دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Acknowledgement of Reviewers 2021
doi : 10.1016/S0167-8140(21)09055-1
Volume 165, December 2021, Page vii
Definitive chemoradiotherapy versus neoadjuvant chemoradiotherapy and esophagectomy for the treatment of esophageal and gastroesophageal carcinoma – A systematic review and meta-analysis
RonaldChowab1KyleMurdyb1MarcusVaskabSangjune LaurenceLeeb
doi : 10.1016/j.radonc.2021.10.013
Volume 165, December 2021, Pages 37-43
There currently exists limited data comparing definitive chemoradiotherapy to neoadjuvant chemoradiotherapy with esophagectomy for patients with esophageal carcinoma. While we await more trials, we conducted a systematic review and meta-analysis of randomized controlled trials and observational studies with either propensity score matched or multivariable analyses, to provide a better understanding of the relative efficacy and effectiveness.
A systematic review of intraluminal high dose rate brachytherapy in the management of malignant biliary tract obstruction and cholangiocarcinoma
Amandeep S.Taggarad1PaveenMannaMichael R.FolkertbShahdradAliakbaridSten D.MyrehaugadLaura A.Dawsoncd
doi : 10.1016/j.radonc.2021.10.011
Volume 165, December 2021, Pages 60-74
To conduct a systematic review evaluating the impact of high dose rate (HDR) intraluminal brachytherapy (ILBT) in the management of malignant biliary obstruction and cholangiocarcinoma with specific focus on stent patency, clinical outcomes and toxicities.
50 years of radiotherapy research: Evolution, trends and lessons for the future
ThomasBergeraDavid J.NoblebLeila E.A.ShelleyaKirsten I.HopkinscDuncan B.McLarenbNeil G.BurnetdWilliam H.Nailonae
doi : 10.1016/j.radonc.2021.09.026
Volume 165, December 2021, Pages 75-86
Rapid and relentless technological advances in an ever-more globalized world have shaped the field of radiation oncology in which we practise today. These developments have drastically modified the habitus1 of health professionals and researchers at an individual and organisational level. In this article we present an analysis of trends in radiation oncology research over the last half a century. To do so, the data from >350,000 scientific publications pertaining to a yearly search of the PubMed database with the keywords cancer radiotherapy was analysed. This analysis revealed that, over the years, radiotherapy research output has declined relative to alternative cancer therapies, representing 64% in 1970 it decreased to 31% in 2019. Also, the pace of research has significantly accelerated with, in the last 15 years, a doubling in the number of articles published by the 10% most productive researchers. Researchers are also facing stronger competition today with a proportion of first authors that will never get to publish as a last author increasing steadily from 58% in 1970 to 84% in 2000. Additionally, radiotherapy research output is extremely unequally distributed in the world, with Africa and South America contributing to ?3% of radiotherapy articles in 2019 while representing 23% of the world’s population. This disparity, reflecting economic situations and radiotherapy capabilities, has a knock-on effect for the provision of routine clinical treatment. Since research activity is inherent to delivery of high quality clinical care, this contributes to the global inequity of radiotherapy services. Learning from these trends is crucial for the future not only of radiation oncology research but also for effective and equitable cancer care.
Pelvic bone marrow sparing radiotherapy for cervical cancer: A systematic review and meta-analysis
PixiaoZhouYingZhangSongguiLuoShuxuZhang
doi : 10.1016/j.radonc.2021.10.015
Volume 165, December 2021, Pages 103-118
Concurrent chemo-radiotherapy in patients with locally advanced cervical cancer has significant hematologic toxicities (HT), leading to treatment disruption and affecting patient prognosis. We performed the meta-analysis to assess the clinical benefit of pelvic (active) bone marrow (BM) sparing radiotherapy.
Radiotherapy for the treatment of optic nerve sheath meningioma: A systematic review and meta-analysis
Laísa Pereirade MeloaGustavoArruda VianibJayter Silvade Paulaa
doi : 10.1016/j.radonc.2021.10.009
Volume 165, December 2021, Pages 135-141
The management of Optic Nerve Sheath Meningiomas (ONSM) has suffered a significant shift due to new radiation techniques. However, there is no conclusive information on which approach presents better results in the literature. This meta-analysis aims to evaluate the outcomes of different radiotherapy (RT) modalities in the management of ONSM.
Whole-lung low-dose radiation therapy (LD-RT) for non-intubated oxygen-dependent patients with COVID-19-related pneumonia receiving dexamethasone and/or remdesevir
Clayton B.HessabTony Y.EngahTahseen H.NastibVishal R.DhereahTroy J.KlebercJeffrey M.SwitchenkodhBrent D.WeinbergeNadineRouphaelfSiboTianahSoumonRudraahLuisa S.TavernagAlvaro PerezDaissongRafiAhmedbMohammad K.Khanach
doi : 10.1016/j.radonc.2021.10.003
Volume 165, December 2021, Pages 20-31
Low-dose radiotherapy (LD-RT) has produced anti-inflammatory effects in both animal models and early human trials of COVID-19-related pneumonia. The role of whole-lung LD-RT within existing treatment paradigms merits further study.
Proton reirradiation for recurrent or new primary breast cancer in the setting of prior breast irradiation
J. IsabelleChoiabAtif J.KhanaSimon N.PowellaBerylMcCormickaAlicia J.Lozanoc1GabrielyDel RosariodJacquelineMamarydHaoyangLiudPamelaFoxdErinGillespieaLior Z.BraunsteinaDennisMahdOrenCahlonab
doi : 10.1016/j.radonc.2021.10.010
Volume 165, December 2021, Pages 142-151
Late local recurrences and second primary breast cancers are increasingly common. Proton beam therapy (PBT) reirradiation (reRT) may allow safer delivery of a second definitive radiotherapy (RT) course. We analyzed outcomes of patients with recurrent or new primary breast cancer who underwent reRT.
Stereotactic body radiotherapy for head and neck skin cancer
Indu S.VorugantiaIanPoonaZain A.HusainaAndrewBayleyaElizabeth A.BarnesaLiyingZhangaLeeChinbDarbyErlercKevinHigginsdDannyEnepekidesdAntoineEskanderdIreneKarama
doi : 10.1016/j.radonc.2021.10.004
Volume 165, December 2021, Pages 1-7
To report outcomes of Stereotactic Body Radiotherapy (SBRT) for head and neck skin cancer (HNSC) patients treated at a high-volume center.
A novel technique of endonasopharyngeal ultrasound-guided transnasopharyngeal needle aspiration in the diagnosis of submucosal recurrence of nasopharyngeal carcinoma after chemoradiotherapy
Zhen-MingZhang1RuiZhao1YuBaoLing-XiaoZhouXiChenWu-SongLiuSheng-PingLiShang-ZhiHuRan-LingWang
doi : 10.1016/j.radonc.2021.10.002
Volume 165, December 2021, Pages 14-19
Recurrence of nasopharyngeal carcinoma (NPC) after chemoradiotherapy is common, but submucosal recurrence of NPC is rare. The final pathological results determine the optimal therapeutic schedule for treatment of NPC recurrence, but tissue retrieval from submucosal lesions is usually difficult. The present study aimed to assess the safety and efficacy of a novel approach of endonasopharyngeal ultrasound-guided transnasopharyngeal needle aspiration (ENUS-TNNA) for submucosal neoplasms in patients with suspected NPC recurrence.
Prognostic importance of radiologic extranodal extension in nasopharyngeal carcinoma treated in a Canadian cohort
OliviaChinaEugeneYuab1BrianO'SullivandeJieSucAnaisTellieraLillianSiufJohnWaldrondeJohnKimdAaronHansenfAndrewHopedJohnChodMeredithGiulianidJolieRingashdeAnnaSpreaficofScottBratmandAliHosnidEzraHahndLiTongdWeiXucShao HuiHuangde1
doi : 10.1016/j.radonc.2021.10.018
Volume 165, December 2021, Pages 94-102
To confirm the prognostic value of radiologic extranodal extension (rENE) and its role in clinical-N classification in nasopharyngeal carcinoma (NPC) treated in a western institution.
Predicted probabilities of brain injury after carbon ion radiotherapy for head and neck and skull base tumors in long-term survivors
SungChulParkaYusukeDemizuabMasakiSugacShingoTaniguchidShinichiTanakadItsumiMaehatadMikuniTakedadDaikiTakahashiaYoshiroMatsuoaNor ShazrinaSulaimanaKazukiTerashimaaSunaoTokumaruaKyojiFurukawaeTomoakiOkimotoa
doi : 10.1016/j.radonc.2021.10.017
Volume 165, December 2021, Pages 152-158
We aimed to determine the risk factors for radiation-induced brain injury (RIBI1) after carbon ion radiotherapy (CIRT) to predict their probabilities in long-term survivors.
Optimal delineation of the clinical target volume for thymomas in the post-resection setting: A multi-center study
FloritMarcuseaStephaniePeetersbKatoHermanaFemkeVaassenbWoutervan ElmptbAlexander P.W.M.MaatcJohnPraagdCharlotteBillietePaulVan SchilfMaartenLambrechtgDirkVan RaemdonckhKimCaoiMadalinaGrigoroiujNicolasGirardklMoniqueHochstenbagaJosMaessenmDirkDe Ruysscherb
doi : 10.1016/j.radonc.2021.10.007
Volume 165, December 2021, Pages 8-13
The definition of the clinical target volume (CTV) for post-operative radiotherapy (PORT) for thymoma is largely unexplored. The aim of this study was to analyze the difference in CTV delineation between radiation oncologists (RTO) and surgeons.
Surgical complications and clinical outcomes after dose-escalated trimodality therapy for non-small cell lung cancer in the era of intensity-modulated radiotherapy
Kevin X.Liua1KailanSierra-Davidsonb1KevinTyancLawrence T.OrlinaaJ. PaulMarcouxeBenjamin H.KannaDavid E.KozonoaRaymond H.MakaAbbyWhitedLisaSingeraf
doi : 10.1016/j.radonc.2021.10.012
Volume 165, December 2021, Pages 44-51
Trimodality therapy (TMT) with preoperative chemoradiation followed by surgical resection is used for locally-advanced non-small-cell lung cancer (LA-NSCLC). Traditionally, preoperative radiation doses ?54 Gy are used due to concerns regarding excess morbidity, but little is known about outcomes and toxicities after TMT with intensity-modulated radiotherapy (IMRT) to higher doses.
Associations between cardiac irradiation and survival in patients with non-small cell lung cancer: Validation and new discoveries in an independent dataset
SinduVivekanandana1John D.Fenwickb1NicholasCounsellcNikiPanakisdRobertStuartdGeoff S.HigginsdeMaria A.Hawkinsf
doi : 10.1016/j.radonc.2021.10.016
Volume 165, December 2021, Pages 119-125
In ‘IDEAL-6? patients (N = 78) treated for locally-advanced non-small-cell lung cancer using isotoxically dose-escalated radiotherapy, overall survival (OS) was associated more strongly with VLAwall-64-73-EQD2, the left atrial (LA) wall volume receiving 64–73 Gy equivalent dose in 2 Gy fractions (EQD2), than with whole-heart irradiation measures. Here we test this in an independent cohort ‘OX-RT’ (N = 64) treated routinely.
Validation and applicability of para-aortic lymph nodal contouring atlas in cervical cancer
ShashankSrinivasanaLavanyaGurramaCarltonJohnnyaSupriyaChopraaA.DheerabAkshayBaheticPalakPopatcNileshSablecVenkateshRangarajandUmeshMahantshettyae
doi : 10.1016/j.radonc.2021.10.014
Volume 165, December 2021, Pages 32-36
CTV delineation guidelines for the para-aortic nodal region for patients with cervical cancer have been proposed (Keenan et al., 2018). The purpose of this study was to validate these guidelines with the use of CT datasets of cervical cancer patients with macroscopic PALN treated with definitive (chemo)radiation (CTRT) at our center.
The role of Ifosfamide–doxorubicin chemotherapy in histology-specific, high grade, locally advanced soft tissue sarcoma, a 14-year experience?,??
Barry W.GoyaSajjadSyedbAswiniPadmanabhancRaoul J.BurchettedChris S.Helmstedtere
doi : 10.1016/j.radonc.2021.10.019
Volume 165, December 2021, Pages 174-178
To compare long-term outcomes of high-grade, primary soft-tissue-sarcoma (STS), using Ifosfamide–Doxorubicin vs local therapy alone, in histology-specific sarcomas.
Can the mean linear energy transfer of organs be directly related to patient toxicities for current head and neck cancer intensity-modulated proton therapy practice?
DirkWagenaaraEwoudSchuitbArjenvan der SchaafaJohannes A.LangendijkaStefanBotha
doi : 10.1016/j.radonc.2021.09.003
Volume 165, December 2021, Pages 159-165
The relative biological effectiveness (RBE) of proton therapy is predicted to vary with the dose-weighted average linear energy transfer (LETd). However, RBE values may substantially vary for different clinical endpoints. Therefore, the aim of this study was to assess the feasibility of relating mean D?LETd parameters to patient toxicity for HNC patients treated with proton therapy.
Prone vs. supine accelerated partial breast irradiation on an MR-Linac: A planning study
Maureen L.Groot KoerkampaFemkevan der LeijaTanjavan 't WesteindeaGijsbert H.BolaVincentScholtenaRoelBouwmansaStefanoMandijaabMarielle E.P.PhilippensaH.J.G. Desiréevan den BongardcAntonetta C.Houwelinga
doi : 10.1016/j.radonc.2021.11.001
Volume 165, December 2021, Pages 193-199
Accelerated partial breast irradiation (APBI) may benefit from the MR-Linac for target definition, patient setup, and motion monitoring. In this planning study, we investigated whether prone or supine position is dosimetrically beneficial for APBI on an MR-Linac and we evaluated patient comfort.
DCE-MRI detected vascular permeability changes in the rat spinal cord do not explain shorter latency times for paresis after carbon ions relative to photons
Alina L.BendingerabThomasWelzelbcLifiHuangabdInnaBabushkinaePeterPeschkeacJürgenDebuscfChristinGlowaabcChristian P.KargerabMariaSaagerab
doi : 10.1016/j.radonc.2021.09.035
Volume 165, December 2021, Pages 126-134
Radiation-induced myelopathy, an irreversible complication occurring after a long symptom-free latency time, is preceded by a fixed sequence of magnetic resonance- (MR-) visible morphological alterations. Vascular degradation is assumed the main reason for radiation-induced myelopathy. We used dynamic contrast-enhanced (DCE-) MRI to identify different vascular changes after photon and carbon ion irradiation, which precede or coincide with morphological changes.
Genetic variants associated with mandibular osteoradionecrosis following radiotherapy for head and neck malignancy
Rachel C.Brookerab1PhilippAntczakefg1TriantafillosLiloglouadJanet M.RiskaJoseph J.SaccoabAndrew G.SchacheacRichard J.Shawac
doi : 10.1016/j.radonc.2021.10.020
Volume 165, December 2021, Pages 87-93
Utilising radiotherapy in the management of head and neck cancer (HNC) often results in long term toxicities. Mandibular osteoradionecrosis (ORN) represents a late toxicity associated with significant morbidity. We aim to identify a panel of common genetic variants which can predict ORN to aid development of personalised radiotherapy protocols.
Radiomics signature based on computed tomography images for the preoperative prediction of lymph node metastasis at individual stations in gastric cancer: A multicenter study
ZepangSuna1YumingJianga1ChuanliChenb1HuanZhengbWeicaiHuangaBenjaminXucWeijingTangdQingyuYuanbKangnengZhoueXiaokunLiangfgHaoChenaZhenHanaHaoFengaShitongYuaYanfengHuaJiangYuaZhiweiZhouhi2WeiWanghi2YikaiXub2GuoxinLia2
doi : 10.1016/j.radonc.2021.11.003
Volume 165, December 2021, Pages 179-190
Specific diagnosis and treatment of gastric cancer (GC) require accurate preoperative predictions of lymph node metastasis (LNM) at individual stations, such as estimating the extent of lymph node dissection. This study aimed to develop a radiomics signat
Deep learning model for automatic contouring of cardiovascular substructures on radiotherapy planning CT images: Dosimetric validation and reader study based clinical acceptability testing
MiguelGarrett Fernandesab2JohanBussinkaBarbaraStamcRobinWijsmandDominic A.X.SchinaglaRenéMonshouwera1JonasTeuwenbc1
doi : 10.1016/j.radonc.2021.10.008
Volume 165, December 2021, Pages 52-59
Large radiotherapy (RT) planning imaging datasets with consistently contoured cardiovascular structures are essential for robust cardiac radiotoxicity research in thoracic cancers. This study aims to develop and validate a highly accurate automatic contouring model for the heart, cardiac chambers, and great vessels for RT planning computed tomography (CT) images that can be used for dose–volume parameter estimation.
Extended application of a CT-based artificial intelligence prognostication model in patients with primary lung cancer undergoing stereotactic ablative radiotherapy
HyungjinKimaJoo HoLeebcdHak JaeKimbcdChang MinParkacdHong-GyunWubcdJin MoGooacd
doi : 10.1016/j.radonc.2021.10.022
Volume 165, December 2021, Pages 166-173
Second malignancy probabilities in prostate cancer patients treated with SBRT and other contemporary radiation techniques: Reply
Edward ChristopherDeeaJonathan E.Leemanb
doi : 10.1016/j.radonc.2021.11.006
Volume 165, December 2021, Pages 191-192
