دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Associate Editorial Board
doi : 10.1016/S0007-0912(21)00527-4
Volume 127, Issue 4, October 2021, Page ii
Intravenous lidocaine, regional blockade, or both: considerations for multiple interventions involving local anaesthetics
HarshaShanthanna1GuyWeinberg2
doi : 10.1016/j.bja.2021.04.024
Volume 127, Issue 4, October 2021, Pages 497-501
Evidence-based guidance for use of intrathecal morphine as an alternative to diamorphine for Caesarean delivery analgesia
PervezSultanBrendanCarvalho
doi : 10.1016/j.bja.2021.06.023
Volume 127, Issue 4, October 2021, Pages 501-505
What we do, what we call ourselves, and how we spell it
J. RobertSneyd
doi : 10.1016/j.bja.2021.04.025
Volume 127, Issue 4, October 2021, Pages 505-508
Lifting the lid on perioperative goal-directed therapy
Daniel S.Martin
doi : 10.1016/j.bja.2021.07.009
Volume 127, Issue 4, October 2021, Pages 508-510
Proteomic signatures for perioperative oxygen delivery in skin after major elective surgery: mechanistic sub-study of a randomised controlled trial
Wendy E.Heywood1EmilyBliss1FatimaBahelil2TrindaCyrus2MarilenaCrescente3TimothyJones2SadafIqbal4Laura G.Paredes4Andrew J.Toner5Ana G.del Arroyo2Edel A.O'Toole6KevinMills1Gareth L.Ackland2
doi : 10.1016/j.bja.2021.06.003
Volume 127, Issue 4, October 2021, Pages 511-520
Maintaining adequate oxygen delivery (DO2) after major surgery is associated with minimising organ dysfunction. Skin is particularly vulnerable to reduced DO2. We tested the hypothesis that reduced perioperative DO2 fuels inflammation in metabolically compromised skin after major surgery.
Goal-directed fluid therapy in emergency abdominal surgery: a randomised multicentre trial
Anne A.Aaen1Anders W.Voldby2NicolasStorm3JeppeKildsig3Egon G.Hansen4ErikZimmermann-Nielsen5Kenneth M.Jensen6PernilleTibæk7AnetteMortensen8Ann M.Møller4BirgitteBrandstrup2
doi : 10.1016/j.bja.2021.06.031
Volume 127, Issue 4, October 2021, Pages 521-531
More than 50% of patients have a major complication after emergency gastrointestinal surgery. Intravenous (i.v.) fluid therapy is a life-saving part of treatment, but evidence to guide what i.v. fluid strategy results in the best outcome is lacking. We hypothesised that goal-directed fluid therapy during surgery (GDT group) reduces the risk of major complications or death in patients undergoing major emergency gastrointestinal surgery compared with standard i.v. fluid therapy (STD group).
Changes in pulse pressure variation to assess preload responsiveness in mechanically ventilated patients with spontaneous breathing activity: an observational study
OlfaHamzaoui1RuiShi23SimoneCarelli2BenjaminSztrymf13DominiquePrat1FredericJacobs1XavierMonnet23CorentinGouëzel1Jean-LouisTeboul23
doi : 10.1016/j.bja.2021.05.034
Volume 127, Issue 4, October 2021, Pages 532-538
Pulse pressure variation (PPV) is not reliable in predicting preload responsiveness in patients receiving mechanical with spontaneous breathing (SB) activity. We hypothesised that an increase in PPV after a tidal volume (VT) challenge (TVC) or a decrease in PPV during passive leg raising (PLR) can predict preload responsiveness in such cases.
Standardized Assessment of Global activities in the Elderly scale in adult cardiac surgery patients
JessicaSpence123JackieBosch34EdwardChongsi3Shun FuLee3LehanaThabane23PabloMendoza23EmilieBelley-Côté235RichardWhitlock236KateBrady3William F.McIntyre235AndreLamy236P.J.Devereaux235
doi : 10.1016/j.bja.2021.05.037
Volume 127, Issue 4, October 2021, Pages 539-546
Different instruments have been used to assess ability to perform everyday functional activities, such as activities of daily living (ADL) and instrumental activities of daily living (IADL). No measures of functional activity have been validated in cardiac surgery. We assessed the reliability and validity of the Standardized Assessment of Global activities in the Elderly (SAGE) scale.
Effects of inorganic nitrate on ischaemia-reperfusion injury after coronary artery bypass surgery: a randomised controlled trial
Karin E.Eriksson12†FredrikEidhagen13†JanLiska45AndersFranco-Cereceda45Jon O.Lundberg1EddieWeitzberg12
doi : 10.1016/j.bja.2021.06.046
Volume 127, Issue 4, October 2021, Pages 547-555
Nitric oxide (NO) is an important signalling molecule in the cardiovascular system with protective properties in ischaemia–reperfusion injury. Inorganic nitrate, an oxidation product of endogenous NO production and a constituent in our diet, can be recycled back to bioactive NO. We investigated if preoperative administration of inorganic nitrate could reduce troponin T release and other plasma markers of injury to the heart, liver, kidney, and brain in patients undergoing cardiac surgery.
Safety and efficacy of tetrastarches in surgery and trauma: a systematic review and meta-analysis of randomised controlled trials
DanielChappell1Philippevan der Linden2JavierRipollés-Melchor34Michael F.M.James5
doi : 10.1016/j.bja.2021.06.040
Volume 127, Issue 4, October 2021, Pages 556-568
Hydroxyethyl starch (HES) 130 is a frequently used fluid to replace intravascular losses during surgery or trauma. In the past years, several trials performed in critically ill patients have raised questions regarding the safety of this product. Our aim in this meta-analysis was to evaluate the safety and efficacy of 6% HES during surgery and in trauma.
Delaying initiation of diuretics in critically ill patients with recent vasopressor use and high positive fluid balance?
ZacharyShahn12Li-Wei H.Lehman13Roger G.Mark3DanielTalmor45SomnathBose45
doi : 10.1016/j.bja.2021.04.035
Volume 127, Issue 4, October 2021, Pages 569-576
Fluid overload is associated with poor outcomes. Clinicians might be reluctant to initiate diuretic therapy for patients with recent vasopressor use. We estimated the effect on 30-day mortality of withholding or delaying diuretics after vasopressor use in patients with probable fluid overload.
Selective mitochondrial antioxidant MitoTEMPO reduces renal dysfunction and systemic inflammation in experimental sepsis in rats
NishkanthaArulkumaran1Sean J.Pollen1RobertTidswell1CharlotteGaupp1Vera B.M.Peters1GiacomoStanzani1Timothy A.C.Snow1Michael R.Duchen2MervynSinger1
doi : 10.1016/j.bja.2021.05.036
Volume 127, Issue 4, October 2021, Pages 577-586
Excess mitochondrial reactive oxygen species (mROS) in sepsis is associated with organ failure, in part by generating inflammation through the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome. We determined the impact of a mitochondrial-targeted antioxidant (MitoTEMPO) on mitochondrial dysfunction in renal proximal tubular epithelial cells, peritoneal immune cell function ex vivo, and organ dysfunction in a rat model of sepsis.
Selective inhibition of gamma aminobutyric acid release from mouse hippocampal interneurone subtypes by the volatile anaesthetic isoflurane
Iris A.Speigel1Hugh C.HemmingsJr.12
doi : 10.1016/j.bja.2021.06.042
Volume 127, Issue 4, October 2021, Pages 587-599
The cellular and molecular mechanisms by which general anaesthesia occurs is poorly understood. Hippocampal interneurone subpopulations, which are critical regulators of cognitive function, have diverse neurophysiological and synaptic properties, but their responses to anaesthetics are unclear.
Chronic disabling postpartum headache after unintentional dural puncture during epidural anaesthesia: a prospective cohort study
Jessica R.Ansari1MeredithBarad2StevenShafer1PamelaFlood1
doi : 10.1016/j.bja.2021.05.020
Volume 127, Issue 4, October 2021, Pages 600-607
Unintentional dural puncture with an epidural needle complicates approximately 1% of epidural anaesthetics and causes an acute headache in 60–80% of these patients. Several retrospective studies suggest an increased risk of chronic headache. We assessed the relationship between unintentional dural puncture and chronic disabling headache, defined as one or more functionally limiting headaches within a 2-week interval ending 2, 6, and 12 months postpartum.
Interactive video games to reduce paediatric procedural pain and anxiety: a systematic review and meta-analysis
Mona F.Sajeev12LaurenKelada12A'tikah BinteYahya Nur12Claire E.Wakefield12Michael A.Wewege34JonathanKarpelowsky567BenedictAkimana8Anne-SophieDarlington9ChristinaSignorelli12
doi : 10.1016/j.bja.2021.06.039
Volume 127, Issue 4, October 2021, Pages 608-619
Procedural pain and anxiety in children can be poorly controlled, leading to significant short- and long-term sequelae, such as longer procedure times or future healthcare avoidance. Caregiver anxiety can exacerbate these effects. We aimed to evaluate the effect of interactive video game interventions on children's procedural pain and anxiety, including the effect of different types of video games on those outcomes.
Renal tissue desaturation and acute kidney injury in infant cardiac surgery: a prospective propensity score-matched cohort study
DongniZhang1†ChuanOuyang1†XuZhao2BoqunCui1FengDai3LingzhongMeng4JunMa1
doi : 10.1016/j.bja.2021.06.045
Volume 127, Issue 4, October 2021, Pages 620-628
Previous studies on the association between renal tissue desaturation and acute kidney injury (AKI) in infant cardiac surgery are limited by small sample sizes and inconsistent results. This prospective study aimed to determine the association between renal desaturation and AKI in infants undergoing surgical repair of an isolated ventricular septal defect (VSD).
Effect of erector spinae plane block on the postoperative quality of recovery after laparoscopic cholecystectomy: a prospective double-blind study
AhmetCan?tez4BetulKozanhan1NergisAksoy2MuniseYildiz1Mahmut S.Tutar3
doi : 10.1016/j.bja.2021.06.030
Volume 127, Issue 4, October 2021, Pages 629-635
Laparoscopic cholecystectomy is a common surgical procedure that frequently results in substantial postoperative pain. Erector spinae plane block (ESPB) has been shown to have beneficial postoperative analgesic effects when used as a part of multimodal analgesia. The aim of this study was to determine whether ESPB improves postoperative recovery quality in patients undergoing laparoscopic cholecystectomy. Evaluation of the effects of ESPB on postoperative pain, opioid consumption, and nausea and vomiting was the secondary objective.
Airway devices for awake tracheal intubation in adults: a systematic review and network meta-analysis
NeelDesai12GamunuRatnayake1Desire N.Onwochei12KariemEl-Boghdadly12ImranAhmad12
doi : 10.1016/j.bja.2021.05.025
Volume 127, Issue 4, October 2021, Pages 636-647
Awake tracheal intubation is commonly performed with flexible bronchoscopes, but the emerging role of alternative airway devices, such as videolaryngoscopes, direct laryngoscopes, and optical stylets, has been recognised.
The central nervous system during lung injury and mechanical ventilation: a narrative review
Guillermo M.Albaiceta1234LaurentBrochard56Claudia C.Dos Santos56RafaelFernández47DimitrisGeorgopoulos8TimothyGirard9AmalJubran1011JosefinaLópez-Aguilar412JordiMancebo13PaoloPelosi1415YoannaSkrobik16Arnaud W.Thille1718Mary E.Wilcox619LluisBlanch412
doi : 10.1016/j.bja.2021.05.038
Volume 127, Issue 4, October 2021, Pages 648-659
Mechanical ventilation induces a number of systemic responses for which the brain plays an essential role. During the last decade, substantial evidence has emerged showing that the brain modifies pulmonary responses to physical and biological stimuli by various mechanisms, including the modulation of neuroinflammatory reflexes and the onset of abnormal breathing patterns. Afferent signals and circulating factors from injured peripheral tissues, including the lung, can induce neuronal reprogramming, potentially contributing to neurocognitive dysfunction and psychological alterations seen in critically ill patients. These impairments are ubiquitous in the presence of positive pressure ventilation. This narrative review summarises current evidence of lung–brain crosstalk in patients receiving mechanical ventilation and describes the clinical implications of this crosstalk. Further, it proposes directions for future research ranging from identifying mechanisms of multiorgan failure to mitigating long-term sequelae after critical illness.
Importance of pain score distribution to interpretation of the minimal clinically important difference
Bruno L. de C.Araujo1Andreia C.de Melo2Luiz C.Santos Thuler23
doi : 10.1016/j.bja.2021.06.032
Volume 127, Issue 4, October 2021, Pages e121-e123
Use of transversus abdominus block for alveolar bone graft analgesia in children
Richard J.Berwick123CharlotteBerwick1JoanneHaidon1JennieCraske1
doi : 10.1016/j.bja.2021.06.047
Volume 127, Issue 4, October 2021, Pages e123-e125
Understanding ‘difficult tracheal intubation’ in neonatal anaesthesia. Comment on Br J Anaesth 2021; 126: 1173–81
Angela L.Gardner1DanielleEusuf2HelenKennedy2BronaghPatterson2VictoriaScott-Warren3Clifford L.Shelton45
doi : 10.1016/j.bja.2021.06.034
Volume 127, Issue 4, October 2021, Pages e125-e127
Perioperative dexmedetomidine and 5-year survival in patients undergoing cardiac surgery. Comment on Br J Anaesth 2021; 127: 215–23
TingjuHu1†RuiDuan2†XiaohuaZou1JingShi1
doi : 10.1016/j.bja.2021.06.035
Volume 127, Issue 4, October 2021, Pages e127-e128
Analysis of the effect of varying protamine-to-heparin ratio on coagulation in vitro
Loretta T.S.Ho12Mark J.McVey134Gerhardus J.A.J.M.Kuiper15Peter L.Gross6KeyvanKarkouti12789
doi : 10.1016/j.bja.2021.06.037
Volume 127, Issue 4, October 2021, Pages e128-e130
Early postoperative nutritional support in hip fracture patients. Comment on Br J Anaesth 2021; 126: 730–7
ChangqiLuoYouYuChengNie
doi : 10.1016/j.bja.2021.07.003
Volume 127, Issue 4, October 2021, Pages e131-e132
DISH10 (Deep Inspiration, Squeeze and Hold for 10 seconds) manoeuvre: a noninvasive treatment for postdural puncture headache
KartikSonawaneChelliahSekarHrudiniDixitTuhinMistry
doi : 10.1016/j.bja.2021.06.044
Volume 127, Issue 4, October 2021, Pages e132-e135
Safety of high-concentration norepinephrine for peripheral intravenous use. Comment on Br J Anaesth 2020; 124: e108–14
LiweiLiu†LanLuo†LuLi†MuJin
doi : 10.1016/j.bja.2021.07.004
Volume 127, Issue 4, October 2021, Pages e135-e137
Structural validity of the 15-item quality of recovery scale
Paul S.Myles
doi : 10.1016/j.bja.2021.07.006
Volume 127, Issue 4, October 2021, Pages e138-e139
The Routine posTsuRgical Anesthesia visit to improve patient outComE (TRACE) study: lessons learned
Markus W.Hollmann1Diannede Korte-de Boer2ChristaBoer3Wolfgang F.F.A.Buhre2on behalf of the TRACE Study investigators†
doi : 10.1016/j.bja.2021.07.011
Volume 127, Issue 4, October 2021, Pages e140-e142
Management of perioperative thromboprophylaxis for surgery following COVID-19: an expert-panel survey
RaquelFerrandis1Juan V.Llau2ArashAfshari3James D.Douketis4AurelioGómez-Luque5Charles-MarcSamama6
doi : 10.1016/j.bja.2021.06.041
Volume 127, Issue 4, October 2021, Pages e143-e145
Vasopressin infusion in COVID-19 critical illness is not associated with impaired viral clearance: a pilot study
Daniel E.Leisman12ArnavMehta3456YijiaLi7Kyle R.Kays8Jonathan Z.Li7Michael R.Filbin489Marcia B.Goldberg341011
doi : 10.1016/j.bja.2021.07.005
Volume 127, Issue 4, October 2021, Pages e146-e148
Pediatric Sedation Outside of the Operating Room: A Multispecialty International Collaboration,, Keira P. Mason (Ed.), Springer Nature, Switzerland (2021), pp. 990. €239.19, ISBN 978-3-030-58405-4
Per-ArneLönnqvist
doi : 10.1016/j.bja.2021.06.022
Volume 127, Issue 4, October 2021, Page 660
