دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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The obesity paradox and hypoglycemia in critically ill patients
Drago Ple?ko, Nicolas Bennett, Johan Mårtensson & Rinaldo Bellomo
doi : 10.1186/s13054-021-03795-z
Critical Care volume 25, Article number: 378 (2021)
A high body mass index (BMI) has been associated with decreased mortality in critically ill patients. This association may, in part, relate to the impact of BMI on glycemia. We aimed to study the relationship between BMI, glycemia and hospital mortality.
Study conclude that TXA in severely injured was associated with lower mortality: beware of potential confounders
Patrick M. Honore, Sebastien Redant, Thierry Preseau, Sofie Moorthamers, Keitiane Kaefer, Leonel Barreto Gutierrez, Rachid Attou, Andrea Gallerani, Willem Boer & David De Bels
doi : 10.1186/s13054-021-03790-4
Critical Care volume 25, Article number: 379 (2021)
Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis
Shuhei Murao, Hidekazu Nakata, Ian Roberts & Kazuma Yamakawa
doi : 10.1186/s13054-021-03799-9
Critical Care volume 25, Article number: 380 (2021)
Tranexamic acid (TXA) reduces surgical bleeding and reduces death from bleeding after trauma and childbirth. However, its effects on thrombotic events and seizures are less clear. We conducted a systematic review and meta-analysis to examine the safety of TXA in bleeding patients.
Peripheral microcirculatory alterations are associated with the severity of acute respiratory distress syndrome in COVID-19 patients admitted to intermediate respiratory and intensive care units
Jaume Mesquida, A. Caballer, L. Cortese, C. Vila, U. Karadeniz, M. Pagliazzi, M. Zanoletti, A. Pérez Pacheco, P. Castro, M. García-de-Acilu, R. C. Mesquita, D. R. Busch, T. Durduran on behalf of the HEMOCOVID-19 Consortium
doi : 10.1186/s13054-021-03803-2
Critical Care volume 25, Article number: 381 (2021)
COVID-19 is primarily a respiratory disease; however, there is also evidence that it causes endothelial damage in the microvasculature of several organs. The aim of the present study is to characterize in vivo the microvascular reactivity in peripheral skeletal muscle of severe COVID-19 patients.
The impact of COVID-19 critical illness on new disability, functional outcomes and return to work at 6 months: a prospective cohort study
Carol L. Hodgson, Alisa M. Higgins, Michael J. Bailey, Anne M. Mather, Lisa Beach, Rinaldo Bellomo, Bernie Bissett, Ianthe J. Boden, Scott Bradley, Aidan Burrell, D. James Cooper, Bentley J. Fulcher, Kimberley J. Haines, Jack Hopkins, Alice Y. M. Jones, Stuart Lane, Drew Lawrence, Lisa van der Lee, Jennifer Liacos, Natalie J. Linke, Lonni Marques Gomes, Marc Nickels, George Ntoumenopoulos, Paul S. Myles, Shane Patman, Michelle Paton, Gemma Pound, Sumeet Rai, Alana Rix, Thomas C. Rollinson, Janani Sivasuthan, Claire J. Tipping, Peter Thomas, Tony Trapani, Andrew A. Udy, Christina Whitehead, Isabelle T. Hodgson, Shannah Anderson, Ary Serpa Neto & The COVID-Recovery Study Investigators and the ANZICS Clinical Trials Group
doi : 10.1186/s13054-021-03794-0
Critical Care volume 25, Article number: 382 (2021)
There are few reports of new functional impairment following critical illness from COVID-19. We aimed to describe the incidence of death or new disability, functional impairment and changes in health-related quality of life of patients after COVID-19 critical illness at 6 months.
Letter to the Editor in response to “Course and predictors of posttraumatic stress-related symptoms among family members of deceased ICU patients during the first year of bereavement”
Susumu Yagome, Michihiro Tsubaki & Yoshiyasu Ito
doi : 10.1186/s13054-021-03806-z
Critical Care volume 25, Article number: 384 (2021)
Prolonged time from intubation to cannulation in VV-ECMO for COVID-19: does it really matter?
Pierre-Yves Olivier, Gregoire Ottavy, Jerome Hoff, Johann Auchabie, Cedric Darreau & Marc Pierrot
doi : 10.1186/s13054-021-03800-5
Critical Care volume 25, Article number: 385 (2021)
Clinical phenotype and outcomes of pneumococcal versus meningococcal purpura fulminans: a multicenter retrospective cohort study
Damien Contou, Nicolas de Prost on behalf of the HOPEFUL Study group
doi : 10.1186/s13054-021-03812-1
Critical Care volume 25, Article number: 386 (2021)
Association between longer duration of citrate accumulation and 90-day mortality of acute-on-chronic liver failure
Ming Wang, Yuanji Ma, Lingyao Du, Hong Tang & Lang Bai
doi : 10.1186/s13054-021-03819-8
Critical Care volume 25, Article number: 387 (2021)
Targeted high mean arterial pressure aggravates cerebral hemodynamics after extracorporeal resuscitation in swine
Yael Levy, Alice Hutin, Fanny Lidouren, Nicolas Polge, Rocio Fernandez, Matthias Kohlhauer, Pierre-Louis Leger, Guillaume Debaty, Keith Lurie, Lionel Lamhaut, Bijan Ghaleh & Renaud Tissier
doi : 10.1186/s13054-021-03783-3
Critical Care volume 25, Article number: 369 (2021)
Extracorporeal cardiopulmonary resuscitation (E-CPR) is used for the treatment of refractory cardiac arrest. However, the optimal target to reach for mean arterial pressure (MAP) remains to be determined. We hypothesized that MAP levels critically modify cerebral hemodynamics during E-CPR and tested two distinct targets (65–75 vs 80–90 mmHg) in a porcine model.
Early prediction of hemodynamic interventions in the intensive care unit using machine learning
Asif Rahman, Yale Chang, Junzi Dong, Bryan Conroy, Annamalai Natarajan, Takahiro Kinoshita, Francesco Vicario, Joseph Frassica & Minnan Xu-Wilson
doi : 10.1186/s13054-021-03808-x
Critical Care volume 25, Article number: 388 (2021)
Timely recognition of hemodynamic instability in critically ill patients enables increased vigilance and early treatment opportunities. We develop the Hemodynamic Stability Index (HSI), which highlights situational awareness of possible hemodynamic instability occurring at the bedside and to prompt assessment for potential hemodynamic interventions.
Why the renin–angiotensin–aldosterone system (RAAS) in critically ill patients can no longer be ignored
Alexander Zarbock, Lakhmir Chawla & Rinaldo Bellomo
doi : 10.1186/s13054-021-03816-x
Critical Care volume 25, Article number: 389 (2021)
Vasodilatory shock is a common form of shock, characterized by preserved or increased cardiac output and peripheral vasodilation. Inflammatory syndromes or states, such as sepsis and major surgery, are common causes of vasodilatory shock. Acute kidney injury (AKI) is a common complication of a vasodilatory shock and is associated with increased mortality [1]. Sepsis is the most common cause of AKI [2]. The pathophysiology of vasoplegia is complex and not fully understood, but different hormonal systems are involved in the regulation of systemic vascular resistance, including the renin–angiotensin–aldosterone system (RAAS).
40th International Symposium on Intensive Care & Emergency Medicine 2021
doi : 10.1186/s13054-021-03769-1
Critical Care volume 25, Article number: 383 (2021)
Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS
Jose Angel Lorente, Nicolas Nin, Palmira Villa, Dovami Vasco, Ana B. Miguel-Coello, Ignacio Rodriguez, Raquel Herrero, Oscar Peñuelas, Jesús Ruiz-Cabello & Jose L. Izquierdo-Garcia
doi : 10.1186/s13054-021-03810-3
Critical Care volume 25, Article number: 390 (2021)
Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by lung inflammation and pulmonary edema. Coronavirus disease 2019 (COVID-19) is associated with ARDS in the more severe cases. This study aimed to compare the specificity of the metabolic alterations induced by COVID-19 or Influenza A pneumonia (IAP) in ARDS.
Prediction of extubation outcome in critically ill patients: a systematic review and meta-analysis
Flavia Torrini, Ségolène Gendreau, Johanna Morel, Guillaume Carteaux, Arnaud W. Thille, Massimo Antonelli & Armand Mekontso Dessap
doi : 10.1186/s13054-021-03802-3
Critical Care volume 25, Article number: 391 (2021)
Extubation failure is an important issue in ventilated patients and its risk factors remain a matter of research. We conducted a systematic review and meta-analysis to explore factors associated with extubation failure in ventilated patients who passed a spontaneous breathing trial and underwent planned extubation. This systematic review was registered in PROPERO with the Registration ID CRD42019137003.
A systematic review and meta-analysis of enrollment into ARDS and sepsis trials published between 2009 and 2019 in major journals
Dustin C. Krutsinger, Kuldeep N. Yadav, Michael O. Harhay, Karsten Bartels & Katherine R. Courtright
doi : 10.1186/s13054-021-03804-1
Critical Care volume 25, Article number: 392 (2021)
Enrollment problems are common among randomized controlled trials conducted in the ICU. However, little is known about actual trial enrollment rates and influential factors. We set out to determine the overall enrollment rate in recent randomized controlled trials (RCTs) of patients with acute respiratory distress syndrome (ARDS), acute lung injury (ALI), or sepsis, and which factors influenced enrollment rate.
The simple observational critical care studies: estimations by students, nurses, and physicians of in-hospital and 6-month mortality
Eline G. M. Cox, Marisa Onrust, Madelon E. Vos, Wolter Paans, Willem Dieperink, Jacqueline Koeze, Iwan C. C. van der Horst, Renske Wiersema & SICS Study Group & SOCCS Student Team
doi : 10.1186/s13054-021-03809-w
Critical Care volume 25, Article number: 393 (2021)
Prognostic assessments of the mortality of critically ill patients are frequently performed in daily clinical practice and provide prognostic guidance in treatment decisions. In contrast to several sophisticated tools, prognostic estimations made by healthcare providers are always available and accessible, are performed daily, and might have an additive value to guide clinical decision-making. The aim of this study was to evaluate the accuracy of students’, nurses’, and physicians’ estimations and the association of their combined estimations with in-hospital mortality and 6-month follow-up.
Continuous wireless postoperative monitoring using wearable devices: further device innovation is needed
William Xu, Armen A. Gharibans, Ian P. Bissett, Gregory O’Grady, Cameron I. Wells, Carlos Areia, Christopher Biggs, Mauro Santos, Neal Thurley, Stephen Gerry, Lionel Tarassenko, Peter Watkinson & Sarah Vollam
doi : 10.1186/s13054-021-03805-0
Critical Care volume 25, Article number: 394 (2021)
A combination of Bohr and Haldane effects provide a physiologic explanation for the increase in arterial oxygen saturation when a face mask is added to a high-flow nasal cannula in severely hypoxemic COVID-19 patients
Pablo Born & Ricardo Castro
doi : 10.1186/s13054-021-03791-3
Critical Care volume 25, Article number: 395 (2021)
Effects of levosimendan on occurrence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a case–control study
Antoine Trinh-Duc, Marc-Antoine Labeyrie, Anaïs Caillard, Wagih Ben Hassen, Alexandre Mebazaa & Benjamin Glenn Chousterman
doi : 10.1186/s13054-021-03824-x
Critical Care volume 25, Article number: 396 (2021)
Background frequency can enhance the prognostication power of EEG patterns categories in comatose cardiac arrest survivors: a prospective, multicenter, observational cohort study
Youn-Jung Kim, Min-Jee Kim, Yong Hwan Kim, Chun Song Youn, In Soo Cho, Su Jin Kim, Jung Hee Wee, Yoo Seok Park, Joo Suk Oh, Dong Hoon Lee, Won Young Kim on behalf of the Korean Hypothermia Network Investigators
doi : 10.1186/s13054-021-03823-y
Critical Care volume 25, Article number: 398 (2021)
We assessed the prognostic accuracy of the standardized electroencephalography (EEG) patterns (“highly malignant,” “malignant,” and “benign”) according to the EEG timing (early vs. late) and investigated the EEG features to enhance the predictive power for poor neurologic outcome at 1 month after cardiac arrest.
In the eye of the storm: impact of COVID-19 pandemic on admission patterns to paediatric intensive care units in the UK and Eire
Hari Krishnan Kanthimathinathan, Hannah Buckley, Peter J. Davis, Richard G. Feltbower, Caroline Lamming, Lee Norman, Lyn Palmer, Mark J. Peters, Adrian Plunkett, Padmanabhan Ramnarayan, Barnaby R. Scholefield & Elizabeth S. Draper
doi : 10.1186/s13054-021-03779-z
Critical Care volume 25, Article number: 399 (2021)
The coronavirus disease-19 (COVID-19) pandemic had a relatively minimal direct impact on critical illness in children compared to adults. However, children and paediatric intensive care units (PICUs) were affected indirectly. We analysed the impact of the pandemic on PICU admission patterns and patient characteristics in the UK and Ireland.
Equilibrating SSC guidelines with individualized care
Jean-Louis Vincent, Mervyn Singer, Sharon Einav, Rui Moreno, Julia Wendon, Jean-Louis Teboul, Jan Bakker, Glenn Hernandez, Djillali Annane, Angélique M. E. de Man, Xavier Monnet, V. Marco Ranieri, Olfa Hamzaoui, Jukka Takala, Nicole Juffermans, Jean-Daniel Chiche, Sheila N. Myatra & Daniel De Backer
doi : 10.1186/s13054-021-03813-0
Critical Care volume 25, Article number: 397 (2021)
AVDS should not dethrone ARDS
Yazine Mahjoub, Daniel Rodenstein & Vincent Jounieaux
doi : 10.1186/s13054-021-03807-y
Critical Care volume 25, Article number: 400 (2021)
Telomere shortening during human septic shock: influence of sepsis mediators, role in organ failures, and septic myocardial dysfunction
Keyvan Razazi, Elisabeth Marcos, Sophie Hüe, Laurent Boyer, Serge Adnot & Armand Mekontso Dessap
doi : 10.1186/s13054-021-03818-9
Critical Care volume 25, Article number: 401 (2021)
Cardiogenic shock in Taiwan from 2003 to 2017 (CSiT-15 study)
Shih-Chieh Chien, Chien-Yi Hsu, Hung-Yi Liu, Chao-Feng Lin, Chung-Lieh Hung, Chun-Yao Huang & Li-Nien Chien
doi : 10.1186/s13054-021-03820-1
Critical Care volume 25, Article number: 402 (2021)
This study investigated temporal trends in the treatment and mortality of patients with cardiogenic shock (CS) in Taiwan in relation to acute myocardial infarction (AMI) accreditation implemented in 2009 and the unavailability of percutaneous ventricular assist devices.
The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study
Lauro Damonti, Andreas Kronenberg, Jonas Marschall, Philipp Jent, Rami Sommerstein, Marlieke E. A. De Kraker, Stephan Harbarth, Michael Gasser & Niccolò Buetti
doi : 10.1186/s13054-021-03814-z
Critical Care volume 25, Article number: 403 (2021)
Evidence about the impact of the pandemic of COVID-19 on the incidence rates of blood cultures contaminations and bloodstream infections in intensive care units (ICUs) remains scant. The objective of this study was to investigate the nationwide epidemiology of positive blood cultures drawn in ICUs during the first two pandemic waves of COVID-19 in Switzerland.
Promises and challenges of personalized medicine to guide ARDS therapy
Katherine D. Wick, Daniel F. McAuley, Joseph E. Levitt, Jeremy R. Beitler, Djillali Annane, Elisabeth D. Riviello, Carolyn S. Calfee & Michael A. Matthay
doi : 10.1186/s13054-021-03822-z
Critical Care volume 25, Article number: 404 (2021)
Identifying new effective treatments for the acute respiratory distress syndrome (ARDS), including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving increasingly toward innovative approaches such as the personalization of therapy to biological and clinical sub-phenotypes. Additionally, there is growing recognition of the importance of the global context to identify effective ARDS treatments. This review highlights emerging opportunities and continued challenges for personalizing therapy for ARDS, from identifying treatable traits to innovative clinical trial design and recognition of patient-level factors as the field of critical care investigation moves forward into the twenty-first century.
Development and evaluation of the focused assessment of sonographic pathologies in the intensive care unit (FASP-ICU) protocol
Stefan Schmidt, Jana-Katharina Dieks, Michael Quintel & Onnen Moerer
doi : 10.1186/s13054-021-03811-2
Critical Care volume 25, Article number: 405 (2021)
The use of ultrasonography in the intensive care unit (ICU) is steadily increasing but is usually restricted to examinations of single organs or organ systems. In this study, we combine the ultrasound approaches the most relevant to ICU to design a whole-body ultrasound (WBU) protocol. Recommendations and training schemes for WBU are sparse and lack conclusive evidence. Our aim was therefore to define the range and prevalence of abnormalities detectable by WBU to develop a simple and fast bedside examination protocol, and to evaluate the value of routine surveillance WBU in ICU patients.
Indirect calorimetry is the gold standard to assess REE in ICU patients: some limitations to consider
Patrick M. Honore, Sebastien Redant, Thierry Preseau, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Rachid Attou, Andrea Gallerani & David De Bels
doi : 10.1186/s13054-021-03817-w
Critical Care volume 25, Article number: 406 (2021)
Role of MR-proADM in the risk stratification of COVID-19 patients assessed at the triage of the Emergency Department
Marilena Minieri, Vito N. Di Lecce, Maria Stella Lia, Massimo Maurici, Sergio Bernardini & Jacopo M. Legramante
doi : 10.1186/s13054-021-03834-9
Critical Care volume 25, Article number: 407 (2021)
Dispatcher instructions for bystander cardiopulmonary resuscitation and neurologically intact survival after bystander-witnessed out-of-hospital cardiac arrests: a nationwide, population-based observational study
Yoshikazu Goto, Akira Funada, Tetsuo Maeda & Yumiko Goto
doi : 10.1186/s13054-021-03825-w
Critical Care volume 25, Article number: 408 (2021)
The International Liaison Committee on Resuscitation recommends that dispatchers provide instructions to perform compression-only cardiopulmonary resuscitation (CPR) to callers responding to adults with out-of-hospital cardiac arrest (OHCA). This study aimed to determine the optimal dispatcher-assisted CPR (DA-CPR) instructions for OHCA.
Randomised trials of temperature management in cardiac arrest: Are we observing the Zeno’s paradox of the Tortoise and Achilles?
Tommaso Scquizzato, Paul J. Young, Giovanni Landoni, Luisa Zaraca & Alberto Zangrillo
doi : 10.1186/s13054-021-03826-9
Critical Care volume 25, Article number: 409 (2021)
Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support
Jonathan Rilinger, Klara Krötzsch, Xavier Bemtgen, Markus Jäckel, Viviane Zotzmann, Corinna N. Lang, Klaus Kaier, Daniel Duerschmied, Alexander Supady, Christoph Bode, Dawid L. Staudacher & Tobias Wengenmayer
doi : 10.1186/s13054-021-03821-0
Critical Care volume 25, Article number: 410 (2021)
There is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Most studies focused on short- to mid-term follow-up. We aimed to investigate long-term survival and health-related quality of life (HRQL) in these patients.
Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry
Ryuta Nakae, Tetsuro Sekine, Takashi Tagami, Yasuo Murai, Eigo Kodani, Geoffrey Warnock, Hidetaka Sato, Akio Morita, Hiroyuki Yokota & Shoji Yokobori
doi : 10.1186/s13054-021-03828-7
Critical Care volume 25, Article number: 411 (2021)
Sepsis is often associated with multiple organ failure; however, changes in brain volume with sepsis are not well understood. We assessed brain atrophy in the acute phase of sepsis using brain computed tomography (CT) scans, and their findings’ relationship to risk factors and outcomes.
Effects of intermittent hemodialysis on plasmatic levels of endocan
Maxence Hureau, Julien Poissy, Daniel Mathieu, Sylvain Dubucquoi & Alexandre Gaudet
doi : 10.1186/s13054-021-03829-6
Critical Care volume 25, Article number: 412 (2021)
Complete countrywide mortality in COVID patients receiving ECMO in Germany throughout the first three waves of the pandemic
Christian Karagiannidis, Arthur S. Slutsky, Thomas Bein, Wolfram Windisch, Steffen Weber-Carstens & Daniel Brodie
doi : 10.1186/s13054-021-03831-y
Critical Care volume 25, Article number: 413 (2021)
Efficacy of non-invasive and invasive respiratory management strategies in adult patients with acute hypoxaemic respiratory failure: a systematic review and network meta-analysis
Masaaki Sakuraya, Hiromu Okano, Tomoyuki Masuyama, Shunsuke Kimata & Satoshi Hokari
doi : 10.1186/s13054-021-03835-8
Critical Care volume 25, Article number: 414 (2021)
Although non-invasive respiratory management strategies have been implemented to avoid intubation, patients with de novo acute hypoxaemic respiratory failure (AHRF) are high risk of treatment failure. In the previous meta-analyses, the effect of non-invasive ventilation was not evaluated according to ventilation modes in those patients. Furthermore, no meta-analyses comparing non-invasive respiratory management strategies with invasive mechanical ventilation (IMV) have been reported. We performed a network meta-analysis to compare the efficacy of non-invasive ventilation according to ventilation modes with high-flow nasal oxygen (HFNO), standard oxygen therapy (SOT), and IMV in adult patients with AHRF.
