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Hospital networks and patient transport capacity during the COVID-19 pandemic when intensive care resources become scarce
Alexander Supady, Dawid Staudacher, Christoph Bode, Guido Michels, Tobias Wengenmayer
doi : 10.1186/s13054-021-03462-3
Crit Care. 2021; 25: 28. Published online 2021 Jan 12.
Utility of AI models in critical care: union of man and the machine
Amos Lal, Vitaly Herasevich, Ognjen Gajic
doi : 10.1186/s13054-021-03478-9
Crit Care. 2021; 25: 46. Published online 2021 Feb 2.
Use of the lung ultrasound score in monitoring COVID-19 patients: it’s time for a reappraisal
Luigi Vetrugno, Daniele Orso, Cristian Deana, Flavio Bassi, Gianmaria Cammarota, Tiziana Bove
doi : 10.1186/s13054-021-03483-y
Crit Care. 2021; 25: 47. Published online 2021 Feb 3.
Letter on “(1,3)-?-d-Glucan-based empirical antifungal interruption in suspected invasive candidiasis: a randomized trial”
Antonios Kritikos, Frederic Lamoth
doi : 10.1186/s13054-020-03450-z
Crit Care. 2021; 25: 55. Published online 2021 Feb 9.
Septic shock, noradrenaline requirements and alpha-2 agonists: Fishing in the right pond?
Auguste Dargent, Luc Quintin, Jean-Pierre Quenot
doi : 10.1186/s13054-020-03377-5
Crit Care. 2021; 25: 56. Published online 2021 Feb 9.
Epinephrine’s effects on cerebrovascular and systemic hemodynamics during cardiopulmonary resuscitation: metabolic changes may limit the persistence of the effect
Romain Jouffroy, Benoît Vivien
doi : 10.1186/s13054-020-03378-4
Crit Care. 2021; 25: 67. Published online 2021 Feb 16.
Reduced gastric acidity, proton pump inhibitors and increased severity of COVID-19 infections
Elizabeth Price, David F. Treacher
doi : 10.1186/s13054-021-03497-6
Crit Care. 2021; 25: 73. Published online 2021 Feb 18.
Closed-loop circuit for reduce oxygen waste on hollow-fiber oxygenators during extracorporeal technologies
Ignazio Condello, Flavio Rimmaudo, Giuseppe Speziale
doi : 10.1186/s13054-021-03514-8
Crit Care. 2021; 25: 85. Published online 2021 Feb 25.
Towards use of POCUS to evaluate hemodynamics in critically ill neonates: caution before adoption in this population
Patrick J. McNamara, Piers Barker, Amish Jain, Wyman W. Lai
doi : 10.1186/s13054-020-03394-4
Crit Care. 2021; 25: 92. Published online 2021 Mar 3.
Early rehabilitation in ICU for COVID-19: what about FES-cycling?
Gaëlle Deley, Davy Laroche, Jean-Pierre Quenot
doi : 10.1186/s13054-021-03526-4
Crit Care. 2021; 25: 94. Published online 2021 Mar 8.
Letter to the editor regarding “Accelerated versus standard initiation of renal replacement therapy for critically ill patients with acute kidney injury: a systematic review and meta-analysis of RCT studies”
Kate Magner, Edward Clark, Swapnil Hiremath
doi : 10.1186/s13054-021-03528-2
Crit Care. 2021; 25: 96. Published online 2021 Mar 9.
Extracorporeal myoglobin removal in severe rhabdomyolysis with high cut-off membranes—intermittent dialysis achieves much greater clearances than continuous methods
Jakob Gubensek, Vanja Persic, Alexander Jerman, Vladimir Premru
doi : 10.1186/s13054-021-03531-7
Crit Care. 2021; 25: 97. Published online 2021 Mar 9.
Prone mechanical ventilation in acute brain injury
Varun Suresh, Saurabh Sharma
doi : 10.1186/s13054-021-03530-8
Crit Care. 2021; 25: 100. Published online 2021 Mar 10.
D-dimer specificity and clinical context: an old unlearned story
Matteo Marin, Daniele Orso, Nicola Federici, Luigi Vetrugno, Tiziana Bove
doi : 10.1186/s13054-021-03532-6
Crit Care. 2021; 25: 101. Published online 2021 Mar 10.
Letter to the Editor: Stroke volume is the key measure of fluid responsiveness
Jon-Emile S. Kenny, Igor Barjaktarevic
doi : 10.1186/s13054-021-03498-5
Crit Care. 2021; 25: 104. Published online 2021 Mar 15.
Goal-directed therapy in the perioperative management: is a complete hemodynamics bundle of care better?
Nicolas Herzog, Jean-Baptiste Dablin, Christophe Giacardi, Marc Danguy des Déserts
doi : 10.1186/s13054-021-03527-3
Crit Care. 2021; 25: 105. Published online 2021 Mar 16.
Lung compartmentalization of inflammatory biomarkers in COVID-19-related ARDS
Youenn Jouan, Thomas Baranek, Mustapha Si-Tahar, Christophe Paget, Antoine Guillon
doi : 10.1186/s13054-021-03513-9
Crit Care. 2021; 25: 120. Published online 2021 Mar 24.
Re: Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs (Friedrichson et al., Critical Care, January 2021)
Alex Warren, Luigi Camporota, Stephane Ledot, Ian Scott, Alain Vuylsteke
doi : 10.1186/s13054-021-03529-1
Crit Care. 2021; 25: 123. Published online 2021 Mar 26.
Comments on ‘Comparison of anticoagulation strategies for veno-venous ECMO support in acute respiratory failure’: the bitter truth about unfractionated heparin monitoring assays
Mouhamed Djahoum Moussa, Osama Abou-Arab, Emmanuel Robin, André Vincentelli
doi : 10.1186/s13054-021-03525-5
Crit Care. 2021; 25: 124. Published online 2021 Mar 29.
Fast recovery of cardiac function in PIMS-TS patients early using intravenous anti-IL-1 treatment
Maria Vincenza Mastrolia, Edoardo Marrani, Giovanni Battista Calabri, Manuela L’Erario, Ilaria Maccora, Silvia Favilli, Pier Paolo Duchini, Ilaria Pagnini, Gabriele Simonini
doi : 10.1186/s13054-021-03548-y
Crit Care. 2021; 25: 131. Published online 2021 Apr 7.
The prone position must accommodate changes in IAP in traumatic brain injury patients
Wojciech Dabrowski, Dorota Siwicka-Gieroba, Chiara Robba, Rafael Badenes, Manu L. N. G. Malbrain
doi : 10.1186/s13054-021-03506-8
Crit Care. 2021; 25: 132. Published online 2021 Apr 7.
Comments on “Right ventricular failure in septic shock: characterization, incidence and impact on fluid responsiveness”: which parameter to assess right ventricular failure and venous congestion?
Osama Abou-Arab, Mouhamed D. Moussa, Christophe Beyls, Yazine Mahjoub
doi : 10.1186/s13054-021-03473-0
Crit Care. 2021; 25: 136. Published online 2021 Apr 9.
Iron Deficiency Defined by Hepcidin in Critically Ill Patients
Michele F. Eisenga
doi : 10.1186/s13054-021-03542-4
Crit Care. 2021; 25: 138. Published online 2021 Apr 12.
PEEP-induced alveolar recruitment in patients with COVID-19 pneumonia: take the right time!
Gianmaria Cammarota, Rachele Simonte, Edoardo De Robertis
doi : 10.1186/s13054-021-03573-x
Crit Care. 2021; 25: 163. Published online 2021 Apr 30.
Comparison between first and second wave among critically ill COVID-19 patients admitted to a French ICU: no prognostic improvement during the second wave?
Damien Contou, Megan Fraissé, Olivier Pajot, Jo-Anna Tirolien, Hervé Mentec, Gaëtan Plantefève
doi : 10.1186/s13054-020-03449-6
Crit Care. 2021; 25: 3. Published online 2021 Jan 4.
Carboxyhemoglobin, a reliable diagnosis biomarker for hemolysis in intensive care unit: a retrospective study
Geoffroy Hariri, Kyann Hodjat Panah, Bénédicte Beneteau-Burnat, Michael Chaquin, Arsene Mekinian, Hafid Ait-Oufella
doi : 10.1186/s13054-020-03437-w
Crit Care. 2021; 25: 7. Published online 2021 Jan 5.
Endotracheal aspirates contain a limited number of lower respiratory tract immune cells
Marika Orlov, Eric D. Morrell, Victoria Dmyterko, Jessica A. Hamerman, Mark M. Wurfel, Carmen Mikacenic
doi : 10.1186/s13054-020-03432-1
Crit Care. 2021; 25: 14. Published online 2021 Jan 6.
Can prone positioning be a safe procedure in patients with acute brain injury and moderate-to-severe acute respiratory distress syndrome?
Pauline Bernon, Ségolène Mrozek, Guillaume Dupont, Frédéric Dailler, Anne-Claire Lukaszewicz, Baptiste Balança
doi : 10.1186/s13054-020-03454-9
Crit Care. 2021; 25: 30. Published online 2021 Jan 18.
Rate control in atrial fibrillation using Landiolol is safe in critically ill Covid-19 patients
Geoffroy Hariri, Tomas Urbina, Sandie Mazerand, Naike Bige, Jean-Luc Baudel, Hafid Ait-Oufella
doi : 10.1186/s13054-021-03470-3
Crit Care. 2021; 25: 33. Published online 2021 Jan 22.
Lung ultrasound can predict response to the prone position in awake non-intubated patients with COVID?19 associated acute respiratory distress syndrome
Sergey N. Avdeev, Galina V. Nekludova, Natalia V. Trushenko, Natalia A. Tsareva, Andrey I. Yaroshetskiy, Djuro Kosanovic
doi : 10.1186/s13054-021-03472-1
Crit Care. 2021; 25: 35. Published online 2021 Jan 25.
Severe acute kidney injury associated with progression of chronic kidney disease after critical COVID-19
Michael Hultstr?m, Miklos Lipcsey, Ewa Wallin, Ing-Marie Larsson, Anders Larsson, Robert Frithiof
doi : 10.1186/s13054-021-03461-4
Crit Care. 2021; 25: 37. Published online 2021 Jan 25.
YKL-40 as a new promising prognostic marker of severity in COVID infection
Lauranne Schoneveld, Aurélie Ladang, Monique Henket, Anne-Noëlle Frix, Etienne Cavalier, Julien Guiot, the COVID-19 clinical investigators of the CHU de Liège
doi : 10.1186/s13054-020-03383-7
Crit Care. 2021; 25: 66. Published online 2021 Feb 16.
Case fatality ratio of COVID-19 patients requiring invasive mechanical ventilation in Mexico: an analysis of nationwide data
Silvio A. ?amendys-Silva
doi : 10.1186/s13054-021-03485-w
Crit Care. 2021; 25: 68. Published online 2021 Feb 16.
Factors influencing local signs at catheter insertion site regardless of catheter-related bloodstream infections
Niccol? Buetti, Stéphane Ruckly, Jean-Christophe Lucet, Olivier Mimoz, Bertrand Souweine, Jean-François Timsit
doi : 10.1186/s13054-021-03490-z
Crit Care. 2021; 25: 71. Published online 2021 Feb 17.
Causes and timing of death in critically ill COVID-19 patients
Damien Contou, Radj Cally, Florence Sarfati, Paul Desaint, Megan Fraissé, Gaëtan Plantefève
doi : 10.1186/s13054-021-03492-x
Crit Care. 2021; 25: 79. Published online 2021 Feb 23.
Effects of surgical masks on droplet dispersion under various oxygen delivery modalities
Takahiro Takazono, Kazuko Yamamoto, Ryuta Okamoto, Shimpei Morimoto, Koichi Izumikawa, Hiroshi Mukae
doi : 10.1186/s13054-021-03512-w
Crit Care. 2021; 25: 89. Published online 2021 Feb 27.
Survival after extracorporeal membrane oxygenation in severe COVID-19 ARDS: results from an international multicenter registry
Alexander Supady, Fabio Silvio Taccone, Philipp M. Lepper, Stephan Ziegeler, Dawid L. Staudacher, for the COVEC-Study Group
doi : 10.1186/s13054-021-03486-9
Crit Care. 2021; 25: 90. Published online 2021 Mar 1.
Renin–angiotensin system dysregulation in critically ill patients with acute respiratory distress syndrome due to COVID-19: a preliminary report
Davide Eleuteri, Luca Montini, Salvatore Lucio Cutuli, Cristina Rossi, Francesca Alcaro, Massimo Antonelli
doi : 10.1186/s13054-021-03507-7
Crit Care. 2021; 25: 91. Published online 2021 Mar 1.
Impact of withholding early parenteral nutrition in adult critically ill patients on ketogenesis in relation to outcome
Astrid De Bruyn, Lies Langouche, Sarah Vander Perre, Jan Gunst, Greet Van den Berghe
doi : 10.1186/s13054-021-03519-3
Crit Care. 2021; 25: 102. Published online 2021 Mar 11.
Noninvasive sampling of the distal airspace via HME-filter fluid is not useful to detect SARS-CoV-2 in intubated patients
Joerg Reifart, Christoph Liebetrau, Christian Troidl, Katharina Madlener, Andreas Rolf
doi : 10.1186/s13054-021-03549-x
Crit Care. 2021; 25: 126. Published online 2021 Mar 30.
Cerebral venous sinus thrombosis associated with thrombocytopenia post-vaccination for COVID-19
Gian Paolo Castelli, Claudio Pognani, Carlo Sozzi, Massimo Franchini, Luigi Vivona
doi : 10.1186/s13054-021-03572-y
Crit Care. 2021; 25: 137. Published online 2021 Apr 12.
Necrotizing soft-tissue infections in pediatric intensive care: a prospective multicenter case-series study
Stéphane Dauger, Renaud Blondé, Olivier Brissaud, Marie-Odile Marcoux, François Angoulvant, Michael Levy, Groupe Francophone de Réanimation et Urgences Pédiatriques (GFRUP), Réseau Mères-Enfants de la Francophonie (RMEF)
doi : 10.1186/s13054-021-03562-0
Crit Care. 2021; 25: 139. Published online 2021 Apr 12.
A practical integrated radiomics model predicting intensive care hospitalization in COVID-19
Chiara Giraudo, Giovanni Frattin, Giulia Fichera, Raffaella Motta, Roberto Stramare
doi : 10.1186/s13054-021-03564-y
Crit Care. 2021; 25: 145. Published online 2021 Apr 14.
Toward the personalized and integrative management of voriconazole dosing during COVID-19-associated pulmonary aspergillosis
Brendan Le Daré, Christelle Boglione-Kerrien, Florian Reizine, Jean-Pierre Gangneux, Astrid Bacle
doi : 10.1186/s13054-021-03568-8
Crit Care. 2021; 25: 152. Published online 2021 Apr 20.
Elevated carboxyhaemoglobin as a novel indicator for extracorporeal membrane haemolysis and oxygenator exchange
Kenneth R. Hoffman, Aidan J. C. Burrell, Arne Diehl, Warwick Butt
doi : 10.1186/s13054-021-03582-w
Crit Care. 2021; 25: 159. Published online 2021 Apr 27.
Extracorporeal membrane oxygenation in non-intubated immunocompromised patients
Klaus Stahl, Heiko Schenk, Christian Kühn, Olaf Wiesner, Marius M. Hoeper, Sascha David
doi : 10.1186/s13054-021-03584-8
Crit Care. 2021; 25: 164. Published online 2021 Apr 30.
Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”
Daniel Agustin Godoy, Rafael Badenes, Paolo Pelosi, Chiara Robba
doi : 10.1186/s13054-020-03452-x
Crit Care. 2021; 25: 19. Published online 2021 Jan 6.
Maintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achieving these goals. Ketamine is an agent with attractive pharmacological and pharmacokinetics characteristics. Current evidence shows that ketamine does not increase and may instead decrease intracranial pressure, and its safety profile makes it a reliable tool in the prehospital environment. In this point of view, we discuss different aspects of the use of ketamine in the acute phase of TBI, with its potential benefits and pitfalls.
COVID-19: What we’ve done well and what we could or should have done better—the 4 Ps
Jean-Louis Vincent, Julia Wendon, Greg S. Martin, Nicole P. Juffermans, Jacques Creteur, Maurizio Cecconi
doi : 10.1186/s13054-021-03467-y
Crit Care. 2021; 25: 40. Published online 2021 Jan 28.
The current coronavirus pandemic has impacted heavily on ICUs worldwide. Although many hospitals and healthcare systems had plans in place to manage multiple casualties as a result of major natural disasters or accidents, there was insufficient preparation for the sudden, massive influx of severely ill patients with COVID-19. As a result, systems and staff were placed under immense pressure as everyone tried to optimize patient management. As the pandemic continues, we must apply what we have learned about our response, both good and bad, to improve organization and thus patient care in the future.
Long-term outcomes after critical illness: recent insights
Anne-Françoise Rousseau, Hallie C. Prescott, Stephen J. Brett, Bj?rn Weiss, Elie Azoulay, Jacques Creteur, Nicola Latronico, Catherine L. Hough, Steffen Weber-Carstens, Jean-Louis Vincent, Jean-Charles Preiser
doi : 10.1186/s13054-021-03535-3
Crit Care. 2021; 25: 108. Published online 2021 Mar 17.
Intensive care survivors often experience post-intensive care sequelae, which are frequently gathered together under the term “post-intensive care syndrome” (PICS). The consequences of PICS on quality of life, health-related costs and hospital readmissions are real public health problems. In the present Viewpoint, we summarize current knowledge and gaps in our understanding of PICS and approaches to management.
Addressing gender imbalance in intensive care
Jean-Louis Vincent, Nicole P. Juffermans, Karen E. A. Burns, V. Marco Ranieri, Chryssa Pourzitaki, Francesca Rubulotta
doi : 10.1186/s13054-021-03569-7
Crit Care. 2021; 25: 147. Published online 2021 Apr 16.
There is a large gender gap in critical care medicine with women underrepresented, particularly in positions of leadership. Yet gender diversity better reflects the current critical care community and has multiple beneficial effects at individual and societal levels. In this Viewpoint, we discuss some of the reasons for the persistent gender imbalance in critical care medicine, and suggest some possible strategies to help achieve greater equity and inclusion. An explicit and consistent focus on eliminating gender inequity is needed until gender diversity and inclusion become the norms in critical care medicine.
“I AM THOR/DUST DAHO”: mnemonic devices used by the Paris Fire Brigade to teach initial measures in undertaking a CBRN event
Louise Giaume, Yann Daniel, Franck Calamai, Clément Derkenne, Romain Kedzierewicz, Aude Demeny, Kilian Bertho, Stéphane Travers, Bertrand Prunet, Fréderic Dorandeu
doi : 10.1186/s13054-021-03539-z
Crit Care. 2021; 25: 116. Published online 2021 Mar 22.
In 2019, the Paris Fire Brigade described the chemical, biological, radiological, and nuclear chain of survival (CBRN-CS) to point out five essential tasks that first responders should perform in managing individuals in a CBRN situation [1].
Knowledge translation tools to guide care of non-intubated patients with acute respiratory illness during the COVID-19 Pandemic
David Leasa, Paul Cameron, Kimia Honarmand, Tina Mele, Karen J. Bosma, for the LHSC Ventilation Strategy for COVID-19 Working Group
doi : 10.1186/s13054-020-03415-2
Crit Care. 2021; 25: 22. Published online 2021 Jan 8.
Providing optimal care to patients with acute respiratory illness while preventing hospital transmission of COVID-19 is of paramount importance during the pandemic; the challenge lies in achieving both goals simultaneously.
SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review
Maria Clara Saad Menezes, Diego Vinicius Santinelli Pestana, Gustavo Rosa Gameiro, Luiz Fernando Ferraz da Silva, ?lodie Baron, Jean-Jacques Rouby, José Otavio Costa Auler Jr
doi : 10.1186/s13054-020-03399-z
Crit Care. 2021; 25: 53. Published online 2021 Feb 8.
The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-based explanations for the immune response, and COVID-19-associated hypercoagulability.
Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps
Daniele De Luca, Paola Cogo, Martin C. Kneyber, Paolo Biban, Malcolm Grace Semple, Jesus Perez-Gil, Giorgio Conti, Pierre Tissieres, Peter C. Rimensberger
doi : 10.1186/s13054-021-03489-6
Crit Care. 2021; 25: 75. Published online 2021 Feb 22.
Pediatric (PARDS) and neonatal (NARDS) acute respiratory distress syndrome have different age-specific characteristics and definitions. Trials on surfactant for ARDS in children and neonates have been performed well before the PARDS and NARDS definitions and yielded conflicting results.
Drug dosing in the critically ill obese patient: a focus on medications for hemodynamic support and prophylaxis
Brian L. Erstad, Jeffrey F. Barletta
doi : 10.1186/s13054-021-03495-8
Crit Care. 2021; 25: 77. Published online 2021 Feb 23.
Medications used for supportive care or prophylaxis constitute a significant portion of drug utilization in the intensive care unit. Evidence-based guidelines are available for many aspects of supportive care but drug doses listed are typically for patients with normal body habitus and not morbid obesity.
Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation
Takashi Ito, Midori Kakuuchi, Ikuro Maruyama
doi : 10.1186/s13054-021-03524-6
Crit Care. 2021; 25: 95. Published online 2021 Mar 8.
Endothelial cells play a key role in maintaining intravascular patency through their anticoagulant properties. They provide a favorable environment for plasma anticoagulant proteins, including antithrombin, tissue factor pathway inhibitor, and protein C.
Systematic review of cognitive impairment and brain insult after mechanical ventilation
Thiago G. Bassi, Elizabeth C. Rohrs, Steven C. Reynolds
doi : 10.1186/s13054-021-03521-9
Crit Care. 2021; 25: 99. Published online 2021 Mar 10.
We conducted a systematic review following the PRISMA protocol primarily to identify publications that assessed any links between mechanical ventilation (MV) and either cognitive impairment or brain insult, independent of underlying medical conditions.
Mechanical ventilation parameters in critically ill COVID-19 patients: a scoping review
Giacomo Grasselli, Emanuele Cattaneo, Gaetano Florio, Mariachiara Ippolito, Alberto Zanella, Andrea Cortegiani, Jianbo Huang, Antonio Pesenti, Sharon Einav
doi : 10.1186/s13054-021-03536-2
Crit Care. 2021; 25: 115. Published online 2021 Mar 20.
The mortality of critically ill patients with COVID-19 is high, particularly among those receiving mechanical ventilation (MV). Despite the high number of patients treated worldwide, data on respiratory mechanics are currently scarce and the optimal setting of MV remains to be defined. This scoping review aims to provide an overview of available data about respiratory mechanics, gas exchange and MV settings in patients admitted to intensive care units (ICUs) for COVID-19-associated acute respiratory failure, and to identify knowledge gaps.
Bedside voluntary and evoked forces evaluation in intensive care unit patients: a narrative review
Djahid Kennouche, Eric Luneau, Thomas Lapole, Jérome Morel, Guillaume Y. Millet, Julien Gondin
doi : 10.1186/s13054-021-03567-9
Crit Care. 2021; 25: 157. Published online 2021 Apr 22.
Around one third of intensive care unit (ICU) patients will develop severe neuromuscular alterations, known as intensive care unit-acquired weakness (ICUAW), during their stay. The diagnosis of ICUAW is difficult and often delayed as a result of sedation or delirium.
How I prescribe continuous renal replacement therapy
Emily J. See, Rinaldo Bellomo
doi : 10.1186/s13054-020-03448-7
Crit Care. 2021; 25: 1. Published online 2021 Jan 2.
Clinical application of esophageal manometry: how I do it
Elias Baedorf Kassis, Daniel Talmor
doi : 10.1186/s13054-020-03453-w
Crit Care. 2021; 25: 6. Published online 2021 Jan 5.
Beyond survival: identifying what matters to survivors of critical illness
Somnath Bose, Benjamin Hoenig, Maria Karamourtopoulos, Valerie Banner-Goodspeed, Samuel Brown
doi : 10.1186/s13054-021-03565-x
Crit Care. 2021; 25: 129. Published online 2021 Apr 6.
Ventilator-associated pneumonia in the era of COVID-19 pandemic: How common and what is the impact?
Paul-Henri Wicky, Michael S. Niedermann, Jean-François Timsit
doi : 10.1186/s13054-021-03571-z
Crit Care. 2021; 25: 153. Published online 2021 Apr 21.
We reviewed similarities and differences of ventilator associated pneumonia in Sars-Cov2 infection and with other ARDS. The differences in epidemiology and outcome will be detailed. Possible explanations of differences in pathophysiology of VAP in Sarscov2 infections will be cited and discussed.
COVID-19: spot urine rather than bronchoalveolar lavage fluid analysis?
Faeq Husain-Syed, Claudio Ronco, Thorsten Wiech, Matthias Hecker, Werner Seeger
doi : 10.1186/s13054-021-03579-5
Crit Care. 2021; 25: 162. Published online 2021 Apr 30.
Early corticosteroids are associated with lower mortality in critically ill patients with COVID-19: a cohort study
Pablo Monedero, Alfredo Gea, Pedro Castro, Angel M. Candela-Toha, Mar?a L. Hern?ndez-Sanz, Egoitz Arruti, Jes?s Villar, Carlos Ferrando, for the COVID-19 Spanish ICU Network
doi : 10.1186/s13054-020-03422-3
Crit Care. 2021; 25: 2. Published online 2021 Jan 4.
Critically ill patients with coronavirus disease 19 (COVID-19) have a high fatality rate likely due to a dysregulated immune response. Corticosteroids could attenuate this inappropriate response, although there are still some concerns regarding its use, timing, and dose.
Protective reactive thymus hyperplasia in COVID-19 acute respiratory distress syndrome
Pelagia Cuvelier, Hélène Roux, Anne Couëdel-Courteille, Jacques Dutrieux, Cécile Naudin, Bénédicte Charmeteau de Muylder, Rémi Cheynier, Pierre Squara, Stefano Marullo
doi : 10.1186/s13054-020-03440-1
Crit Care. 2021; 25: 4. Published online 2021 Jan 4.
Patients with COVID-19 (COVID) may develop acute respiratory distress syndrome with or without sepsis, coagulopathy and visceral damage. While chest CT scans are routinely performed in the initial assessment of patients with severe pulmonary forms, thymus involvement and reactivation have not been investigated so far.
Accelerated versus standard initiation of renal replacement therapy for critically ill patients with acute kidney injury: a systematic review and meta-analysis of RCT studies
Heng-Chih Pan, Ying-Ying Chen, I-Jung Tsai, Chih-Chung Shiao, Tao-Min Huang, Chieh-Kai Chan, Hung-Wei Liao, Tai-Shuan Lai, Yvonne Chueh, Vin-Cent Wu, Yung-Ming Chen
doi : 10.1186/s13054-020-03434-z
Crit Care. 2021; 25: 5. Published online 2021 Jan 5.
Acute kidney injury (AKI) is a common yet possibly fatal complication among critically ill patients in intensive care units (ICU). Although renal replacement therapy (RRT) is an important supportive management for severe AKI patients, the optimal timing of RRT initiation for these patients is still unclear.
Prevalence of burnout among intensivists in mainland China: a nationwide cross-sectional survey
Jing Wang, Bo Hu, Zhiyong Peng, Huimin Song, Shuhan Cai, Xin Rao, Lu Li, Jianguo Li
doi : 10.1186/s13054-020-03439-8
Crit Care. 2021; 25: 8. Published online 2021 Jan 5.
Burnout has gained increasing attention worldwide; however, there is a lack of relevant research in China. This study investigated the prevalence and factors associated with burnout in physicians of the intensive care unit (ICU) in mainland China.
Venoarterial extracorporeal membrane oxygenation induces early immune alterations
Aurélien Frerou, Mathieu Lesouhaitier, Murielle Gregoire, Fabrice Uhel, Arnaud Gacouin, Florian Reizine, Caroline Moreau, Aurélie Loirat, Adel Maamar, Nicolas Nesseler, Amedeo Anselmi, Erwan Flecher, Jean-Philippe Verhoye, Yves Le Tulzo, Michel Cogné, Mikael Roussel, Karin Tarte, Jean-Marc Tadié
doi : 10.1186/s13054-020-03444-x
Crit Care. 2021; 25: 9. Published online 2021 Jan 6.
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides heart mechanical support in critically ill patients with cardiogenic shock. Despite important progresses in the management of patients under VA-ECMO, acquired infections remain extremely frequent and increase mortality rate. Since immune dysfunctions have been described in both critically ill patients and after surgery with cardiopulmonary bypass, VA-ECMO initiation may be responsible for immune alterations that may expose patients to nosocomial infections (NI). Therefore, in this prospective study, we aimed to study immune alterations induced within the first days by VA-ECMO initiation.
Problems in care and avoidability of death after discharge from intensive care: a multi-centre retrospective case record review study
Sarah Vollam, Owen Gustafson, J. Duncan Young, Benjamin Attwood, Liza Keating, Peter Watkinson
doi : 10.1186/s13054-020-03420-5
Crit Care. 2021; 25: 10. Published online 2021 Jan 6.
Over 138,000 patients are discharged to hospital wards from intensive care units (ICUs) in England, Wales and Northern Ireland annually. More than 8000 die before leaving hospital. In hospital-wide populations, 6.7–18% of deaths have some degree of avoidability. For patients discharged from ICU, neither the proportion of avoidable deaths nor the reasons underlying avoidability have been determined. We undertook a retrospective case record review within the REFLECT study, examining how post-ICU ward care might be improved.
Characteristics and clinical outcomes of culture-negative and culture-positive septic shock: a single-center retrospective cohort study
June-sung Kim, Youn-Jung Kim, Won Young Kim
doi : 10.1186/s13054-020-03421-4
Crit Care. 2021; 25: 11. Published online 2021 Jan 6.
We evaluated the characteristics and outcomes of culture-negative versus culture-positive septic shock.
Association of inflammatory biomarkers with subsequent clinical course in suspected late onset sepsis in preterm neonates
?erife Kurul, Sinno H. P. Simons, Christian R. B. Ramakers, Yolanda B. De Rijke, René F. Kornelisse, Irwin K. M. Reiss, H. Rob Taal
doi : 10.1186/s13054-020-03423-2
Crit Care. 2021; 25: 12. Published online 2021 Jan 6.
Sepsis is a major health issue in preterm infants. Biomarkers are used to diagnose and monitor patients with sepsis, but C-reactive protein (CRP) is proven not predictive at onset of late onset neonatal sepsis (LONS) diagnosis. The aim of this study was to evaluate the association of interleukin-6(IL-6), procalcitonin (PCT) and CRP with subsequent sepsis severity and mortality in preterm infants suspected of late onset neonatal sepsis.
Mechanical power during extracorporeal membrane oxygenation and hospital mortality in patients with acute respiratory distress syndrome
Li-Chung Chiu, Shih-Wei Lin, Li-Pang Chuang, Hsin-Hsien Li, Pi-Hua Liu, Feng-Chun Tsai, Chih-Hao Chang, Chen-Yiu Hung, Chung-Shu Lee, Shaw-Woei Leu, Han-Chung Hu, Chung-Chi Huang, Huang-Pin Wu, Kuo-Chin Kao
doi : 10.1186/s13054-020-03428-x
Crit Care. 2021; 25: 13. Published online 2021 Jan 6.
Mechanical power (MP) refers to the energy delivered by a ventilator to the respiratory system per unit of time. MP referenced to predicted body weight (PBW) or respiratory system compliance have better predictive value for mortality than MP alone in acute respiratory distress syndrome (ARDS). Our objective was to assess the potential impact of consecutive changes of MP on hospital mortality among ARDS patients receiving extracorporeal membrane oxygenation (ECMO).
Timing of renal replacement therapy initiation for acute kidney injury in critically ill patients: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis
Xiaoming Li, Chao Liu, Zhi Mao, Qinglin Li, Feihu Zhou
doi : 10.1186/s13054-020-03451-y
Crit Care. 2021; 25: 15. Published online 2021 Jan 6.
Acute kidney injury (AKI) is a common serious complication in critically ill patients. AKI occurs in up to 50% patients in intensive care unit (ICU), with poor clinical prognosis. Renal replacement therapy (RRT) has been widely used in critically ill patients with AKI. However, in patients without urgent indications such as acute pulmonary edema, severe acidosis, and severe hyperkalemia, the optimal timing of RRT initiation is still under debate. We conducted this systematic review of randomized clinical trials (RCTs) with meta-analysis and trial sequential analysis (TSA) to compare the effects of early RRT initiation versus delayed RRT initiation.
Systematic early versus late mobilization or standard early mobilization in mechanically ventilated adult ICU patients: systematic review and meta-analysis
This systematic review and meta-analysis aimed to determine the effectiveness of systematic early mobilization in improving muscle strength and physical function in mechanically ventilated intensive care unit (ICU) patients.
doi : 10.1186/s13054-020-03446-9
Crit Care. 2021; 25: 16. Published online 2021 Jan 6.
Dominik Menges, Bianca Seiler, Yuki Tomonaga, Matthias Schwenkglenks, Milo A. Puhan, Henock G. Yebyo
Mortality in septic patients treated with vitamin C: a systematic meta-analysis
Sean S. Scholz, Rainer Borgstedt, Nicole Ebeling, Leoni C. Menzel, Gerrit Jansen, Sebastian Rehberg
doi : 10.1186/s13054-020-03438-9
Crit Care. 2021; 25: 17. Published online 2021 Jan 6.
Supplementation of vitamin C in septic patients remains controversial despite eight large clinical trials published only in 2020. We aimed to evaluate the evidence on potential effects of vitamin C treatment on mortality in adult septic patients.
A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients
Etienne Macedo, Bethany Karl, Euyhyun Lee, Ravindra L. Mehta
doi : 10.1186/s13054-020-03441-0
Crit Care. 2021; 25: 18. Published online 2021 Jan 6.
Intradialytic hypotension (IDH) is a frequent complication of intermittent hemodialysis (IHD), occurring from 15 to 50% of ambulatory sessions, and is more frequent among hospitalized patients with hypoalbuminemia. IDH limits adequate fluid removal and increases the risk for vascular access thrombosis, early hemodialysis (HD) termination, and mortality. Albumin infusion before and during therapy has been used for treating IDH with the varying results. We evaluated the efficacy of albumin infusion in preventing IDH during IHD in hypoalbuminemic inpatients.
The immune modulatory effects of mitochondrial transplantation on cecal slurry model in rat
Jung Wook Hwang, Min Ji Lee, Tae Nyoung Chung, Han A. Reum Lee, Jung Ho Lee, Seo Yoon Choi, Ye Jin Park, Chul Hee Kim, Isom Jin, Seong Hoon Kim, Hyo-Bum Kwak, Jun-Won Heo, Kwangmin Na, Sangchun Choi, Yong-Soo Choi, Kyuseok Kim
doi : 10.1186/s13054-020-03436-x
Crit Care. 2021; 25: 20. Published online 2021 Jan 7.
Sepsis has a high mortality rate, but no specific drug has been proven effective, prompting the development of new drugs. Immunologically, sepsis can involve hyperinflammation, immune paralysis, or both, which might pose challenges during drug development. Recently, mitochondrial transplantation has emerged as a treatment modality for various diseases involving mitochondrial dysfunction, but it has never been tested for sepsis.
Hemodynamic and anti-inflammatory effects of early esmolol use in hyperkinetic septic shock: a pilot study
Bruno Levy, Caroline Fritz, Caroline Piona, Kevin Duarte, Andrea Morelli, Philippe Guerci, Antoine Kimmoun, Nicolas Girerd
doi : 10.1186/s13054-020-03445-w
Crit Care. 2021; 25: 21. Published online 2021 Jan 7.
Several studies have shown that heart rate control with selective beta-1 blockers in septic shock is safe. In these trials, esmolol was administered 24 h after onset of septic shock in patients who remained tachycardic. While an earlier use of beta-blockers might be beneficial, such use remains challenging due to the difficulty in distinguishing between compensatory and non-compensatory tachycardia. Therefore, the Esmosepsis study was designed to study the effects of esmolol aimed at reducing the heart rate by 20% after the initial resuscitation process in hyperkinetic septic shock patients on (1) cardiac index and (2) systemic and regional hemodynamics as well as inflammatory patterns.
Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS
Inès Bendib, Asma Beldi-Ferchiou, Frédéric Schlemmer, Mathieu Surenaud, Bernard Maitre, Anne Plonquet, Guillaume Carteaux, Keyvan Razazi, Veronique Godot, Sophie Hüe, Armand Mekontso Dessap, Nicolas de Prost
doi : 10.1186/s13054-020-03427-y
Crit Care. 2021; 25: 23. Published online 2021 Jan 9.
Biomarkers of disease severity might help individualizing the management of patients with the acute respiratory distress syndrome (ARDS). Whether the alveolar compartmentalization of biomarkers has a clinical significance in patients with pneumonia-related ARDS is unknown. This study aimed at assessing the interrelation of ARDS/sepsis biomarkers in the alveolar and blood compartments and explored their association with clinical outcomes.
Burden of pneumococcal pneumonia requiring ICU admission in France: 1-year prognosis, resources use, and costs
Claire Dupuis, Ayman Sabra, Juliette Patrier, Gwendoline Chaize, Amine Saighi, Céline Féger, Alexandre Vainchtock, Jacques Gaillat, Jean-François Timsit
doi : 10.1186/s13054-020-03442-z
Crit Care. 2021; 25: 24. Published online 2021 Jan 10.
Community-acquired pneumonia (CAP), especially pneumococcal CAP (P-CAP), is associated with a heavy burden of illness as evidenced by high rates of intensive care unit (ICU) admission, mortality, and costs. Although well-defined acutely, determinants influencing long-term burden are less known. This study assessed determinants of 28-day and 1-year mortality and costs among P-CAP patients admitted in ICUs.
Ventilator-associated pneumonia in critically ill patients with COVID-19
Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Solderholm, Sally Forrest, Sushmita Sridhar, Nicholas M. Brown, Stephen Baker, Vilas Navapurkar, Gordon Dougan, Josefin Bartholdson Scott, Andrew Conway Morris
doi : 10.1186/s13054-021-03460-5
Crit Care. 2021; 25: 25. Published online 2021 Jan 11.
Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients require admission to an intensive care unit (ICU) for invasive ventilation and are at significant risk of developing a secondary, ventilator-associated pneumonia (VAP).
Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients
Michael Chaim Sklar, Fabiana Madotto, Annemijn Jonkman, Michela Rauseo, Ibrahim Soliman, L. Felipe Damiani, Irene Telias, Sebastian Dubo, Lu Chen, Nuttapol Rittayamai, Guang-Qiang Chen, Ewan C. Goligher, Martin Dres, Remi Coudroy, Tai Pham, Ricard M. Artigas, Jan O. Friedrich, Christer Sinderby, Leo Heunks, Laurent Brochard
doi : 10.1186/s13054-020-03435-y
Crit Care. 2021; 25: 26. Published online 2021 Jan 11.
In patients intubated for mechanical ventilation, prolonged diaphragm inactivity could lead to weakness and poor outcome. Time to resume a minimal diaphragm activity may be related to sedation practice and patient severity.
Incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients: data from two prospective cohort studies
Ruben J. Eck, Lisa Hulshof, Renske Wiersema, Chris H. L. Thio, Bart Hiemstra, Niels C. Gritters van den Oever, Reinold O. B. Gans, Iwan C. C. van der Horst, Karina Meijer, Frederik Keus
doi : 10.1186/s13054-021-03457-0
Crit Care. 2021; 25: 27. Published online 2021 Jan 12.
The objective of this study was to describe the prevalence, incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients receiving contemporary thrombosis prophylaxis.
Development and validation of new poisoning mortality score system for patients with acute poisoning at the emergency department
Kap Su Han, Su Jin Kim, Eui Jung Lee, Joong Ho Shin, Ji Sung Lee, Sung Woo Lee
doi : 10.1186/s13054-020-03408-1
Crit Care. 2021; 25: 29. Published online 2021 Jan 18.
A prediction model of mortality for patients with acute poisoning has to consider both poisoning-related characteristics and patients’ physiological conditions; moreover, it must be applicable to patients of all ages. This study aimed to develop a scoring system for predicting in-hospital mortality of patients with acute poisoning at the emergency department (ED). doi: 10.1186/s13054-020-03408-1
Semi-elemental versus polymeric formula for enteral nutrition in brain-injured critically ill patients: a randomized trial
Laurent Carteron, Emmanuel Samain, Hadrien Winiszewski, Gilles Blasco, Anne-Sophie Balon, Camille Gilli, Gael Piton, Gilles Capellier, Sebastien Pili-Floury, Guillaume Besch
doi : 10.1186/s13054-020-03456-7
Crit Care. 2021; 25: 31. Published online 2021 Jan 20.
The properties of semi-elemental enteral nutrition might theoretically improve gastrointestinal tolerance in brain-injured patients, known to suffer gastroparesis. The purpose of this study was to compare the efficacy and tolerance of a semi-elemental versus a polymeric formula for enteral nutrition (EN) in brain-injured critically ill patients.
Serum neurofilament measurement improves clinical risk scores for outcome prediction after cardiac arrest: results of a prospective study
Sabina Hunziker, Adrian Quinto, Maja Ramin-Wright, Christoph Becker, Katharina Beck, Alessia Vincent, Kai Tisljar, Giulio Disanto, Pascal Benkert, David Leppert, Hans Pargger, Stephan Marsch, Raoul Sutter, Nils Peters, Jens Kuhle
doi : 10.1186/s13054-021-03459-y
Crit Care. 2021; 25: 32. Published online 2021 Jan 20.
A recent study found serum neurofilament light chain (NfL) levels to be strongly associated with poor neurological outcome in patients after cardiac arrest. Our aim was to confirm these findings in an independent validation study and to investigate whether NfL improves the prognostic value of two cardiac arrest-specific risk scores.
Bedside POCUS during ward emergencies is associated with improved diagnosis and outcome: an observational, prospective, controlled study
Laurent Zieleskiewicz, Alexandre Lopez, Sami Hraiech, Karine Baumstarck, Bruno Pastene, Mathieu Di Bisceglie, Benjamin Coiffard, Gary Duclos, Alain Boussuges, Xavier Bobbia, Sharon Einav, Laurent Papazian, Marc Leone
doi : 10.1186/s13054-021-03466-z
Crit Care. 2021; 25: 34. Published online 2021 Jan 22.
Rapid response teams are intended to improve early diagnosis and intervention in ward patients who develop acute respiratory or circulatory failure. A management protocol including the use of a handheld ultrasound device for immediate point-of-care ultrasound (POCUS) examination at the bedside may improve team performance. The main objective of the study was to assess the impact of implementing such a POCUS-guided management on the proportion of adequate immediate diagnoses in two groups. Secondary endpoints included time to treatment and patient outcomes.
Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI
Elisabeth C. van der Slikke, Bastiaan S. Star, Matijs van Meurs, Robert H. Henning, Jill Moser, Hjalmar R. Bouma
doi : 10.1186/s13054-020-03424-1
Crit Care. 2021; 25: 36. Published online 2021 Jan 25.
Sepsis is a life-threatening condition accompanied by organ dysfunction subsequent to a dysregulated host response to infection. Up to 60% of patients with sepsis develop acute kidney injury (AKI), which is associated with a poor clinical outcome. The pathophysiology of sepsis-associated AKI (sepsis-AKI) remains incompletely understood, but mitochondria have emerged as key players in the pathogenesis. Therefore, our aim was to identify mitochondrial damage in patients with sepsis-AKI.
Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs
Benjamin Friedrichson, Haitham Mutlak, Kai Zacharowski, Florian Piekarski
doi : 10.1186/s13054-021-03463-2
Crit Care. 2021; 25: 38. Published online 2021 Jan 28.
Extracorporeal life support (ECLS) has become an integral part of modern intensive therapy. The choice of support mode depends largely on the indication. Patients with respiratory failure are predominantly treated with a venovenous (VV) approach. We hypothesized that mortality in Germany in ECLS therapy did not differ from previously reported literature
Clearance of inflammatory cytokines in patients with septic acute kidney injury during renal replacement therapy using the EMiC2 filter (Clic-AKI study)
Nuttha Lumlertgul, Anna Hall, Luigi Camporota, Siobhan Crichton, Marlies Ostermann
doi : 10.1186/s13054-021-03476-x
Crit Care. 2021; 25: 39. Published online 2021 Jan 28.
The EMiC2 membrane is a medium cut-off haemofilter (45 kiloDalton). Little is known regarding its efficacy in eliminating medium-sized cytokines in sepsis. This study aimed to explore the effects of continuous veno-venous haemodialysis (CVVHD) using the EMiC2 filter on cytokine clearance.
Blood purification with a cytokine adsorber for the elimination of myoglobin in critically ill patients with severe rhabdomyolysis
Christina Scharf, Uwe Liebchen, Michael Paal, Michael Irlbeck, Michael Zoller, Ines Schroeder
doi : 10.1186/s13054-021-03468-x
Crit Care. 2021; 25: 41. Published online 2021 Jan 28.
Rhabdomyolysis is frequently occurring in critically ill patients, resulting in a high risk of acute kidney injury (AKI) and potentially permanent kidney damage due to increased myoglobin levels. The extracorporeal elimination of myoglobin might be an approach to prevent AKI, but its molecular weight of 17 kDa complicates an elimination with conventional dialysis membranes. Question of interest is, if myoglobin can be successfully eliminated with the cytokine adsorber Cytosorb® (CS) integrated in a high-flux dialysis system.
The feasibility and reliability of actigraphy to monitor sleep in intensive care patients: an observational study
L. J. Delaney, E. Litton, K. L. Melehan, H.-C. C. Huang, V. Lopez, F. Van Haren
doi : 10.1186/s13054-020-03447-8
Crit Care. 2021; 25: 42. Published online 2021 Jan 29.
Sleep amongst intensive care patients is reduced and highly fragmented which may adversely impact on recovery. The current challenge for Intensive Care clinicians is identifying feasible and accurate assessments of sleep that can be widely implemented. The objective of this study was to investigate the feasibility and reliability of a minimally invasive sleep monitoring technique compared to the gold standard, polysomnography, for sleep monitoring.
Association between perioperative fluid administration and postoperative outcomes: a 20-year systematic review and a meta-analysis of randomized goal-directed trials in major visceral/noncardiac surgery
Antonio Messina, Chiara Robba, Lorenzo Calabr?, Daniel Zambelli, Francesca Iannuzzi, Edoardo Molinari, Silvia Scarano, Denise Battaglini, Marta Baggiani, Giacomo De Mattei, Laura Saderi, Giovanni Sotgiu, Paolo Pelosi, Maurizio Cecconi
doi : 10.1186/s13054-021-03464-1
Crit Care. 2021; 25: 43. Published online 2021 Feb 1.
Appropriate perioperative fluid management is of pivotal importance to reduce postoperative complications, which impact on early and long-term patient outcome. The so-called perioperative goal-directed therapy (GDT) approach aims at customizing perioperative fluid management on the individual patients’ hemodynamic response. Whether or not the overall amount of perioperative volume infused in the context of GDT could influence postoperative surgical outcomes is unclear.
The epidemiology and clinical outcomes of ventilator-associated events among 20,769 mechanically ventilated patients at intensive care units: an observational study
Qiao He, Wen Wang, Shichao Zhu, Mingqi Wang, Yan Kang, Rui Zhang, Kang Zou, Zhiyong Zong, Xin Sun
doi : 10.1186/s13054-021-03484-x
Crit Care. 2021; 25: 44. Published online 2021 Feb 2.
Ventilator-associated pneumonia (VAP) is the most common hospital-acquired infection (HAI) in intensive care units (ICUs). Ventilator-associated event (VAE), a more objective definition, has replaced traditional VAP surveillance and is now widely used in the USA. However, the adoption outside the USA is limited. This study aims to describe the epidemiology and clinical outcomes of VAEs in China, based on a prospectively maintained registry.
Incidence and management of metabolic acidosis with sodium bicarbonate in the ICU: An international observational study
Tomoko Fujii, Andrew A. Udy, Alistair Nichol, Rinaldo Bellomo, Adam M. Deane, Khaled El-Khawas, Naorungroj Thummaporn, Ary Serpa Neto, Hannah Bergin, Robert Short-Burchell, Chin-Ming Chen, Kuang-Hua Cheng, Kuo-Chen Cheng, Clemente Chia, Feng-Fan Chiang, Nai-Kuan Chou, Timothy Fazio, Pin-Kuei Fu, Victor Ge, Yoshiro Hayashi, Jennifer Holmes, Ting-Yu Hu, Shih-Feng Huang, Naoya Iguchi, Sarah L. Jones, Toshiyuki Karumai, Shinshu Katayama, Shih-Chi Ku, Chao-Lun Lai, Bor-Jen Lee, Wen-Jinn Liaw, Chelsea T. W. Ong, Lisa Paxton, Chloe Peppin, Owen Roodenburg, Shinjiro Saito, John D. Santamaria, Yahya Shehabi, Aiko Tanaka, Ravindranath Tiruvoipati, Hsiao-En Tsai, An-Yi Wang, Chen-Yu Wang, Yu-Chang Yeh, Chong-Jen Yu, Kuo-Ching Yuan, for the SODA-BIC investigators
doi : 10.1186/s13054-020-03431-2
Crit Care. 2021; 25: 45. Published online 2021 Feb 2.
Metabolic acidosis is a major complication of critical illness. However, its current epidemiology and its treatment with sodium bicarbonate given to correct metabolic acidosis in the ICU are poorly understood.
Angiopoietin-2 outperforms other endothelial biomarkers associated with severe acute kidney injury in patients with severe sepsis and respiratory failure
Wen-Kuang Yu, J. Brennan McNeil, Nancy E. Wickersham, Ciara M. Shaver, Julie A. Bastarache, Lorraine B. Ware
doi : 10.1186/s13054-021-03474-z
Crit Care. 2021; 25: 48. Published online 2021 Feb 4.
Endothelial dysfunction and injury is a major pathophysiologic feature of sepsis. Sepsis is also the most frequent cause of acute kidney injury (AKI) in critically ill patients. Though most studies of AKI in sepsis have focused on tubular epithelial injury, the role of endothelial dysfunction and injury is less well studied. The goal of this study was first to investigate whether endothelial dysfunction and injury biomarkers were associated with severe AKI in sepsis patients. The second goal was to determine the best performing biomarker for severe AKI and whether this biomarker was associated with severe AKI across different etiologies of sepsis and clinical outcomes.
Acute cholangitis in intensive care units: clinical, biological, microbiological spectrum and risk factors for mortality: a multicenter study
Jean-Rémi Lavillegrand, Emmanuelle Mercier-Des-Rochettes, Elodie Baron, Frédéric Pène, Damien Contou, Raphael Favory, Sébastien Préau, Arnaud Galbois, Chloé Molliere, Arnaud-Félix Miailhe, Jean Reignier, Mehran Monchi, Claire Pichereau, Sara Thietart, Thibault Vieille, Gael Piton, Gabriel Preda, Idriss Abdallah, Marine Camus, Eric Maury, Bertrand Guidet, Guillaume Dumas, Hafid Ait-Oufella
doi : 10.1186/s13054-021-03480-1
Crit Care. 2021; 25: 49. Published online 2021 Feb 6.
Little is known on the outcome and risk factors for mortality of patients admitted in Intensive Care units (ICUs) for Acute cholangitis (AC).
Identification and characterization of neutrophil heterogeneity in sepsis
Xinxin Qi, Yao Yu, Ran Sun, Jiamin Huang, Lu Liu, Yunxi Yang, Tao Rui, Bingwei Sun
doi : 10.1186/s13054-021-03481-0
Crit Care. 2021; 25: 50. Published online 2021 Feb 6.
Although the immune function of neutrophils in sepsis has been well described, the heterogeneity of neutrophils remains unclear during the process of sepsis.
Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients
Yue Zhang, Kai Han, Chunjing Du, Rui Li, Jingyuan Liu, Hui Zeng, Liuluan Zhu, Ang Li
doi : 10.1186/s13054-021-03482-z
Crit Care. 2021; 25: 51. Published online 2021 Feb 8.
Thrombosis and coagulopathy are highly prevalent in critically ill patients with COVID-19 and increase the risk of death. Immunothrombosis has recently been demonstrated to contribute to the thrombotic events in COVID-19 patients with coagulopathy. As the primary components of immunothrombosis, neutrophil extracellular traps (NETs) could be induced by complement cascade components and other proinflammatory mediators. We aimed to explore the clinical roles of NETs and the regulation of complement on the NET formation in COVID-19.
Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study
Benoit Vandenbunder, Stephan Ehrmann, Michael Piagnerelli, Bertrand Sauneuf, Nicolas Serck, Thibaud Soumagne, Julien Textoris, Christophe Vinsonneau, Nadia Aissaoui, Gauthier Blonz, Giuseppe Carbutti, Romain Courcelle, Alain D’hondt, Stephane Gaudry, Julien Higny, Geoffroy Horlait, Sami Hraiech, Laurent Lefebvre, Francois Lejeune, Andre Ly, Jean-Baptiste Lascarrou, David Grimaldi, for the COVADIS study group
doi : 10.1186/s13054-020-03433-0
Crit Care. 2021; 25: 52. Published online 2021 Feb 8.
Controversies exist on the nature of COVID-19 related acute respiratory distress syndrome (ARDS) in particular on the static compliance of the respiratory system (Crs). We aimed to analyze the association of Crs with outcome in COVID-19-associated ARDS, to ascertain its determinants and to describe its evolution at day-14.
Characterization of esophageal motor activity, gastroesophageal reflux, and evaluation of prokinetic effectiveness in mechanically ventilated critically ill patients: a high-resolution impedance manometry study
Karel Balihar, Jan Kotyza, Lucie Zdrhova, Jana Kozeluhova, Michal Krcma, Martin Matejovic
doi : 10.1186/s13054-021-03479-8
Crit Care. 2021; 25: 54. Published online 2021 Feb 8.
Motility disorders of upper gastrointestinal tract are common in critical illness and associated with significant clinical consequences. However, detailed quantitative and qualitative analyses of esophageal motor functions are lacking. Therefore, we aimed to characterize the key features of esophageal motility functions using high-resolution impedance manometry (HRIM) and to evaluate an objective link between esophageal motor patterns, gastric emptying, and gastroesophageal reflux. We also studied the prokinetic effects of metoclopramide.
Renal dysfunction improves risk stratification and may call for a change in the management of intermediate- and high-risk acute pulmonary embolism: results from a multicenter cohort study with external validation
Romain Chopard, David Jimenez, Guillaume Serzian, Fiona Ecarnot, Nicolas Falvo, Elsa Kalbacher, Benjamin Bonnet, Gilles Capellier, François Schiele, Laurent Bertoletti, Manuel Monreal, Nicolas Meneveau
doi : 10.1186/s13054-021-03458-z
Crit Care. 2021; 25: 57. Published online 2021 Feb 9.
Renal dysfunction influences outcomes after pulmonary embolism (PE). We aimed to determine the incremental value of adding renal dysfunction, defined by estimated glomerular filtration rate (eGFR), on top of the European Society of Cardiology (ESC) prognostic model, for the prediction of 30-day mortality in acute PE patients, which in turn could lead to the optimization of acute PE management.
High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure
Ricard Mellado-Artigas, Bruno L. Ferreyro, Federico Angriman, Mar?a Hern?ndez-Sanz, Egoitz Arruti, Antoni Torres, Jes?s Villar, Laurent Brochard, Carlos Ferrando, for the COVID-19 Spanish ICU Network
doi : 10.1186/s13054-021-03469-w
Crit Care. 2021; 25: 58. Published online 2021 Feb 11.
Whether the use of high-flow nasal oxygen in adult patients with COVID-19 associated acute respiratory failure improves clinically relevant outcomes remains unclear. We thus sought to assess the effect of high-flow nasal oxygen on ventilator-free days, compared to early initiation of invasive mechanical ventilation, on adult patients with COVID-19.
Airway Pseudomonas aeruginosa density in mechanically ventilated patients: clinical impact and relation to therapeutic efficacy of antibiotics
Yohei Migiyama, Shinya Sakata, Shinji Iyama, Kentaro Tokunaga, Koichi Saruwatari, Yusuke Tomita, Sho Saeki, Shinichiro Okamoto, Hidenori Ichiyasu, Takuro Sakagami
doi : 10.1186/s13054-021-03488-7
Crit Care. 2021; 25: 59. Published online 2021 Feb 11.
The bacterial density of Pseudomonas aeruginosa is closely related to its pathogenicity. We evaluated the effect of airway P. aeruginosa density on the clinical course of mechanically ventilated patients and the therapeutic efficacy of antibiotics.
Automated detection and quantification of reverse triggering effort under mechanical ventilation
Tài Pham, Jaume Montanya, Irene Telias, Thomas Piraino, Rudys Magrans, Rémi Coudroy, L. Felipe Damiani, Ricard Mellado Artigas, Mat?as Madorno, Lluis Blanch, Laurent Brochard, the BEARDS study investigators
doi : 10.1186/s13054-020-03387-3
Crit Care. 2021; 25: 60. Published online 2021 Feb 15.
Reverse triggering (RT) is a dyssynchrony defined by a respiratory muscle contraction following a passive mechanical insufflation. It is potentially harmful for the lung and the diaphragm, but its detection is challenging. Magnitude of effort generated by RT is currently unknown. Our objective was to validate supervised methods for automatic detection of RT using only airway pressure (Paw) and flow. A secondary objective was to describe the magnitude of the efforts generated during RT.
Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study
Alice Blet, Benjamin Deniau, Karine Santos, Dirk P. T. van Lier, Feriel Azibani, Xavier Wittebole, Benjamin G. Chousterman, Etienne Gayat, Oliver Hartmann, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin, Charles Damoisel, Nicolas Deye, Salvatore Di Somma, Thierry Dugernier, Bruno François, Stephane Gaudry, Vincent Huberlant, Jean-Baptiste Lascarrou, Gernot Marx, Emmanuelle Mercier, Haikel Oueslati, Peter Pickkers, Romain Sonneville, Matthieu Legrand, Pierre-François Laterre, Alexandre Mebazaa, AdrenOSS-1 Study Investigators
doi : 10.1186/s13054-021-03471-2
Crit Care. 2021; 25: 61. Published online 2021 Feb 15.
Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the degradation of various cardiovascular and endorphin mediators. High levels of circulating DPP3 (cDPP3) indicate a high risk of organ dysfunction and mortality in cardiogenic shock patients.
Impact of treating iron deficiency, diagnosed according to hepcidin quantification, on outcomes after a prolonged ICU stay compared to standard care: a multicenter, randomized, single-blinded trial
Sigismond Lasocki, Pierre Asfar, Samir Jaber, Martine Ferrandiere, Thomas Kerforne, Karim Asehnoune, Philippe Montravers, Philippe Seguin, Katell Peoc’h, Soizic Gergaud, Nicolas Nagot, Thibaud Lefebvre, Sylvain Lehmann, the Hepcidane study group
doi : 10.1186/s13054-020-03430-3
Crit Care. 2021; 25: 62. Published online 2021 Feb 15.
Anemia is a significant problem in patients on ICU. Its commonest cause, iron deficiency (ID), is difficult to diagnose in the context of inflammation. Hepcidin is a new marker of ID. We aimed to assess whether hepcidin levels would accurately guide treatment of ID in critically ill anemic patients after a prolonged ICU stay and affect the post-ICU outcomes.
Deploying unsupervised clustering analysis to derive clinical phenotypes and risk factors associated with mortality risk in 2022 critically ill patients with COVID-19 in Spain
Alejandro Rodr?guez, Manuel Ruiz-Botella, Ignacio Mart?n-Loeches, Mar?a Jimenez Herrera, Jordi Solé-Violan, Josep G?mez, Mar?a Bod?, Sandra Trefler, Elisabeth Papiol, Emili D?az, Borja Suberviola, Montserrat Vallverdu, Eric Mayor-V?zquez, Antonio Albaya Moreno, Alfonso Canabal Berlanga, Miguel S?nchez, Mar?a del Valle Ort?z, Juan Carlos Ballesteros, Lorena Mart?n Iglesias, Judith Mar?n-Corral, Esther L?pez Ramos, Virginia Hidalgo Valverde, Loreto Vidaur Vidaur Tello, Susana Sancho Chinesta, Francisco Javier Gonz?les de Molina, Sandra Herrero Garc?a, Carmen Carolina Sena Pérez, Juan Carlos Pozo Laderas, Raquel Rodr?guez Garc?a, Angel Estella, Ricard Ferrer, on behalf of COVID-19 SEMICYUC Working Group
doi : 10.1186/s13054-021-03487-8
Crit Care. 2021; 25: 63. Published online 2021 Feb 15.
The identification of factors associated with Intensive Care Unit (ICU) mortality and derived clinical phenotypes in COVID-19 patients could help for a more tailored approach to clinical decision-making that improves prognostic outcomes.
Diaphragm echodensity in mechanically ventilated patients: a description of technique and outcomes
Benjamin Coiffard, Stephen Riegler, Michael C. Sklar, Martin Dres, Stefannie Vorona, W. Darlene Reid, Laurent J. Brochard, Niall D. Ferguson, Ewan C. Goligher
doi : 10.1186/s13054-021-03494-9
Crit Care. 2021; 25: 64. Published online 2021 Feb 16.
Acute increases in muscle sonographic echodensity reflect muscle injury. Diaphragm echodensity has not been measured in mechanically ventilated patients. We undertook to develop a technique to characterize changes in diaphragm echodensity during mechanical ventilation and to assess whether these changes are correlated with prolonged mechanical ventilation.
The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis
Arno Téblick, Sarah Vander Perre, Lies Pauwels, Sarah Derde, Tim Van Oudenhove, Lies Langouche, Greet Van den Berghe
doi : 10.1186/s13054-021-03475-y
Crit Care. 2021; 25: 65. Published online 2021 Feb 16.
Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ We hypothesized that sepsis acutely activates the hypothalamus to generate, via corticotropin-releasing hormone (CRH) and vasopressin (AVP), ACTH-induced hypercortisolemia. Thereafter, via increased availability of free cortisol, of which breakdown is reduced, feedback inhibition at the pituitary level interferes with normal processing of pro-opiomelanocortin (POMC) into ACTH, explaining the ACTH–cortisol dissociation. We further hypothesized that, in this constellation, POMC leaches into the circulation and can contribute to adrenocortical steroidogenesis.
Prevalence of post-intensive care syndrome among Japanese intensive care unit patients: a prospective, multicenter, observational J-PICS study
Daisuke Kawakami, Shigeki Fujitani, Takeshi Morimoto, Hisashi Dote, Mumon Takita, Akihiro Takaba, Masaaki Hino, Michitaka Nakamura, Hiromasa Irie, Tomohiro Adachi, Mami Shibata, Jun Kataoka, Akira Korenaga, Tomoya Yamashita, Tomoya Okazaki, Masatoshi Okumura, Takefumi Tsunemitsu
doi : 10.1186/s13054-021-03501-z
Crit Care. 2021; 25: 69. Published online 2021 Feb 16.
Many studies have compared quality of life of post-intensive care syndrome (PICS) patients with age-matched population-based controls. Many studies on PICS used the 36-item Short Form (SF-36) health survey questionnaire version 2, but lack the data for SF-36 values before and after intensive care unit (ICU) admission. Thus, clinically important changes in the parameters of SF-36 are unknown. Therefore, we determined the frequency of co-occurrence of PICS impairments at 6 months after ICU admission. We also evaluated the changes in SF-36 subscales and interpreted the patients’ subjective significance of impairment.
Surge effects and survival to hospital discharge in critical care patients with COVID-19 during the early pandemic: a cohort study
Christopher R. Dale, Rachael W. Starcher, Shu Ching Chang, Ari Robicsek, Guilford Parsons, Jason D. Goldman, Andre Vovan, David Hotchkin, Tyler J. Gluckman
doi : 10.1186/s13054-021-03504-w
Crit Care. 2021; 25: 70. Published online 2021 Feb 17.
The early months of the COVID-19 pandemic were fraught with much uncertainty and some resource constraint. We assessed the change in survival to hospital discharge over time for intensive care unit patients with COVID-19 during the first 3 months of the pandemic and the presence of any surge effects on patient outcomes.
Epidemiology and microbiology of ventilator-associated pneumonia in COVID-19 patients: a multicenter retrospective study in 188 patients in an un-inundated French region
Gauthier Blonz, Achille Kouatchet, Nicolas Chudeau, Emmanuel Pontis, Julien Lorber, Anthony Lemeur, Lucie Planche, Jean-Baptiste Lascarrou, Gwenhael Colin
doi : 10.1186/s13054-021-03493-w
Crit Care. 2021; 25: 72. Published online 2021 Feb 18.
The COVID-19 pandemic is responsible for many hospitalizations in intensive care units (ICU), with widespread use of invasive mechanical ventilation (IMV) which exposes patients to the risk of ventilator-associated pneumonia (VAP). The characteristics of VAP in COVID-19 patients remain unclear.
Markers of endothelial and epithelial pulmonary injury in mechanically ventilated COVID-19 ICU patients
Savino Spadaro, Alberto Fogagnolo, Gianluca Campo, Ottavio Zucchetti, Marco Verri, Irene Ottaviani, Tanushree Tunstall, Salvatore Grasso, Valentina Scaramuzzo, Francesco Murgolo, Elisabetta Marangoni, Francesco Vieceli Dalla Sega, Francesca Fortini, Rita Pavasini, Paola Rizzo, Roberto Ferrari, Alberto Papi, Carlo Alberto Volta, Marco Contoli
doi : 10.1186/s13054-021-03499-4
Crit Care. 2021; 25: 74. Published online 2021 Feb 19.
Biomarkers can be used to detect the presence of endothelial and/or alveolar epithelial injuries in case of ARDS. Angiopoietin-2 (Ang-2), soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion protein-1 (VCAM-1), P-selectin and E-selectin are biomarkers of endothelial injury, whereas the receptor for advanced glycation end-products (RAGE) reflects alveolar epithelial injury. The aims of this study were to evaluate whether the plasma concentration of the above-mentioned biomarkers was different 1) in survivors and non-survivors of COVID-19-related ARDS and 2) in COVID-19-related and classical ARDS.
Role of endothelial microRNA 155 on capillary leakage in systemic inflammation
Valerie Etzrodt, Temitayo O. Idowu, Heiko Schenk, Benjamin Seeliger, Antje Prasse, Kristina Thamm, Thorben Pape, Janina Müller-Deile, Matijs van Meurs, Thomas Thum, Ankita Garg, Robert Geffers, Klaus Stahl, Samir M. Parikh, Hermann Haller, Sascha David
doi : 10.1186/s13054-021-03500-0
Crit Care. 2021; 25: 76. Published online 2021 Feb 22.
Capillary leakage is a key contributor to the pathological host response to infections. The underlying mechanisms remain incompletely understood, and the role of microRNAs (MIR) has not been investigated in detail. We hypothesized that specific MIRs might be regulated directly in the endothelium thereby contributing to vascular leakage.
Use and impact of high intensity treatments in patients with traumatic brain injury across Europe: a CENTER-TBI analysis
Jilske A. Huijben, Abhishek Dixit, Nino Stocchetti, Andrew I. R. Maas, Hester F. Lingsma, Mathieu van der Jagt, David Nelson, Giuseppe Citerio, Lindsay Wilson, David K. Menon, Ari Ercole, the CENTER-TBI investigators and participants
doi : 10.1186/s13054-020-03370-y
Crit Care. 2021; 25: 78. Published online 2021 Feb 23.
To study variation in, and clinical impact of high Therapy Intensity Level (TIL) treatments for elevated intracranial pressure (ICP) in patients with traumatic brain injury (TBI) across European Intensive Care Units (ICUs).
Helmet CPAP to treat hypoxic pneumonia outside the ICU: an observational study during the COVID-19 outbreak
Andrea Coppadoro, Annalisa Benini, Robert Fruscio, Luisa Verga, Paolo Mazzola, Giuseppe Bellelli, Marco Carbone, Giacomo Mulinacci, Alessandro Soria, Beatrice Noè, Eduardo Beck, Riccardo Di Sciacca, Davide Ippolito, Giuseppe Citerio, Maria Grazia Valsecchi, Andrea Biondi, Alberto Pesci, Paolo Bonfanti, Davide Gaudesi, Giacomo Bellani, Giuseppe Foti
doi : 10.1186/s13054-021-03502-y
Crit Care. 2021; 25: 80. Published online 2021 Feb 24.
Respiratory failure due to COVID-19 pneumonia is associated with high mortality and may overwhelm health care systems, due to the surge of patients requiring advanced respiratory support. Shortage of intensive care unit (ICU) beds required many patients to be treated outside the ICU despite severe gas exchange impairment. Helmet is an effective interface to provide continuous positive airway pressure (CPAP) noninvasively. We report data about the usefulness of helmet CPAP during pandemic, either as treatment, a bridge to intubation or a rescue therapy for patients with care limitations (DNI).
Respiratory failure due to COVID-19 pneumonia is associated with high mortality and may overwhelm health care systems, due to the surge of patients requiring advanced respiratory support. Shortage of intensive care unit (ICU) beds required many patients to be treated outside the ICU despite severe gas exchange impairment. Helmet is an effective interface to provide continuous positive airway pressure (CPAP) noninvasively. We report data about the usefulness of helmet CPAP during pandemic, either as treatment, a bridge to intubation or a rescue therapy for patients with care limitations (DNI).
Lorenzo Ball, Chiara Robba, Lorenzo Maiello, Jacob Herrmann, Sarah E. Gerard, Yi Xin, Denise Battaglini, Iole Brunetti, Giuseppe Minetti, Sara Seitun, Antonio Vena, Daniele Roberto Giacobbe, Matteo Bassetti, Patricia R. M. Rocco, Maurizio Cereda, Lucio Castellan, Nicol? Patroniti, Paolo Pelosi, GECOVID (GEnoa COVID-19) group
doi : 10.1186/s13054-021-03477-w
Crit Care. 2021; 25: 81. Published online 2021 Feb 24.
There is a paucity of data concerning the optimal ventilator management in patients with COVID-19 pneumonia; particularly, the optimal levels of positive-end expiratory pressure (PEEP) are unknown. We aimed to investigate the effects of two levels of PEEP on alveolar recruitment in critically ill patients with severe COVID-19 pneumonia.
Long-term health-related quality of life and burden of disease after intensive care: development of a patient-reported outcome measure
Johan Malmgren, Ann-Charlotte Waldenstr?m, Christian Rylander, Elias Johannesson, Stefan Lundin
doi : 10.1186/s13054-021-03496-7
Crit Care. 2021; 25: 82. Published online 2021 Feb 25.
ICU survivorship includes a diverse burden of disease. Current questionnaires used for collecting information about health-related problems and their relation to quality of life lack detailed questions in several areas relevant to ICU survivors. Our aim was to construct a provisional questionnaire on health-related issues based on interviews with ICU survivors and to test if this questionnaire was able to show differences between ICU survivors and a control group.
Predicting neurological outcome after out-of-hospital cardiac arrest with cumulative information; development and internal validation of an artificial neural network algorithm
Peder Andersson, Jesper Johnsson, Ola Bj?rnsson, Tobias Cronberg, Christian Hassager, Henrik Zetterberg, Pascal Stammet, Johan Undén, Jesper Kjaergaard, Hans Friberg, Kaj Blennow, Gisela Lilja, Matt P. Wise, Josef Dankiewicz, Niklas Nielsen, Attila Frigyesi
doi : 10.1186/s13054-021-03505-9
Crit Care. 2021; 25: 83. Published online 2021 Feb 25.
Prognostication of neurological outcome in patients who remain comatose after cardiac arrest resuscitation is complex. Clinical variables, as well as biomarkers of brain injury, cardiac injury, and systemic inflammation, all yield some prognostic value. We hypothesised that cumulative information obtained during the first three days of intensive care could produce a reliable model for predicting neurological outcome following out-of-hospital cardiac arrest (OHCA) using artificial neural network (ANN) with and without biomarkers.
Frailty status among older critically ill patients with severe acute kidney injury
William Beaubien-Souligny, Alan Yang, Gerald Lebovic, Ron Wald, Sean M. Bagshaw
doi : 10.1186/s13054-021-03510-y
Crit Care. 2021; 25: 84. Published online 2021 Feb 25.
Frailty status among critically ill patients with acute kidney injury (AKI) is not well described despite its importance for prognostication and informed decision-making on life-sustaining therapies. In this study, we aim to describe the epidemiology of frailty in a cohort of older critically ill patients with severe AKI, the outcomes of patients with pre-existing frailty before AKI and the factors associated with a worsening frailty status among survivors.
Long-term outcome after intensive care for COVID-19: differences between men and women—a nationwide cohort study
Erik Zettersten, Lars Engerstr?m, Max Bell, Gabriella J?derling, Johan M?rtensson, Linda Block, Emma Larsson
doi : 10.1186/s13054-021-03511-x
Crit Care. 2021; 25: 86. Published online 2021 Feb 25.
Questions remain about long-term outcome for COVID-19 patients in general, and differences between men and women in particular given the fact that men seem to suffer a more dramatic course of the disease. We therefore analysed outcome beyond 90 days in ICU patients with COVID-19, with special focus on differences between men and women.
Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts
Yasser Sakr, Bruno François, Jordi Solé-Violan, Katarzyna Kotfis, Ulrich Jaschinski, Angel Estella, Marc Leone, Stephan M. Jakob, Xavier Wittebole, Luis E. Fontes, Miguel de Melo Gurgel, Thais Midega, Jean-Louis Vincent, V. Marco Ranieri, the SOAP and ICON Investigators
doi : 10.1186/s13054-020-03455-8
Crit Care. 2021; 25: 87. Published online 2021 Feb 25.
Mortality rates for patients with ARDS remain high. We assessed temporal changes in the epidemiology and management of ARDS patients requiring invasive mechanical ventilation in European ICUs. We also investigated the association between ventilatory settings and outcome in these patients.
Energy delivery guided by indirect calorimetry in critically ill patients: a systematic review and meta-analysis
Jing-Yi Duan, Wen-He Zheng, Hua Zhou, Yuan Xu, Hui-Bin Huang
doi : 10.1186/s13054-021-03508-6
Crit Care. 2021; 25: 88. Published online 2021 Feb 27.
The use of indirect calorimetry (IC) is increasing due to its precision in resting energy expenditure (REE) measurement in critically ill patients. Thus, we aimed to evaluate the clinical outcomes of an IC-guided nutrition therapy compared to predictive equations strategy in such a patient population.
Complete percutaneous angio-guided approach using preclosing for venoarterial extracorporeal membrane oxygenation implantation and explantation in patients with refractory cardiogenic shock or cardiac arrest
Anne-Sophie Martin-Tuffreau, François Bagate, Madjid Boukantar, Gabriel Saiydoun, Andrea Mangiameli, Laura Rostain, Gauthier Mouillet, Antonio Fiore, Olivier Langeron, Armand Mekontso-Dessap, Nicolas Mongardon, Thierry Folliguet, Emmanuel Teiger, Romain Gallet
doi : 10.1186/s13054-021-03522-8
Crit Care. 2021; 25: 93. Published online 2021 Mar 7.
The approach for veno-arterial extracorporeal membrane oxygenation implantation (VA-ECMO) in patients with cardiogenic shock can be either surgical or percutaneous. Complete angio-guided percutaneous implantation and explantation could decrease vascular complications. We sought to describe the initial results of complete percutaneous angio-guided ECMO implantation and explantation using preclosing.
Diuretics decrease fluid balance in patients on invasive mechanical ventilation: the randomized-controlled single blind, IRIHS study
Raphaël Cinotti, Jean-Baptiste Lascarrou, Marie-Ange Azais, Gwenhaël Colin, Jean-Pierre Quenot, Pierre-Joachim Mahé, Antoine Roquilly, Aurélie Gaultier, Karim Asehnoune, Jean Reignier
doi : 10.1186/s13054-021-03509-5
Crit Care. 2021; 25: 98. Published online 2021 Mar 10.
Fluid overload has been associated with increased morbidity and mortality in critically ill patients. The goal of this study was to assess the efficacy and safety of a diuretic strategy to overcome positive fluid balance in patients on invasive mechanical ventilation.
Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood–brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study
Caroline Lindblad, Elisa Pin, David Just, Faiez Al Nimer, Peter Nilsson, Bo-Michael Bellander, Mikael Svensson, Fredrik Piehl, Eric Peter Thelin
doi : 10.1186/s13054-021-03503-x
Crit Care. 2021; 25: 103. Published online 2021 Mar 12.
Severe traumatic brain injury (TBI) is associated with blood–brain barrier (BBB) disruption and a subsequent neuroinflammatory process. We aimed to perform a multiplex screening of brain enriched and inflammatory proteins in blood and cerebrospinal fluid (CSF) in order to study their role in BBB disruption, neuroinflammation and long-term functional outcome in TBI patients and healthy controls.
Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method
Prashant Nasa, Elie Azoulay, Ashish K. Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M. Arabi, Jan Bakker, Laurent J. Brochard, Adam M. Deane, Bin Du, Sharon Einav, Andrés Esteban, Ognjen Gajic, Samuel M. Galvagno, Jr., Claude Guérin, Samir Jaber, Gopi C. Khilnani, Younsuck Koh, Jean-Baptiste Lascarrou, Flavia R. Machado, Manu L. N. G. Malbrain, Jordi Mancebo, Michael T. McCurdy, Brendan A. McGrath, Sangeeta Mehta, Armand Mekontso-Dessap, Mervyn Mer, Michael Nurok, Pauline K. Park, Paolo Pelosi, John V. Peter, Jason Phua, David V. Pilcher, Lise Piquilloud, Peter Schellongowski, Marcus J. Schultz, Manu Shankar-Hari, Suveer Singh, Massimiliano Sorbello, Ravindranath Tiruvoipati, Andrew A. Udy, Tobias Welte, Sheila N. Myatra
doi : 10.1186/s13054-021-03491-y
Crit Care. 2021; 25: 106. Published online 2021 Mar 16.
Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory failure (C-ARF) has resulted in wide variation in clinical practice.
Neurological complications during veno-venous extracorporeal membrane oxygenation: Does the configuration matter? A retrospective analysis of the ELSO database
Roberto Lorusso, Mirko Belliato, Michael Mazzeffi, Michele Di Mauro, Fabio Silvio Taccone, Orlando Parise, Ayat Albanawi, Veena Nandwani, Paul McCarthy, Zachary Kon, Jay Menaker, Daniel M. Johnson, Sandro Gelsomino, Daniel Herr
doi : 10.1186/s13054-021-03533-5
Crit Care. 2021; 25: 107. Published online 2021 Mar 17.
Single- (SL) and double-lumen (DL) catheters are used in clinical practice for veno-venous extracorporeal membrane oxygenation (V-V ECMO) therapy. However, information is lacking regarding the effects of the cannulation on neurological complications.
Galectin-3 in septic acute kidney injury: a translational study
Haibing Sun, Huiping Jiang, Amity Eliaz, John A. Kellum, Zhiyong Peng, Isaac Eliaz
doi : 10.1186/s13054-021-03538-0
Crit Care. 2021; 25: 109. Published online 2021 Mar 18.
Galectin-3 (Gal-3) is a pleiotropic glycan-binding protein shown to be involved in sepsis and acute kidney injury (AKI). However, its role has never been elucidated in sepsis-associated AKI (S-AKI). We aimed to explore Gal-3’s role and its potential utility as a therapeutic target in S-AKI.
Do changes in pulse pressure variation and inferior vena cava distensibility during passive leg raising and tidal volume challenge detect preload responsiveness in case of low tidal volume ventilation?
Temistocle Taccheri, Francesco Gavelli, Jean-Louis Teboul, Rui Shi, Xavier Monnet
doi : 10.1186/s13054-021-03515-7
Crit Care. 2021; 25: 110. Published online 2021 Mar 18.
In patients ventilated with tidal volume (Vt)?<?8 mL/kg, pulse pressure variation (PPV) and, likely, the variation of distensibility of the inferior vena cava diameter (IVCDV) are unable to detect preload responsiveness. In this condition, passive leg raising (PLR) could be used, but it requires a measurement of cardiac output. The tidal volume (Vt) challenge (PPV changes induced by a 1-min increase in Vt from 6 to 8 mL/kg) is another alternative, but it requires an arterial line. We tested whether, in case of Vt?=?6 mL/kg, the effects of PLR could be assessed through changes in PPV (?PPVPLR) or in IVCDV (?IVCDVPLR) rather than changes in cardiac output, and whether the effects of the Vt challenge could be assessed by changes in IVCDV (?IVCDVVt) rather than changes in PPV (?PPVVt).
Early effects of ventilatory rescue therapies on systemic and cerebral oxygenation in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome: a prospective observational study
Chiara Robba, Lorenzo Ball, Denise Battaglini, Danilo Cardim, Emanuela Moncalvo, Iole Brunetti, Matteo Bassetti, Daniele R. Giacobbe, Antonio Vena, Nicol? Patroniti, Patricia R. M. Rocco, Basil F. Matta, Paolo Pelosi, collaborators
doi : 10.1186/s13054-021-03537-1
Crit Care. 2021; 25: 111. Published online 2021 Mar 19.
In COVID-19 patients with acute respiratory distress syndrome (ARDS), the effectiveness of ventilatory rescue strategies remains uncertain, with controversial efficacy on systemic oxygenation and no data available regarding cerebral oxygenation and hemodynamics.
Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study
Alexandros Rovas, Jan Sackarnd, Jan Rossaint, Stefanie Kampmeier, Hermann Pavenst?dt, Hans Vink, Philipp Kümpers
doi : 10.1186/s13054-021-03520-w
Crit Care. 2021; 25: 112. Published online 2021 Mar 19.
The availability of handheld, noninvasive sublingual video-microscopes allows for visualization of the microcirculation in critically ill patients. Recent studies demonstrate that reduced numbers of blood-perfused microvessels and increased penetration of erythrocytes into the endothelial glycocalyx are essential components of microvascular dysfunction. The aim of this study was to identify novel microvascular variables to determine the level of microvascular dysfunction in sepsis and its relationship with clinical variables.
Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS
Arianna Piotti, Deborah Novelli, Jennifer Marie Theresia Anna Meessen, Daniela Ferlicca, Sara Coppolecchia, Antonella Marino, Giovanni Salati, Monica Savioli, Giacomo Grasselli, Giacomo Bellani, Antonio Pesenti, Serge Masson, Pietro Caironi, Luciano Gattinoni, Marco Gobbi, Claudia Fracasso, Roberto Latini, the ALBIOS Investigators
doi : 10.1186/s13054-021-03545-1
Crit Care. 2021; 25: 113. Published online 2021 Mar 19.
Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death. Albumin has shown benefit in septic shock patients. Our aims were: (1) to identify the relations between circulating levels of syndecan-1 (SYN-1), sphingosine-1-phosphate (S1P) (endothelial glycocalyx), and VE-cadherin (endothelial cell junctions), severity of the disease, and survival; (2) to evaluate the effects of albumin supplementation on endothelial dysfunction in patients with septic shock.
Coagulation phenotypes in sepsis and effects of recombinant human thrombomodulin: an analysis of three multicentre observational studies
Daisuke Kudo, Tadahiro Goto, Ryo Uchimido, Mineji Hayakawa, Kazuma Yamakawa, Toshikazu Abe, Atsushi Shiraishi, Shigeki Kushimoto
doi : 10.1186/s13054-021-03541-5
Crit Care. 2021; 25: 114. Published online 2021 Mar 19.
A recent randomised trial showed that recombinant thrombomodulin did not benefit patients who had sepsis with coagulopathy and organ dysfunction. Several recent studies suggested presence of clinical phenotypes in patients with sepsis and heterogenous treatment effects across different sepsis phenotypes. We examined the latent phenotypes of sepsis with coagulopathy and the associations between thrombomodulin treatment and the 28-day and in-hospital mortality for each phenotype.
Comparison of clinical outcomes between nurse practitioner and registrar-led medical emergency teams: a propensity-matched analysis
Sachin Gupta, Mayurathan Balachandran, Gaby Bolton, Naomi Pratt, Jo Molloy, Eldho Paul, Ravindranath Tiruvoipati
doi : 10.1186/s13054-021-03534-4
Crit Care. 2021; 25: 117. Published online 2021 Mar 22.
Medical emergency teams (MET) are mostly led by physicians. Some hospitals are currently using nurse practitioners (NP) to lead MET calls. These are no studies comparing clinical outcomes between these two care models. To determine whether NP-led MET calls are associated with lower risk of acute patient deterioration, when compared to intensive care (ICU) registrar (ICUR)-led MET calls.
Urinary metabolites predict mortality or need for renal replacement therapy after combat injury
Sarah Gisewhite, Ian J. Stewart, Greg Beilman, Elizabeth Lusczek
doi : 10.1186/s13054-021-03544-2
Crit Care. 2021; 25: 119. Published online 2021 Mar 23.
Traditionally, patient risk scoring is done by evaluating vital signs and clinical severity scores with clinical intuition. Urinary biomarkers can add objectivity to these models to make risk prediction more accurate. We used metabolomics to identify prognostic urinary biomarkers of mortality or need for renal replacement therapy (RRT). Additionally, we assessed acute kidney injury (AKI) diagnosis, injury severity score (ISS), and AKI stage.
Effect of timing of intubation on clinical outcomes of critically ill patients with COVID-19: a systematic review and meta-analysis of non-randomized cohort studies
Eleni Papoutsi, Vassilis G. Giannakoulis, Eleni Xourgia, Christina Routsi, Anastasia Kotanidou, Ilias I. Siempos
doi : 10.1186/s13054-021-03540-6
Crit Care. 2021; 25: 121. Published online 2021 Mar 25.
Although several international guidelines recommend early over late intubation of patients with severe coronavirus disease 2019 (COVID-19), this issue is still controversial. We aimed to investigate the effect (if any) of timing of intubation on clinical outcomes of critically ill patients with COVID-19 by carrying out a systematic review and meta-analysis.
Decreased mortality in acute respiratory distress syndrome patients treated with corticosteroids: an updated meta-analysis of randomized clinical trials with trial sequential analysis
Ping Lin, Yuean Zhao, Xiaoqian Li, Faming Jiang, Zongan Liang
doi : 10.1186/s13054-021-03546-0
Crit Care. 2021; 25: 122. Published online 2021 Mar 26.
The possible benefits associated with corticosteroid treatment in acute respiratory distress syndrome (ARDS) patients are not fully known. We conducted an updated meta-analysis to assess the effect of corticosteroids in the treatment of patients with ARDS.
Agreement between continuous and intermittent pulmonary artery thermodilution for cardiac output measurement in perioperative and intensive care medicine: a systematic review and meta-analysis
Karim Kouz, Frederic Michard, Alina Bergholz, Christina Vokuhl, Luisa Briesenick, Phillip Hoppe, Moritz Flick, Gerhard Sch?n, Bernd Saugel
doi : 10.1186/s13054-021-03523-7
Crit Care. 2021; 25: 125. Published online 2021 Mar 29.
Pulmonary artery thermodilution is the clinical reference method for cardiac output monitoring. Because both continuous and intermittent pulmonary artery thermodilution are used in clinical practice it is important to know whether cardiac output measurements by the two methods are clinically interchangeable.
Anti-Xa activity and hemorrhagic events under extracorporeal membrane oxygenation (ECMO): a multicenter cohort study
Richard Descamps, Mouhamed D. Moussa, Emmanuel Besnier, Marc-Olivier Fischer, Sébastien Preau, Fabienne Tamion, Cédric Daubin, Nicolas Cousin, André Vincentelli, Julien Goutay, Damien Du Cheyron
doi : 10.1186/s13054-021-03554-0
Crit Care. 2021; 25: 127. Published online 2021 Apr 2.
Hemorrhagic events remain a major concern in patients under extracorporeal membrane oxygenation (ECMO) support. We tested the association between anticoagulation levels and hemorrhagic events under ECMO using anti-Xa activity monitoring.
Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients
Thomas Langer, Matteo Brioni, Amedeo Guzzardella, Eleonora Carlesso, Luca Cabrini, Gianpaolo Castelli, Francesca Dalla Corte, Edoardo De Robertis, Martina Favarato, Andrea Forastieri, Clarissa Forlini, Massimo Girardis, Domenico Luca Grieco, Lucia Mirabella, Valentina Noseda, Paola Previtali, Alessandro Protti, Roberto Rona, Francesca Tardini, Tommaso Tonetti, Fabio Zannoni, Massimo Antonelli, Giuseppe Foti, Marco Ranieri, Antonio Pesenti, Roberto Fumagalli, Giacomo Grasselli, PRONA-COVID Group
doi : 10.1186/s13054-021-03552-2
Crit Care. 2021; 25: 128. Published online 2021 Apr 6.
Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave.
FDG-PET/CT in intensive care patients with bloodstream infection
Jordy P. Pijl, Mark Londema, Thomas C. Kwee, Maarten W. N. Nijsten, Riemer H. J. A. Slart, Rudi A. J. O. Dierckx, Peter H. J. van der Voort, Andor W. J. M. Glaudemans, Janesh Pillay
doi : 10.1186/s13054-021-03557-x
Crit Care. 2021; 25: 133. Published online 2021 Apr 7.
2-Deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) is an advanced imaging technique that can be used to examine the whole body for an infection focus in a single examination in patients with bloodstream infection (BSI) of unknown origin. However, literature on the use of this technique in intensive care patients is scarce. The purpose of this study was to evaluate the diagnostic yield of FDG-PET/CT in intensive care patients with BSI.
A 5G-powered robot-assisted teleultrasound diagnostic system in an intensive care unit
Shaobo Duan, Luwen Liu, Yongqing Chen, Long Yang, Ye Zhang, Shuaiyang Wang, Liuwei Hao, Lianzhong Zhang
doi : 10.1186/s13054-021-03563-z
Crit Care. 2021; 25: 134. Published online 2021 Apr 7.
Teleultrasound provides an effective solution to problems that arise from limited medical resources, a lack of local expertise, and scenarios where the risk of infection is high. This study aims to explore the feasibility of the application of a 5G-powered robot-assisted teleultrasound diagnostic system in an intensive care unit.
Post-extubation oxygenation strategies in acute respiratory failure: a systematic review and network meta-analysis
Hideto Yasuda, Hiromu Okano, Takuya Mayumi, Chihiro Narita, Yu Onodera, Masaki Nakane, Nobuaki Shime
doi : 10.1186/s13054-021-03550-4
Crit Care. 2021; 25: 135. Published online 2021 Apr 9.
High-flow nasal cannula oxygenation (HFNC) and noninvasive positive-pressure ventilation (NPPV) possibly decrease tracheal reintubation rates better than conventional oxygen therapy (COT); however, few large-scale studies have compared HFNC and NPPV. We conducted a network meta-analysis (NMA) to compare the effectiveness of three post-extubation respiratory support devices (HFNC, NPPV, and COT) in reducing the mortality and reintubation risk.
Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome
Fabienne Venet, Martin Cour, Thomas Rimmelé, Sebastien Viel, Hodane Yonis, Remy Coudereau, Camille Amaz, Paul Abraham, Céline Monard, Jean-Sebastien Casalegno, Karen Brengel-Pesce, Anne-Claire Lukaszewicz, Laurent Argaud, Guillaume Monneret, the RICO study group
doi : 10.1186/s13054-021-03558-w
Crit Care. 2021; 25: 140. Published online 2021 Apr 12.
Since the onset of the pandemic, only few studies focused on longitudinal immune monitoring in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) whereas their hospital stay may last for several weeks. Consequently, the question of whether immune parameters may drive or associate with delayed unfavorable outcome in these critically ill patients remains unsolved.
Negative drift of sedation depth in critically ill patients receiving constant minimum alveolar concentration of isoflurane, sevoflurane, or desflurane: a randomized controlled trial
Adrian-Iustin Georgevici, Theodoros Kyprianou, Jennifer Herzog-Niescery, Livia Procopiuc, Sivakkanan Loganathan, Thomas Peter Weber, Martin Bellgardt
doi : 10.1186/s13054-021-03556-y
Crit Care. 2021; 25: 141. Published online 2021 Apr 13.
Intensive care unit (ICU) physicians have extended the minimum alveolar concentration (MAC) to deliver and monitor long-term volatile sedation in critically ill patients. There is limited evidence of MAC’s reliability in controlling sedation depth in this setting. We hypothesized that sedation depth, measured by the electroencephalography (EEG)-derived Narcotrend-Index (burst-suppression N_Index 0—awake N_Index 100), might drift downward over time despite constant MAC values.
Validation of the Critical-Care Pain Observation Tool-Neuro in brain-injured adults in the intensive care unit: a prospective cohort study
Céline Gélinas, Mélanie Bérubé, Kathleen A. Puntillo, Madalina Boitor, Melissa Richard-Lalonde, Francis Bernard, Virginie Williams, Aaron M. Joffe, Craig Steiner, Rebekah Marsh, Louise Rose, Craig M. Dale, Darina M. Tsoller, Manon Choinière, David L. Streiner
doi : 10.1186/s13054-021-03561-1
Crit Care. 2021; 25: 142. Published online 2021 Apr 13.
Pain assessment in brain-injured patients in the intensive care unit (ICU) is challenging and existing scales may not be representative of behavioral reactions expressed by this specific group. This study aimed to validate the French-Canadian and English revised versions of the Critical-Care Pain Observation Tool (CPOT-Neuro) for brain-injured ICU patients.
Death in hospital following ICU discharge: insights from the LUNG SAFE study
Fabiana Madotto, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, John G. Laffey, Giacomo Bellani, the LUNG SAFE Investigators, the ESICM Trials Group
doi : 10.1186/s13054-021-03465-0
Crit Care. 2021; 25: 144. Published online 2021 Apr 13.
To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward.
Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis
Victoria S. Owen, Brianna K. Rosgen, Stephana J. Cherak, Andre Ferland, Henry T. Stelfox, Kirsten M. Fiest, Daniel J. Niven
doi : 10.1186/s13054-021-03553-1
Crit Care. 2021; 25: 146. Published online 2021 Apr 16.
It is unclear whether vasopressors can be safely administered through a peripheral intravenous (PIV). Systematic review and meta-analysis methodology was used to examine the incidence of local anatomic adverse events associated with PIV vasopressor administration in patients of any age cared for in any acute care environment.
Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study
Pavan K. Bhatraju, Eric D. Morrell, Leila Zelnick, Neha A. Sathe, Xin-Ya Chai, Sana S. Sakr, Sharon K. Sahi, Anthony Sader, Dawn M. Lum, Ted Liu, Neall Koetje, Ashley Garay, Elizabeth Barnes, Jonathan Lawson, Gail Cromer, Mary K. Bray, Sudhakar Pipavath, Bryan R. Kestenbaum, W. Conrad Liles, Susan L. Fink, T. Eoin West, Laura Evans, Carmen Mikacenic, Mark M. Wurfel
doi : 10.1186/s13054-021-03547-z
Crit Care. 2021; 25: 148. Published online 2021 Apr 19.
Analyses of blood biomarkers involved in the host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection can reveal distinct biological pathways and inform development and testing of therapeutics for COVID-19. Our objective was to evaluate host endothelial, epithelial and inflammatory biomarkers in COVID-19.
The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study
Christian Jung, Hans Flaatten, Jesper Fj?lner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Brian Marsh, Finn H. Andersen, Rui Moreno, Maurizio Cecconi, Susannah Leaver, Ariane Boumendil, Dylan W. De Lange, Bertrand Guidet, COVIP study group
doi : 10.1186/s13054-021-03551-3
Crit Care. 2021; 25: 149. Published online 2021 Apr 19.
The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both the triage into intensive care, and decisions regarding treatment limitations. Our study sought to determine the interaction of frailty and age in elderly COVID-19 ICU patients.
Novel criteria to classify ARDS severity using a machine learning approach
Mohammed Sayed, David Ria?o, Jes?s Villar
doi : 10.1186/s13054-021-03566-w
Crit Care. 2021; 25: 150. Published online 2021 Apr 20.
Usually, arterial oxygenation in patients with the acute respiratory distress syndrome (ARDS) improves substantially by increasing the level of positive end-expiratory pressure (PEEP). Herein, we are proposing a novel variable [PaO2/(FiO2xPEEP) or P/FPE] for PEEP???5 to address Berlin’s definition gap for ARDS severity by using machine learning (ML) approaches.
Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study
Jérôme Pugin, Thomas Daix, Jean-Luc Pagani, Davide Morri, Angelo Giacomucci, Pierre-François Dequin, Christophe Guitton, Yok-Ai Que, Gianluca Zani, David Brealey, Alain Lepape, Ben Creagh-Brown, Duncan Wyncoll, Daniela Silengo, Irina Irincheeva, Laurie Girard, Fabien Rebeaud, Iwan Maerki, Philippe Eggimann, Bruno François
doi : 10.1186/s13054-021-03576-8
Crit Care. 2021; 25: 151. Published online 2021 Apr 20.
The early recognition and management of sepsis improves outcomes. Biomarkers may help in identifying earlier sub-clinical signs of sepsis. We explored the potential of serial measurements of C-reactive protein (CRP), procalcitonin (PCT) and pancreatic stone protein (PSP) for the early recognition of sepsis in patients hospitalized in the intensive care unit (ICU).
Latent class analysis to predict intensive care outcomes in Acute Respiratory Distress Syndrome: a proposal of two pulmonary phenotypes
Pedro D. Wendel Garcia, Alessio Caccioppola, Silvia Coppola, Tommaso Pozzi, Arianna Ciabattoni, Stefano Cenci, Davide Chiumello
doi : 10.1186/s13054-021-03578-6
Crit Care. 2021; 25: 154. Published online 2021 Apr 22.
Acute respiratory distress syndrome remains a heterogeneous syndrome for clinicians and researchers difficulting successful tailoring of interventions and trials. To this moment, phenotyping of this syndrome has been approached by means of inflammatory laboratory panels. Nevertheless, the systemic and inflammatory expression of acute respiratory distress syndrome might not reflect its respiratory mechanics and gas exchange.
Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients during the first wave of the pandemic: observational report from 28 European intensive care units
Andrea Lavinio, Ari Ercole, Denise Battaglini, Sandra Magnoni, Rafael Badenes, Fabio Silvio Taccone, Raimund Helbok, William Thomas, Paolo Pelosi, Chiara Robba, collaborators
doi : 10.1186/s13054-021-03543-3
Crit Care. 2021; 25: 155. Published online 2021 Apr 22.
Critical illness from SARS-CoV-2 infection (COVID-19) is associated with a high burden of pulmonary embolism (PE) and thromboembolic events despite standard thromboprophylaxis. Available guidance is discordant, ranging from standard care to the use of therapeutic anticoagulation for enhanced thromboprophylaxis (ET). Local ET protocols have been empirically determined and are generally intermediate between standard prophylaxis and full anticoagulation. Concerns have been raised in regard to the potential risk of haemorrhage associated with therapeutic anticoagulation. This report describes the prevalence and safety of ET strategies in European Intensive Care Unit (ICUs) and their association with outcomes during the first wave of the COVID pandemic, with particular focus on haemorrhagic complications and ICU mortality.
Day-to-day progression of vital-sign circadian rhythms in the intensive care unit
Shaun Davidson, Mauricio Villarroel, Mirae Harford, Eoin Finnegan, Jo?o Jorge, Duncan Young, Peter Watkinson, Lionel Tarassenko
doi : 10.1186/s13054-021-03574-w
Crit Care. 2021; 25: 156. Published online 2021 Apr 22.
Disrupted vital-sign circadian rhythms in the intensive care unit (ICU) are associated with complications such as immune system disruption, delirium and increased patient mortality. However, the prevalence and extent of this disruption is not well understood. Tools for its detection are currently limited.
Implications of cardiac markers in risk-stratification and management for COVID-19 patients
Pengping Li, Wei Wu, Tingting Zhang, Ziyu Wang, Jie Li, Mengyan Zhu, Yuan Liang, Wenhua You, Kening Li, Rong Ding, Bin Huang, Lingxiang Wu, Weiwei Duan, Yi Han, Xuesong Li, Xin Tang, Xin Wang, Han Shen, Qianghu Wang, Hong Yan, Xinyi Xia, Yong Ji, Hongshan Chen
doi : 10.1186/s13054-021-03555-z
Crit Care. 2021; 25: 158. Published online 2021 Apr 26.
COVID-19 has resulted in high mortality worldwide. Information regarding cardiac markers for precise risk-stratification is limited. We aim to discover sensitive and reliable early-warning biomarkers for optimizing management and improving the prognosis of COVID-19 patients.
Argatroban versus heparin in patients without heparin-induced thrombocytopenia during venovenous extracorporeal membrane oxygenation: a propensity-score matched study
Christoph Fisser, Maren Winkler, Maximilian V. Malfertheiner, Alois Philipp, Maik Foltan, Dirk Lunz, Florian Zeman, Lars S. Maier, Matthias Lubnow, Thomas Müller
doi : 10.1186/s13054-021-03581-x
Crit Care. 2021; 25: 160. Published online 2021 Apr 29.
During venovenous extracorporeal membrane oxygenation (vvECMO), direct thrombin inhibitors are considered by some potentially advantageous over unfractionated heparin (UFH). We tested the hypothesis that Argatroban is non-inferior to UFH regarding thrombosis and bleeding during vvECMO.
Trajectories of depression in sepsis survivors: an observational cohort study
Monique Boede, Jochen S. Gensichen, James C. Jackson, Fiene Ei?ler, Thomas Lehmann, Sven Schulz, Juliana J. Petersen, Florian P. Wolf, Tobias Dreischulte, Konrad F. R. Schmidt
doi : 10.1186/s13054-021-03577-7
Crit Care. 2021; 25: 161. Published online 2021 Apr 29.
Advances in critical care medicine have led to a growing number of critical illness survivors. A considerable part of them suffers from long-term sequelae, also known as post-intensive care syndrome. Among these, depressive symptoms are frequently observed. Depressive symptom trajectories and associated factors of critical illness survivors have rarely been investigated. Study objective was to explore and compare different trajectories of depressive symptoms in sepsis survivors over 1 year after discharge from ICU.
Correction to: Risks of ventilator-associated pneumonia and invasive pulmonary aspergillosis in patients with viral acute respiratory distress syndrome related or not to Coronavirus 19 disease
Keyvan Razazi, Romain Arrestier, Anne Fleur Haudebourg, Brice Benelli, Guillaume Carteaux, Jean?Winoc Decousser, Slim Fourati, Paul Louis Woerther, Frederic Schlemmer, Anais Charles-Nelson, Francoise Botterel, Nicolas de Prost, Armand Mekontso Dessap
doi : 10.1186/s13054-021-03517-5
Crit Care. 2021; 25: 118. Published online 2021 Mar 22.
Correction to: Ventilator-associated pneumonia in critically ill patients with COVID-19
Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Soderholm, Sally Forrest, Sushmita Sridhar, Nicholas M. Brown, Stephen Baker, Vilas Navapurkar, Gordon Dougan, Josefn Bartholdson Scott, Andrew Conway Morris
doi : 10.1186/s13054-021-03560-2
Crit Care. 2021; 25: 130. Published online 2021 Apr 6.
Correction to: CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS
Mathieu Blot, Marine Jacquier, Ludwig-Serge Aho Glele, Guillaume Beltramo, Maxime Nguyen, Philippe Bonniaud, Sebastien Prin, Pascal Andreu, Belaid Bouhemad, Jean-Baptiste Bour, Christine Binquet, Lionel Piroth, Jean-Paul Pais de Barros, David Masson, Jean-Pierre Quenot, Pierre-Emmanuel Charles, Pneumochondrie Study Group
doi : 10.1186/s13054-021-03559-9
Crit Care. 2021; 25: 143. Published online 2021 Apr 13.
