Journal of Anesthesia




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سفارش

Is there a role for pregabalin as premedication in pediatric anesthesia?

Jessica Nghiem, Stephen C. Brown & Kazuyoshi Aoyama

doi : 10.1007/s00540-021-02929-5

Journal of Anesthesia volume 35, pages775–777 (2021)

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Practical guidelines for the response to perioperative anaphylaxis

Tomonori Takazawa, Ken Yamaura, Tetsuya Hara, Tomoko Yorozu, Hiromasa Mitsuhata, Hiroshi Morimatsu & The Working Group for the Preparation of Practical Guidelines for the Response to Anaphylaxis, Safety Committee of the Japanese Society of Anesthesiologists

doi : 10.1007/s00540-021-03005-8

Journal of Anesthesia volume 35, pages778–793 (2021)

Perioperative anaphylaxis is a severe adverse event during anesthesia that requires prompt diagnosis and treatment by physicians, including anesthesiologists. Muscle relaxants and antibiotics are the most common drugs that cause perioperative anaphylaxis in Japan, as in many countries. In addition, sugammadex appears to be a primary causative agent. Obtaining previous anesthesia records is necessary in a patient with a history of allergic reactions during anesthesia, whenever possible, to avoid recurrence of anaphylaxis. Although medical staff are likely to notice abnormal vital signs because of complete monitoring during anesthesia, surgical drapes make it difficult to notice the appearance of skin symptoms. Even if there are no skin symptoms, anaphylaxis should be suspected, especially when hypotension resistant to inotropes and vasopressors persists. For improving the diagnostic accuracy of anaphylaxis, it is helpful to collect blood samples to measure histamine/tryptase concentrations immediately after the events and at baseline. The first-line treatment for anaphylaxis is adrenaline. In the perioperative setting, adrenaline should be administered through the intravenous route, which has a faster effect onset and is secured in most cases. Adrenaline can cause serious complications including severe arrhythmias if the appropriate dose is not selected according to the severity of symptoms. The anesthesiologist should identify the causative agent after adverse events. The gold standard for identifying the causative agent is the skin test, but in vitro tests including specific IgE antibody measurements and basophil activation tests are also beneficial. The Working Group of the Japanese Society of Anesthesiologists has developed this practical guide to help appropriate prevention, early diagnosis and treatment, and postoperative diagnosis of anaphylaxis during anesthesia.

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Oral acetaminophen as an adjunct to continuous epidural infusion and patient-controlled epidural analgesia in laboring parturients: a randomized controlled trial

Reecha Panghal, Sukanya Mitra, Jasveer Singh, Rashi Sarna & Bharti Goel

doi : 10.1007/s00540-021-02975-z

Journal of Anesthesia volume 35, pages794–800 (2021)

Intravenous acetaminophen is safe and effective as an adjunct to labor analgesia with combined spinal–epidural (CSE) analgesia and patient-controlled epidural analgesia (PCEA). Oral acetaminophen is a much cheaper and safe option but has not been studied as an adjunct to labor analgesia till date. The aim of the present study is to evaluate the effect of oral acetaminophen as an adjunct in patients receiving local anesthetic-opioid combination using CSE analgesia.

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Central venous catheterization site choice based on anatomical landmark technique: a systematic review and meta-analysis

Yang Gu, Keting Min, Qingqing Zhang, Zhigang Chen, Di Feng, Juan Wei, Xiaohong Jin, Huanping Zhou, Jiong Song & Xin Lv

doi : 10.1007/s00540-021-02976-y

Journal of Anesthesia volume 35, pages801–810 (2021)

Internal jugular vein catheterization (IJVC) and subclavian vein catheterization (SCVC) have been the most preferred central venous catheterizations (CVC) clinically. Individual preference and institutional routine dominate the traditional CVC choice; however, it is lack of high-level evidence. We sought to provide better clinical strategy for CVC site choice based on anatomical landmark technique between IJVC and SCVC.

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A two-handed airway maneuver of mandibular advancement and mouth opening in the neutral neck position for immobilization of the cervical spine

Atsushi Sawada, Gen Ochiai & Michiaki Yamakage

doi : 10.1007/s00540-021-02981-1

Journal of Anesthesia volume 35, pages811–817 (2021)

Immobilization of the cervical spine after trauma is recommended as standard care to prevent secondary injury. We tested the hypothesis that a two-handed airway maneuver, consisting of mandibular advancement and mouth opening in the neutral neck position, would minimize changes in the angle of the cervical vertebrae at the C0/4 level and tidal volume in non-obese patients under anesthesia with neuromuscular blockade.

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Allopurinol attenuates postoperative pain and modulates the purinergic system in patients undergoing abdominal hysterectomy: a randomized controlled trial

André P. Schmidt, Enderson D. de Oliveira, Aécio C. Fagundes, Gisele Hansel, Renata O. Pedrini, Aline Valdameri, Eduarda S. Martinelli, Sérgio R. G. Schmidt, Cristiano F. Andrade, Diogo R. Lara & Diogo O. Souza

doi : 10.1007/s00540-021-02983-z

Journal of Anesthesia volume 35, pages818–826 (2021)

Allopurinol is a potent inhibitor of the enzyme xanthine oxidase used primarily in the treatment of hyperuricemia and gout. The aim of this study was to compare the analgesic efficacy of preanesthetic allopurinol versus placebo on postoperative pain and anxiety in patients undergoing abdominal hysterectomy.

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Peripheral oxygen saturation to inspiratory oxygen fraction ratio-based identification of critically ill coronavirus disease patients for early therapeutic interventions

Masaru Shimizu & Satoru Hashimoto

doi : 10.1007/s00540-021-02986-w

Journal of Anesthesia volume 35, pages827–836 (2021)

Early identification of critically ill coronavirus disease (COVID-19) patients in clinical settings is crucial in reducing the mortality rate. Therefore, this study aimed to determine whether the saturation of peripheral oxygen (SpO2) to fraction of inspiratory oxygen (FiO2) ratio (SF ratio) at admission is useful for the early identification of severe COVID-19.

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Changes in peripheral perfusion index during intraoperative end-expiratory occlusion tests do not predict the response to fluid administration in patients undergoing lung protective ventilation

Yusuke Iizuka, Masamitsu Sanui, Yuji Otsuka, Koichi Yoshinaga, Takeshi Nakatomi & Alan Kawarai Lefor

doi : 10.1007/s00540-021-02988-8

Journal of Anesthesia volume 35, pages837–843 (2021)

The end-expiratory occlusion test (EEOT) may predict the response to fluid administration in patients undergoing lung-protective ventilation, but arterial catheter insertion is necessary to evaluate changes in stroke volume (SV). The peripheral perfusion index is a potential noninvasive alternative to evaluate SV. The aim of this study is to investigate whether changes in perfusion index during an intraoperative EEOT can predict the response to fluid administration in patients undergoing lung-protective ventilation (tidal volume 7 ml/kg predicted body weight).

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Postoperative neurological complications after brachial plexus block: a retrospective study conducted at a teaching hospital

Pablo Oliver-Fornies, Juan Pablo Ortega Lahuerta, Roberto Gomez Gomez, Inmaculada Gonzalo Pellicer, Pilar Herranz Andres & Agustin Sancho-Saldana

doi : 10.1007/s00540-021-02989-7

Journal of Anesthesia volume 35, pages844–853 (2021)

Serious complications after ultrasound-guided regional anaesthesia can be devastating for the patient. The pathogenesis of postoperative neurological complications (PONC) is multifactorial and includes mechanical, vascular and chemical factors besides the nerve puncture itself. The primary aim of this study was to assess the incidence of PONC after brachial plexus block (BPB).

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Intraoperative panic attack in patients undergoing awake craniotomy: a retrospective analysis of risk factors

Kotoe Kamata, Takashi Maruyama, Ryu Komatsu & Makoto Ozaki

doi : 10.1007/s00540-021-02990-0

Journal of Anesthesia volume 35, pages854–861 (2021)

Intraoperative anxiety is the most common psychological response of the patient during awake craniotomy. Psychological stress can trigger patient decline, resulting in failed awake craniotomy and significantly poor outcomes. This study aimed to identify the risk factors for panic attack (PA) during awake craniotomies.

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The short-term effect of COVID-19 pandemic on disability, pain intensity, psychological status, and exercise habits in patients with chronic pain

Aki Fujiwara, Keisuke Watanabe, Mitsuru Ida, Hideaki Kawanishi, Katsuhiro Kimoto, Kie Yoshimura, Kozue Shinohara & Masahiko Kawaguchi

doi : 10.1007/s00540-021-02992-y

Journal of Anesthesia volume 35, pages862–869 (2021)

The coronavirus disease 2019 (COVID-19) pandemic has affected the lives of people worldwide. The first declaration of a state of emergency in Japan, based on the Act on Special Measures for the Prevention and Control of the Novel Coronavirus, was issued from 16 April 2020 to 14 May 2020 to reduce person-to-person contact. Restrictions on going out, participating in community activities, and visiting hospitals were in place. This study investigates the short-term effects of the COVID-19 pandemic on patients with chronic pain.

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Clinically relevant concentration of propofol and benzodiazepines did not affect in vitro angiogenesis

Kazumi Takaishi, Yasusei Kudo, Shinji Kawahito & Hiroshi Kitahata

doi : 10.1007/s00540-021-02993-x

Journal of Anesthesia volume 35, pages870–878 (2021)

Angiogenesis, one of regenerative medicine, is essential in the process of wound healing. The detailed effects of intravenous anesthetics and sedatives used during perioperative period have not yet been clarified. We investigated the effects of benzodiazepines and propofol on in vitro capillary tube formation.

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Peripheral nerve block use in ankle arthroplasty and ankle arthrodesis: utilization patterns and impact on outcomes

Jimmy J. Chan, Evan Garden, Jesse C. Chan, Jashvant Poeran, Nicole Zubizarreta, Madhu Mazumdar, Leesa M. Galatz & Ettore Vulcano

doi : 10.1007/s00540-021-02994-w

Journal of Anesthesia volume 35, pages879–888 (2021)

Ankle arthrodesis and total ankle arthroplasty (TAA) are often associated with significant postoperative pain. While this may be mitigated by the use of peripheral nerve blocks (PNB), large-scale data are lacking. Using national data, we aimed to evaluate PNB utilization pattern and its impact on outcomes.

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The relationship between core temperature and perioperative shivering during caesarean section under intrathecal anesthesia with bupivacaine and ropivacaine: a randomized controlled study

Guangju Feng, Yu Wang, Jiehua Feng, Xiaomin Luo, Chaoyang Li & Shanglong Yao

doi : 10.1007/s00540-021-02995-9

Journal of Anesthesia volume 35, pages889–895 (2021)

To assess the incidence rate of perioperative shivering for cesarean section and explore the associations between the occurrence of shivering and hypothermia, core temperature change, local anesthetic.

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Tocilizumab in patients with COVID-19: which patient, time, and dose?

Ahmed Hasanin & Maha Mostafa

doi : 10.1007/s00540-021-02974-0

Journal of Anesthesia volume 35, pages896–902 (2021)

Tocilizumab (TCZ) is a recombinant anti-interleukin-6 monoclonal antibody which showed uprising evidence as an anti-inflammatory agent which modulates the cytokine storm in patients with COVID-19. However, proper use of the drug requires selection of the appropriate patient and timing. The two main factors which might improve patient selection are the degree of respiratory failure and systemic inflammation. TCZ can decrease the mortality and progression to invasive mechanical ventilation in patients with severe COVID-19 who are not yet invasively ventilated. However, its use in invasively ventilated patients did not yet gain the same level of evidence especially when administered after?>?1 day from mechanical ventilation. Being an anti-inflammatory and immunomodulatory drug, TCZ was mostly used in patients with COVID-19 who have clear signs of cytokine storm. However, the drug still showed positive response in some studies which did not strictly select patients with elevated markers of systemic inflammation. Thus, it is warranted to investigate and/or re-analyze the role of the drug in patients with severe COVID-19 and with no signs of systemic inflammation. TCZ is used in a dose of 8 mg/kg which can be repeated if there was no clinical improvement. However, there are no clear criteria for judgment of the success of the first dose. Being a drug with a major effect on gross outcomes in a serious pandemic with millions of mortalities, TCZ should be meticulously investigated to reach definitive indications and number of doses to avoid drug overuse, shortage, and side effects.

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Adrenal function/dysfunction in critically ill patients: a concise narrative review of recent novel insights

Greet Van den Berghe

doi : 10.1007/s00540-021-02977-x

Journal of Anesthesia volume 35, pages903–910 (2021)

The “fight or flight” response to critical illness relies on increased cortisol availability, traditionally attributed to several-fold-increased cortisol production via hypothalamus–pituitary–adrenal-axis activation. Recent studies provided evidence against this concept with clinical implications. First, high cortisol availability during critical illness is driven by suppressed cortisol binding and reduced cortisol breakdown rather than increased cortisol production. This implies reduction of hydrocortisone doses when prescribed in ICU. Second, plasma ACTH is low, explained by feedback inhibition by peripherally driven high free cortisol and/or other central glucocorticoid-receptor ligands. Third, ICU patients have elevated plasma concentrations of the ACTH-precursor hormone, pro-opiomelanocortin, because of impaired pituitary processing into ACTH, and pro-opiomelanocortin could drive some adrenocortical cortisol production in face of low ACTH. Fourth, in prolonged critically ill patients, endogenously suppressed ACTH, aggravated by exogenous corticosteroids, associates with poor outcome. In long-stay ICU patients, central adrenal insufficiency may occur due to lack of trophic ACTH signaling. Finally, the Cosyntropin test is not suitable to assess adrenocortical reserve in ICU patients as the test is confounded by increased cortisol distribution volume. These insights necessitate further research focusing on the need, if any, of treating ICU patients with corticosteroids, and timing thereof, outside indications for pharmacological anti-inflammatory drugs.

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Effects of intrathecal opioids on cesarean section: a systematic review and Bayesian network meta-analysis of randomized controlled trials

Hiroyuki Seki, Toshiya Shiga, Takahiro Mihara, Hiroshi Hoshijima, Yuki Hosokawa, Shunsuke Hyuga, Tomoe Fujita, Kyotaro Koshika, Reina Okada, Hitomi Kurose, Satoshi Ideno & Takashi Ouchi

doi : 10.1007/s00540-021-02980-2

Journal of Anesthesia volume 35, pages911–927 (2021)

Purpose: We aimed to compare the beneficial and harmful effects of opioids used as adjuncts to local anesthetics in patients undergoing cesarean section under spinal anesthesia. Methods: We searched electronic databases and ClinicalTrials.gov from their inception until March, 2021 without language restrictions. The primary outcome was the complete analgesia duration (Time to VAS?>?0). Data were synthesized using the Bayesian random-effects model. Evidence confidence was evaluated using the Confidence In Network Meta-Analysis. Results: We identified 66 placebo-controlled randomized controlled trials (RCTs) comprising 4400 patients undergoing elective cesarean section. Compared with the placebo, intrathecal opioids (fentanyl, sufentanil, and morphine) significantly prolonged the analgesia duration by 96, 96, and 190 min, respectively (mean difference). Despite morphine ranking first, opioid efficacy was similar; the results were inconsistent with respect to other analgesic outcomes. Except for diamorphine, all opioids were associated with significant increases in the pruritus incidence. Sufentanil and morphine were associated with increases in the respiratory depression incidence. Conclusions: We confirmed that intrathecal opioids benefit postoperative analgesia. Although morphine seems to be the most appropriate agent, some results were inconsistent, and the evidence confidence was often moderate or low, especially for adverse outcomes. Well-designed RCTs with an evidence-based approach are imperative for determining the most appropriate opioid for cesarean sections.

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Oxygen therapy for critically Ill and post-operative patients

Paul J. Young & Daniel Frei

doi : 10.1007/s00540-021-02996-8

Journal of Anesthesia volume 35, pages928–938 (2021)

Nearly all patients receiving treatment in a peri-operative or intensive care setting receive supplemental oxygen therapy. It is biologically plausible that the dose of oxygen used might affect important patient outcomes. Most peri-operative research has focussed on oxygen regimens that target higher than normal blood oxygen levels. Whereas, intensive care research has mostly focussed on conservative oxygen regimens which assiduously avoid exposure to higher than normal blood oxygen levels. While such conservative oxygen therapy is preferred for spontaneously breathing patients with chronic obstructive pulmonary disease, the optimal oxygen regimen in other patient groups is not clear. Some data suggest that conservative oxygen therapy might be preferred for patients with hypoxic ischaemic encephalopathy. However, unless oxygen supplies are constrained, routinely aggressively down-titrating oxygen in either the peri-operative or intensive care setting is not necessary based on available data. Targeting higher than normal levels of oxygen might reduce surgical site infections in the perioperative setting and/or improve outcomes for intensive care patients with sepsis but further research is required and available data are not sufficiently strong to warrant routine implementation of such oxygen strategies.

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Self-coiling catheter for continuous interscalene block

Yuki Aoyama, Shinichi Sakura & Kotaro Gunji

doi : 10.1007/s00540-021-02999-5

Journal of Anesthesia volume 35, pages939–940 (2021)

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Acknowledgment to reviewers

doi : 10.1007/s00540-021-03011-w

Journal of Anesthesia volume 35, pages941–943 (2021)

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