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Insulin-like Growth Factor 2 mRNA-Binding Protein 2—a Potential Link Between Type 2 Diabetes Mellitus and Cancer
Junguo Cao, Weijia Yan, Xiujian Ma, Haiyan Huang, Hong Yan
doi : 10.1210/clinem/dgab391
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2807–2818
Type 2 diabetes mellitus (T2DM) and cancer share a variety of risk factors and pathophysiological features. It is becoming increasingly accepted that the 2 diseases are related, and that T2DM increases the risk of certain malignancies.
Endocrine Dysfunction in Patients With Myotonic Dystrophy
Stephen J Winters
doi : 10.1210/clinem/dgab430
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2819–2827
Myotonic dystrophy is a dominantly inherited multisystem disorder that results from increased CTG repeats in the 3? region of the myotonic dystrophy protein kinase gene (DMPK). The mutant DMPK mRNA remains in the nucleus and sequesters RNA-binding proteins, including regulators of mRNA splicing. Myotonic dystrophy is characterized by a highly variable phenotype that includes muscle weakness and myotonia, and the disorder may affect the function of many endocrine glands. DMPK mRNA is expressed in muscle, testis, liver, pituitary, thyroid, and bone; the mutated form leads to disruption of meiosis and an increase in fetal insulin receptor-A relative to adult insulin receptor-B, resulting in adult primary testicular failure and insulin resistance predisposing to diabetes, respectively. Patients with myotonic dystrophy are also at increased risk for hyperlipidemia, nonalcoholic fatty liver disease, erectile dysfunction, benign and malignant thyroid nodules, bone fractures, miscarriage, preterm delivery, and failed labor during delivery. Circulating parathyroid hormone and adrenocorticotropic hormone levels may be elevated, but the mechanisms for these associations are unclear. This review summarizes what is known about endocrine dysfunction in individuals with myotonic dystrophy.
Association of Kidney Function With NMR-Quantified Lipids, Lipoproteins, and Metabolic Measures in Mexican Adults
Diego Aguilar-Ramirez, Jesus Alegre-Díaz, William G Herrington, Natalie Staplin, Raúl Ramirez-Reyes, Louisa Gnatiuc, Michael Hill, Frederik Romer, Jason Torres, Eirini Trichia, Rachel Wade, Rory Collins, Jonathan R Emberson, Pablo Kuri-Morales, Roberto Tapia-Conyer
doi : 10.1210/clinem/dgab497
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2828–2839
Chronic kidney disease (CKD) and diabetes are associated with dyslipidemia, metabolic abnormalities, and atherosclerotic risk. Nuclear magnetic resonance (NMR) spectroscopy provides much more detail on lipoproteins than traditional assays.
Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years
Adam Mitchell, Tove Fall, Håkan Melhus, Lars Lind, Karl Michaëlsson, Liisa Byberg
doi : 10.1210/clinem/dgab490
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2840–2854
In a cross-sectional study, we found an association between type 2 diabetes mellitus (T2DM) and smaller bone area together with greater bone mineral density (BMD) at the total hip.
Interleukin-2 Transiently Inhibits Pulsatile Growth Hormone Secretion in Young but not Older Healthy Men
Ferdinand Roelfsema, Rebecca Yang, Johannes D Veldhuis
doi : 10.1210/clinem/dgab484
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2855–2864
Interleukin-2 (IL-2), a proinflammatory cytokine, has been used to treat malignancies. Increased cortisol and adrenocorticotropin (ACTH) were noted, but growth hormone (GH) secretion was not investigated in detail.
Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age
Laura Koljonen, Maria Enlund-Cerullo, Helena Hauta-alus, Elisa Holmlund-Suila, Saara Valkama, Jenni Rosendahl, Sture Andersson, Minna Pekkinen, Outi Mäkitie
doi : 10.1210/clinem/dgab495
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2865–2875
Phosphate homeostasis and its modifiers in early childhood are inadequately characterized.
FSH Level and Changes in Bone Mass and Body Composition in Older Women and Men
Karin C Wu, Susan K Ewing, Xiaojuan Li, Sigurður Sigurðsson, Vilmundur Guðnason, Deborah M Kado, Trisha F Hue, Gina N Woods, Annegreet G Veldhuis-Vlug, Eric Vittinghoff, Mone Zaidi, Clifford J Rosen, Thomas Lang, Tiffany Y Kim, Ann V Schwartz, Anne L Schafer
doi : 10.1210/clinem/dgab481
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2876–2889
FSH may have independent actions on bone remodeling and body fat regulation. Cross-sectionally, we have shown that serum FSH is associated with bone mineral density (BMD) and body fat in older postmenopausal women, but it remains unknown whether FSH predicts bone and fat changes.
Aging, Cardiovascular Risk, and SHBG Levels in Men and Women From the General Population
Elif Aribas, Maryam Kavousi, Joop S E Laven, M Arfan Ikram, Jeanine E Roeters van Lennep
doi : 10.1210/clinem/dgab470
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2890–2900
Prior studies have reported inconsistent results for the association between sex hormone-binding globulin (SHBG) and cardiovascular disease among men and women. Although it is suggested that SHBG levels change with aging, the exact trend of SHBG across age and cardiovascular risk and the underlying mechanisms of these changes remain to be elucidated.
Brown Adipose Tissue, Adiposity, and Metabolic Profile in Preschool Children
Mya Thway Tint, Navin Michael, Suresh Anand Sadananthan, Jonathan Yinhao Huang, Chin Meng Khoo, Keith M Godfrey, Lynette Pei-Chi Shek, Ngee Lek, Kok Hian Tan, Fabian Yap, S Sendhil Velan, Peter D Gluckman, Yap-Seng Chong, Neerja Karnani, Shiao-Yng Chan, Melvin Khee-Shing Leow, Kuan Jin Lee, Yung-Seng Lee, Houchun Harry Hu, Cuilin Zhang, Marielle V Fortier, Johan G Eriksson
doi : 10.1210/clinem/dgab447
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2901–2914
An inverse relationship between brown adipose tissue (BAT) and obesity has previously been reported in older children and adults but is unknown in young children.
Mild Idiopathic Infantile Hypercalcemia—Part 1: Biochemical and Genetic Findings
Nina Lenherr-Taube, Edwin J Young, Michelle Furman, Yesmino Elia, Esther Assor, David Chitayat, Tami Uster, Susan Kirwin, Katherine Robbins, Kathleen M B Vinette, Alan Daneman, Christian R Marshall, Carol Collins, Kenneth Thummel, Etienne Sochett, Michael A Levine
doi : 10.1210/clinem/dgab431
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2915–2937
Idiopathic infantile hypercalcemia (IIH), an uncommon disorder characterized by elevated serum concentrations of 1,25 dihydroxyvitamin D (1,25(OH)2D) and low parathyroid hormone (PTH) levels, may present with mild to severe hypercalcemia during the first months of life. Biallelic variants in the CYP24A1 or SLC34A1 genes are associated with severe IIH. Little is known about milder forms.
Mild Idiopathic Infantile Hypercalcemia—Part 2: A Longitudinal Observational Study
Nina Lenherr-Taube, Michelle Furman, Esther Assor, Yesmino Elia, Carol Collins, Kenneth Thummel, Michael A Levine, Etienne Sochett
doi : 10.1210/clinem/dgab432
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2938–2948
Idiopathic infantile hypercalcemia (IIH) is an uncommon disorder with variable clinical features. The natural history and response to dietary calcium and vitamin D restriction in IIH remains unclear.
Central Insulin Modulates Dopamine Signaling in the Human Striatum
Stephanie Kullmann, Dominik Blum, Benjamin Assad Jaghutriz, Christoph Gassenmaier, Benjamin Bender, Hans-Ulrich Häring, Gerald Reischl, Hubert Preissl, Christian la Fougère, Andreas Fritsche, Matthias Reimold, Martin Heni
doi : 10.1210/clinem/dgab410
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2949–2961
Activity in the dopaminergic pathways of the brain is highly sensitive to body weight and metabolic states. Animal studies show that dopamine neurons are important targets for the metabolic hormone insulin with abolished effects in the insulin-resistant state, leading to increases in body weight and food intake. In humans, the influence of central acting insulin on dopamine and effects of their interplay are still elusive.
A High-throughput Approach to Identify Effective Systemic Agents for the Treatment of Anaplastic Thyroid Carcinoma
Ying C Henderson, Abdallah S R Mohamed, Anastasios Maniakas, Yunyun Chen, Reid T Powell, Shaohua Peng, Maria Cardenas, Michelle D Williams, Diana Bell, Mark E Zafereo, Rui Jennifer Wang, Steve E Scherer, David A Wheeler, Maria E Cabanillas, Marie-Claude Hofmann, Faye M Johnson, Clifford C Stephan, Vlad Sandulache, Stephen Y Lai
doi : 10.1210/clinem/dgab424
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2962–2978
Despite the use of aggressive multimodality treatment, most anaplastic thyroid carcinoma (ATC) patients die within a year of diagnosis. Although the combination of BRAF and MEK inhibitors has recently been approved for use in BRAF-mutated ATC, they remain effective in a minority of patients who are likely to develop drug resistance. There remains a critical clinical need for effective systemic agents for ATC with a reasonable toxicity profile to allow for rapid translational development.
Relationship Between Insulin Sensitivity and Menstrual Cycle Is Modified by BMI, Fitness, and Physical Activity in NHANES
Kirstin A MacGregor, Iain J Gallagher, Colin N Moran
doi : 10.1210/clinem/dgab415
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2979–2990
There is evidence demonstrating variation in insulin sensitivity across the menstrual cycle. However, to date, research has yielded inconsistent results.
Implication of Heterozygous Variants in Genes of the Leptin–Melanocortin Pathway in Severe Obesity
Sophie Courbage, Christine Poitou, Johanne Le Beyec-Le Bihan, Alexandra Karsenty, Julie Lemale, Véronique Pelloux, Jean-Marc Lacorte, Jean-Claude Carel, Nathalie Lecomte, Caroline Storey, Gianpaolo De Filippo, Muriel Coupaye, Jean-Michel Oppert, Patrick Tounian, Karine Clément, Béatrice Dubern
doi : 10.1210/clinem/dgab404
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2991–3006
Unlike homozygous variants, the implication of heterozygous variants on the leptin–melanocortin pathway in severe obesity has not been established.
The Cortisol and ACTH Response to Dex/CRH Testing in Women With and Without Perimenopausal Depression
Gioia M Guerrieri, Rivka Ben Dor, Xiaobai Li, Shau-Ming Wei, Pedro E Martinez, Lynnette K Neiman, David R Rubinow, Peter J Schmidt
doi : 10.1210/clinem/dgab407
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 3007–3018
Abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis are frequent accompaniments of depression, and studies have documented the role of stress and stressful life events in the ontogeny of perimenopausal depressions (PMD). Because HPA axis function in women is further modulated both by aging and ovarian steroids, it is possible that a dysregulated HPA axis contributes to the increased risk of PMD.
Exenatide, Dapagliflozin, or Phentermine/Topiramate Differentially Affect Metabolic Profiles in Polycystic Ovary Syndrome
Karen E Elkind-Hirsch, N Chappell, Ericka Seidemann, John Storment, Drake Bellanger
doi : 10.1210/clinem/dgab408
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 3019–3033
Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors reduce weight and improve insulin sensitivity via different mechanisms.
The Integration of Sex and Gender Considerations Into Biomedical Research: Lessons From International Funding Agencies
Jamie White, Cara Tannenbaum, Ineke Klinge, Londa Schiebinger, Janine Clayton
doi : 10.1210/clinem/dgab434
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 3034–3048
To improve the outcomes of research and medicine, government-based international research funding agencies have implemented various types of policies and mechanisms with respect to sex as a biological variable and gender as a sociocultural factor. After the 1990s, the US National Institutes of Health (NIH), the Canadian Institutes of Health Research (CIHR), and the European Commission (EC) began requesting that applicants address sex and gender considerations in grant proposals, and offering resources to help the scientific community integrate sex and gender into biomedical research. Although it is too early to analyze data on the success of all of the policies and mechanisms implemented, here we review the use both of carrots (incentives) and sticks (requirements) developed to motivate researchers and the entire scientific research enterprise to consider sex and gender influences on health and in science. The NIH focused on sex as a biological variable (SABV) aligned with an initiative to enhance reproducibility through rigor and transparency; CIHR instituted a sex- and gender-based analysis (SGBA) policy; and the EC required the integration of the “gender dimension,” which incorporates sex, gender, and intersectional analysis into research and innovation. Other global efforts are briefly summarized. Although we are still learning what works, we share lessons learned to improve the integration of sex and gender considerations into research. In conjunction with refining and expanding the policies of funding agencies and mechanisms, private funders/philanthropic groups, editors of peer-reviewed journals, academic institutions, professional organizations, ethics boards, health care systems, and industry also need to make concerted efforts to integrate sex and gender into research, and we all must bridge across silos to promote systemwide solutions throughout the biomedical enterprise. For example, policies that encourage researchers to disaggregate data by sex and gender, the development of tools to better measure gender effects, or policies similar to SABV and/or SGBA adopted by private funders would accelerate progress. Uptake, accountability for, and a critical appraisal of sex and gender throughout the biomedical enterprise will be crucial to achieving the goal of relevant, reproducible, replicable, and responsible science that will lead to better evidence-based, personalized care for all, but especially for women.
Examination of the Igls Criteria for Defining Functional Outcomes of ?-cell Replacement Therapy: IPITA Symposium Report
Cyril P Landstra, Axel Andres, Mikael Chetboun, Caterina Conte, Yvonne Kelly, Thierry Berney, Eelco J P de Koning, Lorenzo Piemonti, Peter G Stock, François Pattou, Marie-Christine Vantyghem, Melena D Bellin, Michael R Rickels
doi : 10.1210/clinem/dgab386
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 3049–3059
The Igls criteria were developed to provide a consensus definition for outcomes of ?-cell replacement therapy in the treatment of diabetes during a January 2017 workshop sponsored by the International Pancreas & Islet Transplant Association (IPITA) and the European Pancreas & Islet Transplant Association. In July 2019, a symposium at the 17th IPITA World Congress was held to examine the Igls criteria after 2 years in clinical practice, including validation against continuous glucose monitoring (CGM)-derived glucose targets, and to propose future refinements that would allow for comparison of outcomes with artificial pancreas system approaches.
Glucose-lowering Drugs and Hospitalization for Heart Failure: A Systematic Review and Additive-effects Network Meta-analysis With More Than 500 000 Patient-years
Riobaldo M Cintra, Ana Claudia Nogueira, Isabella Bonilha, Beatriz M Luchiari, Otavio R Coelho-Filho, Otavio R Coelho, Pedro Schwartzmann, Elza Muscellie, Wilson Nadruz, Luiz Sergio F Carvalho, Andrei C Sposito
doi : 10.1210/clinem/dgab428
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 3060–3067
Sodium glucose co-transporter 2 inhibitors (SGLT2is) prevent hospitalization resulting from heart failure (HHF). However, patients with type 2 diabetes mellitus use multiple antihyperglycemic drugs to achieve glycosylated hemoglobin (HbA1c) targets. In these drug combinations, the risk of HHF is unpredictable and so is the parallel effect of glucose-lowering.
Growth Hormone Treatment for Adults With Prader-Willi Syndrome: A Meta-Analysis
Anna G W Rosenberg, Caroline G B Passone, Karlijn Pellikaan, Durval Damiani, Aart J van der Lely, Michel Polak, Wanderley M Bernardo, Laura C G de Graaff
doi : 10.1210/clinem/dgab406
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 3068–3091
Features of Prader-Willi syndrome (PWS) overlap with features of growth hormone (GH) deficiency, like small hands and feet, short stature, increased body fat, and low muscle mass and strength. In children with PWS, GH treatment (GHt) improves physical health and cognition. GHt has become the standard of care in PWS children, but in adults this is not yet the case.
Serum Inflammation-based Scores in Endocrine Tumors
Pedro Marques, Friso de Vries, Olaf M Dekkers, Márta Korbonits, Nienke R Biermasz, Alberto M Pereira
doi : 10.1210/clinem/dgab238
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3796–e3819
Serum inflammation-based scores reflect systemic inflammatory response and/or patients’ nutritional status, and may predict clinical outcomes in cancer. While these are well-described and increasingly used in different cancers, their clinical usefulness in the management of patients with endocrine tumors is less known.
Childhood-onset Craniopharyngioma
Anna Otte, Hermann L Müller
doi : 10.1210/clinem/dgab397
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3820–e3836
Craniopharyngiomas are rare embryonic malformational tumors of the sellar/parasellar region, classified by the World Health Organization (WHO) as tumors with low-grade malignancy (WHO I). The childhood adamantinomatous subtype of craniopharyngioma is usually cystic with calcified areas. At the time of diagnosis, hypothalamic/pituitary deficits, visual disturbances, and increased intracranial pressure are major symptoms. The treatment of choice in case of favorable tumor location (without hypothalamic involvement) is complete resection. It is important to ensure that optical and hypothalamic functionality are preserved. In case of unfavorable tumor location, that is with hypothalamic involvement, a hypothalamus-sparing surgical strategy with subsequent local irradiation of residual tumor is recommended. In the further course of the disease, recurrences and progression often occur. Nevertheless, overall survival rates are high at 92%. Severe impairment of quality of life and comorbidities such as metabolic syndrome, hypothalamic obesity, and neurological consequences can be observed in patients with disease- and/or treatment-related lesions of hypothalamic structures. Childhood-onset craniopharyngioma frequently manifests as a chronic disease so that patients require lifelong, continuous care by experienced multidisciplinary teams to manage clinical and quality of life consequences. For this review, a search for original articles and reviews published between 1986 and 2020 was performed in Pubmed, Science Citation Index Expanded, EMBASE, and Scopus. The search terms used were “craniopharyngioma, hypothalamus, pituitary obesity, irradiation, neurosurgery.
DNA Methylation Changes Associated With Type 2 Diabetes and Diabetic Kidney Disease in an East Asian Population
Hakyung Kim, Jae Hyun Bae, Kyong Soo Park, Joohon Sung, Soo Heon Kwak
doi : 10.1210/clinem/dgab488
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3837–e3851
There is a growing body of evidence that epigenetic changes including DNA methylation influence the risk of type 2 diabetes (T2D) and its microvascular complications.
The Association of Gut Microbiota With Osteoporosis Is Mediated by Amino Acid Metabolism: Multiomics in a Large Cohort
Chu-wen Ling, Zelei Miao, Mian-li Xiao, Hongwei Zhou, Zengliang Jiang, Yuanqing Fu, Feng Xiong, Luo-shi-yuan Zuo, Yu-ping Liu, Yan-yan Wu, Li-peng Jing, Hong-Li Dong, Geng-dong Chen, Ding Ding, Cheng Wang, Fang-fang Zeng, Hui-lian Zhu, Yan He, Ju-Sheng Zheng, Yu-ming Chen
doi : 10.1210/clinem/dgab492
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3852–e3864
Several small studies have suggested that the gut microbiome might influence osteoporosis, but there is little evidence from human metabolomics studies to explain this association.
An Open-label Phase I/IIa Clinical Trial of 11?-HSD1 Inhibitor for Cushing’s Syndrome and Autonomous Cortisol Secretion
Satoko Oda, Kenji Ashida, Makiko Uchiyama, Shohei Sakamoto, Nao Hasuzawa, Ayako Nagayama, Lixiang Wang, Hiromi Nagata, Ryuichi Sakamoto, Junji Kishimoto, Koji Todaka, Yoshihiro Ogawa, Yoichi Nakanishi, Masatoshi Nomura
doi : 10.1210/clinem/dgab450
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3865–e3880
11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1) inhibitors demonstrate antimetabolic and antisarcopenic effects in Cushing’s syndrome (CS) and autonomous cortisol secretion (ACS) patients.
Superficial vs Deep Subcutaneous Adipose Tissue: Sex-Specific Associations With Hepatic Steatosis and Metabolic Traits
Tessa Brand, Inge Christina Lamberta van den Munckhof, Marinette van der Graaf, Kiki Schraa, Helena Maria Dekker, Leonardus Antonius Bernardus Joosten, Mihai Gheorghe Netea, Niels Peter Riksen, Jacqueline de Graaf, Joseph Henricus Wilhelmus Rutten
doi : 10.1210/clinem/dgab426
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3881–e3889
Subcutaneous adipose tissue (SAT) is not homogeneous, as the fascia scarpa separates the deep SAT (dSAT) from the superficial SAT (sSAT).
Thyroid Hormone Therapy and Incident Stroke
Maria Papaleontiou, Deborah A Levine, David Reyes-Gastelum, Sarah T Hawley, Mousumi Banerjee, Megan R Haymart
doi : 10.1210/clinem/dgab444
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3890–e3900
Stroke is a leading cause of death and disability and there is a need to identify modifiable risk factors.
Combined Indeterminate and Impaired Glucose Tolerance Is a Novel Group at High Risk of Cystic Fibrosis-Related Diabetes
Kathryn J Potter, Quitterie Reynaud, Valérie Boudreau, Florence Racine, François Tremblay, Annick Lavoie, Maite Carricart, Geneviève Mailhot, Isabelle Durieu, Peter A Senior, Rémi Rabasa-Lhoret
doi : 10.1210/clinem/dgab384
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3901–e3910
Indeterminate glycemia (INDET) and impaired glucose tolerance (IGT) are independently associated with cystic fibrosis-related diabetes (CFRD) risk. We determined whether patients meeting both criteria have increased risk of diabetes in 2 separate adult cohorts.
Avidity and Outcomes of Radioiodine Therapy for Distant Metastasis of Distinct Types of Differentiated Thyroid Cancer
Joana Simões-Pereira, Nádia Mourinho, Teresa C Ferreira, Edward Limbert, Branca Maria Cavaco, Valeriano Leite
doi : 10.1210/clinem/dgab436
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3911–e3922
The recommendations for radioactive-iodine treatment (RAIT) in metastatic differentiated thyroid cancer (DTC) are mostly based in the experience with papillary histotype and do not consider the differences within the distinct types of DTC, in terms of RAIT uptake and response.
Childhood Adiposity Associated With Expanded Effector Memory CD8+ and V?2+V?9+ T Cells
Kirsten I M Looman, Susana Santos, Henriette A Moll, Charlotte W E Leijten, Christina Grosserichter-Wagener, Trudy Voortman, Vincent V W Jaddoe, Menno C van Zelm, Jessica C Kiefte-de Jong
doi : 10.1210/clinem/dgab433
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3923–e3935
Adult obesity is associated with chronic low-grade inflammation and may give rise to future chronic disease. However, it is unclear whether adiposity-related inflammation is already apparent in childhood.
Toward a Lowest Effective Dose of Cyproterone Acetate in Trans Women: Results From the ENIGI Study
Suzanne M E Kuijpers, Chantal M Wiepjes, Elfi B Conemans, Alessandra D Fisher, Guy T’Sjoen, Martin den Heijer
doi : 10.1210/clinem/dgab427
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3936–e3945
Cyproterone acetate (CPA) is a competitive inhibitor of the androgen receptor and exerts negative hypothalamic feedback. It is often used in combination with estrogens in trans women to achieve feminization. However, CPA has been associated with side effects such as changes in liver enzyme concentrations and increases in prolactin concentrations. The question is whether the testosterone-lowering effect, as well as these side effects, are dose dependent.
Definition, Prevalence, and Risk Factors of Low Sex Hormone-Binding Globulin in US Adults
Yutang Wang
doi : 10.1210/clinem/dgab416
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3946–e3956
Lower sex hormone-binding globulin (SHBG) is associated with many diseases including cardiovascular disease, cancer, polycystic ovarian syndrome, arthritis, and liver disease. However, the definition of low SHBG and its prevalence in US adults are unknown.
New Nonalcoholic Fatty Liver Disease and Fibrosis Progression Associate With the Risk of Incident Chronic Kidney Disease
Guangmin Zuo, Liping Xuan, Zhuojun Xin, Yu Xu, Jieli Lu, Yuhong Chen, Meng Dai, Di Zhang, Weiqing Wang, Mian Li, Yufang Bi, Guang Ning, Min Xu
doi : 10.1210/clinem/dgab425
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3957–e3968
Little is known about the link between nonalcoholic fatty liver disease (NAFLD) evolution and incident chronic kidney disease (CKD).
ACTH Stimulation Maximizes the Accuracy of Peripheral Steroid Profiling in Primary Aldosteronism Subtyping
Yuta Tezuka, Kae Ishii, Lili Zhao, Yuto Yamazaki, Ryo Morimoto, Hironobu Sasano, Aaron M Udager, Fumitoshi Satoh, Adina F Turcu
doi : 10.1210/clinem/dgab420
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3969–e3978
Adrenocorticotropic hormone (ACTH) can contribute to aldosterone excess in primary aldosteronism (PA) via increased melanocortin type 2 receptor expression. Dynamic manipulation of the hypothalamic-pituitary-adrenal (HPA) axis could assist PA subtyping, but a direct comparison of dynamic tests is lacking.
Concomitant Peripheral Neuropathy and Type 2 Diabetes Impairs Postexercise Cutaneous Perfusion and Flowmotion
Cécile Reynès, Jean-Baptiste Beaume, Françoise Latil-Plat, Houda Ennaifer, Laure Rocher, Sophie Antoine-Jonville, Eric Benamo, Yannick Knapp, Agnès Vinet
doi : 10.1210/clinem/dgab414
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3979–e3989
Type 2 diabetes and peripheral neuropathy exhibit microvascular dysfunction at rest. However, data regarding their microvascular perfusion during exercise remain scarce.
Cognitive and White Matter Microstructure Development in Congenital Hypothyroidism and Familial Thyroid Disorders
Katia Perri, Letizia De Mori, Domenico Tortora, Maria Grazia Calevo, Anna E M Allegri, Flavia Napoli, Giuseppa Patti, Daniela Fava, Marco Crocco, Maurizio Schiavone, Emilio Casalini, Mariasavina Severino, Andrea Rossi, Natascia Di Iorgi, Roberto Gastaldi, Mohamad Maghnie
doi : 10.1210/clinem/dgab412
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e3990–e4006
Children with congenital hypothyroidism (CH) are at risk for suboptimal neurodevelopment.
Use of Continuous Glucose Monitor in Critically Ill COVID-19 Patients Requiring Insulin Infusion: An Observational Study
Eileen R Faulds, Andrew Boutsicaris, Lyndsey Sumner, Laureen Jones, Molly McNett, Keaton S Smetana, Casey C May, Elizabeth Buschur, Matthew C Exline, Matthew D Ringel, Kathleen Dungan
doi : 10.1210/clinem/dgab409
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4007–e4016
The coronavirus disease 2019 (COVID-19) pandemic has created a need for remote blood glucose (BG) monitoring in the intensive care unit (ICU).
Calcifediol Treatment and COVID-19–Related Outcomes
Xavier Nogues, Diana Ovejero, Marta Pineda-Moncusí, Roger Bouillon, Dolors Arenas, Julio Pascual, Anna Ribes, Robert Guerri-Fernandez, Judit Villar-Garcia, Abora Rial, Carme Gimenez-Argente, Maria Lourdes Cos, Jaime Rodriguez-Morera, Isabel Campodarve, José Manuel Quesada-Gomez, Natalia Garcia-Giralt
doi : 10.1210/clinem/dgab405
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4017–e4027
COVID-19 is a major health problem because of saturation of intensive care units (ICU) and mortality. Vitamin D has emerged as a potential treatment able to reduce the disease severity.
Correlation Between Plasma Catecholamines, Weight, and Diabetes in Pheochromocytoma and Paraganglioma
Lauren N Krumeich, Andrew J Cucchiara, Katherine L Nathanson, Rachel R Kelz, Lauren Fishbein, Douglas L Fraker, Robert E Roses, Debbie L Cohen, Heather Wachtel
doi : 10.1210/clinem/dgab401
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4028–e4038
Pheochromocytomas and paragangliomas (PCC/PGL) are neuroendocrine tumors with discrete catecholamine profiles that cause incompletely understood metabolic and physiologic changes.
Association Between Serum 25-hydroxyvitamin D Concentrations and Mortality Among Adults With Prediabetes
Qi Lu, Zhenzhen Wan, Jingyu Guo, Liegang Liu, An Pan, Gang Liu
doi : 10.1210/clinem/dgab402
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4039–e4048
To investigate the association of circulating 25-hydroxyvitamin D [25(OH)D] levels with mortality among adults with prediabetes.
Time Course of Metabolic, Neuroendocrine, and Adipose Effects During 2 Years of Follow-up After Gastric Bypass in Patients With Type 2 Diabetes
Kristina E Almby, Petros Katsogiannos, Maria J Pereira, F Anders Karlsson, Magnus Sundbom, Urban Wiklund, Prasad G Kamble, Jan W Eriksson
doi : 10.1210/clinem/dgab398
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4049–e4061
Roux-en-Y gastric bypass surgery (RYGB) markedly improves glycemia in patients with type 2 diabetes (T2D), but underlying mechanisms and changes over time are incompletely understood.
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German Tapia, Tommi Suvitaival, Linda Ahonen, Nicolai A Lund-Blix, Pål R Njølstad, Geir Joner, Torild Skrivarhaug, Cristina Legido-Quigley, Ketil Størdal, Lars C Stene
doi : 10.1210/clinem/dgab400
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4062–e4071
Genetic markers are established as predictive of type 1 diabetes, but unknown early life environment is believed to be involved. Umbilical cord blood may reflect perinatal metabolism and exposures. We studied whether selected polar metabolites in cord blood contribute to prediction of type 1 diabetes.
Whole Tumor Capsule Is Prognostic of Very Good Outcome in the Classical Variant of Papillary Thyroid Cancer
Carlotta Giani, Liborio Torregrossa, Teresa Ramone, Cristina Romei, Antonio Matrone, Eleonora Molinaro, Laura Agate, Gabriele Materazzi, Paolo Piaggi, Clara Ugolini, Fulvio Basolo, Raffaele Ciampi, Rossella Elisei
doi : 10.1210/clinem/dgab396
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4072–e4083
Tumor capsule integrity is becoming a relevant issue to predict the biological behavior of human tumors, including thyroid cancer.
GCM2 Silencing in Parathyroid Adenoma Is Associated With Promoter Hypermethylation and Gain of Methylation on Histone 3
Priyanka Singh, Sanjay Kumar Bhadada, Divya Dahiya, Uma Nahar Saikia, Ashutosh Kumar Arya, Naresh Sachdeva, Jyotdeep Kaur, Arunanshu Behera, Maria Luisa Brandi, Sudhaker Dhanwada Rao
doi : 10.1210/clinem/dgab374
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4084–e4096
Glial cells missing 2 (GCM2), a zinc finger-transcription factor, is essentially required for the development of the parathyroid glands.
Associations Between Fruit Intake and Risk of Diabetes in the AusDiab Cohort
Nicola P Bondonno, Raymond J Davey, Kevin Murray, Simone Radavelli-Bagatini, Catherine P Bondonno, Lauren C Blekkenhorst, Marc Sim, Dianna J Magliano, Robin M Daly, Jonathan E Shaw, Joshua R Lewis, Jonathan M Hodgson
doi : 10.1210/clinem/dgab335
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4097–e4108
Fruit, but not fruit juice, intake is inversely associated with type 2 diabetes mellitus (T2DM). However, questions remain about the mechanisms by which fruits may confer protection.
Tall cell percentage alone in PTC without aggressive features should not guide patients’ clinical management
Anello Marcello Poma, David Viola, Elisabetta Macerola, Agnese Proietti, Eleonora Molinaro, Dario De Vietro, Rossella Elisei, Gabriele Materazzi, Paolo Miccoli, Fulvio Basolo, Clara Ugolini
doi : 10.1210/clinem/dgab388
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4109–e4117
Recent diagnostic criteria updates of the tall cell variant of papillary thyroid carcinoma (TCPTC) by the World Health Organization (WHO) have determined the inclusion of tumors with 30% to 49% of tall cells. However, the impact of tall cell percentage on papillary thyroid carcinoma (PTC) patients’ prognosis is still debated.
Maternal Midpregnancy Leptin and Adiponectin Levels as Predictors of Autism Spectrum Disorders: A Prenatal Cohort Study
Kyoung Eun Joung, Sheryl L Rifas-Shiman, Emily Oken, Christos S Mantzoros
doi : 10.1210/clinem/dgab378
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4118–e4127
Autism spectrum disorders (ASDs) are a group of conditions characterized by impaired social function and repetitive behaviors. Their etiology is largely unknown.
Association of Gut Microbiota during Early Pregnancy with Risk of Incident Gestational Diabetes Mellitus
Ping Hu, Xiuyi Chen, Xufeng Chu, Mengran Fan, Yi Ye, Yi Wang, Maozhen Han, Xue Yang, Jiaying Yuan, Li Zha, Bin Zhao, Chun-Xia Yang, Xiao-Rong Qi, Kang Ning, Justin Debelius, Weimin Ye, Bo Xiong, Xiong-Fei Pan, An Pan
doi : 10.1210/clinem/dgab346
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4128–e4141
We aimed to assess the association between gut bacterial biomarkers during early pregnancy and subsequent risk of gestational diabetes mellitus (GDM) in Chinese pregnant women.
Dysgenesis and Dysfunction of the Pancreas and Pituitary Due to FOXA2 Gene Defects
Sare Betul Kaygusuz, Esra Arslan Ates, Maria Lillina Vignola, Burcu Volkan, Bilgen Bilge Geckinli, Serap Turan, Abdullah Bereket, Carles Gaston-Massuet, Tulay Guran
doi : 10.1210/clinem/dgab352
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4142–e4154
Developmental disorders of the pituitary gland leading to congenital hypopituitarism can either be isolated or associated with extrapituitary abnormalities (syndromic hypopituitarism). A large number of syndromic hypopituitarism cases are linked to mutations in transcription factors. The forkhead box A2 (FOXA2) is a transcription factor that plays a key role in the central nervous system, foregut, and pancreatic development.
The Duration of Denosumab Treatment and the Efficacy of Zoledronate to Preserve Bone Mineral Density After Its Discontinuation
Polyzois Makras, Natasha M Appelman-Dijkstra, Socrates E Papapoulos, Sandra van Wissen, Elizabeth M Winter, Stergios A Polyzos, Maria P Yavropoulou, Athanasios D Anastasilakis
doi : 10.1210/clinem/dgab321
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4155–e4162
Zoledronate is used to prevent bone loss following denosumab discontinuation but its efficacy differs among studies.
Leptin Decreases Energy Expenditure Despite Increased Thyroid Hormone in Patients With Lipodystrophy
Andrew Grover, Emmanuel Quaye, Robert J Brychta, John Christensen, Megan S Startzell, Cristina Adelia Meehan, Areli Valencia, Brandon Marshall, Kong Y Chen, Rebecca J Brown
doi : 10.1210/clinem/dgab269
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4163–e4178
Leptin is an adipokine that signals energy sufficiency. In rodents, leptin deficiency decreases energy expenditure (EE), which is corrected following leptin replacement. In humans, data are mixed regarding leptin-mediated effects on EE.
Effects of Behavioral Weight Loss and Metformin on IGFs in Cancer Survivors: A Randomized Trial
Hsin-Chieh Yeh, Nisa M Maruthur, Nae-Yuh Wang, Gerald J Jerome, Arlene T Dalcin, Eva Tseng, Karen White, Edgar R Miller, III, Stephen P Juraschek, Noel T Mueller, Jeanne Charleston, Nowella Durkin, Ahmed Hassoon, Dina G Lansey, Norma F Kanarek, Michael A Carducci, Lawrence J Appel
doi : 10.1210/clinem/dgab266
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4179–e4191
Higher levels of insulin-like growth factor-1 (IGF-1) are associated with increased risk of cancers and higher mortality. Therapies that reduce IGF-1 have considerable appeal as means to prevent recurrence.
Foregut Exclusion Enhances Incretin and Insulin Secretion After Roux-en-Y Gastric Bypass in Adults With Type 2 Diabetes
John P Kirwan, Christopher L Axelrod, Emily L Kullman, Steven K Malin, Wagner S Dantas, Kathryn Pergola, Juan Pablo del Rincon, Stacy A Brethauer, Sangeeta R Kashyap, Philip R Schauer
doi : 10.1210/clinem/dgab255
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4192–e4201
Patients with type 2 diabetes experience resolution of hyperglycemia within days after Roux-en-Y gastric bypass (RYGB) surgery. This is attributed, in part, to enhanced secretion of hindgut factors following exclusion of the gastric remnant and proximal intestine during surgery. However, evidence of the mechanisms of remission remain limited due to the challenges of metabolic evaluation during the early postoperative period. The purpose of this investigation was to determine the role of foregut exclusion in the resolution of type 2 diabetes after RYGB.
Utility of 18F-AlF-NOTA-Octreotide PET/CT in the Localization of Tumor-Induced Osteomalacia
Tingting Long, Jiale Hou, Nengan Yang, Ming Zhou, Yulai Li, Jian Li, Yongxiang Tang, Dengming Chen, Shuo Hu
doi : 10.1210/clinem/dgab258
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4202–e4209
Tumor-induced osteomalacia (TIO) is a paraneoplastic disorder, usually caused by benign mesenchymal tumors that produce high levels of fibroblast growth factor 23. The only curative therapy is resection of the causative tumors.
Predictive Value of Serum Lipid for Intravenous Immunoglobulin Resistance and Coronary Artery Lesion in Kawasaki Disease
Shuran Shao, Kaiyu Zhou, Xiaoliang Liu, Lei Liu, Mei Wu, Yuxin Deng, Hongyu Duan, Yifei Li, Yimin Hua, Chuan Wang
doi : 10.1210/clinem/dgab230
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4210–e4220
Intravenous immunoglobulin (IVIG) resistance and coronary artery lesions (CALs) prediction are pivotal topic of interests in Kawasaki disease (KD). However, data on the predictive value of lipid profile for both IVIG resistance and CALs are limited.
Psychological Distress and Sleep Disturbance Throughout Thyroid Nodule Screening, Diagnosis, and Treatment
Ruicen Li, Genpeng Li, Yuting Wang, Ting Bao, Yali Lei, Liuyan Tian, Zhihui Li, Jingqiang Zhu, Jianyong Lei, Huairong Tang
doi : 10.1210/clinem/dgab224
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4221–e4230
Many controversies exist regarding screening and treatment of thyroid cancer (TC), especially papillary thyroid microcarcinoma (PTMC).
Health-Related Quality of Life in Patients With Early-Detected Central Congenital Hypothyroidism
Jolanda C Naafs, Jan Pieter Marchal, Paul H Verkerk, Eric Fliers, A S Paul van Trotsenburg, Nitash Zwaveling-Soonawala
doi : 10.1210/clinem/dgab209
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4231–e4241
Central congenital hypothyroidism (CH) requires lifelong medical treatment. The majority of children with central CH have multiple pituitary hormone deficiencies (MPHD), but in some cases central CH is isolated. Most pituitary hormone deficiencies are associated with impaired health-related quality of life (HRQoL). However, studies on HRQoL in central CH are lacking.
Predictors of Bilateral Disease in Pediatric Differentiated Thyroid Cancer
Christine E Cherella, Danielle M Richman, Enju Liu, Mary C Frates, Biren P Modi, Benjamin Zendejas, Jessica R Smith, Justine A Barletta, Monica L Hollowell, Ari J Wassner
doi : 10.1210/clinem/dgab210
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4242–e4250
Total thyroidectomy is recommended for children with papillary thyroid carcinoma, partly because of a high prevalence of bilateral disease. Identifying characteristics that predict bilateral disease might identify candidates for more limited surgery.
Causal Association Between Serum Thyrotropin and Obesity: A Bidirectional, Mendelian Randomization Study
Xichang Wang, Xiaotong Gao, Yutong Han, Fan Zhang, Zheyu Lin, Hong Wang, Weiping Teng, Zhongyan Shan
doi : 10.1210/clinem/dgab183
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4251–e4259
The association between serum thyrotropin (TSH) and obesity traits has been investigated previously in several epidemiological studies. However, the underlying causal association has not been established.
Association Between Midlife Obesity and Its Metabolic Consequences, Cerebrovascular Disease, and Cognitive Decline
Filip Morys, Mahsa Dadar, Alain Dagher
doi : 10.1210/clinem/dgab135
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4260–e4274
Chronic obesity is associated with several complications, including cognitive impairment and dementia. However, we have only piecemeal knowledge of the mechanisms linking obesity to central nervous system damage. Among candidate mechanisms are other elements of obesity-associated metabolic syndrome, such as hypertension, dyslipidemia, and diabetes, but also systemic inflammation. While there have been several neuroimaging studies linking adiposity to changes in brain morphometry, a comprehensive investigation of the relationship has so far not been done.
Targeting Elevated GnRH Pulsatility to Treat Polycystic Ovary Syndrome
Ali Abbara, Waljit S Dhillo
doi : 10.1210/clinem/dgab422
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4275–e4277
Breaking Down or Waking Up? Psychological Distress and Sleep Disturbance in Patients With Thyroid Nodules and Cancer
Susan C Pitt, Megan R Haymart
doi : 10.1210/clinem/dgab319
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4278–e4280
The Association Between Obesity and the Thyroid: Is the “Chicken or the Egg” Conundrum Finally Solved?
Gabriela Brenta
doi : 10.1210/clinem/dgab291
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4281–e4283
Half the Body in One Model: How Obesity Impacts the Brain
Henning Tiemeier
doi : 10.1210/clinem/dgab247
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4284–e4286
Inherited Risk Factors for Nonmedullary Thyroid Carcinoma
Carl D Malchoff
doi : 10.1210/clinem/dgab185
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4287–e4289
Letter to the Editor from Xu and Yang: “Laser Ablation Versus Radiofrequency Ablation for Thyroid Nodules: 12-Month Results of a Randomized Trial (LARA II Study)”
Shijie Yang, Xiequn Xu
doi : 10.1210/clinem/dgab491
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4290–e4291
Letter to the Editor from Rui Zhu et al: “Performance of the Aldosterone-to-Renin Ratio as a Screening Test for Primary Aldosteronism: A Systematic Review and Meta-Analysis”
Rui Zhu, Tungalagtamir Shagjaa, Teresa Maria Seccia, Gian Paolo Rossi
doi : 10.1210/clinem/dgab485
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4292–e4293
Letter to the Editor from Dr Nicholas Fuller: “Metabolic Impact of Intermittent Fasting in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Interventional Studies”
Nicholas R Fuller
doi : 10.1210/clinem/dgab418
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4294–e4295
Letter to the Editor From Grill et al: “Islet Function and Insulin Sensitivity in Latent Autoimmune Diabetes in Adults Taking Sitagliptin: A Randomized Trial”
Valdemar Grill, Anneli Björklund, Ingrid Hals
doi : 10.1210/clinem/dgab411
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4296–e4297
Letter to the Editor from McKee and McGill: “Glycemic Control and Variability of Diabetes Secondary to Total Pancreatectomy Assessed by Continuous Glucose Monitoring”
Alexis M McKee, Janet B McGill
doi : 10.1210/clinem/dgab220
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4298–e4299
Response Letter to the Editor from Zhu et al: “Performance of the Aldosterone-to-Renin Ratio as a Screening Test for Primary Aldosteronism: A Systematic Review and Meta-Analysis”
Gregory L Hundemer, Gregory A Kline, Alexander A Leung
doi : 10.1210/clinem/dgab486
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4300–e4301
Response to Letter to the Editor from Varady et al: “Metabolic Impact of Intermittent Fasting in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Interventional Studies”
Emily Borgundvaag, Jessica Mak, Caroline K Kramer
doi : 10.1210/clinem/dgab299
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4302–e4303
Response to the Letter to the Editor from Valdemar Grill et al: “Islet Function and Insulin Sensitivity in Latent Autoimmune Diabetes in Adults Taking Sitagliptin: A Randomized Trial”
Huiying Liang, Lin Yang, Xiangbing Wang, Zhiguang Zhou
doi : 10.1210/clinem/dgab413
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4304–e4305
Response to the Letter to the Editor from Fuller: “Metabolic Impact of Intermittent Fasting in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Interventional Studies”
Emily Borgundvaag, Jessica Mak, Caroline K Kramer
doi : 10.1210/clinem/dgab419
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Page e4306
Response to Letter to the Editor from McKee and McGill: “Glycemic Control and Variability of Diabetes Secondary to Total Pancreatectomy Assessed by Continuous Glucose Monitoring”
Caroline T B Juel, Thomas F Dejgaard, Carsten P Hansen, Jan H Storkholm, Tina Vilsbøll, Asger Lund, Filip K Knop
doi : 10.1210/clinem/dgab221
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages e4307–e4308
