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Local COVID-19 Epicenter in Detroit Metropolitan Area Causing Profound and Pervasive Reorganization of Clinical, Educational, Research, and Financial Programs of a Large Academic Gastroenterology Division with a GI Fellowship and Primary Medical School Affiliation
Mitchell S. Cappell
doi : 10.1007/s10620-021-07192-y
Digestive Diseases and Sciences volume 66, pages3635–3658 (2021)
To report revolutionary reorganization of academic gastroenterology division from COVID-19 pandemic surge at metropolitan Detroit epicenter from 0 infected patients on March 9, 2020, to?>?300 infected patients in hospital census in April 2020 and?>?200 infected patients in April 2021.
Paying Attention to Miss(ed) FITs
Pascale M. White & Steven H. Itzkowitz
doi : 10.1007/s10620-021-06871-0
Digestive Diseases and Sciences volume 66, pages3659–3660 (2021)
Back to the Source: Molecular Identification of Methanogenic Archaea as Markers of Colonic Methane Production
Zhe Lyu
doi : 10.1007/s10620-021-06839-0
Digestive Diseases and Sciences volume 66, pages3661–3664 (2021)
Probiotic-Derived Polyphosphate Prevents Pancreatitis
Kosuke Minaga, Tomohiro Watanabe & Masatoshi Kudo
doi : 10.1007/s10620-020-06809-y
Digestive Diseases and Sciences volume 66, pages3665–3667 (2021)
Special FX: Harnessing the Farnesoid-X-Receptor to Control Bile Acid Synthesis
Stefano Fiorucci, Eleonora Distrutti & Michele Biagioli
doi : 10.1007/s10620-021-06840-7
Digestive Diseases and Sciences volume 66, pages3668–3671 (2021)
More Than Just Heartburn: Does Famotidine Effectively Treat Patients with COVID-19?
Robert W. Malone MD, MS
doi : 10.1007/s10620-021-06875-w
Digestive Diseases and Sciences volume 66, pages3672–3673 (2021)
Why I Like Being in with the Inpatient Crowd: How I Took the Non-traditional Path of the GI Hospitalist
Michelle L. Hughes
doi : 10.1007/s10620-021-07242-5
Digestive Diseases and Sciences volume 66, pages3674–3675 (2021)
A Review of the Epidemiology, Pathophysiology, and Efficacy of Anti-diabetic Drugs Used in the Treatment of Nonalcoholic Fatty Liver Disease
Paul P. Manka, Eda Kaya, Ali Canbay & Wing-Kin Syn
doi : 10.1007/s10620-021-07206-9
Digestive Diseases and Sciences volume 66, pages3676–3688 (2021)
In recent years, epidemiological studies have consistently demonstrated that the coexistence of nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) is strongly associated with increased mortality and morbidity related to hepatic- and extrahepatic causes. Indeed, compared with the general population, patients with T2DM are more likely to be diagnosed with more severe forms of NAFLD (i.e., nonalcoholic steatohepatitis (NASH) with liver fibrosis). There is an ongoing debate whether NALFD is a consequence of diabetes or whether NAFLD is simply a component and manifestation of the metabolic syndrome, since liver fat (steatosis) and even more advanced stages of liver fibrosis can occur in the absence of diabetes. Nevertheless, insulin resistance is a key component of the mechanism of NAFLD development; furthermore, therapies that lower blood glucose concentrations also appear to be effective in the treatment of NAFLD. Here, we will discuss the pathophysiological and epidemiological associations between NAFLD and T2DM. We will also review currently available anti-diabetic agents with their regard to their efficacy of NAFLD/NASH treatment.
Association Between Obstructive Sleep Apnea and Barrett’s Esophagus: A Systematic Review and Meta-Analysis
Yousef Elfanagely, Amporn Atsawarungruangkit, James Scharfen, Laura Pavlech & Steven F. Moss
doi : 10.1007/s10620-020-06709-1
Digestive Diseases and Sciences volume 66, pages3689–3697 (2021)
Obstructive sleep apnea (OSA) has gastrointestinal implications as it is associated with gastroesophageal reflux disease. Less certain is an independent association between OSA and Barrett’s esophagus. We performed a systematic review and meta-analysis to evaluate the association between OSA and Barrett’s esophagus.
Anticoagulant Reversal in Gastrointestinal Bleeding: Review of Treatment Guidelines
Truman J. Milling, Majed A. Refaai & Neil Sengupta
doi : 10.1007/s10620-020-06728-y
Digestive Diseases and Sciences volume 66, pages3698–3714 (2021)
Patients receiving anticoagulant therapies, such as vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs), commonly experience gastrointestinal (GI) bleeding as a complication and may require anticoagulant reversal prior to endoscopic treatment. Anticoagulant reversal agents include prothrombin complex concentrates (PCCs; including 3 or 4 coagulation factors), plasma, vitamin K, and target-specific DOAC reversal agents (e.g., idarucizumab and andexanet alfa).
Chronic Viral Hepatitis Is Associated with Colorectal Neoplasia: A Systematic Review and Meta-Analysis
Seung Wook Hong, Won-Mook Choi, Ha Won Hwang, Dae Sung Kim, Jiyoung Yoon, Jin Wook Lee, Ju Hyun Shim, Dong-Hoon Yang, Seung-Jae Myung, Suk-Kyun Yang & Jeong-Sik Byeon
doi : 10.1007/s10620-020-06745-x
Digestive Diseases and Sciences volume 66, pages3715–3724 (2021)
Chronic viral hepatitis is associated with a wide range of extrahepatic diseases; however, evidence on a link between chronic viral hepatitis and colorectal neoplasia is still lacking.
Annoyed with Haemorrhoids? Risks of the Emborrhoid Technique
Chiara Eberspacher, Fabrizio Ficuccilli, Laura Tessieri, Vito D’Andrea, Augusto Lauro, Lisa Fralleone & Domenico Mascagni
doi : 10.1007/s10620-021-07208-7
Digestive Diseases and Sciences volume 66, pages3725–3729 (2021)
Haemorrhoids, a common ailment afflicting mostly Western patients, can produce bothersome symptoms, in particular pain, pruritus, and bleeding. There is a wide choice of surgical treatment options available for haemorrhoids in patients that cannot be treated with medical therapy, such as those that are prolapsed. Many patients refuse surgery due to the fear of potential complications; to overcome this obstacle, novel alternative techniques have been developed in recent years that are focussed on ligation or occlusion of haemorrhoidal arterial blood flow. We describe a patient who developed recto-sigmoidal ischaemia after embolization of the haemorrhoidal arteries, known as the “emborrhoid” technique, with persistence of rectal bleeding and progressive rectal stenosis.
Author Spotlight: Lisa Fralleone
Lisa Fralleone
doi : 10.1007/s10620-021-07209-6
Digestive Diseases and Sciences volume 66, page3730 (2021)
Cec and You Shall Find: Cecal Perforation in a Patient with COVID-19
Ioana Baiu, Erna Forgó, Cindy Kin & Thomas G. Weiser
doi : 10.1007/s10620-020-06810-5
Digestive Diseases and Sciences volume 66, pages3731–3734 (2021)
Author Spotlight: Ioana Baiu
Ioana Baiu
doi : 10.1007/s10620-020-06811-4
Digestive Diseases and Sciences volume 66, page3735 (2021)
Personalized Best: Toward Improving Care in Ulcerative Colitis
Nannaya Jampala, Animesh Jain, Hans H. Herfarth, Millie D. Long, Kimberly N. Weaver & Edward L. Barnes
doi : 10.1007/s10620-021-07221-w
Digestive Diseases and Sciences volume 66, pages3736–3739 (2021)
A Microsimulation Model to Project the 5-Year Impact of Using Hyperbaric Oxygen Therapy for Ulcerative Colitis Patients Hospitalized for Acute Flares
Parambir S. Dulai & Vipul Jairath
doi : 10.1007/s10620-020-06707-3
Digestive Diseases and Sciences volume 66, pages3740–3752 (2021)
Hyperbaric oxygen therapy (HBOT) improves short-term outcomes for ulcerative colitis (UC) patients hospitalized for acute flares. Longer-term impacts and cost-effectiveness are unknown.
Implementation of an Inpatient IBD Service Is Associated with Improvement in Quality of Care and Long-Term Outcomes
Simon J. Hong, Janice Jang, Dana Berg, Tarik Kirat, Feza Remzi, Shannon Chang, Lisa B. Malter, Jordan E. Axelrad & David P. Hudesman
doi : 10.1007/s10620-020-06749-7
Digestive Diseases and Sciences volume 66, pages3753–3759 (2021)
There is wide variation in the quality of care of hospitalized patients with inflammatory bowel disease (IBD). Prior studies have demonstrated that a specialized inpatient IBD service improves short-term outcomes. In this study, we assessed the impact of a dedicated IBD service on the quality of care and long-term outcomes.
Patient Navigation After Positive Fecal Immunochemical Test Results Increases Diagnostic Colonoscopy and Highlights Multilevel Barriers to Follow-Up
Vivy T. Cusumano, Anthony Myint, Edgar Corona, Liu Yang, Jennifer Bocek, Antonio G. Lopez, Marcela Zhou Huang, Naveen Raja, Anna Dermenchyan, Lily Roh, Maria Han, Daniel Croymans & Folasade P. May
doi : 10.1007/s10620-021-06866-x
Digestive Diseases and Sciences volume 66, pages3760–3768 (2021)
The fecal immunochemical test (FIT) is a common colorectal cancer screening modality in the USA but often is not followed by diagnostic colonoscopy.
Differential Cytokine Expression in the Duodenum and Rectum of Children with Non-Immunoglobulin E-Mediated Cow’s Milk Protein Allergy
Erick M. Toro-Monjaraz, Gabriela Fonseca-Camarillo, Flora Zárate-Mondragón, Ericka Montijo-Barrios, José Cadena-León, David Avelar-Rodríguez, Jaime Ramírez-Mayans, Roberto Cervantes-Bustamante & Jesús K. Yamamoto-Furusho
doi : 10.1007/s10620-020-06743-z
Digestive Diseases and Sciences volume 66, pages3769–3775 (2021)
Cow’s milk protein allergy (CMPA) is the most prevalent food allergy in children, and its pathogenesis remains poorly understood. It has been shown that the combination of genetic predisposition, perinatal factors, and intestinal imbalance of the immune response mediated by cytokines may play an essential role in CMPA pathogenesis.
Vancomycin-Induced Changes in Host Immunity and Behavior: Comparative Genomic and Metagenomic Analysis in C57BL/6 and BALB/c Mice
Pratikshya Ray, Uday Pandey, Debasmita Das & Palok Aich
doi : 10.1007/s10620-020-06729-x
Digestive Diseases and Sciences volume 66, pages3776–3791 (2021)
The consequence of treatment with antibiotics on the gut microbiota can be destructive. The antibiotics, however, can be utilized to understand the role of gut microbiota on the host physiology.
Sertraline and Citalopram Actions on Gut Barrier Function
Johana Eyzaguirre-Velásquez, María Paz González-Toro, Camila González-Arancibia, Jorge Escobar-Luna, Caroll J. Beltrán, Javier A. Bravo & Marcela Julio-Pieper
doi : 10.1007/s10620-020-06702-8
Digestive Diseases and Sciences volume 66, pages3792–3802 (2021)
Disruption of intestinal barrier is a key component to various diseases. Whether barrier dysfunction is the cause or effect in these situations is still unknown, although it is believed that translocation of luminal content may initiate gastrointestinal or systemic inflammatory disorders. Since trauma- or infection-driven epithelial permeability depends on Toll-like receptor (TLR) activity, inhibition of TLR signaling has been proposed as a strategy to protect intestinal barrier integrity after infection or other pathological conditions. Recently, selective serotonin recapture inhibitors including sertraline and citalopram were shown to inhibit TLR-3 activity, but the direct effects of these antidepressant drugs on the gut mucosa barrier remain largely unexplored.
Thalidomide Attenuates Colitis and Is Associated with the Suppression of M1 Macrophage Polarization by Targeting the Transcription Factor IRF5
Jiaxi Lu, Deliang Liu, Yuyong Tan, Rong Li, Xuehong Wang & Feihong Deng
doi : 10.1007/s10620-021-07067-2
Digestive Diseases and Sciences volume 66, pages3803–3812 (2021)
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The TNF-? inhibitor thalidomide is reported to be effective for inducing remission in pediatric Crohn’s disease (CD) and adults with refractory CD. The mechanisms underlying the immunomodulatory and anti-inflammatory properties of thalidomide are unclear.
Vitamin D Deficiency Exacerbates Colonic Inflammation Due to Activation of the Local Renin–Angiotensin System in the Colon
Xinzhi Wei, Xue Li, Jie Du, Xin Ge, Yue Sun, Xin Li, Zhe Xun, Weicheng Liu, Zhan-You Wang & Yan Chun Li
doi : 10.1007/s10620-020-06713-5
Digestive Diseases and Sciences volume 66, pages3813–3821 (2021)
The renin–angiotensin system (RAS) is activated in inflammatory bowel disease (IBD), and vitamin D deficiency aggravates the development of colitis, but the relationship between the local colonic RAS and vitamin D is unclear with regard to the pathogenesis of IBD.
Methanogen Abundance Thresholds Capable of Differentiating In Vitro Methane Production in Human Stool Samples
Levi Teigen, Prince P. Mathai, Michael Matson, Sharon Lopez, Daria Kozysa, Amanda J. Kabage, Matthew J. Hamilton, Byron P. Vaughn, Michael J. Sadowsky & Alexander Khoruts
doi : 10.1007/s10620-020-06721-5
Digestive Diseases and Sciences volume 66, pages3822–3830 (2021)
Intestinal methane (CH4) gas production has been associated with a number of clinical conditions and may have important metabolic and physiological effects.
Circulating MicroRNAs in Relation to Esophageal Adenocarcinoma Diagnosis and Survival
Jessica L. Petrick, Ruth M. Pfeiffer, Linda M. Liao, Christian C. Abnet, Xiaolin Wu, Marilie D. Gammon, Thomas L. Vaughan & Michael B. Cook
doi : 10.1007/s10620-020-06740-2
Digestive Diseases and Sciences volume 66, pages3831–3841 (2021)
Tissue miRNA can discriminate between esophageal adenocarcinoma (EA) and normal epithelium. However, no studies have examined a comprehensive panel of circulating miRNAs in relation to EA diagnosis and survival.
Circular RNA Paired-Related Homeobox 1 Promotes Gastric Carcinoma Cell Progression via Regulating MicroRNA-665/YWHAZ Axis
Wei Liu, Weigao Hu, Kezhu Hou & Song Zhu
doi : 10.1007/s10620-020-06705-5
Digestive Diseases and Sciences volume 66, pages3842–3853 (2021)
Gastric carcinoma (GC) is a ubiquitous malignant tumor worldwide. Circular RNA paired-related homeobox 1 (circ-PRRX1), one kind of non-coding RNAs, has been reported to act as a promoter in tumor growth. This study aims to explore the effects of circ-PRRX1 on proliferation, apoptosis, and metastasis in GC and the underlying regulatory mechanisms.
Value of Plasma Methylated SFRP2 in Prognosis of Gastric Cancer
Haijiao Yan, Wenyu Chen, Kele Ge, Xizheng Mao, Xiaodong Li, Wensong Liu & Jun Wu
doi : 10.1007/s10620-020-06710-8
Digestive Diseases and Sciences volume 66, pages3854–3861 (2021)
Secreted frizzled-related protein 2 (SFRP2) in circulating tumor DNA (ctDNA) is related to gastric cancer (GC) proliferation. However, whether methylated SFRP2 in ctDNA serves as the biomarker in GC patients remains unknown.
Circ-LDLRAD3 Enhances Cell Growth, Migration, and Invasion and Inhibits Apoptosis by Regulating MiR-224-5p/NRP2 Axis in Gastric Cancer
Yan Wang, Hailin Yin & Xin Chen
doi : 10.1007/s10620-020-06733-1
Digestive Diseases and Sciences volume 66, pages3862–3871 (2021)
Emerging as a newly discovered type of noncoding RNAs, circular RNAs have been manifested as a crucial regulator in tumorigenesis of human malignancies, including gastric cancer (GC). Although circ-LDLRAD3 has been revealed as an oncogene in pancreatic cancer, the underlying role of circ-LDLRAD3 in GC remains poorly understood.
Polyphosphate, Derived from Lactobacillus brevis, Modulates the Intestinal Microbiome and Attenuates Acute Pancreatitis
Shuhei Takauji, Hiroaki Konishi, Mikihiro Fujiya, Nobuhiro Ueno, Hiroki Tanaka, Hiroki Sato, Shotaro Isozaki, Shin Kashima, Kentaro Moriichi, Yusuke Mizukami & Toshikatsu Okumura
doi : 10.1007/s10620-020-06747-9
Digestive Diseases and Sciences volume 66, pages3872–3884 (2021)
We previously showed that Lactobacillus brevis-derived polyphosphate (poly P) exerts a curative effect on intestinal inflammation. However, whether or not poly P improves the inflammation and injury of distant organs remains unclear.
Bile Acid Synthesis Disorders in Japan: Long-Term Outcome and Chenodeoxycholic Acid Treatment
Akihiko Kimura, Tatsuki Mizuochi, Hajime Takei, Akira Ohtake, Jun Mori, Kunihiro Shinoda, Takuji Hashimoto, Mureo Kasahara, Takao Togawa, Tsuyoshi Murai, Takashi Iida & Hiroshi Nittono
doi : 10.1007/s10620-020-06722-4
Digestive Diseases and Sciences volume 66, pages3885–3892 (2021)
We encountered 7 Japanese patients with bile acid synthesis disorders (BASD) including 3?-hydroxy-?5-C27-steroid dehydrogenase/isomerase (3?-HSD) deficiency (n?=?3), ?4-3-oxosteroid 5?-reductase (5?-reductase) deficiency (n?=?3), and oxysterol 7?-hydroxylase deficiency (n?=?1) over 21 years between 1996 and 2017.
DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1
Ying Zheng, Bing Xu, Yitong Zhao, Suzhen Yang, Shuhui Wang, Lin Ma & Lei Dong
doi : 10.1007/s10620-020-06735-z
Digestive Diseases and Sciences volume 66, pages3893–3902 (2021)
DEAD-Box Helicase 3 X-Linked (DDX3X) is a member of the DEAD-box helicases that play a crucial role in RNA metabolism. Although DDX3X has been shown to contribute to tumorigenesis, the detailed mechanisms by which DDX3X functions in pancreatic ductal adenocarcinoma (PDAC) biogenesis remain poorly understood.
Pseudogene Annexin A2 Pseudogene 1 Contributes to Hepatocellular Carcinoma Progression by Modulating Its Parental Gene ANXA2 via miRNA-376a-3p
Huohui Ou, Qingbo Liu, Jie Lin, Wei He, Weijie Zhang, Jing Ma & Weidong Wang
doi : 10.1007/s10620-020-06734-0
Digestive Diseases and Sciences volume 66, pages3903–3915 (2021)
Pseudogenes are defined as key regulators in cancer initiation and progression. But their biological function and clinical significance in hepatocellular carcinoma (HCC) remain to be elucidated. In the current study, we identified a novel pseudogene, Annexin A2 pseudogene 1 (ANXA2P1), in HCC and explored its underlining molecular mechanism.
Silencing of Long Non-coding RNA TTN-AS1 Inhibits Hepatocellular Carcinoma Progression by the MicroRNA-134/ITGB1 Axis
Yong Huang, Peng Chu & Guangjian Bao
doi : 10.1007/s10620-020-06737-x
Digestive Diseases and Sciences volume 66, pages3916–3928 (2021)
Hepatocellular carcinoma (HCC) causes considerable mortality worldwide. Long non-coding RNA (lncRNA) TTN-AS1 has been recently identified as an oncogene in several cancers, but its role in HCC and the molecules remain largely unknown.
Does Famotidine Reduce the Risk of Progression to Severe Disease, Death, and Intubation for COVID-19 Patients? A Systemic Review and Meta-Analysis
Chenyu Sun, Yue Chen, Lei Hu, Yile Wu, Mingming Liang, Mubashir Ayaz Ahmed, Chandur Bhan, Zhichun Guo, Hongru Yang, Yijing Zuo, Yue Yan & Qin Zhou
doi : 10.1007/s10620-021-06872-z
Digestive Diseases and Sciences volume 66, pages3929–3937 (2021)
Famotidine was reported to potentially provide benefits to Coronavirus Disease 2019 (COVID-19) patients. However, it remains controversial whether it is effective in treating COVID-19.
High-Dose Opioid Use Among Veterans with Unexplained Gastrointestinal Symptoms Versus Structural Gastrointestinal Diagnoses
Salva N. Balbale, Lishan Cao, Itishree Trivedi, Jonah J. Stulberg, Katie J. Suda, Walid F. Gellad, Charlesnika T. Evans, Bruce L. Lambert, Neil Jordan & Laurie A. Keefer
doi : 10.1007/s10620-020-06742-0
Digestive Diseases and Sciences volume 66, pages3938–3950 (2021)
In a cohort of Veterans dually enrolled in the Department of Veterans Affairs (VA) and Medicare Part D, we sought to describe high-dose daily opioid use among Veterans with unexplained gastrointestinal (GI) symptoms and structural GI diagnoses and examine factors associated with high-dose use.
Food Residue During Esophagogastroduodenoscopy Is Commonly Encountered and Is Not Pathognomonic of Delayed Gastric Emptying
Danse Bi, Chansong Choi, John League, Michael Camilleri & David O. Prichard
doi : 10.1007/s10620-020-06718-0
Digestive Diseases and Sciences volume 66, pages3951–3959 (2021)
Retained gastric food (RGF) identified during esophagogastroduodenoscopy (EGD) is often attributed to gastroparesis. This retrospective study evaluated the prevalence of RGF, risk factors for RGF, and the association between RGF and delayed gastric emptying (GE).
Esophageal High-Resolution Manometry for Diagnosing the Severity of the Chronic Intestinal Pseudo-Obstruction: A Case Series
Hiroki Sato, Kenya Kamimura, Hideaki Matsui, Takashi Owaki, Shinichi Morita, Yuto Tanaka, Natsuki Ishikawa, Yoshifumi Shimada, Junji Yokoyama, Toshifumi Wakai & Shuji Terai
doi : 10.1007/s10620-020-06701-9
Digestive Diseases and Sciences volume 66, pages3960–3967 (2021)
Chronic intestinal pseudo-obstruction (CIPO) is a severe and refractory intestinal motility disorder. However, due to its rarity and difficult histological investigation, its pathophysiology has not been characterized.
Predictors of Abnormal Functional Luminal Impedance Planimetry Findings in Non-mechanical Esophagogastric Junction Outflow Obstruction
Alexander T. Reddy, Rahul A. Shimpi, Alice Parish, Donna Niedzwiecki & David A. Leiman
doi : 10.1007/s10620-020-06726-0
Digestive Diseases and Sciences volume 66, pages3968–3975 (2021)
Esophagogastric junction outflow obstruction (EGJOO) is a common but nonspecific motility pattern identified by esophageal high-resolution manometry (HRM). Functional luminal impedance planimetry (FLIP) provides information regarding lower esophageal sphincter (LES) mechanics, which can identify achalasia spectrum disorders and is useful in evaluating EGJOO. However, the relationship between HRM and FLIP parameters in EGJOO is not clearly defined.
Lymphocytic Esophagitis: Assessing Risk Factors and Clinical Outcomes
Himesh B. Zaver, Hassan Ghoz, Balkishan J. Malviya, Bhaumik Brahmbhatt, William C. Palmer, Brian E. Lacy, Kenneth R. DeVault, Murli Krishna & Yan Bi
doi : 10.1007/s10620-020-06706-4
Digestive Diseases and Sciences volume 66, pages3976–3984 (2021)
Lymphocytic esophagitis is a rare esophageal condition. Our knowledge of potential risk factors and treatment outcomes of lymphocytic esophagitis is limited.
Concomitant 5-Aminosalicylate Therapy in Moderate-to-Severe Ulcerative Colitis Patients Escalated to Infliximab Is Not Beneficial
Bhairavi Balram, Harshad Joshi, Karen Wong, Karen I. Kroeker, Levinus A. Dieleman, Brendan P. Halloran, Daniel C. Baumgart & Farhad Peerani
doi : 10.1007/s10620-020-06704-6
Digestive Diseases and Sciences volume 66, pages3985–3992 (2021)
While there is recent literature to support the discontinuation of 5-aminosalicylate (5-ASA) upon the initiation of biologics, continuing 5-ASA after treatment failure is relatively common. We aimed to assess the impact of concomitant 5-ASA therapy on clinical outcomes in ulcerative colitis (UC) patients escalated to infliximab.
Development and Validation of a Risk Scoring Model for Early Prediction of Severe Colon Ischemia
Min Young Shin, Hee Seok Moon, In Sun Kwon, Jae Ho Park, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee & Hyun Yong Jeong
doi : 10.1007/s10620-020-06717-1
Digestive Diseases and Sciences volume 66, pages3993–4000 (2021)
Colon ischemia (CI) is injury to the intestines secondary to insufficient blood flow. Its clinical severity can range from mild to life-threatening.
History of Cholecystectomy and Risk of Clostridium Difficile Infection
Anqi Jin, Tony Chien, Qiwen Huang, Pragati Kenkare, Mai Vu, Sandra Wilson & Edward S. Huang
doi : 10.1007/s10620-020-06714-4
Digestive Diseases and Sciences volume 66, pages4001–4007 (2021)
Cholecystectomy affects bile acid physiology. There is growing evidence that both primary and secondary bile acids play a role in the pathogenesis of Clostridium difficile infections (CDIs).
Prevalence and Risk Factors for Osteopathy in Chronic Pancreatitis
Xin-Ying Tang, Nan Ru, Qing Li, Yang-Yang Qian, Hui Sun, Jia-Hui Zhu, Lin He, Yuan-Chen Wang, Liang-Hao Hu, Zhao-Shen Li, Wen-Bin Zou & Zhuan Liao
doi : 10.1007/s10620-020-06732-2
Digestive Diseases and Sciences volume 66, pages4008–4016 (2021)
The high incidence of osteopathy among patients with chronic pancreatitis (CP) has garnered increased attention over recent years. The aims of this study were to assess the prevalence and risk factors for osteopathy in Chinese patients with CP.
Efficacy of Pregabalin and Antioxidants Combination in Reducing Pain in Chronic Pancreatitis: A Double Blind Randomized Trial
Sathasivam Sureshkumar, Agrawal Omang, Amaranathan Anandhi, B. S. Rajesh, K. M. Abdulbasith, Chellappa Vijayakumar, Chinnakali Palanivel, Mohan Pazhanivel & Vikram Kate
doi : 10.1007/s10620-020-06711-7
Digestive Diseases and Sciences volume 66, pages4017–4025 (2021)
In patients with chronic pancreatitis (CP), pain relief is a dilemma. Antioxidants with pregabalin therapy have been reported to be useful. Hence, this study was carried out to determine the efficacy of the combination of antioxidant and pregabalin therapy in reducing pain in patients with CP.
Risk of Hepatitis B Virus Reactivation in Rheumatoid Arthritis Patients Undergoing Tocilizumab-Containing Treatment
Meng Hsuan Kuo, Chih-Wei Tseng, Ming-Chi Lu, Chien-Hsueh Tung, Kuo-Chih Tseng, Kuang-Yung Huang, Chi-Hui Lee & Ning-Sheng Lai
doi : 10.1007/s10620-020-06725-1
Digestive Diseases and Sciences volume 66, pages4026–4034 (2021)
To investigate the risk of hepatitis B virus reactivation in patients undergoing long-term tocilizumab therapy for rheumatoid arthritis.
Factors Associated with Delayed Paracentesis in Patients with Spontaneous Bacterial Peritonitis
Backer Abdu, Shalaka Akolkar, Christopher Picking, Judith Boura & Marc Piper
doi : 10.1007/s10620-020-06750-0
Digestive Diseases and Sciences volume 66, pages4035–4045 (2021)
In patients with spontaneous bacterial peritonitis (SBP), studies show that delayed paracentesis (DP) is associated with worse outcomes and mortality. We aimed to assess the rate of DP in the community setting and associated factors with early versus delayed paracentesis.
A Stepwise Algorithmic Approach and External Validation Study for Noninvasive Prediction of Advanced Fibrosis in Nonalcoholic Fatty Liver Disease
Heather Mary-Kathleen Kosick, Aline Keyrouz, Oyedele Adeyi, Giada Sebastiani & Keyur Patel
doi : 10.1007/s10620-020-06748-8
Digestive Diseases and Sciences volume 66, pages4046–4057 (2021)
Advanced F3–4 fibrosis predicts liver-related mortality in nonalcoholic fatty liver disease (NAFLD). Noninvasive tests, designed to rule in/out advanced fibrosis, are limited by indeterminates, necessitating biopsy. We aimed to determine whether stepwise combinations of noninvasive serum-based tests and elastography (VCTE) could predict F3–4, reduce indeterminates, and decrease liver biopsies.
High Incidence of Hepatic Encephalopathy After Viatorr Controlled Expansion Transjugular Intrahepatic Portosystemic Shunt Creation
Marie-Louise Kloster, Albert Ren, Ketan Y. Shah, Murad M. Alqadi, James T. Bui, Andrew J. Lipnik, Matthew M. Niemeyer, Charles E. Ray & Ron C. Gaba
doi : 10.1007/s10620-020-06716-2
Digestive Diseases and Sciences volume 66, pages4058–4062 (2021)
The Viatorr Controlled Expansion (VCX) stent-graft was designed to mitigate hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS) creation.
A Case of Benign Hepatic Cyst with Supra-elevated Cyst Fluid Tumor Markers
Alexander Tonthat, Danvi Bui, Miriam Romero, Emily Lo, Gary Kanel & Takeshi Saito
doi : 10.1007/s10620-020-06727-z
Digestive Diseases and Sciences volume 66, pages4063–4067 (2021)
