JAMA Neurology




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سفارش

Practical Advice on Surviving and Thriving as an Academic Physician-Neuroscientist

Juliet K. Knowles, MD, PhD1; Brenda E. Porter, MD, PhD1

doi : 10.1001/jamaneurol.2021.3889

JAMA Neurol. 2021;78(12):1439-1440

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Full Circle

Allison Ho Kay, MD1

doi : 10.1001/jamaneurol.2021.3909

JAMA Neurol. 2021;78(12):1441-1442

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Citius, Fortius, Altius—Understanding Which Components Drive Exercise Benefits in Parkinson Disease

Nienke M. de Vries, PhD1,2; Sirwan K. L. Darweesh, MD, PhD1,2; Bastiaan R. Bloem, MD, PhD1,2

doi : 10.1001/jamaneurol.2021.3744

JAMA Neurol. 2021;78(12):1443-1445

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Association of Physical Activity, Including Amount and Maintenance, With All-Cause Mortality in Parkinson Disease

Seo Yeon Yoon, MD, PhD1; Jee Hyun Suh, MD, PhD2; Seung Nam Yang, MD, PhD1; Kyungdo Han, PhD3; Yong Wook Kim, MD, PhD4

doi : 10.1001/jamaneurol.2021.3926

JAMA Neurol. 2021;78(12):1446-1453

The protective effects of physical activity (PA) against Parkinson disease (PD) development have been suggested; however, the association of PA with mortality in PD has rarely been investigated.

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Left Ventricular Dysfunction Among Patients With Embolic Stroke of Undetermined Source and the Effect of Rivaroxaban vs Aspirin

Alexander E. Merkler, MD, MS1,2; Lesly A. Pearce, MS3; Scott E. Kasner, MD4; Ashkan Shoamanesh, MD5; Lee A. Birnbaum, MD6; Hooman Kamel, MD, MS1,2; Kevin N. Sheth, MD7; Richa Sharma, MD, MPH7

doi : 10.1001/jamaneurol.2021.3828

JAMA Neurol. 2021;78(12):1454-1460

It is uncertain whether anticoagulation is superior to aspirin at reducing recurrent stroke in patients with recent embolic strokes of undetermined source (ESUS) and left ventricular (LV) dysfunction.

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Long-term Risk of Parkinson Disease Following Influenza and Other Infections

Noelle M. Cocoros, DSc, MPH1; Elisabeth Svensson, PhD2,3; Szimonetta Komjáthine Szépligeti, MSc2; Søren Viborg Vestergaard, MD2; Péter Szentkúti, MSc2; Reimar W. Thomsen, MD, PhD2; Per Borghammer, MD, PhD, DMSc4; Henrik Toft Sørensen, MD, PhD, DMSc, DSc2,5; Victor W. Henderson, MD, MS2,6,7

doi : 10.1001/jamaneurol.2021.3895

JAMA Neurol. 2021;78(12):1461-1470

Influenza has been associated with the risk of developing Parkinson disease, but the association is controversial.

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Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum

Andréa L. Benedet, PhD1,2; Marta Milà-Alomà, MSc3,4,5,6; Agathe Vrillon, MD, MSc1,7,8; Nicholas J. Ashton, PhD1,9,10,11; Tharick A. Pascoal, MD, PhD2; Firoza Lussier, BSc2; Thomas K. Karikari, PhD1; Claire Hourregue, MD8; Emmanuel Cognat, MD, PhD7,8; Julien Dumurgier, MD, PhD8; Jenna Stevenson, BSc2; Nesrine Rahmouni, BSc2; Vanessa Pallen, BSc2; Nina M. Poltronetti, MSc2; Gemma Salvadó, PhD3,4; Mahnaz Shekari, MSc3,4,6; Gregory Operto, PhD3,4,5; Juan Domingo Gispert, PhD3,4,6,12; Carolina Minguillon, PhD3,4,5; Karine Fauria, PhD3,5; Gwendlyn Kollmorgen, PhD13; Ivonne Suridjan, PhD14; Eduardo R. Zimmer, PhD15; Henrik Zetterberg, MD, PhD1,16,17,18; José Luis Molinuevo, MD, PhD3,4,5; Claire Paquet, MD, PhD7,8; Pedro Rosa-Neto, MD, PhD2,19,20; Kaj Blennow, MD, PhD1,16; Marc Suárez-Calvet, MD, PhD3,4,5,21; for the Translational Biomarkers in Aging and Dementia (TRIAD) study, Alzheimer’s and Families (ALFA) study, and BioCogBank Paris Lariboisière cohort

doi : 10.1001/jamaneurol.2021.3671

JAMA Neurol. 2021;78(12):1471-1483

Glial fibrillary acidic protein (GFAP) is a marker of reactive astrogliosis that increases in the cerebrospinal fluid (CSF) and blood of individuals with Alzheimer disease (AD). However, it is not known whether there are differences in blood GFAP levels across the entire AD continuum and whether its performance is similar to that of CSF GFAP.

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Association Between Increased Seizures During Rewarming After Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy and Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up

Lina F. Chalak, MD, MSCS1; Athina Pappas, MD2; Sylvia Tan, MS3; Abhik Das, PhD4; Pablo J. Sánchez, MD5; Abbot R. Laptook, MD6; Krisa P. Van Meurs, MD7; Seetha Shankaran, MD2; Edward F. Bell, MD8; Alexis S. Davis, MD, MSEpi7; Roy J. Heyne, MD9; Claudia Pedroza, PhD10; Brenda B. Poindexter, MD, MS11,12; Kurt Schibler, MD13; Jon E. Tyson, MD, MPH14; M. Bethany Ball, BS, CCRC7; Rebecca Bara, RN, BSN2; Cathy Grisby, BSN13; Gregory M. Sokol, MD11; Carl T. D’Angio, MD15; Shannon E. G. Hamrick, MD12; Kevin C. Dysart, MD16; C. Michael Cotten, MD, MHS17; William E. Truog, MD18; Kristi L. Watterberg, MD19; Christopher J. Timan, MD5; Meena Garg, MD20; Waldemar A. Carlo, MD21; Rosemary D. Higgins, MD22; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

doi : 10.1001/jamaneurol.2021.3723

JAMA Neurol. 2021;78(12):1484-1493

Compared with normothermia, hypothermia has been shown to reduce death or disability in neonatal hypoxic ischemic encephalopathy but data on seizures during rewarming and associated outcomes are scarce.

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Association of White Matter Hyperintensities With Pathology and Progression of Parkinsonism in Aging

Shahram Oveisgharan, MD1,2; Lei Yu, PhD1,2; Victoria N. Poole, PhD1,3,4; Arnold M. Evia, PhD1,3; Lisa L. Barnes, PhD1,2,5; Julie A. Schneider, MD1,2,6; Konstantinos Arfanakis, PhD1,3,7; David A. Bennett, MD1,2; Aron S. Buchman, MD1,2

doi : 10.1001/jamaneurol.2021.3996

JAMA Neurol. 2021;78(12):1494-1502

Progressive parkinsonism is common in older adults without a diagnosis of Parkinson disease and is associated with adverse health outcomes, but its pathologic basis is controversial.

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Anti–SARS-CoV-2 and Autoantibody Profiles in the Cerebrospinal Fluid of 3 Teenaged Patients With COVID-19 and Subacute Neuropsychiatric Symptoms

Christopher M. Bartley, MD, PhD1,2,3; Claire Johns, MD4; Thomas T. Ngo, BS2,3; Ravi Dandekar, MS2,5; Rita L. Loudermilk, BS2,5; Bonny D. Alvarenga, BA2,5; Isobel A. Hawes, BA2,5,6; Colin R. Zamecnik, PhD2,5; Kelsey C. Zorn, MHS7; Jessa R. Alexander, BA2,5; Anne E. Wapniarski, BA2,5; Joseph L. DeRisi, PhD7,8; Carla Francisco, MD2,5; Kendall B. Nash, MD2,4,5; Sharon O. Wietstock, MD2,5; Samuel J. Pleasure, MD, PhD2,5; Michael R. Wilson, MD2,5

doi : 10.1001/jamaneurol.2021.3821

JAMA Neurol. 2021;78(12):1503-1509

Neuropsychiatric manifestations of COVID-19 have been reported in the pediatric population.

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Humoral and T-Cell Response to SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Treated With Ocrelizumab

Livnat Brill, PhD1; Ariel Rechtman, BSc1; Omri Zveik, BMedSc1; Nitzan Haham, BMedSc1; Esther Oiknine-Djian, PhD2,3; Dana G. Wolf, MD, PhD2,3; Netta Levin, MD, PhD1; Catarina Raposo, PhD4; Adi Vaknin-Dembinsky, MD, PhD1

doi : 10.1001/jamaneurol.2021.3599

JAMA Neurol. 2021;78(12):1510-1514

B-cell–depleting therapies may affect the development of a protective immune response following vaccination. Understanding the ability to develop vaccine-specific immunity to COVID-19 in patients with multiple sclerosis (MS) treated with B-cell–depleting therapy is of importance for clinical decisions.

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Health Disparities, Inequities, and Social Determinants of Health in Multiple Sclerosis and Related Disorders in the US

Lilyana Amezcua, MD, MS1; Victor M. Rivera, MD2; Teresa Corona Vazquez, MD3; Lourdes Baezconde-Garbanati, PhD4; Annette Langer-Gould, MD, PhD5

doi : 10.1001/jamaneurol.2021.3416

JAMA Neurol. 2021;78(12):1515-1524

There is empirical evidence that social determinants of health (SDOH) impact health outcomes in Black and Hispanic and Latinx individuals in the US. Recently, SDOH have risen to the top as essential intervention targets that could help alleviate racial and ethnic disparities. Neuromyelitis optica spectrum disorder (NMOSD) disproportionately affects Black individuals, and multiple sclerosis (MS) has seen a recent shift in select racial groups. It is unclear to what degree SDOH have been investigated and contribute to racial and ethnic health disparities and inequities.

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Changes in Blood Biomarkers of Brain Injury and Degeneration Following Long-Duration Spaceflight

Peter zu Eulenburg, MD, PhD1; Judith-Irina Buchheim, MD2; Nicholas J. Ashton, PhD, MD3; Galina Vassilieva, MD4; Kaj Blennow, MD, PhD3; Henrik Zetterberg, MD, PhD3; Alexander Choukér, MD2

doi : 10.1001/jamaneurol.2021.3589

JAMA Neurol. 2021;78(12):1525-1527

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Association of Targeting Vascular Risk Factors With a Reduction in Dementia Incidence in Old Age

Marieke P. Hoevenaar-Blom, PhD1,2,3; Edo Richard, MD1,3; Eric P. Moll van Charante, MD1,4; Lennard L. van Wanrooij, PhD2; Wim B. Busschers, PhD4; Jan W. van Dalen, PhD1,2,3; Wim A. van Gool, MD1

doi : 10.1001/jamaneurol.2021.3542

JAMA Neurol. 2021;78(12):1527-1528

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Association of Disease-Modifying Treatment and Anti-CD20 Infusion Timing With Humoral Response to 2 SARS-CoV-2 Vaccines in Patients With Multiple Sclerosis

Giulio Disanto, MD, PhD1; Rosaria Sacco, MD, PhD1; Enos Bernasconi, MD2,3,4; Gladys Martinetti, MD5; Franco Keller, MD, PhD5; Claudio Gobbi, MD1,3; Chiara Zecca, MD1,3

doi : 10.1001/jamaneurol.2021.3609

JAMA Neurol. 2021;78(12):1529-1531

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Visual Neglect After an Isolated Lesion of the Superior Colliculus

Thomas Nyffeler, MD1,2,3; Brigitte C. Kaufmann, PhD1,4; Dario Cazzoli, PhD1,2,5

doi : 10.1001/jamaneurol.2021.3863

JAMA Neurol. 2021;78(12):1531-1533

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