; Kim, Myoung Soo MD, PhD3; and the Korean Organ Transplantation Registry (KOTRY) study group
doi : 10.1097/TP.0000000000003660
October 2021 - Volume 105 - Issue 10 - p 2213-2225
Tacrolimus (TAC) is an immunosuppressant widely prescribed following an allogenic organ transplant. Due to wide interindividual pharmacokinetic (PK) variability, optimizing TAC dosing based on genetic factors is required to minimize nephrotoxicity and acute rejections.
Adenugba, Akinbami PhD1; Hornung, Matthias MD1; Weigand, Kilian MD2; Peschel, Georg MD2; Junger, Henrik MD1; Kupke, Paul1; Lang, Hauke MD3; Marquardt, Jens U. MD4; Zimmermann, Tim MD5; Geissler, Edward K. PhD1; Schlitt, Hans J. MD1; Werner, Jens M. MD1
doi : 10.1097/TP.0000000000003612
October 2021 - Volume 105 - Issue 10 - p 2226-2238
Chronic hepatitis C virus (HCV) infection is characterized by activation of natural killer (NK) cells. Here, we asked whether HCV elimination by sofosbuvir-based direct-acting antivirals (DAAs) and the addition of ribavirin (RBV) improve NK cell function in liver transplant (LTx) recipients.
Yoeli, Dor MD1; Choudhury, Rashikh A. MD1; Nydam, Trevor L. MD1; Pomposelli, James J. MD1; Goss, John A. MD2; Pomfret, Elizabeth A. MD1; Wachs, Michael E. MD1; Adams, Megan A. MD1
doi : 10.1097/TP.0000000000003491
October 2021 - Volume 105 - Issue 10 - p 2239-2244
This study aimed to compare trends in use of drug overdose (DO) donors in adult versus pediatric liver transplants and the utilization of split liver transplantation in this donor population.
Gómez-Gavara, Concepción MD1; Moya-Herraiz, Ángel MD2; Hervás, David MD3; Pérez-Rojas, Judith MD4; LaHoz, Agustín MD5; López-Andújar, Rafael MD6
doi : 10.1097/TP.0000000000003487
October 2021 - Volume 105 - Issue 10 - p 2245-2254
N-acetylcysteine infusions have been widely used to reduce ischemia/reperfusion damage to the liver; however, convincing evidence of their benefits is lacking.
Berenguer, Marina MD1; Di Maira, Tommaso MD2; Baumann, Ulrich MD3,4; Mirza, Darius F. MS5; Heneghan, Michael A. MD6; Klempnauer, Jurgen L. PhD7; Bennet, William PhD8; Ericzon, Bo-Goran MD9; Line, Pål-Dag PhD10; Lodge, Peter A. MD11; Zieniewicz, Krzysztof MD12; Watson, Christopher J. E. MD13; Metselaar, Herold J. MD14; Adam, René MD15; Karam, Vincent PhD16; Aguilera, Victoria MD2; all the other contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA)
doi : 10.1097/TP.0000000000003542
October 2021 - Volume 105 - Issue 10 - p 2255-2262
The influence of sex on primary sclerosing cholangitis (PSC), pre- and postliver transplantation (LT) is unclear. Aims are to assess whether there have been changes in incidence, profile, and outcome in LT-PSC patients in Europe with specific emphasis on sex.
Ziogas, Ioannis A. MD1,2; Giannis, Dimitrios MD, MSc2,3; Economopoulos, Konstantinos P. MD, PhD2,4; Hayat, Muhammad H. MD5; Montenovo, Martin I. MD1; Matsuoka, Lea K. MD1; Alexopoulos, Sophoclis P. MD1
doi : 10.1097/TP.0000000000003539
October 2021 - Volume 105 - Issue 10 - p 2263-2271
Intrahepatic cholangiocarcinoma (iCCA) is a contraindication to liver transplantation in most centers worldwide. Therefore, only a few such cases have been performed in each individual center, and the need for a systematic review and meta-analysis to cumulatively pool these results is apparent.
Zhou, Guang-Peng MD1,2; Jiang, Yi-Zhou MD1,2; Wu, Shan-Shan PhD3; Kong, Yuan-Yuan PhD3; Sun, Li-Ying PhD1,2,4; Zhu, Zhi-Jun PhD1,2
doi : 10.1097/TP.0000000000003501
October 2021 - Volume 105 - Issue 10 - p 2272-2282
The worldwide experience of liver transplantation (LT) in the treatment of propionic acidemia (PA) remains limited and fragmented. This review aims to provide a comprehensive and quantitative understanding of posttransplant clinical outcomes in PA patients.
Cartin-Ceba, Rodrigo MD1; Burger, Charles MD2; Swanson, Karen DO1; Vargas, Hugo MD3; Aqel, Bashar MD3; Keaveny, Andrew P. MD4; Heimbach, Julie MD5; Taner, Timucin MD5; Nyberg, Scott PhD5; Rosen, Charles MD5; Cajigas, Hector MD6; DuBrock, Hilary MD6; Krowka, Michael J. MD6
doi : 10.1097/TP.0000000000003490
October 2021 - Volume 105 - Issue 10 - p 2283-2290
Portopulmonary hypertension (POPH) is the presence of pulmonary arterial (PA) hypertension in patients with portal hypertension and is associated with significant morbidity and mortality. In a cohort of POPH patients, we describe the clinical outcomes of POPH patients who underwent liver transplantation (LT).
Permpalung, Nitipong MD, MPH1,2; Kittipibul, Veraprapas MD3; Mekraksakit, Poemlarp MD4; Rattanawong, Pattara MD5; Nematollahi, Saman MD1; Zhang, Sean X. MD, PhD6; Steinke, Seema Mehta MD, MS1
doi : 10.1097/TP.0000000000003576
October 2021 - Volume 105 - Issue 10 - p 2291-2306
There is no consensus guidance on when to reinitiate Pneumocystis jirovecii pneumonia (PJP) prophylaxis in solid organ transplant (SOT) recipients at increased risk. The 2019 American Society of Transplantation Infectious Diseases Community of Practice (AST IDCOP) guidelines suggested to continue or reinstitute PJP prophylaxis in those receiving intensified immunosuppression for graft rejection, cytomegalovirus (CMV) infection, higher dose of corticosteroids, or prolonged neutropenia.
Taherkhani, Nasrin PhD1; Sepehri, Mohammad Mehdi PhD2; Khasha, Roghaye PhD3; Shafaghi, Shadi MD, PhD4
doi : 10.1097/TP.0000000000003623
October 2021 - Volume 105 - Issue 10 - p 2307-2315
Kidney transplantation is the best alternative treatment for end-stage renal disease. To optimal use of donated kidneys, graft predicted survival can be used as a factor to allocate kidneys. The performance of prediction techniques is highly dependent on the correct selection of predictors. Hence, the main objective of this research is to propose a novel method for ranking the effective variables for predicting the kidney transplant survival.
L'Huillier, Arnaud G. MD1; Hirzel, Cedric MD2; Ferreira, Victor H. PhD3; Ierullo, Matthew MSc3; Ku, Terrance MSc3; Selzner, Nazia MD3; Schiff, Jeffrey MD3; Juvet, Stephen MD3; Miao, Congrong PhD4; Schmid, D. Scott PhD4; Humar, Atul MD3; Kumar, Deepali MD3
doi : 10.1097/TP.0000000000003621
October 2021 - Volume 105 - Issue 10 - p 2316-2323
Immunization of varicella-zoster virus (VZV)-seronegative solid organ transplant (SOT) patients using the live-attenuated varicella vaccine is generally contraindicated, leaving no widely applicable immunization option. The recombinant subunit herpes zoster vaccine (RZV) is indicated for VZV-seropositive persons to prevent shingles but could potentially also protect VZV-seronegative persons against varicella. We performed a safety and immunogenicity evaluation of RZV in VZV-seronegative SOT recipients as an option for protection.
Ison, Michael G. MD, MS1,2; Avery, Robin MD3; Blumberg, Emily MD4; Chin-Hong, Peter MD5; Halasa, Natasha MD, MPH6; Kaul, Dan MD7; Pergam, Steve MD, MPH8,9; Theodoropoulos, Nicole M. MD, MS10; Wolfe, Cameron R. MBBS, MPH11
doi : 10.1097/TP.0000000000003747
October 2021 - Volume 105 - Issue 10 - p e131-e132
Yi, Stephanie G. MD, MPH1,2; Eagar, Todd PhD3; Moore, Linda PhD1; Huang, Howard J. MD2,4; Ibrahim, Hassan MD, MS2,5; Hobeika, Mark J. MD1,2; McMillan, Robert MD, MPH1,2; Podder, Hemangshu MD, PhD1,2; Ghobrial, R. Mark MD, PhD1,2; Gaber, A. Osama MD1,2; Knight, Richard J. MD1,2
doi : 10.1097/TP.0000000000003872
October 2021 - Volume 105 - Issue 10 - p e133-e134
Mohamadou, I. MD1; Nkok, J. MD2; Galichon, P. MD, PhD1; Cazenave, M. MD2; Arzouk, N. MD2; Ouali, N. MD3; Rondeau, E. MD, PhD4; Barrou, B. MD, PhD5; Amiel, C. MD, PhD6; Boutolleau, D. MD, PhD7; Tourret, J. MD, PhD8
doi : 10.1097/TP.0000000000003862
October 2021 - Volume 105 - Issue 10 - p e135-e136
Boyarsky, Brian J. MD, PhD1; Chiang, Teresa P.-Y. MD, MPH1; Teles, Aura T. BS1; Greenberg, Ross S. BA1; Krach, Michelle R. BA1; Ou, Michael T. BS1; Massie, Allan B. PhD1; Tobian, Aaron A. R. MD, PhD2; Garonzik-Wang, Jacqueline M. MD, PhD1; Segev, Dorry L. MD, PhD1,3; Werbel, and William A. MD4
doi : 10.1097/TP.0000000000003863
October 2021 - Volume 105 - Issue 10 - p e137-e138
Anjan, Shweta MD1,2; Natori, Yoichiro MD1,2; Fernandez Betances, Anmary A. MD1; Agritelley, Matthew S. BA1; Mattiazzi, Adela MD2; Arosemena, Leopoldo MD2; Andrews, David M. MD3; Simkins, Jacques MD1,2; Guerra, Giselle MD2; Abbo, Lilian M. MD1,2
doi : 10.1097/TP.0000000000003902
October 2021 - Volume 105 - Issue 10 - p e139-e141
Devresse, Arnaud PhD1; Saad Albichr, Imane PharmD2; Georgery, Hélène MD1; Yombi, Jean Cyr MD3; De Greef, Julien MD3; Belkhir, Leila PhD3; Mzougui, Samy2; Scohy, Anais PharmD2; Darius, Tom PhD4; Buemi, Antoine MD4; Goffin, Eric MD1; Kabamba, Benoit PhD2; Kanaan, Nada MD1
doi : 10.1097/TP.0000000000003892
October 2021 - Volume 105 - Issue 10 - p e142-e143
Centonze, Leonardo MD1; Lauterio, Andrea MD, FEBS1; De Carlis, Riccardo MD1; Ferla, Fabio MD1; De Carlis, Luciano MD, FEBS1,2
doi : 10.1097/TP.0000000000003875
October 2021 - Volume 105 - Issue 10 - p e144-e145
Del Bello, Arnaud MD1,2; Marion, Olivier MD1,2,3; Vellas, Camille PharmD4; Faguer, Stanislas MD, PhD1,3; Izopet, Jacques PharmD, PhD2,3,4; Kamar, Nassim MD, PhD1,2,3
doi : 10.1097/TP.0000000000003883
October 2021 - Volume 105 - Issue 10 - p e146-e147
Georgery, Hélène MD1; Devresse, Arnaud MD1,2; Yombi, Jean-Cyr MD2,3; Belkhir, Leila MD, PhD2,3; De Greef, Julien MD2,3; Darius, Tom MD, PhD2,4; Buemi, Antoine MD2,4; Scohy, Anais PharmD5; Kabamba, Benoit MD2,5; Goffin, Eric MD1,2; Kanaan, Nada MD1,2
doi : 10.1097/TP.0000000000003818
October 2021 - Volume 105 - Issue 10 - p e148-e149
Midtvedt, Karsten MD, PhD1; Onsøien, Mari O.2; Åsberg, Anders PhD1,3,4
doi : 10.1097/TP.0000000000003831
October 2021 - Volume 105 - Issue 10 - p e150
Wyld, Melanie L. R. BEc (Hons), MBBS, MBA, MPH, PhD1,2; De La Mata, Nicole L. MBiostats, PhD3; Masson, Philip MBChB, PhD4; O’Lone, Emma MBChB3,5; Kelly, Patrick J. PhD3; Webster, Angela C. MBBS, MM, PhD2,3
doi : 10.1097/TP.0000000000003832
October 2021 - Volume 105 - Issue 10 - p e151
Jain, Ashokkumar MD1; Xu, Ruichao MS2; Venkataramanan, Raman PhD2; Farooq, Umar MD3; Butt, Fauzia MD1; Ghahramani, Nasrollah MD3; Kadry, Zakiyah MD1
doi : 10.1097/TP.0000000000003840
October 2021 - Volume 105 - Issue 10 - p e152-e153
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