Rectal Indomethacin Does Not Mitigate the Systemic Inflammatory Response Syndrome in Acute Pancreatitis: A Randomized Trial

Machicado, Jorge D. MD, MPH1,*; Mounzer, Rawad MD2,*; Paragomi, Pedram MD3; Pothoulakis, Ioannis MD3; Hart, Phil A. MD4; Conwell, Darwin L. MD, MSc4; de-Madaria, Enrique MD, PhD5; Greer, Phil MS3; Yadav, Dhiraj MD, MPH3; Whitcomb, David C. MD, PhD3; Lee, Peter J. MD4; Hinton, Alice PhD6; Papachristou, Georgios I. MD, PhD4

doi : 10.14309/ctg.0000000000000415

November 2021 - Volume 12 - Issue 11 - p e00415

Experimental data suggest that nonsteroidal antiinflammatory drugs may prevent disease severity and mortality in acute pancreatitis (AP). The aim of this study was to compare the efficacy of rectal indomethacin vs placebo in reducing the systemic inflammatory response syndrome (SIRS) score in a high-risk AP population for clinical progression.

خرید پکیج و مشاهده آنلاین مقاله

Pancreatic Cancer–Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis

Cowan, Robert W. PhD1,2; Pratt, Erica D. PhD1,2; Kang, Jin Muk PhD1,2; Zhao, Jun PhD1,3; Wilhelm, Joshua J. MS4,5; Abdulla, Muhamad BS5; Qiao, Edmund M. BS6; Brennan, Luke P. MS7; Ulintz, Peter J. PhD6,8; Bellin, Melena D. MD4,5; Rhim, Andrew D. MD1,2

doi : 10.14309/ctg.0000000000000431

November 2021 - Volume 12 - Issue 11 - p e00431

Chronic pancreatitis is associated with an increased risk of developing pancreatic cancer, and patients with inherited forms of pancreatitis are at greatest risk. We investigated whether clinical severity of pancreatitis could also be an indicator of cancer risk independent of etiology by performing targeted DNA sequencing to assess the mutational burden in 55 cancer-associated genes.

خرید پکیج و مشاهده آنلاین مقاله

Changing Trends of Cirrhotic and Noncirrhotic Hepatocellular Carcinoma in the Era of Directly-Acting Antiviral Agents

Mathur, Karan MD1; Mazhar, Areej MD2; Patel, Milin MD2; Dakhoul, Lara MD3; Burney, Heather MS4; Liu, Hao PhD4; Nephew, Lauren MD1; Chalasani, Naga MD1; deLemos, Andrew MD2; Gawrieh, Samer MD1

doi : 10.14309/ctg.0000000000000420

November 2021 - Volume 12 - Issue 11 - p e00420

The impact of direct-acting antivirals (DAAs) for hepatitis C virus (HCV) on burden of cirrhotic and noncirrhotic hepatocellular carcinoma (HCC) has not been examined. We assessed recent trends in liver disease etiologies of HCC and proportion of noncirrhotic HCC since DAAs introduction.

خرید پکیج و مشاهده آنلاین مقاله

Double-Negative ?-Fetoprotein and Carbohydrate Antigen 19-9 Predict a Good Prognosis in Intrahepatic Cholangiocarcinoma: A Propensity Score Matching Analysis

Zhang, Xiaoyun MD1,2,3; Zhou, Yongjie MD2,3; Wu, Zhenru MM3; Peng, Wei MD1,2; Li, Chuan MD1,2; Yan, Lvnan MD, PhD1,2; Yang, Jiayin MD, PhD1,2; Wen, Tianfu MD, PhD1,2

doi : 10.14309/ctg.0000000000000425

November 2021 - Volume 12 - Issue 11 - p e00425

Carbohydrate antigen 19-9 (CA19-9) and ?-fetoprotein (AFP) are routinely tested in patients with liver malignancies before surgery. However, few reports have explored the relevance of the expression pattern of these 2 tumor markers regarding the prognosis of intrahepatic cholangiocarcinoma (ICC). We herein combined these 2 tumor markers to investigate the influence on ICC malignancy and patient prognosis.

خرید پکیج و مشاهده آنلاین مقاله

Assessment of Duodenal Intraepithelial Lymphocyte Composition (Lymphogram) for Accurate and Prompt Diagnosis of Celiac Disease in Pediatric Patients

Camarero, Cristina MD, PhD1,*; De Andrés, Ana MD2,*; García-Hoz, Carlota PhD2; Roldán, Belén MD, PhD1; Muriel, Alfonso MD, PhD3; León, Francisco MD, PhD4; Roy, Garbiñe MD, PhD2

doi : 10.14309/ctg.0000000000000426

November 2021 - Volume 12 - Issue 11 - p e00426

Quantitative and phenotypic analyses of duodenal intraepithelial lymphocytes (IELs) by flow cytometry (IEL lymphogram) confer specificity and enable the diagnosis even in unconventional presentations of celiac disease (CD). To evaluate the validity of the IEL lymphograms in the pediatric population for new insights into their use as biomarkers in the natural history of CD.

خرید پکیج و مشاهده آنلاین مقاله

The Impact of KRAS Mutation in Patients With Sporadic Nonampullary Duodenal Epithelial Tumors

Kinugasa, Hideaki MD, PhD1; Kanzaki, Hiromitsu MD, PhD1; Tanaka, Takehiro MD, PhD2; Yamamoto, Shumpei MD1; Yamasaki, Yasushi MD, PhD1; Nouso, Kazuhiro MD, PhD1; Ichimura, Kouichi MD, PhD3; Nakagawa, Masahiro MD, PhD4; Mitsuhashi, Toshiharu MD, PhD5; Okada, Hiroyuki MD, PhD1

doi : 10.14309/ctg.0000000000000424

November 2021 - Volume 12 - Issue 11 - p e00424

The genomic characterization of primary nonampullary duodenal adenocarcinoma indicates a genetic resemblance to gastric and colorectal cancers. However, a correlation between the clinical and molecular characteristics of these cancers has not been established. This study aimed to elucidate the clinicopathological features of sporadic nonampullary duodenal epithelial tumors, including their molecular characteristics and prognostic factors.

خرید پکیج و مشاهده آنلاین مقاله

Polygenic Risk Scores for Prediction of Gastric Cancer Based on Bioinformatics Screening and Validation of Functional lncRNA SNPs

Duan, Fujiao PhD1,2; Song, Chunhua PhD2,3; Wang, Peng PhD2,3; Ye, Hua PhD2,3; Dai, Liping PhD2,3; Zhang, Jianying PhD2,3; Wang, Kaijuan PhD2,3

doi : 10.14309/ctg.0000000000000430

November 2021 - Volume 12 - Issue 11 - p e00430

Single-nucleotide polymorphisms (SNPs) are used to stratify the risk of gastric cancer. However, no study included gastric cancer–related long noncoding RNA (lncRNA) SNPs into the risk model for evaluation. This study aimed to replicate the associations of 21 lncRNA SNPs and to construct an individual risk prediction model for gastric cancer.

خرید پکیج و مشاهده آنلاین مقاله

Association Between Peripheral Blood Monocyte Count and Mucosal Healing in Japanese Patients With Ulcerative Colitis

Furukawa, Shinya MD, PhD1; Ikeda, Yoshio MD, PhD2; Yagi, Sen MD, PhD3; Miyake, Teruki MD, PhD4; Shiraishi, Kana MD4; Tange, Kazuhiro MD5; Hashimoto, Yu MD4; Mori, Kenichirou MD, PhD6; Ninomiya, Tomoyuki MD, PhD6; Suzuki, Seiyuu MD, PhD7; Shibata, Naozumi MD, PhD8; Murakami, Hidehiro MD, PhD3; Ohashi, Katsuhisa MD, PhD9; Hasebe, Aki MD, PhD10; Tomida, Hideomi MD, PhD2; Yamamoto, Yasunori MD, PhD2; Takeshita, Eiji MD, PhD5; Hiasa, Yoichi MD, PhD4

doi : 10.14309/ctg.0000000000000429

November 2021 - Volume 12 - Issue 11 - p e00429

Monocytes play an important role in innate immunity. Some epidemiological evidence indicates an association between peripheral blood monocytes and ulcerative colitis (UC). The association between peripheral blood monocytes and mucosal healing (MH), however, remains unclear. We evaluated this issue in patients with UC.

خرید پکیج و مشاهده آنلاین مقاله

Automatic Identification of Papillary Projections in Indeterminate Biliary Strictures Using Digital Single-Operator Cholangioscopy

Ribeiro, Tiago MD, MSc1,2,*; Saraiva, Miguel Mascarenhas MD, MSc1,2,3,*; Afonso, João MD, MSc1,2; Ferreira, João P. S. PhD4,5; Boas, Filipe Vilas MD, MSc1,2,3; Parente, Marco P. L. PhD4,5; Jorge, Renato N. PhD4,5; Pereira, Pedro MD, MSc1,2,3; Macedo, Guilherme MD, PhD1,2,3

doi : 10.14309/ctg.0000000000000418

November 2021 - Volume 12 - Issue 11 - p e00418

Characterization of biliary strictures is challenging. Papillary projections (PP) are often reported in biliary strictures with high malignancy potential during digital single-operator cholangioscopy. In recent years, the development of artificial intelligence (AI) algorithms for application to endoscopic practice has been intensely studied. We aimed to develop an AI algorithm for automatic detection of PP in digital single-operator cholangioscopy images.

خرید پکیج و مشاهده آنلاین مقاله

A Potential Treatment of Congenital Sodium Diarrhea in Patients With Activating GUCY2C Mutations

van Vugt, Anke H.M. BSc1,2,*; Bijvelds, Marcel J.C. PhD3,*; de Jonge, Hugo R. PhD3; Meijsen, Kelly F. BASc3; Restin, Tanja MD, PhD4,5; Bryant, Manuel B. MD4; Ballauff, Antje MD6; Koot, Bart MD, PhD7; Müller, Thomas MD8; Houwen, Roderick H.J. MD, PhD1,*; Janecke, Andreas R. MD8,9,*; Middendorp, Sabine PhD1,2,10,*

doi : 10.14309/ctg.0000000000000427

November 2021 - Volume 12 - Issue 11 - p e00427

Gain-of-function mutations in guanylyl cyclase C (GCC) result in persistent diarrhea with perinatal onset. We investigated a specific GCC inhibitor, SSP2518, for its potential to treat this disorder.

خرید پکیج و مشاهده آنلاین مقاله

Misclassification of Obesity in Claims Data

Suissa, Karine PhD1; Kim, Seoyoung C. MD, ScD, MSCE1,2; Patorno, Elisabetta MD, DrPH1

doi : 10.14309/ctg.0000000000000423

November 2021 - Volume 12 - Issue 11 - p e00423

خرید پکیج و مشاهده آنلاین مقاله