دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Biological tissues and components, and synthetic substrates for conjunctival cell transplantation
Aruni K.MakuloluwaaKevin J.HamillaSaaehaRauzbLucyBosworthaAtikahHaneefaVitoRomanoaRachel L.WilliamsaDarlene A.DarttcStephen B.Kayea
doi : 10.1016/j.jtos.2021.06.003
Volume 22, October 2021, Pages 15-26
The conjunctiva is the largest component of the ocular surface. It can be damaged by various pathological processes leading to scarring, loss of tissue and dysfunction. Depending on the amount of damage, restoration of function may require a conjunctival graft. Numerous studies have investigated biological and synthetic substrates in the search for optimal conditions for the ex vivo culture of conjunctival epithelial cells that can be used as tissue grafts for transplantation. These substrates have advantages and disadvantages that are specific to the characteristics of each material; the development of an improved material remains a priority. This review is the second of a two-part review in The Ocular Surface. In the first review, the structure and function of the conjunctiva was evaluated with a focus on the extracellular matrix and the basement membrane, and biological and mechanical characteristics of the ideal substrate with recommendations for further studies. In this review the types of biological and synthetic substrates used for conjunctival transplantation are discussed including substrates based on the extracellular matrix. .
Dry eye disease flares: A rapid evidence assessment
Christopher E.StarraRezaDanabStephen C.PflugfeldercEdward J.HollanddStevenZhangeDesireeOweneKimBrazzelle
doi : 10.1016/j.jtos.2021.07.001
Volume 22, October 2021, Pages 51-59
Characteristics of periodic flares of dry eye disease (DED) are not well understood. We conducted a rapid evidence assessment to identify evidence for and characteristics of DED flares.
Review, analysis, and education of antiseptic related ocular injury in the surgical settings
Jen-YuLiua1Hsiao-SangChuabc1Yi-HsuanWeiacChia-YiChengaMei-ChiTsuiaJo-HsuanWudWei-LunHuangaHsin-YuLiuabcYu-ChihHoueI-JongWangafFung-RongHuafWei-LiChenabf
doi : 10.1016/j.jtos.2021.06.011
Volume 22, October 2021, Pages 60-71
Preoperative skin antiseptic preparation is the gold standard for prevention of surgical infection. However, improper use of antiseptics may lead to severe ocular damage. Currently, the most common surgical antiseptics can be divided into aqueous-based and alcohol-based disinfectants, with chlorhexidine and iodine/iodophors being the two major components. Chlorhexidine has a persistent antimicrobial effect and is resistant to neutralization by blood or organic products in surgical wounds. Nevertheless, due to its toxicity to the ears, meninges, and eyes, application of chlorhexidine should be prohibited in these surgical fields. Iodine/iodophor is better tolerated by the ocular surface and is the recommended antiseptic for ophthalmic or head and neck surgeries close to the periocular area. Alcohol is less pricey and has a rapid antiseptic effect, though its desiccating effect and flammability restrict the use in mucosal or laser surgeries. The single or combined use of these antiseptics may inadvertently induce severe ocular damage, especially during time-consuming head and neck surgeries with prone, hyperextension, or lateral tilt positions, or surgeries under general anesthesia. Apart from the choice of antiseptics, appropriate selection and attachment of bio-occlusive dressings are key to avoiding antiseptic-related ocular injuries. In this review, we provided a comprehensive summary of the characteristics of antiseptics used in surgical settings and the possible mechanisms and outcomes of antiseptic-related ocular injuries. The prevention, diagnosis, and acute management of these complications were also discussed.
Clinical study of laminar resorption: Part 2- outcomes, review and proposal for classification
Venkata S.AvadhanamcJordan V.ChervenkoffabMehranZarei-GhanavatidChristopherLiuabe
doi : 10.1016/j.jtos.2021.08.001
Volume 22, October 2021, Pages 123-132
To analyze and review the clinical features and main outcomes of laminar resorption from the UK osteo-odonto-keratoprosthesis (OOKP) cohort.
Immune signaling in rosacea?
Edward J.WladisaAlejandro P.Adamb
doi : 10.1016/j.jtos.2021.08.017
Volume 22, October 2021, Pages 224-229
Rosacea is a common chronic skin disease affecting mostly people aged 40 and above, with currently no cure. When it affects the eyelids and periocular skin, it leads to dry eye and potentially corneal damage. Research performed over the last decade shed light into the potential mechanisms leading to skin hypersensitivity and provided promising avenues for development of novel, rational therapeutics aimed at reducing the skin inflammatory state. In this review, we discuss the current knowledge on the mechanisms of rosacea in general and of periocular skin-affecting disease in particular, identify key questions that remain to be answered in future research, and offer a disease model that can explain the key characteristics of this disease, with particular emphasis on a potential positive feedback loop that could explain both the acute and chronic features of rosacea.
Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions
L.LattaabF.C.FigueiredocR.Ashery-PadandJ.M.CollinsoneJ.DanielsfS.FerrarigN.SzentmáryaS.SoláhR.Shalom-FeuersteiniM.LakojS.XapelliklD.AberdammnN.Lagaliop
doi : 10.1016/j.jtos.2021.09.001
Volume 22, October 2021, Pages 245-266
Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy (AAK). Due to the characteristics of AAK and its bilateral nature, clinical management is challenging and complicated by the multiple coexisting ocular and systemic morbidities in aniridia. Although it is primarily assumed that AAK originates from a congenital limbal stem cell deficiency, in recent years AAK and its pathogenesis has been questioned in the light of new evidence and a refined understanding of ocular development and the biology of limbal stem cells (LSCs) and their niche. Here, by consolidating and comparing the latest clinical and preclinical evidence, we discuss key unanswered questions regarding ocular developmental aspects crucial to AAK. We also highlight hypotheses on the potential role of LSCs and the ocular surface microenvironment in AAK. The insights thus gained lead to a greater appreciation for the role of developmental and cellular processes in the emergence of AAK. They also highlight areas for future research to enable a deeper understanding of aniridia, and thereby the potential to develop new treatments for this rare but blinding ocular surface disease.
Medication use and dry eye symptoms: A large, hypothesis-free, population-based study in the Netherlands
Laura E.WolpertaHaroldSniederbNomdo M.JansoniusbTor P.UtheimcChristopher J.HammonddJelleVehofbd
doi : 10.1016/j.jtos.2021.06.009
Volume 22, October 2021, Pages 1-12
To date, population-based studies reporting associations between dry eye disease and medications were hypothesis-driven, did not take into account underlying comorbidities, and did not investigate individual drugs. The purpose of this study was to clarify the association of dry eye symptoms with medication classes and individual drugs, using a hypothesis-free approach.
Efficacy and outcome of simple limbal epithelial transplantation for limbal stem cell deficiency verified by epithelial phenotypes integrated with clinical evaluation
PinnitaPrabhasawataChareenunChirapapaisanaPanotsomNgowyutagonaPattamaEkpobcWimolwanTangpagasitdKaevalinLekhanonteRosanunSikarinkulfSutthichaMatamnancChawikanBoonwongcWarinyupaPinitpuwadolaRanidaThamphithakaNutchayaSukonaNutnichaNetia
doi : 10.1016/j.jtos.2021.06.012
Volume 22, October 2021, Pages 27-37
To evaluate the efficacy and outcome of simple limbal epithelial transplantation (SLET) for limbal stem cell deficiency (LSCD) using epithelial phenotype detection integrated with clinical manifestation.
Impact of the COVID-19 pandemic on eye strain and dry eye symptoms
Ian J.SaldanhaaRebeccaPetrisbMatthewMakaracPrabjotChannadEsen K.Akpeke
doi : 10.1016/j.jtos.2021.06.004
Volume 22, October 2021, Pages 38-46
Among adult individuals with dry eye, assess the self-reported impact of the COVID-19 pandemic on (1) dry eye-related visual function, (2) reading efficiency, and (3) dry eye treatments used.
Corneal lymphangiogenesis in dry eye disease is regulated by substance P/neurokinin-1 receptor system through controlling expression of vascular endothelial growth factor receptor 3
Seok JaeLeeab1Sang-TaekIma1JunWuabChang SikChoaDong HyunJocYiheChendeRezaDanadeJeong HunKimabfgSang-MokLeehi
doi : 10.1016/j.jtos.2021.07.003
Volume 22, October 2021, Pages 72-79
To evaluate the role of substance P (SP)/neurokinin-1 receptor (NK1R) system in the regulation of pathologic corneal lymphangiogenesis in dry eye disease (DED).
Anterior segment optical coherence tomography angiography in the assessment of ocular surface lesions
William W.BinottiabHuanMillscRicardo M.NoséabHelen K.WubJay S.DukercPedramHamrahab
doi : 10.1016/j.jtos.2021.07.009
Volume 22, October 2021, Pages 86-93
Describe the utility of anterior segment optical coherence tomography angiography (AS-OCTA) to assess ocular surface lesions.
Human tear fluid modulates the Pseudomonas aeruginosa transcriptome to alter antibiotic susceptibility
Lauren M.Tabora1Melinda R.Grossera12Matteo M.M.E.MetruccioaNaren G.KumaraYvonne T.WuaVincentNietoaDavid J.EvansabSuzanne M.J.Fleiszigac
doi : 10.1016/j.jtos.2021.07.004
Volume 22, October 2021, Pages 94-102
Previously, we showed that tear fluid protects corneal epithelial cells against Pseudomonas aeruginosa without suppressing bacterial viability. Here, we studied how tear fluid affects bacterial gene expression.
Safety and feasibility of subconjunctival injection of mesenchymal stem cells for acute severe ocular burns: A single-arm study
LingyiLianga1XiaohuiLuoa1JianZhangaWenruSuaWenjieZhuaYanyanXieaNuanZhangaYanwenPengbXiaoyongChenbAndy PengXiangbYizhiLiuaDanLianga
doi : 10.1016/j.jtos.2021.07.008
Volume 22, October 2021, Pages 103-109
To investigate the safety and feasibility of topical injection of bone marrow derived mesenchymal stem cells (BM-MSCs) in acute severe ocular burns.
Tear metabolomics highlights new potential biomarkers for differentiating between Sjögren's syndrome and other causes of dry eye
GeoffreyUrbanskiabSophieAssadcFlorisChabrunbdJuan ManuelChao de la BarcabdOdileBlancheteGillesSimardbdGuyLenaersbDelphinePrunier-MirebeaubdPhilippeGohiercChristianLavigneaPascalReynierbd
doi : 10.1016/j.jtos.2021.07.006
Volume 22, October 2021, Pages 110-116
The lacrimal exocrinopathy of primary Sjögren's syndrome (pSS) is one of the main causes of severe dry eye syndrome and a burden for patients. Early recognition and treatment could prevent irreversible damage to lacrimal glands. The aim of this study was to find biomarkers in tears, using metabolomics and data mining approaches, in patients with newly-diagnosed pSS compared to other causes of dry eye syndrome.
Alterations in corneal nerves in different subtypes of dry eye disease: An in vivo confocal microscopy study?
Stephanie M.Coxa1AhmadKheirkhahb1ShrutiAggarwalbFarshadAbedibBernardo M.CavalcantibAndreaCruzatbPedramHamrahab
doi : 10.1016/j.jtos.2021.08.004
Volume 22, October 2021, Pages 135-142
To evaluate corneal subbasal nerve alterations in evaporative and aqueous-deficient dry eye disease (DED) as compared to controls.
Concurrent ocular pain in patients with neurotrophic keratopathy
LeylaYavuz SaricayabBetul N.BayraktutarabBrendan M.KenyonacPedramHamrahabcd
doi : 10.1016/j.jtos.2021.08.003
Volume 22, October 2021, Pages 143-151
To illustrate that ocular pain may occur in patients with neurotrophic keratopathy (NK) that typically are thought to lack symptoms of discomfort, and that aa subset of these patients may also present with neuropathic corneal pain (NCP).
Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice
SaayaFukaseabcTomoakiAndoaMoeMatsuzawaabcMeikoKimuraabcYusukeSonedKumiIzawaaAyakoKaitaniaAnnaKameiaeMayukiKojimaafNobuhiroNakanoaKeikoMaedaagToshiakiShimizuafHideokiOgawaaKoOkumuraaMakotoNishiyamadAkiraMurakamicNobuyukiEbiharabcJiroKitauraae
doi : 10.1016/j.jtos.2021.08.009
Volume 22, October 2021, Pages 152-162
We aimed to clarify the role of particulate allergen exposure to the conjunctiva in the development of allergic conjunctivitis.
IL-36?/IL-36RA/IL-38 signaling mediates inflammation and barrier disruption in human corneal epithelial cells under hyperosmotic stress
Jin-MiaoLiabRongLubYunZhangacJingLinaXiaHuaaStephen C.PflugfelderaDe-QuanLia
doi : 10.1016/j.jtos.2021.08.012
Volume 22, October 2021, Pages 163-171
To explore the distinct expression and diverse roles of IL-36 cytokines in dry eye disease using an in vitro hyperosmolarity model of human corneal epithelial cells (HCECs).
Melanocytes as emerging key players in niche regulation of limbal epithelial stem cells
NareshPolisettiab1AndreasGießla1MatthiasZenkelaLukasHegercDianaDudziakcdefElisabethNaschbergergLenaStichhAlexanderSteinkassererdfhFriedrich E.KruseaUrsulaSchlötzer-Schrehardta
doi : 10.1016/j.jtos.2021.08.006
Volume 22, October 2021, Pages 172-189
Limbal melanocytes (LMel) represent essential components of the corneal epithelial stem cell niche and are known to protect limbal epithelial stem/progenitor cells (LEPCs) from UV damage by transfer of melanosomes. Here, we explored additional functional roles for LMel in niche homeostasis, immune regulation and angiostasis.
Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function
BrianThompsonaYingChenaEmily A.DavidsonabRolandoGarcia-MiliancJaya PrakashGollaadeNicholasApostolopoulosfDavid J.OrlickygKevinScheyhDavid C.ThompsoniVasilisVasilioua
doi : 10.1016/j.jtos.2021.08.010
Volume 22, October 2021, Pages 190-203
The purpose of this study was to elucidate the role and molecular consequences of impaired glutathione (GSH) biosynthesis on eye development.
The pattern of the inferocentral whorl region of the corneal subbasal nerve plexus is altered with age
Reza A.BadianaMattiasAndréassonbcdPerSvenningssonbcdTor PaaskeUtheimefNeilLagalifg
doi : 10.1016/j.jtos.2021.08.015
Volume 22, October 2021, Pages 204-212
To describe the pattern of the nerves in the inferocentral whorl region of the human corneal subbasal nerve plexus (SBNP) in health and diseases known to affect the subbasal nerves.
The effect of Rho Kinase inhibition on corneal nerve regeneration in vitro and in vivo
SonjaMertschaIngaNeumannbCosimaRosebMarcSchargusbcGerdGeerlingbStefanSchradera
doi : 10.1016/j.jtos.2021.08.011
Volume 22, October 2021, Pages 213-223
Impairment of corneal nerves can lead to neurotrophic keratopathy accompanied with severe ocular surface damage, which due to limited treatment options, can result in severe visual deterioration. This study evaluates a possible new treatment by enhancing the corneal nerve regeneration using a Rho Kinase inhibitor (Y27632). ROCK is known to play an important role in regulating cell morphology, adhesion and motility but little is known about its role in corneal nerve regeneration.
Inhibition of ceramide de novo synthesis ameliorates meibomian gland dysfunction induced by SCD1 deficiency
ChunyanJia1YuliGuoa1YingLiuaSennanXuaSichenZhaoaXinLuoaFunanQiubRuiHuangaQingyanXucRuiheZhengaMiaoXiaaYunZhaoaJieRenaYanQiua
doi : 10.1016/j.jtos.2021.08.016
Volume 22, October 2021, Pages 230-241
High expression of stearoyl-CoA desaturase-1 (SCD1) in meibomian glands produces monounsaturated fatty acids that allow the biosynthesis of glycerolipids and other wax-esters but only the low production of sphingolipids. Here, we found that SCD1 deficiency in mice induces the spill of free fatty acids into a parallel pathway for ceramide biosynthesis, resulting in severe meibomian gland dysfunction associated with meibum accumulation in duct lumen and orifices and subsequent atrophy and loss of acinar cells. Genetic and pharmacological inhibition of SCD1 in mice resulted in meibomian gland pathological phenotypes, including local lipid microenvironment alterations, reduced normal cellular differentiation, increased keratinization, inflammatory cell infiltration, cell apoptosis, and mitochondrial dysfunction. However, inhibition of serine palmitoyltransferase, the initial enzyme in ceramide biosynthesis, improved meibomian gland metabolism and morphology in SCD1-deficient mice, resulting in normal cell differentiation and reduced inflammation infiltration, cell apoptosis, and keratinization. These results indicate that elevated levels of endogenous ceramides are a sign of MGD and suggest that inhibition of ceramide de novo biosynthesis could be a new clinical approach to treating MGD.
TFOS: Unique challenges and unmet needs for the management of ocular surface diseases throughout the world
SusanEricksonaAmy GallantSullivanbJuan CarlosAbadcMonicaAlvesdStefanoBarabinoeJennifer P.CraigfMarounEidgSarahFarranthJosé A.P.GomesiLeonardHeydenrychjGeethaIyerkElias F.JaradelShigeruKinoshitamEmmanuelKobia-AcquahnSihemLazregoToddMargolispNicoleMechlebqAlejandroNavasrNaomiNsubugasReeda BouSaidgMohamed ShafikShaheentChieSotozonouFionaStapletonvJelleVehofwPieraVersuraxDavid A.Sullivanb
doi : 10.1016/j.jtos.2021.08.014
Volume 22, October 2021, Pages 242-244
Ocular manifestations of anti-neoplastic immune checkpoint inhibitor-associated Stevens-Johnson syndrome/toxic epidermal necrolysis in cancer patients
Kevin Sheng-KaiMaabcde1Hajirah N.Saeedf1JamesChodoshfChuang-WeiWangghqrYu-ChienChungiLi-ChenWeijMing-TseKuokChang-MinLianglJohn Wen-ChengChangmnoWen-HungChungghnopqrChun-BingChenghnopqr2David Hui-KangMabstu2
doi : 10.1016/j.jtos.2021.06.010
Volume 22, October 2021, Pages 47-50
A new option for treatment of severe cicatricial entropion in patients with Stevens-Johnson syndrome
Ana Estela B.P. P.Sant’AnnaaÉrico B.P. P.Sant’AnnabTammy H.OsakiaJosé ÁlvaroPereira Gomesc
doi : 10.1016/j.jtos.2021.07.005
Volume 22, October 2021, Pages 80-82
Optimising the method for isolating ocular surface microRNA using impression cytology
E.GreenanabcC.C.Murphyabc1J.Ní Gabhann-Dromgoolebc1
doi : 10.1016/j.jtos.2021.07.010
Volume 22, October 2021, Pages 83-85
Relationship between screen time and dry eye symptoms in pediatric population during the COVID-19 pandemic
Abdelrahman M.Elhusseinyab1Taher K.Eleiwac1Magdi S.YacoubdJosephGeorgeeReem H.ElSheikhdAbidHaseebeJamesKwanfIbrahim A.ElsaadanicSheren M.Abo ShanabgOmarSolymangHajirah N.Saeedaf
doi : 10.1016/j.jtos.2021.08.002
Volume 22, October 2021, Pages 117-119
Preliminary experience & rationale of primary allo Simple Limbal Epithelial Transplantation (SLET) following surgical excision of Ocular Surface Tumors
GeethaIyerBhaskarSrinivasanRichaDhimanManokamnaAgarwalRamaRajagopal
doi : 10.1016/j.jtos.2021.07.007
Volume 22, October 2021, Pages 120-122
To report the preliminary outcomes and elucidate the possible rationale of alloSLET for primary ocular surface reconstruction following excision of extensive ocular surface tumors.
Compounded medications for ocular surface disease
Edward H.LeeGary D.Novack
doi : 10.1016/j.jtos.2021.09.004
Volume 22, October 2021, Pages 267-270
Evaluation of the impact of intensive care support for COVID-19 on the ocular surface in a prospective cohort of 40 eyes
SophieStéphanMDFlorianCohenMDFloreSalviatMD, MSc, MSPHSophieTheveninMScJean-MichelDevysMDIsabelleCochereauMD, PhDEricGabisonMD, PhD
doi : 10.1016/j.jtos.2021.06.008
Volume 22, October 2021, Pages 13-14
Corrigendum to “Human precorneal tear film and lipid layer dynamics in meibomian gland dysfunction” [Ocul Surf 21 (2021) 250–256]
YuqiangBaiaWilliamNgobSafalKhanalaKelly K.NicholsaJason J.Nicholsa
doi : 10.1016/j.jtos.2021.08.005
Volume 22, October 2021, Pages 133-134
