Journal of the American College of Cardiology




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doi : 10.1016/S0735-1097(21)07963-8

Volume 78, Issue 23, 7 December 2021, Page e287

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Contents

doi : 10.1016/S0735-1097(21)07965-1

Volume 78, Issue 23, 7 December 2021, Pages e289-e292

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Exercise-Induced Ventricular Ectopy and Cardiovascular Mortality in Asymptomatic Individuals

Marwan M.RefaatMDab?CharbelGhariosMDac?M. VinayagaMoorthyPhDdFarahAbdulhaiMDaRoger S.BlumenthalMDeMiran A.JaffaPhDf†SamiaMoraMD, MHSd†

doi : 10.1016/j.jacc.2021.09.1366

Volume 78, Issue 23, 7 December 2021, Pages 2267-2277

The prognosis of exercise-induced premature ventricular contractions (PVCs) in asymptomatic individuals is unclear.

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Premature Ventricular Complexes During Exercise in Asymptomatic Adults: Do They Deserve a Closer Look??

Sandeep A.SahaMD, MS

doi : 10.1016/j.jacc.2021.09.1365

Volume 78, Issue 23, 7 December 2021, Pages 2278-2280

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Preeclampsia Predicts Risk of Hospitalization for Heart Failure With Preserved Ejection Fraction

DominiqueWilliamsMDaMolly J.StoutMD, MSCIbJoshua I.RosenbloomMD, MPHcMargaret A.OlsenPhD, MPHdKaren E.Joynt MaddoxMD, MPHaElenaDeychMSaVictor G.Davila-RomanMDaKathryn J.LindleyMDac

doi : 10.1016/j.jacc.2021.09.1360

Volume 78, Issue 23, 7 December 2021, Pages 2281-2290

Preeclampsia is associated with increased risk of future heart failure (HF), but the relationship between preeclampsia and HF subtypes are not well-established.

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Understanding Heart Failure in Women With Preeclampsia: A Call for Prevention?

Michael C.HonigbergMD, MPP

doi : 10.1016/j.jacc.2021.09.1361

Volume 78, Issue 23, 7 December 2021, Pages 2291-2293

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Evolution of Late Right Heart Failure With Left Ventricular Assist Devices and Association With Outcomes

J. EduardoRameMDabFrancis D.PaganiMD, PhDcMichael S.KiernanMD, MSdGuilherme H.OliveiraMDeEdo Y.BiratiMDaPavanAtluriMDfAnnGaffeyMDfE. WilsonGrandinMD, MPH, MDgSusan L.MyersBBAhCraigCollumMPHhRobert L.KormosMDijJames K.KirklinMDhJeffrey J.TeutebergMDk

doi : 10.1016/j.jacc.2021.09.1362

Volume 78, Issue 23, 7 December 2021, Pages 2294-2308

A revised definition of right heart failure (RHF) for the Society of Thoracic Surgeons Intermacs database of left ventricular assist devices (LVADs) was introduced in June 2014.

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The Other Ventricle With Left Ventricular Assist Devices?

Lynne WarnerStevensonMDaJordan R.H.HoffmanMDbJonathan N.MenachemMDa

doi : 10.1016/j.jacc.2021.09.1364

Volume 78, Issue 23, 7 December 2021, Pages 2309-2311

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Abnormal Extracardiac Development in Fetuses With Congenital Heart Disease

Gregor O.DovjakMD, PhDaTimZalewskibElisabethSeidl-MlczochMDcPatricia A.UlmdVanessaBerger-KulemannMDaMichaelWeberPhDeDanielaPrayerMDaGregor J.KasprianMD, MBAaBarbaraUlmMDb

doi : 10.1016/j.jacc.2021.09.1358

Volume 78, Issue 23, 7 December 2021, Pages 2312-2322

Knowledge about extracardiac anomalies (ECA) in fetal congenital heart disease (CHD) can improve our understanding of the developmental origins of various outcomes in these infants. The prevalence and spectrum of ECA, including structural brain anomalies (SBA), on magnetic resonance imaging (MRI) in fetuses with different types of CHD and at different gestational ages, is unknown.

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Extracardiac Pathology in Fetal Heart Disease: What You See Is Not Always What You Get?

Lisa K.HornbergerMDAngelaMcBrienMB, BCh, MD

doi : 10.1016/j.jacc.2021.09.1359

Volume 78, Issue 23, 7 December 2021, Pages 2323-2325

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Transcatheter Mitral Valve Therapy in the United States: A Report From the STS-ACC TVT Registry

MichaelMackMDaJohn D.CarrollMDbVinodThouraniMDcSreekanthVemulapalliMDdeJohnSquiersMDaPratikManandharPhDdG. MichaelDeebMDfWayneBatchelorMDgHoward C.HerrmannMDhDavid J.CohenMD, MScijGeorgeHanzelMDkThomasGleasonMDlAjayKirtaneMDimNimeshDesaiMDnKimGuiboneDNP, ACNP-BCoKarenHardyRHIApJoanMichaelsRNqJ. MichaelDiMaioMDaBarbaraChristensenRNqSusanFitzgeraldRN, MSqCaroleKrohnRNrRalph G.BrindisMD, MPHsFredMasoudiMD, MSPHtJosephBavariaMDn

doi : 10.1016/j.jacc.2021.07.058

Volume 78, Issue 23, 7 December 2021, Pages 2326-2353

Data for nearly all patients undergoing transcatheter edge-to-edge repair (TEER) and transcatheter mitral valve replacement (TMVR) with an approved device in the United States is captured in the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry. All data submitted for TEER or TMVR between 2014 and March 31, 2020, are reported. A total of 37,475 patients underwent a mitral transcatheter procedure, including 33,878 TEER and 3,597 TMVR. Annual procedure volumes for TEER have increased from 1,152 per year in 2014 to 10,460 per year in 2019 at 403 sites and for TMVR from 84 per year to 1,120 per year at 301 centers. Mortality rates have decreased for TEER at 30 days (5.6%-4.1%) and 1 year (27.4%-22.0%). Early off-label use data on TMVR in mitral valve-in-valve therapy led to approval by the U.S. Food and Drug Administration in 2017, and the 2019 30-day mortality rate was 3.9%. Overall improvements in outcomes over the last 6 years are apparent. (STS/ACC TVT Registry Mitral Module; NCT02245763)

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Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review

Brian R.LindmanMD, MScaDevrajSukulMD, MSbMarc R.DweckMDcMahesh V.MadhavanMDdBenoit J.ArsenaultPhDeMeganCoylewrightMDfW. DavidMerrymanPhDgDavid E.NewbyMDcJohnLewisMAhFrank E.HarrellJr.PhDiMichael J.MackMDjMartin B.LeonMDdCatherine M.OttoMDkPhilippePibarotDVM, PhDe

doi : 10.1016/j.jacc.2021.09.1367

Volume 78, Issue 23, 7 December 2021, Pages 2354-2376

Despite numerous promising therapeutic targets, there are no proven medical treatments for calcific aortic stenosis (AS). Multiple stakeholders need to come together and several scientific, operational, and trial design challenges must be addressed to capitalize on the recent and emerging mechanistic insights into this prevalent heart valve disease. This review briefly discusses the pathobiology and most promising pharmacologic targets, screening, diagnosis and progression of AS, identification of subgroups that should be targeted in clinical trials, and the need to elicit the patient voice earlier rather than later in clinical trial design and implementation. Potential trial end points and tools for assessment and approaches to implementation and design of clinical trials are reviewed. The efficiencies and advantages offered by a clinical trial network and platform trial approach are highlighted. The objective is to provide practical guidance that will facilitate a series of trials to identify effective medical therapies for AS resulting in expansion of therapeutic options to complement mechanical solutions for late-stage disease.

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Aligning Care and Payment for Chronic Cardiovascular Conditions

Paul N.CasaleMD, MPHabcChristinePerezJDdEileen P.HaganMSN, RNdRachel A.RoilandPhD, RNeRobert S.SaundersPhDe

doi : 10.1016/j.jacc.2021.09.1368

Volume 78, Issue 23, 7 December 2021, Pages 2377-2381

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Weaving Antiracism Practice and Equity Into the Fabric of Cardiovascular Fellowship: A New Training Paradigm

Lauren A.EberlyMD, MPHabcdHowardJulienMD, MPH, MLabcSrinathAdusumalliMD, MSHP, MBMIabcd

doi : 10.1016/j.jacc.2021.07.063

Volume 78, Issue 23, 7 December 2021, Pages 2382-2386

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RESPONSE: Coronary Anatomy, Hemodynamics, and Racism: The New Cardiology Training Curriculum?

QuinnCapersIVMD

doi : 10.1016/j.jacc.2021.07.064

Volume 78, Issue 23, 7 December 2021, Pages 2385-2386

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What Is of Recent Interest in Cardiac Imaging?: Insights From the JACC Family of Journals

Leslee J.ShawPhD(Executive Editor, JACC: Cardiovascular Imaging)Y.ChandrashekharMD(Editor-in-Chief, JACC: Cardiovascular Imaging)JACC: Cardiovascular Imaging Editors

doi : 10.1016/j.jacc.2021.10.029

Volume 78, Issue 23, 7 December 2021, Pages 2387-2391

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Could High-Sensitivity Cardiac Troponin Testing Rule Out Acute Myocardial Infarction in the Prehospital Setting?

Jamie G.CooperMBChBJamesFergusonMBChBLorna A.DonaldsonKim M.M.BlackJudith L.HorrillMScElaine M.DavidsonMSc, PhDNeil W.ScottMSc, PhDTakeshiFujisawaPhDAndrew R.ChapmanMD, PhDNicholas L.MillsMD, PhD

doi : 10.1016/j.jacc.2021.10.004

Volume 78, Issue 23, 7 December 2021, Pages 2392-2394

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Reconsider the MitraClip for High-Risk Patients

XuanJiangMD, PhDJinduoLiuMD, PhDTianxiangGuMD, PhD

doi : 10.1016/j.jacc.2021.07.062

Volume 78, Issue 23, 7 December 2021, Page e293

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Reply: Reconsider the MitraClip for High-Risk Patients

JoannaChikweMDPatrickO’GaraMDAnnetineGelijnsPhD

doi : 10.1016/j.jacc.2021.10.002

Volume 78, Issue 23, 7 December 2021, Page e295

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Does Gestational Hypertension Contribute to Myocardial Fibrosis and Diastolic Dysfunction in Adult Offspring?

David W.J.ArmstrongMD, PhDM. YatTsePhDStephen C.PangPhD

doi : 10.1016/j.jacc.2021.09.1363

Volume 78, Issue 23, 7 December 2021, Page e297

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Reply: Does Gestational Hypertension Contribute to Myocardial Fibrosis and Diastolic Dysfunction in Adult Offspring?

Adam J.LewandowskiDPhil

doi : 10.1016/j.jacc.2021.10.003

Volume 78, Issue 23, 7 December 2021, Page e299

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