doi : 10.1016/S0360-3016(21)02878-9
Volume 111, Issue 5, 1 December 2021, Pages A11-A12
NuradhJosephMD, MRCP, FRCR*†
doi : 10.1016/j.ijrobp.2021.09.021
Volume 111, Issue 5, 1 December 2021, Pages 1097-1100
Horatio R.ThomasMD, MMScSue S.YomMD, PhD
doi : 10.1016/j.ijrobp.2021.03.042
Volume 111, Issue 5, 1 December 2021, Pages 1101-1102
YongYangMD
doi : 10.1016/j.ijrobp.2021.09.043
Volume 111, Issue 5, 1 December 2021, Page 1103
Kheng-WeiYeohFang YueYong
doi : 10.1016/j.ijrobp.2021.09.044
Volume 111, Issue 5, 1 December 2021, Pages 1103-1105
Sarah A.MilgromMDBradley M.HaverkosMD
doi : 10.1016/j.ijrobp.2021.09.045
Volume 111, Issue 5, 1 December 2021, Page 1105
Susan Y.WuM.D.Chelsea C.PinnixM.D., Ph.D.
doi : 10.1016/j.ijrobp.2021.09.046
Volume 111, Issue 5, 1 December 2021, Pages 1105-1106
AnthonyZietmanMD FASTRO(Editor-in-Chief)
doi : 10.1016/j.ijrobp.2021.08.028
Volume 111, Issue 5, 1 December 2021, Pages 1107-1109
Thomas J.EichlerMD
doi : 10.1016/j.ijrobp.2021.08.030
Volume 111, Issue 5, 1 December 2021, Page 1110
Shauna R.CampbellDO*Katherine E.BennettMA†Sue S.YomMD, PhD‡ReshmaJagsiMD, DPhil§
doi : 10.1016/j.ijrobp.2021.07.011
Volume 111, Issue 5, 1 December 2021, Pages 1111-1113
Gastrointestinal Cancer Editors: Christopher G.Willett?Daniel T.Chang†Brian G.Czito?Stanley L.Liauw‡Jennifer Y.Wo§Physics Editors: EricKlein?ZheChen¶David J.Carlson#Indrin J.Chetty??
doi : 10.1016/j.ijrobp.2021.09.007
Volume 111, Issue 5, 1 December 2021, Pages 1114-1117
J. MartinBrownPhD*Michael L.FreemanPhD†BrianMarplesPhD‡MarjanBoermaPhD§
doi : 10.1016/j.ijrobp.2021.06.039
Volume 111, Issue 5, 1 December 2021, Pages 1118-1119
Theodore L.DeWeeseMD*DavidBeyerMD†Leonard L.GundersonMD‡Bruce G.HafftyMD§Paul M.HarariMD?Colleen A.LawtonMD¶Bruce D.MinskyMD#Michael L.SteinbergMD??
doi : 10.1016/j.ijrobp.2021.08.014
Volume 111, Issue 5, 1 December 2021, Pages 1120-1121
Brian D.KavanaghMD, MPH, FASTRO
doi : 10.1016/j.ijrobp.2021.08.040
Volume 111, Issue 5, 1 December 2021, Page 1122
Phillip M.DevlinMD, FACR, FASTRO, FFRRCSI, FABSHelen A.ShihMD, MS, MPH, FASTRO
doi : 10.1016/j.ijrobp.2021.09.001
Volume 111, Issue 5, 1 December 2021, Pages 1123-1124
doi : 10.1016/j.ijrobp.2021.07.037
Volume 111, Issue 5, 1 December 2021, Page 1125
Jeffrey C.BuchsbaumMD, PhD, AM, FASTROC. NormanColemanMD, FASTROEric J.BernhardPhDMichael G.EspeyPhDBhadrasainVikramMD, FASTRO
doi : 10.1016/j.ijrobp.2021.07.1709
Volume 111, Issue 5, 1 December 2021, Pages 1126-1130
Steven H.LinMD, PhD?HenningWillersMD†SunilKrishnanMD‡Jann N.SarkariaMD§MichaelBaumannMD||Theodore S.LawrenceMD, PhD¶
doi : 10.1016/j.ijrobp.2021.08.018
Volume 111, Issue 5, 1 December 2021, Pages 1131-1139
Amanda J.WalkerMD
doi : 10.1016/j.ijrobp.2021.07.1710
Volume 111, Issue 5, 1 December 2021, Pages 1140-1144
RuiYeMPH*†YaweiQiaoMS*Pankaj K.SinghPhD‡YifanWangPhD*JianzhongHeBS*NanLiPhD*SunilKrishnanMD, PhD‡Steven H.LinMD, PhD*†
doi : 10.1016/j.ijrobp.2021.07.1712
Volume 111, Issue 5, 1 December 2021, Pages e27-e37
The combination of cytotoxic chemotherapy with radiation therapy (CRT) has resulted in significant improvements in clinical outcomes for patients with many locally advanced unresectable cancers. Only a small proportion of patients achieve pathologic complete responses to CRT; combination of CRT with targeted agents offers the promise of further improving treatment responses. However, numerous clinical trials have failed to show an improvement in clinical outcomes with the addition of targeted agents. To increase the accessibility of our screening method and accelerate the pace at which novel combinations with CRT are identified and incorporated into standard practices for treatments, we report details on screening method optimization, data generation, and downstream data analysis.
Leslie A.ParselsPhD*QiangZhangPhD*DavidKarnakPhD*Joshua D.ParselsBS*KwokLamPhD*HenningWillersMD†Michael D.GreenMD, PhD*AlnawazRehemtullaPhD*Theodore S.LawrenceMD, PhD*Meredith A.MorganPhD*
doi : 10.1016/j.ijrobp.2021.07.1708
Volume 111, Issue 5, 1 December 2021, Pages e38-e53
SonjaDragojevicPhD*JianxiongJiMD, PhD*†‡Pankaj K.SinghPhD§Margaret A.ConnorsBS?Robert W.MutterMD*Scott C.LesterMD*Surabhi M.TaleleMS?WenjuanZhangMS?Brett L.CarlsonBA?Nicholas B.RemmesPhD*Sean S.ParkMD, PhD*William F.ElmquistPharmD, PhD?SunilKrishnanMBBS, MD§Erik J.TryggestadPhD*Jann N.SarkariaMD*
doi : 10.1016/j.ijrobp.2021.08.003
Volume 111, Issue 5, 1 December 2021, Pages e54-e62
HenningWillersMD?XiaoPanPhD?NathalieBorgeaudPhD†‡§IrinaKorovinaPhD†‡§||LydiaKoiPhD†||¶ReginaEganBS#PatriciaGreningerBA#AlizaRosenkranzBS?JongKungPhD?Andrew S.LissPhD??Leslie A.ParselsPhD††Meredith A.MorganPhD††Theodore S.LawrenceMD, PhD††Steven H.LinMD, PhD‡‡Theodore S.HongMD?Beow Y.YeapScD§§Lori J.WirthMD§§Aaron N.HataMD, PhD#…MechthildKrauseMD†‡§||¶¶¶
doi : 10.1016/j.ijrobp.2021.07.1694
Volume 111, Issue 5, 1 December 2021, Pages e63-e74
Larry A.DeWerdPhD, FAAPMKeithKunugiMBA, MS
doi : 10.1016/j.ijrobp.2021.09.002
Volume 111, Issue 5, 1 December 2021, Pages e75-e81
Nicholas B.FiguraMD?Timothy J.RobinsonMD, PhD*†Austin J.SimMD, JD*XuefengWangPhD†BiweiCaoMS†Julio C.ChavezMD‡§Bijal D.ShahMD‡§FarhadKhimaniMD?AleksandrLazaryanMD, PhD?MarcoDavilaMD, PhD?ChristinaBachmeierPharmD, BCOP?TaigaNishihoriMD?Hien D.LiuMD?SungjuneKimMD, PhD*Frederick L.LockeMD?Michael D.JainMD, PhD?
doi : 10.1016/j.ijrobp.2021.06.038
Volume 111, Issue 5, 1 December 2021, Pages 1145-1154
PremaRassiahPhD?NatiaEsiashviliMD†Arthur J.OlchPhD‡Chia-HoHuaPhD§KenUlinPhD?AndreaMolineuMS¶KarenMarcusMD#MaheshGopalakrishnanMS??SushaPillaiMS††NataliyaKovalchukPhD‡‡AnLiuPhD§§GregNiyazovMS??JosePeñagarícanoMD¶¶FredCheung##Adam C.OlsonMD???Cheng-ChiaWuMD†††Harish K.MalhotraPhD‡‡‡Iain J.MacEwanMD§§§JacquelineFaughtPhD§John C.BrenemanMD???David S.FollowillPhD¶Thomas J.FitzGeraldMD¶¶¶John A.KalapurakalMD??
doi : 10.1016/j.ijrobp.2021.07.1715
Volume 111, Issue 5, 1 December 2021, Pages 1155-1164
Elliot H.Akama-GarrenMSc?†Zachary S.MorrisMD, PhD‡Andrew G.SikoraMD, PhD§RalphWeichselbaumMD?#Jonathan D.SchoenfeldMD, MPH?†
doi : 10.1016/j.ijrobp.2021.08.009
Volume 111, Issue 5, 1 December 2021, Pages 1165-1175
Immune checkpoint inhibitors (ICIs) lead to durable responses in a subset of patients with cancer, but most patients do not respond to ICI, prompting interest in combining immunotherapy with other therapeutic regimens. Preclinical evidence supports the potential for therapeutic synergy between immunotherapy and radiation therapy through modulation of the tumor microenvironment and antitumor immune responses. Local therapy also has the potential to overcome localized sites of relative immune suppression and resistance. Prospective clinical trials have been initiated to test these hypotheses in the clinic as well as to investigate the toxicities and adverse events associated with combination immunotherapy and radiation therapy. In this review, we discuss the emerging results from prospective clinical trials of combination immunotherapy and radiation therapy, the safety and efficacy of their combination, concordance with preclinical and retrospective data, and some of the remaining open questions to be addressed by future clinical trials.
Matthew R.McFarlaneMD, PhD*Kimberly A.HochstedlerMS†Anna M.LaucisMD, MPhil?YilunSunPhD*AulinaChowdhuryBS‡Martha M.MatuszakPhD*JamesHaymanMD*DerekBergsmaMD§ThomasBoikeMD||LarryKestinMD||BenjaminMovsasMD¶IngaGrills#MichaelDominelloMD??Robert T.DessMD*CaitlinSchonewolfMD*Daniel E.SprattMD*LoriPierceMD*PeterPaximadisMD††ShrutiJollyMD*MatthewSchipperPhD*†on behalf of the
doi : 10.1016/j.ijrobp.2021.07.1691
Volume 111, Issue 5, 1 December 2021, Pages 1176-1185
HayeonKimPhD, DABR*AndrewKellerMD?SushilBeriwalMD, MBA*Kenneth J.SmithMD, MS†John A.VargoMD?
doi : 10.1016/j.ijrobp.2021.04.049
Volume 111, Issue 5, 1 December 2021, Pages 1186-1194
GrantHarmonMD*DennisChanMD*BrianLeePhD*ChelseaMillerMD†AlexGorbonosMD‡GopalGuptaMD‡MarcusQuekMD‡MichaelWoodsMD‡BitalSavir-BaruchMD§Matthew M.HarkenriderMD*Abhishek A.SolankiMD, MS?
doi : 10.1016/j.ijrobp.2021.05.009
Volume 111, Issue 5, 1 December 2021, Pages 1195-1203
Miguel R.FerreiraPhD*†‡§Caroline J.SandsPhD||Jia V.LiPhD¶Jervoise N.AndreyevPhD#ElenaChekmenevaPhD||SarahGullifordPhD*??JulianMarchesiPhD¶††Matthew R.LewisPhD||David P.DearnaleyFRCR*†
doi : 10.1016/j.ijrobp.2021.07.1713
Volume 111, Issue 5, 1 December 2021, Pages 1204-1213
Radiation therapy to the prostate and pelvic lymph nodes (PLNRT) is part of the curative treatment of high-risk prostate cancer. Yet, the broader influence of radiation therapy on patient physiology is poorly understood. We conducted comprehensive global metabolomic profiling of urine, plasma, and stools sampled from patients undergoing PLNRT for high-risk prostate cancer.
Parvez M.ShaikhMD*Sarah A.SinghMD*FioriAliteMD†John A.VargoMD‡BahmanEmamiMD§Meng-JiaWuPhD§GeraldineJacobsonMD, MPH, MBA*VeliBakalovMD?WilliamSmallJrMD§BasemDahshanMD*JoshuaWeirDO*Paul B.RenzDO?Matthew M.HarkenriderMD§
doi : 10.1016/j.ijrobp.2021.08.006
Volume 111, Issue 5, 1 December 2021, Pages 1214-1226
JuneCorryMD?†Wai TongNgMD‡§AlishaMooreBMedRadSci?Horace C.W.ChoiPhD§QuynhLeMD¶SofeeHolmesBMedRadSci?ArieMunandarMD#ShengziWangMD??AngelaCamachoMD††JirapornSetakornnukulMD‡‡ChuleepornJiarpinitnunMD§§P.N.HiepMD??Sarbani GhoshLaskarMD¶¶NoureddineBenjaafarMD##MohammadFaheemFRCP???FengJinMD†††Chiraz Nasr BenAmmarMD‡‡‡RubinaAliMCPS§§§KadaBoualgaMD???SherifAbdelwahabMD¶¶¶KiattisaSommatFRCR###YunganTaoMD????BrianO'SullivanMD††††NancyLeeMD‡‡‡‡EduardoZubizarettaMD§§§§BenPrajogiMD§§§§KirstenHopkinsMD§§§§EduardoRosenblattMD§§§§Anne W.M.LeeMD????
doi : 10.1016/j.ijrobp.2021.08.013
Volume 111, Issue 5, 1 December 2021, Pages 1227-1236
Most new nasopharyngeal cancer cases occur in low-income and middle-income countries, and these patients experience poorer overall survival than that of new nasopharyngeal cancer cases in high-income countries. The goal of this research project is to determine whether the introduction of a radiation therapy quality assurance program can ultimately improve outcomes for nasopharyngeal cancer patients in lower-income and middle-income countries. This study reports the results of the first phase of the International Atomic Energy Agency Coordinated Research Project (325-E3-TM-47712).
Bart?omiejTomasikMD, PhD?†‡AnnaPapis-UbychMD§KonradStawiskiMD*JacekFijuthMD, PhD||PiotrK?dzierawskiMD, PhD¶#JacekSadowskiMD¶Rafa?StandoMD¶RobertBibikMD, PhD???ukaszGraczykMD??TomaszLatusekMD, PhD††TomaszRutkowskiMD, PhD‡‡WojciechFendlerMD, PhD?‡
doi : 10.1016/j.ijrobp.2021.07.008
Volume 111, Issue 5, 1 December 2021, Pages 1237-1249
Jia-LingRuanPhD*CarlLeeMSc†ShariWoutersMSc‡§Iain D.C.TullisPhD*MiekeVerslegersPhD‡MohamedMysaraPhD‡Chee KinThenMSc*Sean C.SmartPhD*Mark A.HillPhD*Ruth J.MuschelPhD*Amato J.GiacciaPhD*BorivojVojnovicPhD*Anne E.KiltiePhD*KristofferPeterssonPhD*?
doi : 10.1016/j.ijrobp.2021.08.004
Volume 111, Issue 5, 1 December 2021, Pages 1250-1261
ZoéSchmalPhD*BenHammerMD*AndreasMüllerPhD†Claudia E.RübePhD, MD*
doi : 10.1016/j.ijrobp.2021.07.007
Volume 111, Issue 5, 1 December 2021, Pages 1262-1275
VerdianaTrappettiMSc*CristianFernandez-PalomoPhD*LloydSmythPhD†MitziKleinVMD‡DavidHaberthürPhD*DuncanButlerPhD‡MicahBarnesMSc‡§NahokoShintaniPhD*Michaelde VeerPhD||Jean A.LaissueMD*Marie C.VozeninPhD¶ValentinDjonovMD*
doi : 10.1016/j.ijrobp.2021.07.1717
Volume 111, Issue 5, 1 December 2021, Pages 1276-1288
BrianaFarrugiaBAppSc?†KellieKnightHScD, MHlthSc, BAppSc†CarolineWrightPhD, MSc, PGCE, BSc(Hons), DCR(T)†MarkTaceyMBiostat, BSc?‡FarshadForoudiMBBS MPA DMedSc FRANZCR*MichaelChaoBBS DMedSc, FRANZCR, AFRACMA*RichardKhorMBBS, DMedSc, FRANZCR?§?
doi : 10.1016/j.ijrobp.2021.08.001
Volume 111, Issue 5, 1 December 2021, Pages 1289-1297
For upper abdominal tumors, our institutional-standard motion reduction method is the expiration breath-hold (EBH) technique, using Active Breathing Coordinator (ABC). However, an individual patient's breath-hold (BH) reproducibility (RBH) may be improved in deep inspiration or inspiration breath-hold (DIBH or IBH). This trial compared the tumor position RBH, stability (SBH), and breath-hold time (TBH) of 3 BH methods, using ABC, to personalize the selection of technique, by using a preplanning screening assessment.
Joshua S.NiedzielskiPhD*YufeiLiuMD†Sylvia S.W.NgMD, PhD†Rachael M.MartinPhD*Luis A.PerlesPhD*SamBeddarPhD*NealRebuenoCMD*Eugene J.KoayMD, PhD†CullenTaniguchiMD, PhD†Emma B.HollidayMD†PrajnanDasMD, MS†Grace L.SmithMD, PhD†Bruce D.MinskyMD†Ethan B.LudmirMD†Joseph M.HermanMD, MSc†AlbertKoongMD, PhD†Gabriel O.SawakuchiPhD*‡
doi : 10.1016/j.ijrobp.2021.08.002
Volume 111, Issue 5, 1 December 2021, Pages 1298-1309
To estimate the effects of interfractional anatomic changes on dose to organs at risk (OARs) and tumors, as measured with cone beam computed tomography (CBCT) image guidance for pancreatic stereotactic body radiation therapy.
XiangkunXuPhD?†aZijianDengPhD?†aHamidDehghaniPhD‡IulianIordachitaPhD§MichaelLimMD?||John W.WongPhD*Ken Kang-HsinWangPhD?†
doi : 10.1016/j.ijrobp.2021.08.010
Volume 111, Issue 5, 1 December 2021, Pages 1310-1321
GulerYavasMD1CagdasYavasMD1CemOnalMD12
doi : 10.1016/j.ijrobp.2021.08.011
Volume 111, Issue 5, 1 December 2021, Page 1322
CrystalGrootMD12Jannet C.BeukemaMD3Niek J.H.PrakkenPhD4Christina T.MuijsPhD5
doi : 10.1016/j.ijrobp.2021.08.012
Volume 111, Issue 5, 1 December 2021, Page 1323
D.M.Ma1K.Price2E.J.Moore3S.H.Patel4M.L.Hinni5B.Fruth6N.R.Foster6K.Van Abel3L.X.Yin3M.A.Neben-Wittich1L.A.McGee7J.C.Rwigema8D.M.Routman9S.C.Lester9D.L.Price3J.R.Janus10J.L.Kasperbauer11T.H.Nagel5A.V.Chintakuntlawar12P.Savvides13J.J.Garcia14R.L.Foote9
doi : 10.1016/j.ijrobp.2021.09.012
Volume 111, Issue 5, 1 December 2021, Page 1324
D.A.Palma1E.Prisman2E.Berthelet3E.Tran4S.N.Hamilton5J.Wu3A.Eskander6K.Higgins6I.Karam7I.Poon8Z.A.Husain8D.Enepekides6M.Hier9K.Sultanem9K.Richardson10A.Mlynarek10S.Johnson-Obaseki11L.Eapen12M.Odell11A.J.Bayley13S.Dowthwaite14J.E.Jackson14M.Dzienis14J.O'Neil14S.Chandarana15R.N.Banerjee16R.Hart15J.Chung17T.C.Tenenholz17S.Krishnan18H.V.Le19J.Yoo20A.Mendez20E.Winquist21S.Kuruvilla21P.Stewart22A.Warner1S.Mitchell23J.Chen24C.Parker25B.Wehrli26K.Kwan26J.Theurer27J.Sathya22J.A.Hammond28N.E.Read23V.M.Venkatesan22D.MacNeil20K.Fung25A.Nichols29
doi : 10.1016/j.ijrobp.2021.09.013
Volume 111, Issue 5, 1 December 2021, Pages 1324-1325
C.J.Tsai1J.T.Yang1D.M.Guttmann1N.Shaverdian1A.F.Shepherd1J.Eng2D.Gelblum1A.J.Xu1A.Namakydoust2A.Iqbal2J.M.Mann1I.Preeshagul2C.Hajj1E.F.Gillespie1S.Sugarman2S.Modi2C.Dang2P.Drullinsky2R.Yeh3J.Girshman3J.Das3W.Zhi2Q.LaPlant1M.Reyngold1A.Rimner1J.Y.Shin1A.J.Wu1K.Ng2A.Gucalp2R.Sanford2A.J.Khan1J.Bromberg2A.D.Seidman2E.Comen2T.A.Traina2D.R.Gomez1Z.Zhang4M.E.Robson2C.M.Rudin2S.N.Powell1
doi : 10.1016/j.ijrobp.2021.09.014
Volume 111, Issue 5, 1 December 2021, Pages 1325-1326
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