Anesthesia and Analgesia




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سفارش

Transfusion in Pediatric Cardiac Surgery: A Moving Target

Nathan, Naveen MD; Nalubola, Shreya; Weber, Garret MD

doi : 10.1213/ANE.0000000000005771

Volume 133(5), November 2021, p 1073

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Red Blood Cell Transfusion and Adverse Outcomes in Pediatric Cardiac Surgery Patients: Where Does the Blame Lie?

Faraoni, David MD, PhD, FAHA*,+; DiNardo, James A. MD, FAAP++

doi : 10.1213/ANE.0000000000005498

Volume 133(5), November 2021, p 1074-1076

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Postoperative Hematocrit and Adverse Outcomes in Pediatric Cardiac Surgery Patients: A Cross-Sectional Study From the Society of Thoracic Surgeons and Congenital Cardiac Anesthesia Society Database Collaboration

Long, Justin B. MD*; Engorn, Branden M. MD+; Hill, Kevin D. MD++; Feng, Liqi MS[S]; Chiswell, Karen PhD[S]; Jacobs, Marshall L. MD||; Jacobs, Jeffrey P. MD[P]; Goswami, Dheeraj MD#

doi : 10.1213/ANE.0000000000005416

Volume 133(5), November 2021, p 1077-1088

We sought to examine potential associations between pediatric postcardiac surgical hematocrit values and postoperative complications or mortality.

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The Prognostic Value of Automatic Frailty Assessment

Nathan, Naveen MD

doi : 10.1213/ANE.0000000000005772

Volume 133(5), November 2021, p 1089

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Frailty: More Than the Sum of Its Parts?

Whitlock, Elizabeth L. MD, MSc

doi : 10.1213/ANE.0000000000005672

Volume 133(5), November 2021, p 1090-1093

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A Systematic Review and Meta-Analysis of Preoperative Frailty Instruments Derived From Electronic Health Data

Alkadri, Jamal MD*; Hage, Dima BSc+; Nickerson, Leigh H. MD*; Scott, Lia R. MD++; Shaw, Julia F. BSc[S]; Aucoin, Sylvie D. MD, Msc, FRCPC*; McIsaac, Daniel I. MD, MPH, FRCPC*,[S],||

doi : 10.1213/ANE.0000000000005595

Volume 133(5), November 2021, p 1094-1106

Frailty is a strong predictor of adverse outcomes in the perioperative period. Given the increasing availability of electronic medical data, we performed a systematic review and meta-analysis with primary objectives of describing available frailty instruments applied to electronic data and synthesizing their prognostic value. Our secondary objectives were to assess the construct validity of frailty instruments that have been applied to perioperative electronic data and the feasibility of electronic frailty assessment.

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Relationship Between the Loaded Pressure and Flow Rate of Packed Red Blood Cells and Various Infusion Solutions in Normal Infusion Lines and Catheters

Miyoshi, Hirotsugu MD, PhD; Nakamura, Ryuji MD, PhD; Noda, Yuko MD; Kimura, Hiroshi MD; Kamiya, Satoshi MD; Morio, Atsushi MD; Watanabe, Tomoyuki MD; Narasaki, Soushi MD; Toyota, Yukari MD; Saeki, Noboru MD, PhD; Tsutsumi, Yasuo M. MD, PhD

doi : 10.1213/ANE.0000000000005700

Volume 133(5), November 2021, p 1107-1115

We investigated the relationship between the loaded pressure and flow rate in various catheters and the entire infusion line including the catheters, in several infusion solutions and packed red blood cells.

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Gabapentinoids: When Is the Right Moment to Stop?

Verret, Michael MD, MSc*,+; Turgeon, Alexis F. MD, MSc*,+

doi : 10.1213/ANE.0000000000005727

Volume 133(5), November 2021, p 1116-1118

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Day-of-Surgery Gabapentinoids and Prolonged Opioid Use: A Retrospective Cohort Study of Medicare Patients Using Electronic Health Records

Young, Jessica C. PhD*,+; Dasgupta, Nabarun PhD++; Chidgey, Brooke A. MD[S]; Sturmer, Til MD, PhD*; Pate, Virginia MS*; Hudgens, Michael PhD||; Jonsson Funk, Michele PhD*

doi : 10.1213/ANE.0000000000005656

Volume 133(5), November 2021, p 1119-1128

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Instructions for a Highly Relevant Tool in Line With the United Nations Goals for Sustainable Development

Luedi, Markus M. MD, MBA*; Enright, Angela MB, FRCPC+

doi : 10.1213/ANE.0000000000005728

Volume 133(5), November 2021, p 1129-1131

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The World Federation of Societies of Anaesthesiologists Minimum Capnometer Specifications 2021-A Guide for Health Care Decision Makers

Gelb, Adrian W. MBChB*,+; McDougall, Robert J. MBBS*,++; Gore-Booth, Julian MA*; Mainland, Phoebe-Anne MBBS*,[S]; on behalf of the WFSA Ad Hoc Capnometry Workgroup

doi : 10.1213/ANE.0000000000005682

Volume 133(5), November 2021, p 1132-1137

Capnometry, the measurement of respiratory carbon dioxide, is regarded as a highly recommended safety technology in intubated and nonintubated sedated and/or anesthetized patients. Its utility includes confirmation of initial and ongoing placement of an airway device as well as in detecting gas exchange, bronchospasm, airway obstruction, reduced cardiac output, and metabolic changes.

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General Anesthesia and Progression of Parkinson Disease: A Shaky Association

Crosby, Gregory MD*; Vutskits, Laszlo MD, PhD+,++

doi : 10.1213/ANE.0000000000005735

Volume 133(5), November 2021, p 1138-1139

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Anesthetic Effects on the Progression of Parkinson Disease in the Rat DJ-1 Model

Xu, Daniel A. BS; DeYoung, Timothy P. MSN, RN; Kondoleon, Nicholas P. MD; Eckenhoff, Roderic G. MD; Eckenhoff, Maryellen F. PhD

doi : 10.1213/ANE.0000000000005665

Volume 133(5), November 2021, p 1140-1151

Parkinson disease is a chronic and progressive movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The causes of Parkinson disease are not clear but may involve genetic susceptibilities and environmental factors. As in other neurodegenerative disorders, individuals predisposed to Parkinson disease may have an accelerated onset of symptoms following perioperative stress such as anesthesia, surgery, pain, and inflammation. We hypothesized that anesthesia alone accelerates the onset of Parkinson disease-like pathology and symptoms.

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Association of Delirium during Critical Illness With Mortality: Multicenter Prospective Cohort Study

Hughes, Christopher G. MD, MS*; Hayhurst, Christina J. MD+; Pandharipande, Pratik P. MD, MSCI++,[S]; Shotwell, Matthew S. PhD||; Feng, Xiaoke MS[P]; Wilson, Jo Ellen MD, MPH#; Brummel, Nathan E. MD, MSCI**; Girard, Timothy D. MD, MSCI++,++++; Jackson, James C. PsyD[S][S],||||; Ely, E. Wesley MD, MPH[S][S],[P][P]; Patel, Mayur B. MD, MPH[S],##

doi : 10.1213/ANE.0000000000005544

Volume 133(5), November 2021, p 1152-1161

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Extracellular Vesicles: A New Paradigm for Cellular Communication in Perioperative Medicine, Critical Care, and Pain Management

Zhou, Yingqiu K. MD*,+; Patel, Hemal H. PhD*,+; Roth, David M. PhD, MD*,+

doi : 10.1213/ANE.0000000000005655

Volume 133(5), November 2021, p 1162-1179

Extracellular vesicles (EVs) play critical roles in many health and disease states, including ischemia, inflammation, and pain, which are major concerns in the perioperative period and in critically ill patients. EVs are functionally active, nanometer-sized, membrane-bound vesicles actively secreted by all cells. Cell signaling is essential to physiological and pathological processes, and EVs have recently emerged as key players in intercellular communication. Recent studies in EV biology have improved our mechanistic knowledge of the pathophysiological processes in perioperative and critical care patients. Studies also show promise in using EVs in novel diagnostic and therapeutic clinical applications. This review considers the current advances and gaps in knowledge of EVs in the areas of ischemia, inflammation, pain, and in organ systems that are most relevant to anesthesiology, perioperative medicine, critical care, and pain management. We expect the reader will better understand the relationship between EVs and perioperative and critical care pathophysiological states and their potential use as novel diagnostic and therapeutic modalities.

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Survey of Practice Pattern in Patients With Heparin-Induced Thrombocytopenia Requiring Cardiopulmonary Bypass

Wanat-Hawthorne, Alycia MD*; Tanaka, Kenichi MD, MSc+; Angona, Ronald MS, CCP++; Feng, Changyong PhD[S]; Eaton, Michael MD, FASA||

doi : 10.1213/ANE.0000000000005721

Volume 133(5), November 2021, p 1180-1186

Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse reaction to heparin. Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) are routinely anticoagulated with heparin before the initiation of bypass. Heparin is contraindicated, however, in patients with acute HIT, and alternatives to routine practice are often used. While guidelines have recently been published addressing this topic 10, there remains variance between institutions in how these cases are treated. Our goal was to better delineate practice trends in the diagnosis and management of HIT patients requiring CPB.

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Neurocognitive, Quality of Life, and Behavioral Outcomes for Patients With Covert Stroke After Cardiac Surgery: Exploratory Analysis of Data From a Prospectively Randomized Trial

Lewis, Choy MD*; Levine, Annabelle MD*; Balmert, Lauren C. PhD+; Chen, Liqi MS+; Sherwani, Saadia S. MD, MS*; Nemeth, Alexander J. MD++; Grafman, Jordan PhD[S]; Gottesman, Rebecca MD, PhD||; Brown, Charles H. IV MD, MPH[P]; Hogue, Charles W. MD, FAHA*

doi : 10.1213/ANE.0000000000005690

Volume 133(5), November 2021, p 1187-1196

Asymptomatic brain ischemic injury detected with diffusion-weighted magnetic resonance imaging (DWI) is reported in more than one-half of patients after cardiac surgery. There are conflicting findings on whether DWI-detected covert stroke is associated with neurocognitive dysfunction after surgery, and it is unclear whether such ischemic injury affects quality of life or behavioral outcomes. The purpose of this study was to perform exploratory analysis on whether covert stroke after cardiac surgery is associated with delayed neurocognitive recovery 1 month after surgery, impaired quality of life, anxiety, or depression.

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Driving Pressure-Guided Individualized Positive End-Expiratory Pressure in Abdominal Surgery: A Randomized Controlled Trial

Zhang, Chengmi MD, PhD*; Xu, Fengying MD, PhD+; Li, Weiwei MD, PhD*; Tong, Xingyu MD*; Xia, Ran MD*; Wang, Wei MD*; Du, Jianer MD*; Shi, Xueyin MD*

doi : 10.1213/ANE.0000000000005575

Volume 133(5), November 2021, p 1197-1205

The optimal positive end-expiratory pressure (PEEP) to prevent postoperative pulmonary complications (PPCs) remains unclear. Recent evidence showed that driving pressure was closely related to PPCs. In this study, we tested the hypothesis that an individualized PEEP guided by minimum driving pressure during abdominal surgery would reduce the incidence of PPCs.

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Comparison of Percentage Prolonged Times to Tracheal Extubation Between a Japanese Teaching Hospital and One in the United States, Without and With a Phase I Postanesthesia Care Unit

Sugiyama, Daisuke MD, PhD*; Dexter, Franklin MD, PhD, FASA+; Thenuwara, Kokila MD, MBBS, MME, MHCDS+; Ueda, Kenichi MD*,++

doi : 10.1213/ANE.0000000000005231

Volume 133(5), November 2021, p 1206-1214

Prolonged times to tracheal extubation are those from end of surgery (dressing on the patient) to extubation 15 minutes or longer. They are so long that others in the operating room (OR) generally have exhausted whatever activities can be done. They cause delays in the starts of surgeons' to-follow cases and are associated with longer duration workdays. Anesthesiologists rate them as being inferior quality. We compare prolonged times to extubation between a teaching hospital in the United States with a phase I postanesthesia care unit (PACU) and a teaching hospital in Japan without a PACU. Our report is especially important during the coronavirus disease 2019 (COVID-19) pandemic. Anesthesiologists with some patients undergoing general anesthetics and having initial PACU recovery in the ORs where they had surgery can learn from the Japanese anesthesiologists with all patients recovering in ORs.

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The Effect of Low-Dose Intraoperative Ketamine on Closed-Loop-Controlled General Anesthesia: A Randomized Controlled Equivalence Trial

Napoleone, Gabby BSc*; van Heusden, Klaske PhD+,++; Cooke, Erin BSc*,++; West, Nicholas MSc*; Gorges, Matthias PhD*,++; Dumont, Guy A. PhD+,++; Ansermino, J. Mark MMed, MSc, FRCPC*,++; Merchant, Richard N. MD, FRCPC*,[S]

doi : 10.1213/ANE.0000000000005372

Volume 133(5), November 2021, p 1215-1224

Closed-loop control of propofol-remifentanil anesthesia using the processed electroencephalography depth-of-hypnosis index provided by the NeuroSENSE monitor (WAVCNS) has been previously described. The purpose of this placebo-controlled study was to evaluate the performance (percentage time within +/-10 units of the setpoint during the maintenance of anesthesia) of a closed-loop propofol-remifentanil controller during induction and maintenance of anesthesia in the presence of a low dose of ketamine.

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Beta-Blocker Therapy Is Associated With Increased 1-Year Survival After Hip Fracture Surgery: A Retrospective Cohort Study

Mohammad Ismail, Ahmad MD*,+; Ahl, Rebecka MB BChir, PhD+,++; Forssten, Maximilian Peter MD*,+; Cao, Yang PhD[S]; Wretenberg, Per MD, PhD*,+; Borg, Tomas MD, PhD*,+; Mohseni, Shahin MD, PhD+,||

doi : 10.1213/ANE.0000000000005659

Volume 133(5), November 2021, p 1225-1234

The high mortality rates seen within the first postoperative year after hip fracture surgery have remained relatively unchanged in many countries for the past 15 years. Recent investigations have shown an association between beta-blocker (BB) therapy and a reduction in risk-adjusted mortality within the first 90 days after hip fracture surgery. We hypothesized that preoperative, and continuous postoperative, BB therapy may also be associated with a decrease in mortality within the first year after hip fracture surgery.

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Effect of Different Positions During Surgical Preparation With Combined Spinal-Epidural Anesthesia for Elective Cesarean Delivery: A Randomized Controlled Trial

Liu, Tianyu BSc*,+; Zou, Shiya BSc*,++; Guo, Lulu BSc*,+; Niu, Zheng BSc*,+; Wang, Min BSc*,+; Xu, Chao MD[S],||; Gao, Xiuxiu BSc*,+; Shi, Zeshu BSc*,+; Guo, Xiaowei BSc*,+; Xiao, Hanbing BSc*,+; Qi, Dunyi MD*,+

doi : 10.1213/ANE.0000000000005320

Volume 133(5), November 2021, p 1235-1243

The intraoperative 15[degrees] left-tilt position during cesarean delivery has more recently been questioned regarding its effect on fetal acid-base balance and is a frequent source of complaints by surgeons. We hypothesized that a 30[degrees] left-tilt position during surgical preparation could improve the acid-base balance of the fetus compared with the 15[degrees] left-tilt or supine position during surgical preparation.

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Anesthetic Management of Von Willebrand Disease in Pregnancy: A Retrospective Analysis of a Large Case Series

Reale, Sharon C. MD*; Farber, Michaela K. MD, MS*; Lumbreras-Marquez, Mario I. MBBS, MMSc*; Connors, Jean M. MD+; Carabuena, Jean M. MD*

doi : 10.1213/ANE.0000000000005502

Volume 133(5), November 2021, p 1244-1250

Although Von Willebrand disease (vWD) is the most common heritable bleeding disorder, there are limited reports regarding the safety of neuraxial anesthesia in the obstetric population and no definitive guidelines specifying recommended pretreatment or therapies for patients with vWD. The aim of this study is to describe the anesthetic management of pregnant patients with vWD at a large tertiary-care center.

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A Novel 3-Dimensional Printing Fabrication Approach for the Production of Pediatric Airway Models

Weatherall, Andrew D. BMed*,+; Rogerson, Matthew D. BSc Hons++; Quayle, Michelle R. BSc Hons++; Cooper, Michael G. MBBS*; McMenamin, Paul G. PhD++; Adams, Justin W. PhD++

doi : 10.1213/ANE.0000000000005260

Volume 133(5), November 2021, p 1251-1259

Pediatric airway models currently available for use in education or simulation do not replicate anatomy or tissue responses to procedures. Emphasis on mass production with sturdy but homogeneous materials and low-fidelity casting techniques diminishes these models' abilities to realistically represent the unique characteristics of the pediatric airway, particularly in the infant and younger age ranges. Newer fabrication technologies, including 3-dimensional (3D) printing and castable tissue-like silicones, open new approaches to the simulation of pediatric airways with greater anatomical fidelity and utility for procedure training.

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The Association of Dexmedetomidine on Perioperative Opioid Consumption in Children Undergoing Adenotonsillectomy With and Without Obstructive Sleep Apnea

Adler, Adam C. MS, MD, FAAP, FASE*,+; Daszkowski, Anna BS+; Tan, Joy C. MD++,[S]; Poliner, Anna D. BSA+; Wei, Eric Z. BS+; Nathanson, Brian H. PhD, DSHS||; Chandrakantan, Arvind MD, MBA, FAAP, FASA*,+

doi : 10.1213/ANE.0000000000005410

Volume 133(5), November 2021, p 1260-1268

Dexmedetomidine is used to reduce opioid consumption in pediatric anesthesia. However, there is conflicting evidence in pediatric adenotonsillectomy literature regarding the total perioperative opioid-sparing effects of dexmedetomidine. The aim of this study was to examine the association between dexmedetomidine and total perioperative opioid consumption in children undergoing adenotonsillectomy.

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Comparison of the Spectral Features of the Frontal Electroencephalogram in Patients Receiving Xenon and Sevoflurane General Anesthesia

McGuigan, Steven MBChB*,+; Evered, Lisbeth PhD*,+; Silbert, Brendan MBBS*,+; Scott, David A. MBBS, PhD*,+; Cormack, John R. MBBS*; Devapalasundaram, Abarna MBBS*; Liley, David T. J. MBChB, PhD+

doi : 10.1213/ANE.0000000000005608

Volume 133(5), November 2021, p 1269-1279

Depth-of-anesthesia monitoring is often utilized for patients receiving xenon anesthesia. Processed electroencephalogram (EEG) depth-of-anesthesia monitoring relies to a significant extent on frequency domain analysis of the frontal EEG, and there is evidence that the spectral features observed under anesthesia vary significantly between anesthetic agents. The spectral features of the EEG during xenon anesthesia for a surgical procedure have not previously been described.

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Hospital Volumes of Inpatient Pediatric Surgery in the United States

Berry, Jay G. MD, MPH*,+; Rodean, Jonathan MPP++; Leahy, Izabela RN, BSN, MS[S]; Rangel, Shawn MD, MSCE+,||; Johnson, Connor BS[S]; Crofton, Charis BS*; Staffa, Steven J. MS[S]; Hall, Matt PhD++; Methot, Craig BS[S]; Desmarais, Anna BS+; Ferrari, Lynne MD+,[S]

doi : 10.1213/ANE.0000000000005748

Volume 133(5), November 2021, p 1280-1287

Perioperative outcomes of children depend on the skill and expertise in managing pediatric patients, as well as integration of surgical, anesthesiology, and medical teams. We compared the types of pediatric patients and inpatient surgical procedures performed in low- versus higher-volume hospitals throughout the United States.

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Comparison of the Conventional Downward and Modified Upward Laryngeal Handshake Techniques to Identify the Cricothyroid Membrane: A Randomized, Comparative Study

Chang, Jee-Eun MD*; Kim, Hyerim MD*; Won, Dongwook MD*; Lee, Jung-Man MD, PhD*; Kim, Tae Kyong MD, PhD*,+; Min, Seong-Won MD, PhD*,+; Hwang, Jin-Young MD, PhD*,+

doi : 10.1213/ANE.0000000000005744

Volume 133(5), November 2021, p 1288-1295

Accurate identification of the cricothyroid membrane is crucial for successful cricothyroidotomy. The aim of this study was to compare the conventional downward and modified upward laryngeal handshake techniques in terms of accuracy to identify the cricothyroid membrane in nonobese female patients.

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Safety of Continuous Erector Spinae Catheters in Chest Trauma: A Retrospective Cohort Study

White, L. D. MBBS*; Riley, B. MD+; Davis, K. MD*; Thang, C. MD++; Mitchell, A. MBBS*; Abi-fares, C. MBBS*; Basson, W. MBBS*; Anstey, C. MBBS[S]

doi : 10.1213/ANE.0000000000005730

Volume 133(5), November 2021, p 1296-1302

The erector spinae block is an efficacious analgesic option for the management of rib fracture--related pain. Despite there being minimal published data specifically addressing the safety profile of this block, many societies have made statements regarding its safety and its use as an alternative to traditional regional anesthesia techniques in patients at risk of complications. The primary aim of this study was to characterize the safety profile of erector spinae plane block catheters by determining the incidence of early complications. The secondary aim of this study was to characterize the incidence of late adverse events, as well as the erector spinae plane block catheter failure rate.

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Effects of Local Anesthetic Volume (Standard Versus Low) on Incidence of Hemidiaphragmatic Paralysis and Analgesic Quality for Ultrasound-Guided Superior Trunk Block After Arthroscopic Shoulder Surgery

Kim, Hyunzu MD, PhD*; Han, Jeong Uk MD, PhD*; Lee, Woojoo PhD+; Jeon, Yoon Sang MD++; Jeong, Jimyeong MD*; Yang, Chunwoo MD*; Uhm, Jae Woung MD*; Kim, Youngjun MD*

doi : 10.1213/ANE.0000000000005654

Volume 133(5), November 2021, p 1303-1310

Relative to interscalene block, superior trunk block (STB) provides comparable analgesia and a reduced risk of hemidiaphragmatic paralysis. However, the incidence of hemidiaphragmatic paralysis remains high when a standard volume (15 mL) of local anesthetic is used. This study aimed to evaluate the effects of local anesthetic volume of STB on the incidence of phrenic nerve palsy, as well as its analgesic efficacy following arthroscopic shoulder surgery.

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Acute Visceral Pain in Rats: Vagal Nerve Block Compared to Bupivacaine Administered Intramuscularly

Ben Rehouma, Mouna MD*,+; Kfoury, Toni MD, PhD*,++; Hamdi, Leila PhD*; Bouchouareb, Meriem MS*; Soued, Mickael MD*,[S]; Benhamou, Dan MD*,++; Mazoit, Jean Xavier MD, PhD*

doi : 10.1213/ANE.0000000000005697

Volume 133(5), November 2021, p 1311-1320

Visceral and parietal peritoneum layers have different sensory innervations. Most visceral peritoneum sensory information is conveyed via the vagus nerve to the nucleus of the solitary tract (NTS). We already showed in animal models that intramuscular (i.m.) injection of local anesthetics decreases acute somatic and visceral pain and general inflammation induced by aseptic peritonitis. The goal of the study was to compare the effects of parietal block, i.m. bupivacaine, and vagotomy on spinal cord and NTS stimulation induced by a chemical peritonitis.

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The Programmed Cell Death Ligand-1/Programmed Cell Death-1 Pathway Mediates Pregnancy-Induced Analgesia via Regulating Spinal Inflammatory Cytokines

Tan, HuiLing MD*; Ding, ZhenDong MD+; Zhang, ChengLiang MD++; Yan, JianQin MD[S]; Yang, Yong MD[S]; Li, Ping MD, PhD||,[P]

doi : 10.1213/ANE.0000000000005737

Volume 133(5), November 2021, p 1321-1330

The maternal pain threshold gradually increases during pregnancy, especially in late pregnancy. A series of mechanisms underlying pregnancy-induced analgesia have been reported. However, these mechanisms are still not completely clear, and the underlying molecular mechanisms need further investigation. We examined the relationship between the antinociceptive effect and the expression level of programmed cell death ligand-1 (PD-L1) during pregnancy and further observed the changes in pain thresholds and expression levels of cytokines in late-pregnant mice before and after blockade of PD-L1 or programmed cell death-1 (PD-1).

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A Coronavirus Disease 2019 Pandemic Pivot: Development of the American Board of Anesthesiology's Virtual APPLIED Examination

Keegan, Mark T. MB, BCh, MRCPI, MSc, FCCM*,+; McLoughlin, Thomas M. Jr MD*,++; Patterson, Andrew J. MD, PhD*,[S]; Fiadjoe, John E. MD*,||; Pisacano, Margaret M. BSN, JD, CPHRM*,[P]; Warner, David O. MD*,+; Sun, Huaping PhD*; Harman, Ann E. PhD*

doi : 10.1213/ANE.0000000000005750

Volume 133(5), November 2021, p 1331-1341

In 2020, the coronavirus disease 2019 (COVID-19) pandemic interrupted the administration of the APPLIED Examination, the final part of the American Board of Anesthesiology (ABA) staged examination system for initial certification. In response, the ABA developed, piloted, and implemented an Internet-based "virtual" form of the examination to allow administration of both components of the APPLIED Exam (Standardized Oral Examination and Objective Structured Clinical Examination) when it was impractical and unsafe for candidates and examiners to travel and have in-person interactions. This article describes the development of the ABA virtual APPLIED Examination, including its rationale, examination format, technology infrastructure, candidate communication, and examiner training. Although the logistics are formidable, we report a methodology for successfully introducing a large-scale, high-stakes, 2-element, remote examination that replicates previously validated assessments.

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The First Cardiac Anesthesiology Fellow, William A. Lell: A Brief History

Reves, J.G. MD

doi : 10.1213/ANE.0000000000005396

Volume 133(5), November 2021, p 1342-1347

Fifty years ago, on August 1, 1971, William A. Lell became the first cardiac anesthesia fellow at Harvard's Massachusetts General Hospital (MGH) Department of Anesthesiology, training with the world's first group of anesthesiologists whose clinical practice, teaching, and research efforts were exclusively devoted to cardiac anesthesia. Lell's early interest in cardiovascular medicine and how mentors, particularly at the MGH, influenced his early career development are recounted. The challenges a young pioneer faced in establishing and maintaining an academic cardiac anesthesia program during the initial and rapid growth of an exciting new subspecialty are described. Dr Lell's experience emphasizes the importance of seizing new opportunities and establishing meaningful working relationships with colleagues based on mutual trust as fundamental to successful career development and research in a new medical subspecialty.

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Regional Anesthesia and Compartment Syndrome

Marhofer, Peter MD*; Halm, Jens MD+; Feigl, Georg C. MD++; Schepers, Tim MD+; Hollmann, Markus W. MD, PhD[S]

doi : 10.1213/ANE.0000000000005661

Volume 133(5), November 2021, p 1348-1352

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Is It Time to Abandon Routine Mask Ventilation Before Intubation?

Min, Kevin J. MD*; Rabinowitz, Anna L. MD*; Hess, Cary J. BS+

doi : 10.1213/ANE.0000000000005723

Volume 133(5), November 2021, p 1353-1357

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Enablers and Barriers to Multicenter Perioperative Handoff Collaboration: Lessons Learned From a Successful Model Outside the Operating Room

Michael, Meghan M. MD*; Ambardekar, Aditee P. MD, MSEd*; Pukenas, Erin MD+; Karamchandani, Kunal MD, FCCP, FCCM*; Nguyen, Huong MD*; Potestio, Christopher P. MD+; Tubinis, Michelle D. MD++; Huang, Norman R. DO*; Riesenberg, Lee Ann PhD++

doi : 10.1213/ANE.0000000000005724

Volume 133(5), November 2021, p 1358-1363

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My Experience as a Physician: A Rwandan Perspective

Uwimana, Jean Claude MD

doi : 10.1213/ANE.0000000000005732

Volume 133(5), November 2021, p 1364

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Medication Safety During Anesthesia and the Perioperative Period, 1st ed

Morell, Robert C. MD

doi : 10.1213/ANE.0000000000005695

Volume 133(5), November 2021, p e55

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Lidocaine Is Noninferior to Chloroprocaine, but an Observational Study Would Have Been Superior

Riley, Edward T. MD

doi : 10.1213/ANE.0000000000005717

Volume 133(5), November 2021, p e56-e57

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In Response

Sharawi, Nadir MBBS, MSc, FRCA; Mhyre, Jill M. MD

doi : 10.1213/ANE.0000000000005718

Volume 133(5), November 2021, p e57-e59

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Platelet Counts and Neuraxial Procedures in Parturients

Seiler, F. Arran MD; Arnolds, David E. MD, PhD

doi : 10.1213/ANE.0000000000005725

Volume 133(5), November 2021, p e59-e60

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In Response

Bauer, Melissa E. DO; Rajasekhar, Anita MD; Leffert, Lisa MD

doi : 10.1213/ANE.0000000000005726

Volume 133(5), November 2021, p e60-e61

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Time to Use Peripheral Norepinephrine in the Operating Room: Erratum

doi : 10.1213/ANE.0000000000005775

Volume 133(5), November 2021, p e62

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