JAMA Psychiatry

Cathelijn Tjaden, MSc1,2; Cornelis L. Mulder, MD, PhD3,4; Wouter den Hollander, PhD1; Stynke Castelein, PhD5,6,7; Philippe Delespaul, PhD8,9; Rene Keet, PhD10; Jaap van Weeghel, PhD2,11; Hans Kroon, PhD1,2

doi : 10.1001/jamapsychiatry.2021.2880

JAMA Psychiatry. 2021;78(12):1309-1318

Although the importance of recovery-oriented care for people with severe mental illness (SMI) is widely acknowledged, essential elements such as personalization and involvement of significant others are not adequately implemented in practice.

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Emergency Department Encounters Among Youth With Suicidal Thoughts or Behaviors During the COVID-19 Pandemic

Kathryn K. Ridout, MD, PhD1,2; Mubarika Alavi, MS2; Samuel J. Ridout, MD, PhD1; Maria T. Koshy, MD1; Sameer Awsare, MD1; Brooke Harris, PhD3; David R. Vinson, MD1,2; Constance M. Weisner, DrPH2; Stacy Sterling, DrPH, MSW, MPH2; Esti Iturralde, PhD2

doi : 10.1001/jamapsychiatry.2021.2457

JAMA Psychiatry. 2021;78(12):1319-1328

Population-level reports of suicide-related emergency department (ED) encounters among youth during the COVID-19 pandemic are lacking, along with youth characteristics and preexisting psychiatric service use.

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Methamphetamine Use, Methamphetamine Use Disorder, and Associated Overdose Deaths Among US Adults

Beth Han, MD, PhD, MPH1; Wilson M. Compton, MD, MPE1; Christopher M. Jones, PharmD, DrPH, MPH2; Emily B. Einstein, PhD1; Nora D. Volkow, MD1

doi : 10.1001/jamapsychiatry.2021.2588

JAMA Psychiatry. 2021;78(12):1329-1342

Mortality associated with methamphetamine use has increased markedly in the US. Understanding patterns of methamphetamine use may help inform related prevention and treatment.

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Perturbations in Gut Microbiota Composition in Psychiatric Disorders

Viktoriya L. Nikolova, MRes1; Megan R. B. Hall, BSc2; Lindsay J. Hall, PhD3,4,5; Anthony J. Cleare, MBBS, PhD1,6,7; James M. Stone, MBBS, PhD1,8; Allan H. Young, MD, PhD1,6,7

doi : 10.1001/jamapsychiatry.2021.2573

JAMA Psychiatry. 2021;78(12):1343-1354

Evidence of gut microbiota perturbations has accumulated for multiple psychiatric disorders, with microbiota signatures proposed as potential biomarkers. However, no attempts have been made to evaluate the specificity of these across the range of psychiatric conditions.

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Association Between Genetic Risk for Psychiatric Disorders and the Probability of Living in Urban Settings

Jessye M. Maxwell, MSc1,2; Jonathan R. I. Coleman, PhD1,2; Gerome Breen, PhD1,2; Evangelos Vassos, MD1,2

doi : 10.1001/jamapsychiatry.2021.2983

JAMA Psychiatry. 2021;78(12):1355-1364

Urban residence has been highlighted as an environmental risk factor for schizophrenia and, to a lesser extent, several other psychiatric disorders. However, few studies have explored genetic effects on the choice of residence.

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Use of the PsycheMERGE Network to Investigate the Association Between Depression Polygenic Scores and White Blood Cell Count

Julia M. Sealock, BSc1,2; Younga H. Lee, PhD3,4,5; Arden Moscati, PhD6; Sanan Venkatesh, BSc7,8,9,10,11,12; Georgios Voloudakis, MD, PhD7,8,9,10,11,12; Peter Straub, MS1,2; Kritika Singh, BSc1,2; Yen-Chen A. Feng, PhD3,4; Tian Ge, PhD3,4; Panos Roussos, MD, PhD7,8,9,10,11,12; Jordan W. Smoller, MD, ScD3,4,5; Guanhua Chen, PhD13; Lea K. Davis, PhD1,2,14,15,16,17

doi : 10.1001/jamapsychiatry.2021.2959

JAMA Psychiatry. 2021;78(12):1365-1374

Although depression is a common psychiatric disorder, its underlying biological basis remains poorly understood. Pairing depression polygenic scores with the results of clinical laboratory tests can reveal biological processes involved in depression etiology and in the physiological changes resulting from depression.

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Association of Hypothyroidism and Clinical Depression

Henry Bode1; Beatrice Ivens1; Tom Bschor, MD2; Guido Schwarzer, PhD3; Jonathan Henssler, MD1,4; Christopher Baethge, MD1

doi : 10.1001/jamapsychiatry.2021.2506

JAMA Psychiatry. 2021;78(12):1375-1383

Hypothyroidism is considered a cause of or a strong risk factor for depression, but recent studies provide conflicting evidence regarding the existence and the extent of the association. It is also unclear whether the link is largely due to subsyndromal depression or holds true for clinical depression.

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Pragmatic Precision Psychiatry—A New Direction for Optimizing Treatment Selection

Ronald C. Kessler, PhD1; Alex Luedtke, PhD2,3

doi : 10.1001/jamapsychiatry.2021.2500

JAMA Psychiatry. 2021;78(12):1384-1390

Clinical trials have identified numerous prescriptive predictors of mental disorder treatment response, ie, predictors of which treatments are best for which patients. However, none of these prescriptive predictors is strong enough alone to guide precision treatment planning. This has prompted growing interest in developing precision treatment rules (PTRs) that combine information across multiple prescriptive predictors, but this work has been much less successful in psychiatry than some other areas of medicine. Study designs and analysis schemes used in research on PTR development in other areas of medicine are reviewed, key challenges for implementing similar studies of mental disorders are highlighted, and recent methodological advances to address these challenges are described here.

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