دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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http://medilib.ir
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قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
December 2021 Stroke Highlights
Nicole B. Sur
doi : 10.1161/STROKEAHA.121.036716
Stroke. 2021;52:3749
Phase 1/2a Trial of ISPASM
Mario Zanaty, Lauren Allan, Edgar A. Samaniego, Anthony Piscopo, Eleanor Ryan, James C. Torner, David Hasan
doi : 10.1161/STROKEAHA.121.034578
Stroke. 2021;52:3750–3758
Microthrombosis could play a role in delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Tirofiban has shown promising results in reducing delayed cerebral ischemia in retrospective studies. However, the safety of using tirofiban in aneurysmal subarachnoid hemorrhage is not rigorously established.
Ultrasound-Guided BoNT-A (Botulinum Toxin A) Injection Into the Subscapularis for Hemiplegic Shoulder Pain: A Randomized, Double-Blind, Placebo-Controlled Trial
Botao Tan, Lang Jia
doi : 10.1161/STROKEAHA.121.034049
Stroke. 2021;52:3759–3767
This study aimed to assess the efficacy of an ultrasound-guided lateral approach for BoNT-A (botulinum toxin A) injections into the subscapularis in patients with hemiplegic shoulder pain.
Serious Adverse Events and Their Impact on Functional Outcome in Acute Ischemic Stroke in the WAKE-UP Trial
Iris Lettow, Märit Jensen, Eckhard Schlemm, Florent Boutitie, Fanny Quandt, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Vincent Thijs, Robin Lemmens, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Christian Gerloff, Götz Thomalla, and on behalf of the WAKE-UP Investigators
doi : 10.1161/STROKEAHA.120.033425
Stroke. 2021;52:3768–3776
During the first days and weeks after an acute ischemic stroke, patients are prone to complications that can influence further treatment, recovery, and functional outcome. In clinical trials, severe complications are recorded as serious adverse events (SAE). We analyzed the effect of SAE on functional outcome and predictors of SAE in the randomized controlled WAKE-UP trial (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke).
First-Pass Effect in Basilar Artery Occlusions: Insights From the Endovascular Treatment of Ischemic Stroke Registry
Mathilde Aubertin, David Weisenburger-Lile, Benjamin Gory, Sébastien Richard, Raphael Blanc, Célina Ducroux, Michel Piotin, Julien Labreuche, Ludovic Lucas, Cyril Dargazanli, Amel Benali, Romain Bourcier, Lili Detraz, Stéphane Vannier, Maud Guillen, François Eugene, Gregory Walker, Ronda Lun, Adrien Guenego, Arturo Consoli, Gaultier Marnat, Benjamin Maier, Bertrand Lapergue, Robert Fahed,
doi : 10.1161/STROKEAHA.120.030237
Stroke. 2021;52:3777–3785
In the settings of thrombectomy, the first-pass effect (FPE), defined by a complete recanalization after one pass with no rescue therapy, has been shown to be associated with an improved outcome. As this phenomenon has been predominantly described in anterior circulation strokes, we aimed to study the prevalence, outcomes, and predictors of FPE in patients with a basilar artery occlusion.
Sonothrombolysis in Patients With Acute Ischemic Stroke With Large Vessel Occlusion: An Individual Patient Data Meta-Analysis
Georgios Tsivgoulis, Aristeidis H. Katsanos, Jürgen Eggers, Vincent Larrue, Lars Thomassen, James C. Grotta, Georgios Seitidis, Peter D. Schellinger, Dimitris Mavridis, Andrew Demchuk, Vojtech Novotny, Carlos A. Molina, Areti Angeliki Veroniki, Martin Köhrmann, Lauri Soinne, Andrej Netland Khanevski, Andrew D. Barreto, Maher Saqqur, Theodora Psaltopoulou, Keith W. Muir, Jochen B. Fiebach, Travis Rothlisberger, Thomas A. Kent, Pitchaiah Mandava, Anne W. Alexandrov, Andrei V. Alexandrov
doi : 10.1161/STROKEAHA.120.030960
Stroke. 2021;52:3786–3795
Evidence about the utility of ultrasound-enhanced thrombolysis (sonothrombolysis) in patients with acute ischemic stroke (AIS) is conflicting. We aimed to evaluate the safety and efficacy of sonothrombolysis in patients with AIS with large vessel occlusion, by analyzing individual patient data of available randomized-controlled clinical trials.
Endovascular Thrombectomy for Treatment of Acute Ischemic Stroke During Pregnancy and the Early Postpartum Period
Alis J. Dicpinigaitis, Tolga Sursal, Catherine A. Morse, Camille Briskin, Katarina Dakay, Christeena Kurian, Gurmeen Kaur, Ramandeep Sahni, Christian Bowers, Chirag D. Gandhi, Stephan A. Mayer, Fawaz Al-Mufti
doi : 10.1161/STROKEAHA.121.034303
Stroke. 2021;52:3796–3804
Acute ischemic stroke (AIS) is a rare occurrence during pregnancy and the postpartum period. Existing literature evaluating endovascular mechanical thrombectomy (MT) for this patient population is limited.
Frequency, Characteristics, and Outcomes of Endovascular Thrombectomy in Patients With Stroke Beyond 6 Hours of Onset in US Clinical Practice
Kori S. Zachrison, Lee H. Schwamm, Haolin Xu, Roland Matsouaka, Shreyansh Shah, Eric E. Smith, Ying Xian, Gregg C. Fonarow, Jeffrey Saver
doi : 10.1161/STROKEAHA.121.034069
Stroke. 2021;52:3805–3814
In 2018, 2 randomized controlled trials showed the benefit of endovascular thrombectomy (EVT) in acute ischemic stroke patients treated 6 to 24 hours from last known well using imaging-guided selection. However, little is known about outcomes in contemporary nontrial settings. We assessed the frequency of EVT and outcomes beyond 6 hours in the US Get With The Guidelines–Stroke clinical registry.
Effect of Adjusted Antiplatelet Therapy on Preventing Ischemic Events After Stenting for Intracranial Aneurysms
Wenqiang Li, Wei Zhu, Anxin Wang, Guojun Zhang, Yisen Zhang, Kun Wang, Ying Zhang, Chao Wang, Limin Zhang, Hui Zhao, Ping Wang, Kelin Chen, Jian Liu, Xinjian Yang
doi : 10.1161/STROKEAHA.120.032989
Stroke. 2021;52:3815–3825
This study tests whether patients with unruptured intracranial aneurysm who underwent stent placement benefitted from platelet function monitoring–guided adjustment of antiplatelet therapy.
Platelet Function Testing Is Required for Intracranial Stent Placement
René Chapot
doi : 10.1161/STROKEAHA.121.036457
Stroke. 2021;52:3826–3828
Baseline Characteristics of Patients With Cavernous Angiomas With Symptomatic Hemorrhage in Multisite Trial Readiness Project
Helen Kim, Kelly D. Flemming, Jeffrey A. Nelson, Avery Lui, Jennifer J. Majersik, Michael Dela Cruz, Joseph Zabramski, Odilette Trevizo, Giuseppe Lanzino, Atif Zafar, Michel Torbey, Marc C. Mabray, Myranda Robinson, Jared Narvid, Janine Lupo, Richard E. Thompson, Daniel F. Hanley Jr, Nichol McBee, Kevin Treine, Noeleen Ostapkovich, Agnieszka Stadnik, Kristina Piedad, Nicholas Hobson, Timothy Carroll, Abdallah Shkoukani, Julián Carrión-Penagos, Carolina Mendoza-Puccini, James I. Koenig, Issam Awad
doi : 10.1161/STROKEAHA.120.033487
Stroke. 2021;52:3829–3838
Brain cavernous angiomas with symptomatic hemorrhage (CASH) have a high risk of neurological disability from recurrent bleeding. Systematic assessment of baseline features and multisite validation of novel magnetic resonance imaging biomarkers are needed to optimize clinical trial design aimed at novel pharmacotherapies in CASH.
Corticospinal Tract Microstructure Correlates With Beta Oscillatory Activity in the Primary Motor Cortex After Stroke
Robert Schulz, Marlene Bönstrup, Stephanie Guder, Jingchun Liu, Benedikt Frey, Fanny Quandt, Lutz A. Krawinkel, Bastian Cheng, Götz Thomalla, Christian Gerloff
doi : 10.1161/STROKEAHA.121.034344
Stroke. 2021;52:3839–3847
Cortical beta oscillations are reported to serve as robust measures of the integrity of the human motor system. Their alterations after stroke, such as reduced movement-related beta desynchronization in the primary motor cortex, have been repeatedly related to the level of impairment. However, there is only little data whether such measures of brain function might directly relate to structural brain changes after stroke.
White Matter Hyperintensity Burden and Collateral Circulation in Large Vessel Occlusion Stroke
Imad Derraz, Mohamed Abdelrady, Nicolas Gaillard, Raed Ahmed, Federico Cagnazzo, Cyril Dargazanli, Pierre-Henri Lefevre, Lucas Corti, Carlos Riquelme, Isabelle Mourand, Gregory Gascou, Alain Bonafe, Caroline Arquizan, Vincent Costalat
doi : 10.1161/STROKEAHA.120.031736
Stroke. 2021;52:3848–3854
White matter hyperintensity (WMH), a marker of chronic cerebral small vessel disease, might impact the recruitment of leptomeningeal collaterals. We aimed to assess whether the WMH burden is associated with collateral circulation in patients treated by endovascular thrombectomy for anterior circulation acute ischemic stroke.
Baseline Cognitive Impairment in Patients With Asymptomatic Carotid Stenosis in the CREST-2 Trial
Ronald M. Lazar, Virginia G. Wadley, Terina Myers, Michael R. Jones, Donald V. Heck, Wayne M. Clark, Randolph S. Marshall, Virginia J. Howard, Jenifer H. Voeks, Jennifer J. Manly, Claudia S. Moy, Seemant Chaturvedi, James F. Meschia, Brajesh K. Lal, Thomas G. Brott, George Howard
doi : 10.1161/STROKEAHA.120.032972
Stroke. 2021;52:3855–3863
Studies of carotid artery disease have suggested that high-grade stenosis can affect cognition, even without stroke. The presence and degree of cognitive impairment in such patients have not been reported and compared with a demographically matched population-based cohort.
Impact of Prior Antiplatelet Therapy on Outcomes After Endovascular Therapy for Acute Stroke: Endovascular Treatment in Ischemic Stroke Registry Results
Marie Couture, Stephanos Finitsis, Gaultier Marnat, Sébastien Richard, Romain Bourcier, Pacôme Constant-dits-Beaufils, Cyril Dargazanli, Caroline Arquizan, Mikaël Mazighi, Raphaël Blanc, François Eugène, Stéphane Vannier, Laurent Spelle, Christian Denier, Emmanuel Touzé, Charlotte Barbier, Suzana Saleme, Francisco Macian, Charlotte Rosso, Frédéric Clarençon, Olivier Naggara, Guillaume Turc, Ozlem Ozkul-Wermester, Chrysanthi Papagiannaki, Alain Viguier, Christophe Cognard, Anthony Lebras, Sarah Evain, Valérie Wolff, Raoul Pop, Serge Timsit, Jean-Christophe Gentric, Frédéric Bourdain, Louis Veunac, Bertrand Lapergue, Arturo Consoli, Benjamin Gory, Igor Sibon
doi : 10.1161/STROKEAHA.121.034670
Stroke. 2021;52:3864–3872
The influence of prior antiplatelet therapy (APT) uses on the outcomes of patients with acute ischemic stroke treated with endovascular therapy is unclear. We compared procedural and clinical outcomes of endovascular therapy in patients on APT or not before stroke onset.
Natural History and Clinical Outcomes of Paravertebral Arteriovenous Shunts
Yueshan Feng, Jiaxing Yu, Jiankun Xu, Chuan He, Lisong Bian, Guilin Li, Ming Ye, Peng Hu, Liyong Sun, Nan Jiang, Feng Ling, Tao Hong, Hongqi Zhang
doi : 10.1161/STROKEAHA.120.033963
Stroke. 2021;52:3873–3882
Paravertebral arteriovenous shunts (PVAVSs) are rare. Whether the intradural venous system is involved in drainage may lead to differences in clinical characteristics through specific pathophysiological mechanisms. This study aims to comprehensively evaluate the natural history and clinical outcomes of PVAVSs with or without intradural drainage.
Long-Term Survival, Causes of Death, and Trends in 5-Year Mortality After Intracerebral Hemorrhage: The Tromsø Study
Maria Carlsson, Tom Wilsgaard, Stein Harald Johnsen, Liv-Hege Johnsen, Maja-Lisa Løchen, Inger Njølstad, Ellisiv B. Mathiesen
doi : 10.1161/STROKEAHA.120.032750
Stroke. 2021;52:3883–3890
Data on long-term survival after intracerebral hemorrhage (ICH) are scarce. In a population-based nested case-control study, we compared long-term survival and causes of death within 5 years in 30-day survivors of first-ever ICH and controls, assessed the impact of cardiovascular risk factors on 5-year mortality, and analyzed time trend in 5-year mortality in ICH patients over 2 decades.
Withdrawal of Life-Sustaining Treatment Mediates Mortality in Patients With Intracerebral Hemorrhage With Impaired Consciousness
Ayham Alkhachroum, Antonio J. Bustillo, Negar Asdaghi, Erika Marulanda-Londono, Carolina M. Gutierrez, Daniel Samano, Evie Sobczak, Dianne Foster, Mohan Kottapally, Amedeo Merenda, Sebastian Koch, Jose G. Romano, Kristine O’Phelan, Jan Claassen, Ralph L. Sacco, Tatjana Rundek
doi : 10.1161/STROKEAHA.121.035233
Stroke. 2021;52:3891–3898
Impaired level of consciousness (LOC) on presentation at hospital admission in patients with intracerebral hemorrhage (ICH) may affect outcomes and the decision to withhold or withdraw life-sustaining treatment (WOLST).
Future Shock: Does Pessimism Contribute to Poor Outcome After Intracerebral Hemorrhage?
H.E. Hinson
doi : 10.1161/STROKEAHA.121.036761
Stroke. 2021;52:3899–3900
Serum Sphingosine-1-Phosphate Levels Are Associated With Severity and Outcome in Patients With Cerebral Ischemia
Edzard Schwedhelm, Laura Schwieren, Steffen Tiedt, Mirjam von Lucadou, Nils-Ole Gloyer, Rainer Böger, Tim Magnus, Guenter Daum, Götz Thomalla, Christian Gerloff, Chi-un Choe
doi : 10.1161/STROKEAHA.120.033414
Stroke. 2021;52:3901–3907
The aim of this study was to examine whether sphingosine-1-phosphate (S1P) levels in patients with acute stroke are associated with stroke severity and outcome.
Impact of COVID-19 Infection on the Outcome of Patients With Ischemic Stroke
Joan Martí-Fàbregas, Daniel Guisado-Alonso, Raquel Delgado-Mederos, Alejandro Martínez-Domeño, Luis Prats-Sánchez, Marina Guasch-Jiménez, Pere Cardona, Ana Núñez-Guillén, Manuel Requena, Marta Rubiera, Marta Olivé, Alejandro Bustamante, Meritxell Gomis, Sergio Amaro, Laura Llull, Xavier Ustrell, Gislaine Castilho de Oliveira, Laia Seró, Manuel Gomez-Choco, Luis Mena, Joaquín Serena, Saima Bashir Viturro, Francisco Purroy, Mikel Vicente, Ana Rodríguez-Campello, Angel Ois, Esther Catena, Maria Carmen Garcia-Carreira, Oriol Barrachina, Ernest Palomeras, Jerzky Krupinski, Marta Almeria, Josep Zaragoza, Patricia Esteve, Dolores Cocho, Antia Moreira, Cecile van Eendenburg, Javier Emilio Codas, Natalia Pérez de la Ossa, Mercè Salvat, Pol Camps-Renom, and for the COVICTUS Collaborators
doi : 10.1161/STROKEAHA.121.034883
Stroke. 2021;52:3908–3917
We evaluated whether stroke severity, functional outcome, and mortality are different in patients with ischemic stroke with or without coronavirus disease 2019 (COVID-19) infection.
Rare NOTCH3 Variants in a Chinese Population-Based Cohort and Its Relationship With Cerebral Small Vessel Disease
Jing-Yi Liu, Ming Yao, Yi Dai, Fei Han, Fei-Fei Zhai, Ding-Ding Zhang, Li-Xin Zhou, Jun Ni, Shu-Yang Zhang, Li-Ying Cui, Yi-Cheng Zhu
doi : 10.1161/STROKEAHA.120.032265
Stroke. 2021;52:3918–3925
Researches on rare variants of NOTCH3 in the general Chinese population are lacking. This study aims to describe the spectrum of rare NOTCH3 variants by whole-exome sequencing in a Chinese community-based cohort and to investigate the association between rare NOTCH3 variants and age-related cerebral small vessel disease.
Mendelian Randomization Focused Analysis of Vitamin D on the Secondary Prevention of Ischemic Stroke
Yap-Hang Chan, C. Mary Schooling, Jie Zhao, Shiu-Lun Au Yeung, Jo Jo Hai, G. Neil Thomas, Kar-Keung Cheng, Chao-Qiang Jiang, Yuen-Kwun Wong, Ka-Wing Au, Clara S. Tang, Chloe Y.Y. Cheung, Aimin Xu, Pak-Chung Sham, Tai-Hing Lam, Karen Siu-Ling Lam, Hung-Fat Tse
doi : 10.1161/STROKEAHA.120.032634
Stroke. 2021;52:3926–3937
Experimental studies showed vitamin D (Vit-D) could promote vascular regeneration and repair. Prior randomized studies had focused mainly on primary prevention. Whether Vit-D protects against ischemic stroke and myocardial infarction recurrence among subjects with prior ischemic insults was unknown. Here, we dissected through Mendelian randomization any effect of Vit-D on the secondary prevention of recurrent ischemic stroke and myocardial infarction.
Ethnic Differences in Informal Caregiving After Stroke
Lewis B. Morgenstern, Cecilia N. Hollenhorst, Linda C. Gallo, Chia-Wei Hsu, Sehee Kim, River Gibbs, Erin Case, Lynda D. Lisabeth
doi : 10.1161/STROKEAHA.120.032740
Stroke. 2021;52:3938–3943
Informal (unpaid) caregiving usually provided by family is important poststroke. We studied whether the prevalence of informal caregiving after stroke differs between Mexican Americans (MAs) and non-Hispanic Whites (NHWs).
Racial Differences in Blood Pressure Control Following Stroke: The REGARDS Study
Oluwasegun P. Akinyelure, Byron C. Jaeger, Tony L. Moore, Demetria Hubbard, Suzanne Oparil, Virginia J. Howard, George Howard, Joy N. Buie, Gayenell S. Magwood, Robert J. Adams, Leonardo Bonilha, Daniel T. Lackland, Paul Muntner
doi : 10.1161/STROKEAHA.120.033108
Stroke. 2021;52:3944–3952
In the general population, Black adults are less likely than White adults to have controlled blood pressure (BP), and when not controlled, they are at greater risk for stroke compared with White adults. High BP is a major modifiable risk factor for recurrent stroke, but few studies have examined racial differences in BP control among stroke survivors.
Serum Zinc Levels and Incidence of Ischemic Stroke: The Reasons for Geographic and Racial Differences in Stroke Study
Lindsey Mattern, Cheng Chen, Leslie A. McClure, John Brockman, Mary Cushman, Suzanne Judd, Ka Kahe
doi : 10.1161/STROKEAHA.120.033187
Stroke. 2021;52:3953–3960
Despite zinc’s role as an antioxidant and anti-inflammatory agent, prospective studies relating zinc levels to ischemic stroke risk are lacking. To examine the association between serum zinc levels and incidence of ischemic stroke in a US population.
StrokeCog Markov Model: Projected Prevalent and Incident Cases of Stroke and Poststroke Cognitive Impairment to 2035 in Ireland
Eithne Sexton, Nora-Ann Donnelly, Niamh A. Merriman, Anne Hickey, Maev-Ann Wren, Martin O’Flaherty, Piotr Bandosz, Maria Guzman-Castillo, David J. Williams, Frances Horgan, Niall Pender, Joanne Feeney, Céline de Looze, Rose Anne Kenny, Peter Kelly, Kathleen Bennett
doi : 10.1161/STROKEAHA.121.034005
Stroke. 2021;52:3961–3969
Cognitive impairment no dementia (CIND) and dementia are common stroke outcomes, with significant health and societal implications for aging populations. These outcomes are not included in current epidemiological models. We aimed to develop an epidemiological model to project incidence and prevalence of stroke, poststroke CIND and dementia, and life expectancy, in Ireland to 2035, informing policy and service planning.
Outcomes Among Patients With Reversible Cerebral Vasoconstriction Syndrome: A Nationwide United States Analysis
Smit D. Patel, Karan Topiwala, Fadar Otite Oliver, Hamidreza Saber, Gregory Panza, Gracia Mui, David S. Liebeskind, Jeffrey L. Saver, Mark Alberts, Anne Ducros
doi : 10.1161/STROKEAHA.121.034424
Stroke. 2021;52:3970–3977
Reversible cerebral vasoconstriction syndrome (RCVS) is a well-established cause of stroke, but its demographics and outcomes have not been well delineated.
Risk, Clinical Course, and Outcome of Ischemic Stroke in Patients Hospitalized With COVID-19: A Multicenter Cohort Study
Wouter M. Sluis, Marijke Linschoten, Julie E. Buijs, J. Matthijs Biesbroek, Heleen M. den Hertog, Tessa Ribbers, Dennis J. Nieuwkamp, Reinier C. van Houwelingen, Andreas Dias, Ingeborg W.M. van Uden, Joost P. Kerklaan, H. Paul Bienfait, Sarah E. Vermeer, Sonja W. de Jong, Mariam Ali, Marieke J.H. Wermer, Marieke T. de Graaf, Paul J.A.M. Brouwers, Folkert W. Asselbergs, L. Jaap Kappelle, H. Bart van der Worp, Annemijn M. Algra
doi : 10.1161/STROKEAHA.121.034787
Stroke. 2021;52:3978–3986
The frequency of ischemic stroke in patients with coronavirus disease 2019 (COVID-19) varies in the current literature, and risk factors are unknown. We assessed the incidence, risk factors, and outcomes of acute ischemic stroke in hospitalized patients with COVID-19.
Updated Perspective on Severe Acute Respiratory Syndrome Coronavirus-2 Infection and Ischemic Stroke
Adnan I. Qureshi
doi : 10.1161/STROKEAHA.121.037010
Stroke. 2021;52:3987–3988
Novel Diffusion-Weighted Imaging Score Showed Good Prognostic Value for Acute Basilar Artery Occlusion Following Endovascular Treatment: The Pons-Midbrain and Thalamus Score
Lian Liu, Meiping Wang, Yiming Deng, Gang Luo, Xuan Sun, Ligang Song, Xiaochuan Huo, Feng Gao, Ning Ma, Dapeng Mo, Zhongrong Miao
doi : 10.1161/STROKEAHA.120.032314
Stroke. 2021;52:3989–3997
Prognostic factors for outcome of endovascular treatment remains to be investigated in patients with acute basilar artery occlusion. We aimed to assess the prognostic value of a novel pretreatment diffusion-weighted imaging score: The Pons-Midbrain and Thalamus (PMT) score.
Stroke Patients With Faster Core Growth Have Greater Benefit From Endovascular Therapy
Longting Lin, Hao Zhang, Chushuang Chen, Andrew Bivard, Kenneth Butcher, Carlos Garcia-Esperon, Neil J. Spratt, Christopher R. Levi, Mark W. Parsons, Gang Li,
doi : 10.1161/STROKEAHA.121.034205
Stroke. 2021;52:3998–4006
This study aimed to explore whether the therapeutic benefit of endovascular thrombectomy (EVT) was mediated by core growth rate.
Infarct Core Growth Velocity: Characterizing the Hot Penumbra Without Looking at It
Juan F. Arenillas
doi : 10.1161/STROKEAHA.121.035682
Stroke. 2021;52:4007–4009
Optimizing Emergency Stroke Transport Strategies Using Physiological Models
Daniel A. Paydarfar, David Paydarfar, Peter J. Mucha, Joshua Chang
doi : 10.1161/STROKEAHA.120.031633
Stroke. 2021;52:4010–4020
The criteria for choosing between drip and ship and mothership transport strategies in emergency stroke care is widely debated. Although existing data-driven probability models can inform transport decision-making at an epidemiological level, we propose a novel mathematical, physiologically derived framework that provides insight into how patient characteristics underlying infarct core growth influence these decisions.
CCR5 Activation Promotes NLRP1-Dependent Neuronal Pyroptosis via CCR5/PKA/CREB Pathway After Intracerebral Hemorrhage
Jun Yan, Weilin Xu, Cameron Lenahan, Lei Huang, Jing Wen, Gaigai Li, Xin Hu, Wen Zheng, John H. Zhang, Jiping Tang
doi : 10.1161/STROKEAHA.120.033285
Stroke. 2021;52:4021–4032
Neuronal pyroptosis is a type of regulated cell death triggered by proinflammatory signals. CCR5 (C-C chemokine receptor 5)-mediated inflammation is involved in the pathology of various neurological diseases. This study investigated the impact of CCR5 activation on neuronal pyroptosis and the underlying mechanism involving cAMP-dependent PKA (protein kinase A)/CREB (cAMP response element binding)/NLRP1 (nucleotide-binding domain leucine-rich repeat pyrin domain containing 1) pathway after experimental intracerebral hemorrhage (ICH).
Scavenging Free Iron Reduces Arteriolar Microvasospasms After Experimental Subarachnoid Hemorrhage
Hanhan Liu, Julian Schwarting, Nicole Angela Terpolilli, Kathrin Nehrkorn, Nikolaus Plesnila
doi : 10.1161/STROKEAHA.120.033472
Stroke. 2021;52:4033–4042
Subarachnoid hemorrhage (SAH) is associated with acute and delayed cerebral ischemia resulting in high acute mortality and severe chronic neurological deficits. Spasms of the pial and intraparenchymal microcirculation (microvasospasms) contribute to acute cerebral ischemia after SAH; however, the underlying mechanisms remain unknown. We hypothesize that free iron (Fe3+) released from hemolytic red blood cells into the subarachnoid space may be involved in microvasospasms formation.
Sirtuin 5-Mediated Lysine Desuccinylation Protects Mitochondrial Metabolism Following Subarachnoid Hemorrhage in Mice
Zhi-Peng Xiao, Tao Lv, Pin-Pin Hou, Anatol Manaenko, Yuandong Liu, Yichao Jin, Li Gao, Feng Jia, Yang Tian, Peiying Li, John H. Zhang, Qin Hu, Xiaohua Zhang
doi : 10.1161/STROKEAHA.121.034850
Stroke. 2021;52:4043–4053
Sirt5 (Sirtuin 5) desuccinylates multiple metabolic enzymes and plays an important role in maintaining energy homeostasis. The goal of this study was to determine whether Sirt5-mediated desuccinylation restores the energy metabolism and protects brain against subarachnoid hemorrhage (SAH).
Computed Tomography Perfusion–Based Prediction of Core Infarct and Tissue at Risk: Can Artificial Intelligence Help Reduce Radiation Exposure?
Girish Bathla, Yanan Liu, Honghai Zhang, Milan Sonka, Colin Derdeyn
doi : 10.1161/STROKEAHA.121.034266
Stroke. 2021;52:e755–e759
We explored the feasibility of automated, arterial input function independent, vendor neutral prediction of core infarct, and penumbral tissue using complete and partial computed tomographic perfusion data sets through neural networks.
Optimal Tissue Reperfusion Estimation by Computed Tomography Perfusion Post-Thrombectomy in Acute Ischemic Stroke
Zefeng Tan, Mark Parsons, Andrew Bivard, Gagan Sharma, Peter Mitchell, Richard Dowling, Steven Bush, Anding Xu, Bernard Yan
doi : 10.1161/STROKEAHA.121.034581
Stroke. 2021;52:e760–e763
Modified Thrombolysis in Cerebral Infarction score (mTICI) ?2b is defined as successful reperfusion. However, mTICI has rarely been correlated with dynamic perfusion imaging postendovascular therapy for acute stroke. We aimed to study the proportion of tissue optimal reperfusion (TOR) postendovascular therapy across different grades of mTICI.
Thrombectomy Complications in Large Vessel Occlusions: Incidence, Predictors, and Clinical Impact in the ETIS Registry
Emmanuel Happi Ngankou, Benjamin Gory, Gaultier Marnat, Sébastien Richard, Romain Bourcier, Igor Sibon, Cyril Dargazanli, Caroline Arquizan, Benjamin Maïer, Raphaël Blanc, Bertrand Lapergue, Arturo Consoli, Stéphane Vannier, Laurent Spelle, Christian Denier, Marion Boulanger, Maxime Gauberti, Suzana Saleme, Francisco Macian, Frédéric Clarençon, Charlotte Rosso, Olivier Naggara, Guillaume Turc, Ozlem Ozkul-Wermester, Chrysanthi Papagiannaki, Alain Viguier, Christophe Cognard, Anthony Lebras, Sarah Evain, Valérie Wolff, Raoul Pop, Serge Timsit, Jean-Christophe Gentric, Frédéric Bourdain, Louis Veunac, François Eugène, Stephanos Finitsis
doi : 10.1161/STROKEAHA.121.034865
Stroke. 2021;52:e764–e768
Procedural complications in thrombectomy for large vessel occlusions of the anterior circulation are not well described. We investigated the incidence, risk factors, and clinical implications of thrombectomy complications in daily clinical practice.
ASCOD Phenotyping of Stroke With Anterior Large Vessel Occlusion Treated by Mechanical Thrombectomy
Louis Fontaine, Igor Sibon, Nicolas Raposo, Jean-François Albucher, Michael Mazighi, Vanessa Rousseau, Jean Darcourt, Claire Thalamas, Amel Drif, Agnes Sommet, Alain Viguier, Adrien Guenego, Anne-Christine Januel, Lionel Calvière, Patrice Menegon, Fabrice Bonneville, Thomas Tourdias, Gregory W. Albers, Christophe Cognard, Jean-Marc Olivot
doi : 10.1161/STROKEAHA.121.035282
Stroke. 2021;52:e769–e772
Determining the mechanism of large vessel occlusion related acute ischemic stroke is of major importance to initiate a tailored secondary prevention strategy. We investigated using the atherosclerosis, small vessel disease, cardiac source, other cause, dissection (ASCOD) classification the distribution of the causes of large vessel occlusion related acute ischemic stroke treated by mechanical thrombectomy.
Antiplatelet Use and Ischemic Stroke Risk in Minor Stroke or Transient Ischemic Attack: A Post Hoc Analysis of the POINT Trial
Mohammad Anadani, Adam de Havenon, Nils Henninger, Lindsey Kuohn, Brian Mac Grory, Karen L. Furie, Anthony S. Kim, J. Donald Easton, S. Claiborne Johnston, Shadi Yaghi
doi : 10.1161/STROKEAHA.121.035354
Stroke. 2021;52:e773–e776
Dual antiplatelet therapy has been shown to reduce the risk of recurrent stroke in patients with minor stroke or transient ischemic attack. However, whether the effect of dual antiplatelet therapy is modified by pretreatment antiplatelet status is unclear.
Antithrombotic Therapy for Stroke Prevention in Patients With Ischemic Stroke With Aspirin Treatment Failure
Jay B. Lusk, Haolin Xu, Eric D. Peterson, Deepak L. Bhatt, Gregg C. Fonarow, Eric E. Smith, Roland Matsouaka, Lee H. Schwamm, Ying Xian
doi : 10.1161/STROKEAHA.121.034622
Stroke. 2021;52:e777–e781
Many older patients presenting with acute ischemic stroke were already taking aspirin before admission. However, the management strategy for patients with aspirin treatment failure has not been fully established.
Geographic and Regional Variability in Racial and Ethnic Disparities in Stroke Thrombolysis in the United States
Deji Suolang, Bridget J. Chen, Nae-Yuh Wang, Rebecca F. Gottesman, Roland Faigle
doi : 10.1161/STROKEAHA.121.035220
Stroke. 2021;52:e782–e787
Intravenous thrombolysis (IVT) after ischemic stroke is underutilized in racially/ethnically minoritized groups. We aimed to determine the regional and geographic variability in racial/ethnic IVT disparities in the United States.
Molecular Magnetic Resonance Imaging of Vascular Inflammation After Recanalization in a Rat Ischemic Stroke Model
Bart A.A. Franx, Annette Van der Toorn, Caroline Van Heijningen, Denis Vivien, Thomas Bonnard, Rick M. Dijkhuizen
doi : 10.1161/STROKEAHA.121.034910
Stroke. 2021;52:e788–e791
Brain imaging has become central in the management of acute ischemic stroke. Detection of parenchymal injury and perfusion enables characterization of the extent of ischemic damage, which guides treatment decision-making. Additional assessment of secondary events, such as inflammation, which may particularly arise after recanalization, may improve diagnosis and (supplementary) treatment selection. Therefore, we developed and tested a molecular magnetic resonance imaging (MRI) approach for in vivo detection of vascular inflammation after transient middle cerebral artery occlusion in rats.
Left Atrial Appendage Closure in Patients With Atrial Fibrillation and Coexisting Cerebral Amyloid Angiopathy
Clémence Blanc, Grégoire Blanc, Serge Boveda, Lionel Calvière, Nicolas Combes, Alain Viguier, Pierre Mondoly, Jean-François Albucher, Cédric Gollion, Vincent Fabry, Marianne Barbieux-Guillot, Jean-Marc Olivot, Meyer Elbaz, Nicolas Raposo
doi : 10.1161/STROKEAHA.121.037248
Stroke. 2021;52:e792–e793
Implementation Science
Linda S. Williams, Barbara G. Vickrey
doi : 10.1161/STROKEAHA.121.033971
Stroke. 2021;52:4054–4056
Advances in Epidemiology, Outcomes, and Population Science
Mitchell S.V. Elkind, Graeme J. Hankey
doi : 10.1161/STROKEAHA.121.033973
Stroke. 2021;52:4057–4059
Nursing’s Role in Successful Stroke Care Transitions Across the Continuum: From Acute Care Into the Community
Michelle Camicia, Barbara Lutz, Debbie Summers, Lynn Klassman, Stephanie Vaughn
doi : 10.1161/STROKEAHA.121.033938
Stroke. 2021;52:e794–e805
Facilitating successful care transitions across settings is a key nursing competency. Although we have achieved improvements in acute stroke care, similar advances in stroke care transitions in the postacute and return to community phases have lagged far behind. In the current delivery system, care transitions are often ineffective and inefficient resulting in unmet needs and high rates of unnecessary complications and avoidable hospital readmissions. Nurses must use evidence-based approaches to prepare stroke survivors and their family caregivers for postdischarge self-management, rehabilitation, and recovery. The purpose of this article is to provide evidence on the important nursing roles in stroke care and transition management across the care continuum, discuss cross-setting issues in stroke care, and provide recommendations to leverage nursing’s impact in optimizing outcomes for stroke survivors and their family unit across the continuum. To optimize nursing’s influence in facilitating safe, effective, and efficient care transitions for stroke survivors and their family caregivers across the continuum we have the following recommendations (1) establish a system of coordinated and seamless comprehensive stroke care across the continuum and into the community; (2) implement a stroke nurse liaison role that provides consultant case management for the episode of care across all settings/services for improved consistency, communication and follow-up care; (3) implement a validated caregiver assessment tool to systematically assess gaps in caregiver preparedness and develop a tailored caregiver/family care plan that can be implemented to improve caregiver preparedness; (4) use evidence-based teaching and communication methods to optimize stroke survivor/caregiver learning; and (5) use technology to advance stroke nursing care. Nurses must leverage their substantial influence over the health care delivery system to achieve these improvements in stroke care delivery to improve the health and lives of stroke survivors and their families.
Uncertainties and Controversies in the Management of Ischemic Stroke and Transient Ischemic Attack Patients With Patent Foramen Ovale
Scott E. Kasner, Simona Lattanzi, Ana Catarina Fonseca, Akram Y. Elgendy
doi : 10.1161/STROKEAHA.121.034778
Stroke. 2021;52:e806–e819
Multiple randomized clinical trials have demonstrated the benefit of patent foramen ovale closure over medical therapy alone for patients who have had a stroke that has been attributed to the patent foramen ovale. Nevertheless, there are many areas of uncertainty and controversy related to patient selection, pathophysiology, diagnosis, and treatment. We summarize the available data on these challenging topics and attempt to provide some clarity and future directions for clinicians and investigators.
Embolic Stroke of Undetermined Source: Approaches in Risk Stratification for Cardioembolism
Aditya Bhat, Vipul Mahajan, Henry H.L. Chen, Gary C.H. Gan, Octavio M. Pontes-Neto, Timothy C. Tan
doi : 10.1161/STROKEAHA.121.034498
Stroke. 2021;52:e820–e836
Ischemic stroke is a leading cause of morbidity and mortality worldwide. Embolic stroke of undetermined source has been recently proposed to categorize nonlacunar ischemic strokes without confirmed etiology after adequate investigation with a likely embolic stroke mechanism. A strategy of empirical anticoagulation for embolic stroke of undetermined source patients is attractive but may only be beneficial in a select subset of patients. Strategies which would help identify the subset of embolic stroke of undetermined source patients most likely to have cardioembolic origin of stroke, and hence benefit from anticoagulation, are needed. This article will review current evidence which may be useful in the development of a risk stratification approach based on arrhythmia monitoring, cardiac imaging, and clinical risk stratification. This approach may be beneficial in clinical practice in improving patient outcomes and reducing stroke recurrence in this population; however, further work is required with active trials underway.
Coming to the Rescue: Regulatory T Cells for Promoting Recovery After Ischemic Stroke
Yueman Zhang, Arthur Liesz, Peiying Li
doi : 10.1161/STROKEAHA.121.036072
Stroke. 2021;52:e837–e841
Immune cell infiltration to the injured brain is a key component of the neuroinflammatory response after ischemic stroke. In contrast to the large amount of proinflammatory immune cells, regulatory T cells, are an important subgroup of T cells that are involved in maintaining immune homeostasis and suppress an overshooting immune reaction after stroke. Numerous previous reports have consistently demonstrated the beneficial role of this immunosuppressive immune cell population during the acute phase after experimental stroke by limiting inflammatory lesion progression. Two recent studies expanded now this concept and demonstrate that regulatory T cells-mediated effects also promote chronic recovery after stroke by promoting a proregenerative tissue environment. These recent findings suggest that boosting regulatory T cells could be beneficial beyond modulating the immediate neuroinflammatory response and improve chronic functional recovery.
Organizational Update: The NINDS-Sponsored Stroke Preclinical Assessment Network Is Moving to Its Next Stage
Francesca Bosetti, James I. Koenig, L. Scott Janis, Clinton B. Wright
doi : 10.1161/STROKEAHA.121.035885
Stroke. 2021;52:e842–e843
Asia Pacific Stroke Organization
Kay-Sin Tan, Ruey-Tay Lin, Byung-Woo Yoon, Nijasri Suwanwela, Man Mohan Mehndiratta, Narayanaswamy Venketasubramanian
doi : 10.1161/STROKEAHA.121.035397
Stroke. 2021;52:e844–e845
Interventions for Reducing Sedentary Behavior in People With Stroke
David H. Saunders, Gillian E. Mead, Claire Fitzsimons, Paul Kelly, Frederike van Wijck, Olaf Verschuren, Karianne Backx, Coralie English
doi : 10.1161/STROKEAHA.121.036589
Stroke. 2021;52:e846–e847
Transitioning From Mentee to Mentor: How and When to Start Developing the Skills Needed to Support Others?
Markus Arnold, Else Charlotte Sandset, Diana Aguiar de Sousa, Andrew M. Demchuk
doi : 10.1161/STROKEAHA.121.035918
Stroke. 2021;52:e848–e851
