Nathan, Naveen MD; Nalubola, Shreya; Weber, Garret MD
doi : 10.1213/ANE.0000000000005771
Volume 133(5), November 2021, p 1073
Faraoni, David MD, PhD, FAHA*,+; DiNardo, James A. MD, FAAP++
doi : 10.1213/ANE.0000000000005498
Volume 133(5), November 2021, p 1074-1076
Long, Justin B. MD*; Engorn, Branden M. MD+; Hill, Kevin D. MD++; Feng, Liqi MS[S]; Chiswell, Karen PhD[S]; Jacobs, Marshall L. MD||; Jacobs, Jeffrey P. MD[P]; Goswami, Dheeraj MD#
doi : 10.1213/ANE.0000000000005416
Volume 133(5), November 2021, p 1077-1088
We sought to examine potential associations between pediatric postcardiac surgical hematocrit values and postoperative complications or mortality.
Nathan, Naveen MD
doi : 10.1213/ANE.0000000000005772
Volume 133(5), November 2021, p 1089
Whitlock, Elizabeth L. MD, MSc
doi : 10.1213/ANE.0000000000005672
Volume 133(5), November 2021, p 1090-1093
Alkadri, Jamal MD*; Hage, Dima BSc+; Nickerson, Leigh H. MD*; Scott, Lia R. MD++; Shaw, Julia F. BSc[S]; Aucoin, Sylvie D. MD, Msc, FRCPC*; McIsaac, Daniel I. MD, MPH, FRCPC*,[S],||
doi : 10.1213/ANE.0000000000005595
Volume 133(5), November 2021, p 1094-1106
Frailty is a strong predictor of adverse outcomes in the perioperative period. Given the increasing availability of electronic medical data, we performed a systematic review and meta-analysis with primary objectives of describing available frailty instruments applied to electronic data and synthesizing their prognostic value. Our secondary objectives were to assess the construct validity of frailty instruments that have been applied to perioperative electronic data and the feasibility of electronic frailty assessment.
Miyoshi, Hirotsugu MD, PhD; Nakamura, Ryuji MD, PhD; Noda, Yuko MD; Kimura, Hiroshi MD; Kamiya, Satoshi MD; Morio, Atsushi MD; Watanabe, Tomoyuki MD; Narasaki, Soushi MD; Toyota, Yukari MD; Saeki, Noboru MD, PhD; Tsutsumi, Yasuo M. MD, PhD
doi : 10.1213/ANE.0000000000005700
Volume 133(5), November 2021, p 1107-1115
We investigated the relationship between the loaded pressure and flow rate in various catheters and the entire infusion line including the catheters, in several infusion solutions and packed red blood cells.
Verret, Michael MD, MSc*,+; Turgeon, Alexis F. MD, MSc*,+
doi : 10.1213/ANE.0000000000005727
Volume 133(5), November 2021, p 1116-1118
Young, Jessica C. PhD*,+; Dasgupta, Nabarun PhD++; Chidgey, Brooke A. MD[S]; Sturmer, Til MD, PhD*; Pate, Virginia MS*; Hudgens, Michael PhD||; Jonsson Funk, Michele PhD*
doi : 10.1213/ANE.0000000000005656
Volume 133(5), November 2021, p 1119-1128
Luedi, Markus M. MD, MBA*; Enright, Angela MB, FRCPC+
doi : 10.1213/ANE.0000000000005728
Volume 133(5), November 2021, p 1129-1131
Gelb, Adrian W. MBChB*,+; McDougall, Robert J. MBBS*,++; Gore-Booth, Julian MA*; Mainland, Phoebe-Anne MBBS*,[S]; on behalf of the WFSA Ad Hoc Capnometry Workgroup
doi : 10.1213/ANE.0000000000005682
Volume 133(5), November 2021, p 1132-1137
Capnometry, the measurement of respiratory carbon dioxide, is regarded as a highly recommended safety technology in intubated and nonintubated sedated and/or anesthetized patients. Its utility includes confirmation of initial and ongoing placement of an airway device as well as in detecting gas exchange, bronchospasm, airway obstruction, reduced cardiac output, and metabolic changes.
Crosby, Gregory MD*; Vutskits, Laszlo MD, PhD+,++
doi : 10.1213/ANE.0000000000005735
Volume 133(5), November 2021, p 1138-1139
Xu, Daniel A. BS; DeYoung, Timothy P. MSN, RN; Kondoleon, Nicholas P. MD; Eckenhoff, Roderic G. MD; Eckenhoff, Maryellen F. PhD
doi : 10.1213/ANE.0000000000005665
Volume 133(5), November 2021, p 1140-1151
Parkinson disease is a chronic and progressive movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The causes of Parkinson disease are not clear but may involve genetic susceptibilities and environmental factors. As in other neurodegenerative disorders, individuals predisposed to Parkinson disease may have an accelerated onset of symptoms following perioperative stress such as anesthesia, surgery, pain, and inflammation. We hypothesized that anesthesia alone accelerates the onset of Parkinson disease-like pathology and symptoms.
Hughes, Christopher G. MD, MS*; Hayhurst, Christina J. MD+; Pandharipande, Pratik P. MD, MSCI++,[S]; Shotwell, Matthew S. PhD||; Feng, Xiaoke MS[P]; Wilson, Jo Ellen MD, MPH#; Brummel, Nathan E. MD, MSCI**; Girard, Timothy D. MD, MSCI++,++++; Jackson, James C. PsyD[S][S],||||; Ely, E. Wesley MD, MPH[S][S],[P][P]; Patel, Mayur B. MD, MPH[S],##
doi : 10.1213/ANE.0000000000005544
Volume 133(5), November 2021, p 1152-1161
Zhou, Yingqiu K. MD*,+; Patel, Hemal H. PhD*,+; Roth, David M. PhD, MD*,+
doi : 10.1213/ANE.0000000000005655
Volume 133(5), November 2021, p 1162-1179
Extracellular vesicles (EVs) play critical roles in many health and disease states, including ischemia, inflammation, and pain, which are major concerns in the perioperative period and in critically ill patients. EVs are functionally active, nanometer-sized, membrane-bound vesicles actively secreted by all cells. Cell signaling is essential to physiological and pathological processes, and EVs have recently emerged as key players in intercellular communication. Recent studies in EV biology have improved our mechanistic knowledge of the pathophysiological processes in perioperative and critical care patients. Studies also show promise in using EVs in novel diagnostic and therapeutic clinical applications. This review considers the current advances and gaps in knowledge of EVs in the areas of ischemia, inflammation, pain, and in organ systems that are most relevant to anesthesiology, perioperative medicine, critical care, and pain management. We expect the reader will better understand the relationship between EVs and perioperative and critical care pathophysiological states and their potential use as novel diagnostic and therapeutic modalities.
Wanat-Hawthorne, Alycia MD*; Tanaka, Kenichi MD, MSc+; Angona, Ronald MS, CCP++; Feng, Changyong PhD[S]; Eaton, Michael MD, FASA||
doi : 10.1213/ANE.0000000000005721
Volume 133(5), November 2021, p 1180-1186
Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse reaction to heparin. Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) are routinely anticoagulated with heparin before the initiation of bypass. Heparin is contraindicated, however, in patients with acute HIT, and alternatives to routine practice are often used. While guidelines have recently been published addressing this topic 10, there remains variance between institutions in how these cases are treated. Our goal was to better delineate practice trends in the diagnosis and management of HIT patients requiring CPB.
Lewis, Choy MD*; Levine, Annabelle MD*; Balmert, Lauren C. PhD+; Chen, Liqi MS+; Sherwani, Saadia S. MD, MS*; Nemeth, Alexander J. MD++; Grafman, Jordan PhD[S]; Gottesman, Rebecca MD, PhD||; Brown, Charles H. IV MD, MPH[P]; Hogue, Charles W. MD, FAHA*
doi : 10.1213/ANE.0000000000005690
Volume 133(5), November 2021, p 1187-1196
Asymptomatic brain ischemic injury detected with diffusion-weighted magnetic resonance imaging (DWI) is reported in more than one-half of patients after cardiac surgery. There are conflicting findings on whether DWI-detected covert stroke is associated with neurocognitive dysfunction after surgery, and it is unclear whether such ischemic injury affects quality of life or behavioral outcomes. The purpose of this study was to perform exploratory analysis on whether covert stroke after cardiac surgery is associated with delayed neurocognitive recovery 1 month after surgery, impaired quality of life, anxiety, or depression.
Zhang, Chengmi MD, PhD*; Xu, Fengying MD, PhD+; Li, Weiwei MD, PhD*; Tong, Xingyu MD*; Xia, Ran MD*; Wang, Wei MD*; Du, Jianer MD*; Shi, Xueyin MD*
doi : 10.1213/ANE.0000000000005575
Volume 133(5), November 2021, p 1197-1205
The optimal positive end-expiratory pressure (PEEP) to prevent postoperative pulmonary complications (PPCs) remains unclear. Recent evidence showed that driving pressure was closely related to PPCs. In this study, we tested the hypothesis that an individualized PEEP guided by minimum driving pressure during abdominal surgery would reduce the incidence of PPCs.
Sugiyama, Daisuke MD, PhD*; Dexter, Franklin MD, PhD, FASA+; Thenuwara, Kokila MD, MBBS, MME, MHCDS+; Ueda, Kenichi MD*,++
doi : 10.1213/ANE.0000000000005231
Volume 133(5), November 2021, p 1206-1214
Prolonged times to tracheal extubation are those from end of surgery (dressing on the patient) to extubation 15 minutes or longer. They are so long that others in the operating room (OR) generally have exhausted whatever activities can be done. They cause delays in the starts of surgeons' to-follow cases and are associated with longer duration workdays. Anesthesiologists rate them as being inferior quality. We compare prolonged times to extubation between a teaching hospital in the United States with a phase I postanesthesia care unit (PACU) and a teaching hospital in Japan without a PACU. Our report is especially important during the coronavirus disease 2019 (COVID-19) pandemic. Anesthesiologists with some patients undergoing general anesthetics and having initial PACU recovery in the ORs where they had surgery can learn from the Japanese anesthesiologists with all patients recovering in ORs.
Napoleone, Gabby BSc*; van Heusden, Klaske PhD+,++; Cooke, Erin BSc*,++; West, Nicholas MSc*; Gorges, Matthias PhD*,++; Dumont, Guy A. PhD+,++; Ansermino, J. Mark MMed, MSc, FRCPC*,++; Merchant, Richard N. MD, FRCPC*,[S]
doi : 10.1213/ANE.0000000000005372
Volume 133(5), November 2021, p 1215-1224
Closed-loop control of propofol-remifentanil anesthesia using the processed electroencephalography depth-of-hypnosis index provided by the NeuroSENSE monitor (WAVCNS) has been previously described. The purpose of this placebo-controlled study was to evaluate the performance (percentage time within +/-10 units of the setpoint during the maintenance of anesthesia) of a closed-loop propofol-remifentanil controller during induction and maintenance of anesthesia in the presence of a low dose of ketamine.
Mohammad Ismail, Ahmad MD*,+; Ahl, Rebecka MB BChir, PhD+,++; Forssten, Maximilian Peter MD*,+; Cao, Yang PhD[S]; Wretenberg, Per MD, PhD*,+; Borg, Tomas MD, PhD*,+; Mohseni, Shahin MD, PhD+,||
doi : 10.1213/ANE.0000000000005659
Volume 133(5), November 2021, p 1225-1234
The high mortality rates seen within the first postoperative year after hip fracture surgery have remained relatively unchanged in many countries for the past 15 years. Recent investigations have shown an association between beta-blocker (BB) therapy and a reduction in risk-adjusted mortality within the first 90 days after hip fracture surgery. We hypothesized that preoperative, and continuous postoperative, BB therapy may also be associated with a decrease in mortality within the first year after hip fracture surgery.
Liu, Tianyu BSc*,+; Zou, Shiya BSc*,++; Guo, Lulu BSc*,+; Niu, Zheng BSc*,+; Wang, Min BSc*,+; Xu, Chao MD[S],||; Gao, Xiuxiu BSc*,+; Shi, Zeshu BSc*,+; Guo, Xiaowei BSc*,+; Xiao, Hanbing BSc*,+; Qi, Dunyi MD*,+
doi : 10.1213/ANE.0000000000005320
Volume 133(5), November 2021, p 1235-1243
The intraoperative 15[degrees] left-tilt position during cesarean delivery has more recently been questioned regarding its effect on fetal acid-base balance and is a frequent source of complaints by surgeons. We hypothesized that a 30[degrees] left-tilt position during surgical preparation could improve the acid-base balance of the fetus compared with the 15[degrees] left-tilt or supine position during surgical preparation.
Reale, Sharon C. MD*; Farber, Michaela K. MD, MS*; Lumbreras-Marquez, Mario I. MBBS, MMSc*; Connors, Jean M. MD+; Carabuena, Jean M. MD*
doi : 10.1213/ANE.0000000000005502
Volume 133(5), November 2021, p 1244-1250
Although Von Willebrand disease (vWD) is the most common heritable bleeding disorder, there are limited reports regarding the safety of neuraxial anesthesia in the obstetric population and no definitive guidelines specifying recommended pretreatment or therapies for patients with vWD. The aim of this study is to describe the anesthetic management of pregnant patients with vWD at a large tertiary-care center.
Weatherall, Andrew D. BMed*,+; Rogerson, Matthew D. BSc Hons++; Quayle, Michelle R. BSc Hons++; Cooper, Michael G. MBBS*; McMenamin, Paul G. PhD++; Adams, Justin W. PhD++
doi : 10.1213/ANE.0000000000005260
Volume 133(5), November 2021, p 1251-1259
Pediatric airway models currently available for use in education or simulation do not replicate anatomy or tissue responses to procedures. Emphasis on mass production with sturdy but homogeneous materials and low-fidelity casting techniques diminishes these models' abilities to realistically represent the unique characteristics of the pediatric airway, particularly in the infant and younger age ranges. Newer fabrication technologies, including 3-dimensional (3D) printing and castable tissue-like silicones, open new approaches to the simulation of pediatric airways with greater anatomical fidelity and utility for procedure training.
Adler, Adam C. MS, MD, FAAP, FASE*,+; Daszkowski, Anna BS+; Tan, Joy C. MD++,[S]; Poliner, Anna D. BSA+; Wei, Eric Z. BS+; Nathanson, Brian H. PhD, DSHS||; Chandrakantan, Arvind MD, MBA, FAAP, FASA*,+
doi : 10.1213/ANE.0000000000005410
Volume 133(5), November 2021, p 1260-1268
Dexmedetomidine is used to reduce opioid consumption in pediatric anesthesia. However, there is conflicting evidence in pediatric adenotonsillectomy literature regarding the total perioperative opioid-sparing effects of dexmedetomidine. The aim of this study was to examine the association between dexmedetomidine and total perioperative opioid consumption in children undergoing adenotonsillectomy.
McGuigan, Steven MBChB*,+; Evered, Lisbeth PhD*,+; Silbert, Brendan MBBS*,+; Scott, David A. MBBS, PhD*,+; Cormack, John R. MBBS*; Devapalasundaram, Abarna MBBS*; Liley, David T. J. MBChB, PhD+
doi : 10.1213/ANE.0000000000005608
Volume 133(5), November 2021, p 1269-1279
Depth-of-anesthesia monitoring is often utilized for patients receiving xenon anesthesia. Processed electroencephalogram (EEG) depth-of-anesthesia monitoring relies to a significant extent on frequency domain analysis of the frontal EEG, and there is evidence that the spectral features observed under anesthesia vary significantly between anesthetic agents. The spectral features of the EEG during xenon anesthesia for a surgical procedure have not previously been described.
Berry, Jay G. MD, MPH*,+; Rodean, Jonathan MPP++; Leahy, Izabela RN, BSN, MS[S]; Rangel, Shawn MD, MSCE+,||; Johnson, Connor BS[S]; Crofton, Charis BS*; Staffa, Steven J. MS[S]; Hall, Matt PhD++; Methot, Craig BS[S]; Desmarais, Anna BS+; Ferrari, Lynne MD+,[S]
doi : 10.1213/ANE.0000000000005748
Volume 133(5), November 2021, p 1280-1287
Perioperative outcomes of children depend on the skill and expertise in managing pediatric patients, as well as integration of surgical, anesthesiology, and medical teams. We compared the types of pediatric patients and inpatient surgical procedures performed in low- versus higher-volume hospitals throughout the United States.
Chang, Jee-Eun MD*; Kim, Hyerim MD*; Won, Dongwook MD*; Lee, Jung-Man MD, PhD*; Kim, Tae Kyong MD, PhD*,+; Min, Seong-Won MD, PhD*,+; Hwang, Jin-Young MD, PhD*,+
doi : 10.1213/ANE.0000000000005744
Volume 133(5), November 2021, p 1288-1295
Accurate identification of the cricothyroid membrane is crucial for successful cricothyroidotomy. The aim of this study was to compare the conventional downward and modified upward laryngeal handshake techniques in terms of accuracy to identify the cricothyroid membrane in nonobese female patients.
White, L. D. MBBS*; Riley, B. MD+; Davis, K. MD*; Thang, C. MD++; Mitchell, A. MBBS*; Abi-fares, C. MBBS*; Basson, W. MBBS*; Anstey, C. MBBS[S]
doi : 10.1213/ANE.0000000000005730
Volume 133(5), November 2021, p 1296-1302
The erector spinae block is an efficacious analgesic option for the management of rib fracture--related pain. Despite there being minimal published data specifically addressing the safety profile of this block, many societies have made statements regarding its safety and its use as an alternative to traditional regional anesthesia techniques in patients at risk of complications. The primary aim of this study was to characterize the safety profile of erector spinae plane block catheters by determining the incidence of early complications. The secondary aim of this study was to characterize the incidence of late adverse events, as well as the erector spinae plane block catheter failure rate.
Kim, Hyunzu MD, PhD*; Han, Jeong Uk MD, PhD*; Lee, Woojoo PhD+; Jeon, Yoon Sang MD++; Jeong, Jimyeong MD*; Yang, Chunwoo MD*; Uhm, Jae Woung MD*; Kim, Youngjun MD*
doi : 10.1213/ANE.0000000000005654
Volume 133(5), November 2021, p 1303-1310
Relative to interscalene block, superior trunk block (STB) provides comparable analgesia and a reduced risk of hemidiaphragmatic paralysis. However, the incidence of hemidiaphragmatic paralysis remains high when a standard volume (15 mL) of local anesthetic is used. This study aimed to evaluate the effects of local anesthetic volume of STB on the incidence of phrenic nerve palsy, as well as its analgesic efficacy following arthroscopic shoulder surgery.
Ben Rehouma, Mouna MD*,+; Kfoury, Toni MD, PhD*,++; Hamdi, Leila PhD*; Bouchouareb, Meriem MS*; Soued, Mickael MD*,[S]; Benhamou, Dan MD*,++; Mazoit, Jean Xavier MD, PhD*
doi : 10.1213/ANE.0000000000005697
Volume 133(5), November 2021, p 1311-1320
Visceral and parietal peritoneum layers have different sensory innervations. Most visceral peritoneum sensory information is conveyed via the vagus nerve to the nucleus of the solitary tract (NTS). We already showed in animal models that intramuscular (i.m.) injection of local anesthetics decreases acute somatic and visceral pain and general inflammation induced by aseptic peritonitis. The goal of the study was to compare the effects of parietal block, i.m. bupivacaine, and vagotomy on spinal cord and NTS stimulation induced by a chemical peritonitis.
Tan, HuiLing MD*; Ding, ZhenDong MD+; Zhang, ChengLiang MD++; Yan, JianQin MD[S]; Yang, Yong MD[S]; Li, Ping MD, PhD||,[P]
doi : 10.1213/ANE.0000000000005737
Volume 133(5), November 2021, p 1321-1330
The maternal pain threshold gradually increases during pregnancy, especially in late pregnancy. A series of mechanisms underlying pregnancy-induced analgesia have been reported. However, these mechanisms are still not completely clear, and the underlying molecular mechanisms need further investigation. We examined the relationship between the antinociceptive effect and the expression level of programmed cell death ligand-1 (PD-L1) during pregnancy and further observed the changes in pain thresholds and expression levels of cytokines in late-pregnant mice before and after blockade of PD-L1 or programmed cell death-1 (PD-1).
Keegan, Mark T. MB, BCh, MRCPI, MSc, FCCM*,+; McLoughlin, Thomas M. Jr MD*,++; Patterson, Andrew J. MD, PhD*,[S]; Fiadjoe, John E. MD*,||; Pisacano, Margaret M. BSN, JD, CPHRM*,[P]; Warner, David O. MD*,+; Sun, Huaping PhD*; Harman, Ann E. PhD*
doi : 10.1213/ANE.0000000000005750
Volume 133(5), November 2021, p 1331-1341
In 2020, the coronavirus disease 2019 (COVID-19) pandemic interrupted the administration of the APPLIED Examination, the final part of the American Board of Anesthesiology (ABA) staged examination system for initial certification. In response, the ABA developed, piloted, and implemented an Internet-based "virtual" form of the examination to allow administration of both components of the APPLIED Exam (Standardized Oral Examination and Objective Structured Clinical Examination) when it was impractical and unsafe for candidates and examiners to travel and have in-person interactions. This article describes the development of the ABA virtual APPLIED Examination, including its rationale, examination format, technology infrastructure, candidate communication, and examiner training. Although the logistics are formidable, we report a methodology for successfully introducing a large-scale, high-stakes, 2-element, remote examination that replicates previously validated assessments.
Reves, J.G. MD
doi : 10.1213/ANE.0000000000005396
Volume 133(5), November 2021, p 1342-1347
Fifty years ago, on August 1, 1971, William A. Lell became the first cardiac anesthesia fellow at Harvard's Massachusetts General Hospital (MGH) Department of Anesthesiology, training with the world's first group of anesthesiologists whose clinical practice, teaching, and research efforts were exclusively devoted to cardiac anesthesia. Lell's early interest in cardiovascular medicine and how mentors, particularly at the MGH, influenced his early career development are recounted. The challenges a young pioneer faced in establishing and maintaining an academic cardiac anesthesia program during the initial and rapid growth of an exciting new subspecialty are described. Dr Lell's experience emphasizes the importance of seizing new opportunities and establishing meaningful working relationships with colleagues based on mutual trust as fundamental to successful career development and research in a new medical subspecialty.
Marhofer, Peter MD*; Halm, Jens MD+; Feigl, Georg C. MD++; Schepers, Tim MD+; Hollmann, Markus W. MD, PhD[S]
doi : 10.1213/ANE.0000000000005661
Volume 133(5), November 2021, p 1348-1352
Min, Kevin J. MD*; Rabinowitz, Anna L. MD*; Hess, Cary J. BS+
doi : 10.1213/ANE.0000000000005723
Volume 133(5), November 2021, p 1353-1357
Michael, Meghan M. MD*; Ambardekar, Aditee P. MD, MSEd*; Pukenas, Erin MD+; Karamchandani, Kunal MD, FCCP, FCCM*; Nguyen, Huong MD*; Potestio, Christopher P. MD+; Tubinis, Michelle D. MD++; Huang, Norman R. DO*; Riesenberg, Lee Ann PhD++
doi : 10.1213/ANE.0000000000005724
Volume 133(5), November 2021, p 1358-1363
Uwimana, Jean Claude MD
doi : 10.1213/ANE.0000000000005732
Volume 133(5), November 2021, p 1364
Morell, Robert C. MD
doi : 10.1213/ANE.0000000000005695
Volume 133(5), November 2021, p e55
Riley, Edward T. MD
doi : 10.1213/ANE.0000000000005717
Volume 133(5), November 2021, p e56-e57
Sharawi, Nadir MBBS, MSc, FRCA; Mhyre, Jill M. MD
doi : 10.1213/ANE.0000000000005718
Volume 133(5), November 2021, p e57-e59
Seiler, F. Arran MD; Arnolds, David E. MD, PhD
doi : 10.1213/ANE.0000000000005725
Volume 133(5), November 2021, p e59-e60
Bauer, Melissa E. DO; Rajasekhar, Anita MD; Leffert, Lisa MD
doi : 10.1213/ANE.0000000000005726
Volume 133(5), November 2021, p e60-e61
doi : 10.1213/ANE.0000000000005775
Volume 133(5), November 2021, p e62
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