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The hidden story of the fourth ventricular choroid plexus: the flower basket of an old anatomist…
D. Paladini
doi : 10.1002/uog.23726
Volume 58, Issue 4 p. 505-508
Fetal hydrops and the Incremental yield of Next-generation sequencing over standard prenatal Diagnostic testing (FIND) study: prospective cohort study and meta-analysis
F. Mone,R. Y. Eberhardt,M. E. Hurles,D. J. Mcmullan,E. R. Maher,J. Lord,L. S. Chitty,E. Dempsey,T. Homfray,J. L. Giordano,R. J. Wapner,L. Sun,T. N. Sparks,M. E. Norton,M. D. Kilby
doi : 10.1002/uog.23652
Volume 58, Issue 4 p. 509-518
To determine the incremental yield of exome sequencing (ES) over chromosomal microarray analysis (CMA) or karyotyping in prenatally diagnosed non-immune hydrops fetalis (NIHF).
Incidence of pre-eclampsia and other perinatal complications among pregnant women with congenital heart disease: systematic review and meta-analysis
R. J. Martinez-Portilla,L. C. Poon,L. Benitez-Quintanilla,A. Sotiriadis,M. Lopez,D. L. Lip-Sosa,F. Figueras
doi : 10.1002/uog.22174
Volume 58, Issue 4 p. 519-528
It has been proposed recently that pre-eclampsia (PE) may originate from maternal cardiac maladaptation rather than primary placental insult. As congenital heart disease (CHD) is associated with reduced adaptation to the hemodynamic needs of pregnancy, it is hypothesized that women with CHD have an increased risk of PE. The aim of this systematic review was to investigate the risk of PE in pregnant women with CHD.
Prospective evaluation of first-trimester screening strategy for preterm pre-eclampsia and its clinical applicability in China
J. Hu,J. Gao,J. Liu,H. Meng,N. Hao,Y. Song,L. Ma,W. Luo,J. Sun,W. Gao,W. Meng,Y. Sun
doi : 10.1002/uog.23645
Volume 58, Issue 4 p. 529-539
To evaluate, in a Chinese population, the performance of a screening strategy for preterm pre-eclampsia (PE) using The Fetal Medicine Foundation (FMF)'s competing-risks model and to explore its clinical applicability in mainland China.
Routine?first-trimester?combined?screening for pre-eclampsia: pregnancy-associated plasma protein-A or placental growth factor?
L. Noël,G. P. Guy,S. Jones,K. Forenc,E. Buck,A. T. Papageorghiou,B. Thilaganathan
doi : 10.1002/uog.23669
Volume 58, Issue 4 p. 540-545
To compare the screening performance of serum pregnancy-associated plasma protein-A (PAPP-A) vs placental growth factor (PlGF) in routine first-trimester combined screening for pre-eclampsia (PE), small-for-gestational age (SGA) at birth and trisomy 21.
ASPRE trial: risk factors for development of preterm pre-eclampsia despite aspirin prophylaxis
L. Shen,R. J. Martinez-Portilla,D. L. Rolnik,L. C. Poon
doi : 10.1002/uog.23668
Volume 58, Issue 4 p. 546-552
To examine the possible risk factors amongst maternal characteristics, medical and obstetric history, pre-eclampsia (PE)-specific biomarkers and estimated-risk group, according to The Fetal Medicine Foundation (FMF) algorithm, that are associated with the development of preterm PE with delivery at <?37?weeks' gestation despite aspirin prophylaxis.
Contingent screening in stratification of pregnancy care based on risk of pre-eclampsia at 19–24?weeks' gestation
M. Litwinska,E. Litwinska,A. Bouariu,A. Syngelaki,A. Wright,K. H. Nicolaides
doi : 10.1002/uog.23742
Volume 58, Issue 4 p. 553-560
To explore the possibility of carrying out routine screening for pre-eclampsia (PE) with delivery at <?28, <?32, <?36?weeks' gestation by maternal factors, uterine artery pulsatility index (UtA-PI) and mean arterial pressure (MAP) in all pregnancies and reserving measurements of placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) for only a subgroup of the population.
Prediction of preterm pre-eclampsia according to NICE and ACOG criteria: descriptive study of 597?492 Danish births from 2008 to 2017
L. Rode,C. K. Ekelund,I. Riishede,S. Rasmussen,Ø. Lidegaard,A. Tabor
doi : 10.1002/uog.23693
Volume 58, Issue 4 p. 561-567
The aim of this national study was to examine the incidence of preterm pre-eclampsia (PE) and the proportion of women with risk factors for PE, according to the criteria suggested by the National Institute for Health and Care Excellence (NICE) and the American College of Obstetricians and Gynecologists (ACOG), during a 10-year period in Denmark.
Position of the choroid plexus of the fourth ventricle in first- and second-trimester fetuses: a novel approach to early diagnosis of cystic posterior fossa anomalies
P. Volpe,V. De Robertis,G. Volpe,S. Boito,T. Fanelli,C. Olivieri,C. Votino,N. Persico
doi : 10.1002/uog.23651
Volume 58, Issue 4 p. 568-575
To describe the sonographic appearance and position of the choroid plexus of the fourth ventricle (4V-CP) between 12 and 21?weeks' gestation in normal fetuses and in fetuses with Dandy–Walker malformation (DWM) or Blake's pouch cyst (BPC).
Secondary prevention of congenital cytomegalovirus infection with valacyclovir following maternal primary infection in early pregnancy
V. Faure-Bardon,J. Fourgeaud,J. Stirnemann,M. Leruez-Ville,Y. Ville
doi : 10.1002/uog.23685
Volume 58, Issue 4 p. 576-581
Cytomegalovirus (CMV) maternal primary infection (MPI) in early pregnancy is the main risk factor for congenital CMV (cCMV) infection with long-term sequelae. Our aim was to evaluate, in a single center offering CMV serology screening at 11–14?gestational weeks, secondary prevention of cCMV by administration of high-dosage maternal oral valacyclovir (VACV) in the first trimester of pregnancy.
Percutaneous fetoscopic spina bifida repair: effect on ambulation and need for postnatal cerebrospinal fluid diversion and bladder catheterization
D. A. Lapa,R. H. Chmait,Y. Gielchinsky,M. Yamamoto,N. Persico,M. Santorum,M. M. Gil,L. Trigo,R. A. Quintero,K. H. Nicolaides
doi : 10.1002/uog.23658
Volume 58, Issue 4 p. 582-589
A trial comparing prenatal with postnatal open spina bifida (OSB) repair established that prenatal surgery was associated with better postnatal outcome. However, in the trial, fetal surgery was carried out through hysterotomy. Minimally invasive approaches are being developed to mitigate the risks of open maternal–fetal surgery. The objective of this study was to investigate the impact of a novel neurosurgical technique for percutaneous fetoscopic repair of fetal OSB, the skin-over-biocellulose for antenatal fetoscopic repair (SAFER) technique, on long-term postnatal outcome.
Intrapulmonary artery Doppler to predict mortality and morbidity in fetuses with mild or moderate left-sided congenital diaphragmatic hernia
D. Basurto,J. Fuenzalida,R. J. Martinez-Portilla,F. M. Russo,A. Pertierra,J. M. Martínez,J. Deprest,E. Gratacós,O. Gómez
doi : 10.1002/uog.23701
Volume 58, Issue 4 p. 590-596
In fetuses with isolated left-sided congenital diaphragmatic hernia (LCDH), prenatal detection of severe pulmonary hypoplasia is important, as fetal therapy can improve survival. Cases with mild or moderate lung hypoplasia still carry a considerable risk of mortality and morbidity, but there has been less interest in the accurate prediction of outcome in these cases. In this study of fetuses with mild or moderate isolated LCDH, we aimed to investigate: (1) the association between intrapulmonary artery (IPA) Doppler findings and mortality at discharge; (2) whether adding IPA Doppler findings improves the prediction of mortality based on lung size and liver herniation; and (3) the association between IPA Doppler findings and early neonatal morbidity.
Performance of a targeted cell-free DNA prenatal test for 22q11.2 deletion in a large clinical cohort
E. Bevilacqua,J. C. Jani,R. Chaoui,E.-K. A. Suk,R. Palma-Dias,T.-M. Ko,S. Warsof,R. Stokowski,K. J. Jones,F. R. Grati,M. Schmid
doi : 10.1002/uog.23699
Volume 58, Issue 4 p. 597-602
22q11.2 deletion is more common than trisomies 18 and 13 combined, yet no routine approach to prenatal screening for this microdeletion has been established. This study evaluated the clinical sensitivity and specificity of a targeted cell-free DNA (cfDNA) test to screen for fetal 22q11.2 deletion in a large cohort, using blinded analysis of prospectively enrolled pregnancies and stored clinical samples.
Transperineal ultrasound assessment of fetal head elevation by maneuvers used for managing umbilical cord prolapse
A. H. W. Kwan,P. Chaemsaithong,L. Wong,W. T. Tse,A. S. Y. Hui,L. C. Poon,T. Y. Leung
doi : 10.1002/uog.23544
Volume 58, Issue 4 p. 603-608
To assess objectively the degree of fetal head elevation achieved by different maneuvers commonly used for managing umbilical cord prolapse.
Breech progression angle: new feasible and reliable transperineal ultrasound parameter for assessment of fetal breech descent in birth canal
A. Youssef,E. Brunelli,M. Fiorentini,J. Lenzi,G. Pilu,A. El-Balat
doi : 10.1002/uog.23649
Volume 58, Issue 4 p. 609-615
To assess the feasibility and reliability of transperineal ultrasound in the assessment of fetal breech descent in the birth canal, by measuring the breech progression angle (BPA).
Management of early gestations with low beta-human chorionic gonadotropin conceived by assisted reproductive technologies: performance of M4 predictive model
C. J. Valdera Simbrón,C. Hernández Rodríguez,L. Llanos Jiménez,L. Pérez García,J. Plaza Arranz,M. Albi González
doi : 10.1002/uog.23625
Volume 58, Issue 4 p. 616-624
To assess the safety and performance of the M4 model for classifying as high risk or low risk for ectopic pregnancy (EP) pregnancies conceived by assisted reproductive technologies (ART) that present with low beta-human chorionic gonadotropin (?-hCG) concentration in early gestation.
Ability to successfully image endometrium on transvaginal ultrasound in asymptomatic postmenopausal women
S. R. Goldstein,A. Khafaga
doi : 10.1002/uog.23667
Volume 58, Issue 4 p. 625-629
Numerous studies indicate that endometrial thickness of ??4?mm on transvaginal ultrasound (TVS) is a reliable test to exclude endometrial cancer in women with postmenopausal bleeding (PMB), such that biopsy is not needed. However, not all postmenopausal women have anatomy that allows reliable measurement of endometrial thickness. This study was undertaken to evaluate the frequency of, and the reasons for, an inability to adequately visualize the endometrium on TVS.
Location of obstetric anal sphincter injury scars on translabial tomographic ultrasound
H. P. Dietz,M. Kreft,N. Subramaniam,K. Robledo
doi : 10.1002/uog.23719
Volume 58, Issue 4 p. 630-633
Obstetric anal sphincter injury (OASI) is a common preventable cause of anal incontinence. Both diagnosis and primary repair of OASI are often suboptimal, partly owing to the absence of effective clinical audit. The aim of this study was to evaluate the location of scars or defects of the external anal sphincter (EAS), diagnosed by translabial ultrasound (TLUS), following primary OASI repair.
Antenatal dural sinus malformation of torcular Herophili and straight sinus with unusual outcome of hyperdynamic circulation and cardiac failure
M. Shah,B. S. Ramamurthy,A. Khurana,M. Chatterjee,M. Jain,A. Raut
doi : 10.1002/uog.23597
Volume 58, Issue 4 p. 634-635
Acute kidney injury after valacyclovir administration for prevention of congenital cytomegalovirus infection
J. Schurder,H. Lazareth,J. Mrad,E. Thervet,A. Benachi,A. J. Vivanti
doi : 10.1002/uog.23724
Volume 58, Issue 4 p. 636-637
Renal toxicity of high-dosage valacyclovir for secondary prevention of congenital cytomegalovirus infection: a dose regimen-related issue
Y. Ville,M. Leruez-Ville
doi : 10.1002/uog.24753
Volume 58, Issue 4 p. 637-638
Emerging tool for assessment of left ventricular–arterial coupling after pre-eclampsia
E. Sciatti,R. Orabona,E. Vizzardi
doi : 10.1002/uog.23725
Volume 58, Issue 4 p. 638-640
Transvaginal ultrasound imaging of female urethral diverticulum before and after voiding
L. Shafat Heller,B. Feiner,H. Sharabi,Y. Brodner,A. Shrim
doi : 10.1002/uog.23766
Volume 58, Issue 4 p. 640-641
Re: ASPRE trial: risk factors for development of preterm pre-eclampsia despite aspirin prophylaxis
V. Giorgione,C. Di Fabrizio,B. Thilaganathan
doi : 10.1002/uog.24760
Volume 58, Issue 4 p. 642-643
Cell-free DNA screening for fetal 22q11.2 deletion: a targeted test or genome-wide methodology?
X.-Y. Jing,D.-Z. Li
doi : 10.1002/uog.24751
Volume 58, Issue 4 p. 644-646
Reply
K. J. Jones,E. Bevilacqua,F. R. Grati,M. Schmid,J. C. Jani
doi : 10.1002/uog.24752
Volume 58, Issue 4 p. 646-646
One placenta and four embryos: rare case of abnormal twinning
M. Silva,H. Werner,A. Matias
doi : 10.1002/uog.23656
Volume 58, Issue 4 p. 647-648
