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Watch Your Language!—Misusage and Neologisms in Clinical Communication
Andrew M. Luks, MD; Zachary D. Goldberger, MD
doi : 10.1001/jamainternmed.2020.5679
JAMA Intern Med. 2021;181(1):5-6
No Bad Blood—Surviving Severe Anemia Without Transfusion
Kelly Johnson-Arbor, MD; Richard Verstraete, RN
doi : 10.1001/jamainternmed.2020.6560
JAMA Intern Med. 2021;181(1):7-8
Assessment of Variation in State Regulation of Generic Drug and Interchangeable Biologic Substitutions
Chana A. Sacks, MD, MPH; Victor L. Van de Wiele, LLB, LLM; Lisa A. Fulchino, MPH; et al.
doi : 10.1001/jamainternmed.2020.3588
JAMA Intern Med. 2021;181(1):16-22
Importance Brand-name drugs, including biologics, have been the primary source of increasing prescription drug spending in the US. Each state has drug product selection laws that regulate whether and how pharmacists can substitute prescriptions for brand-name drugs with more affordable equivalents, either small-molecule generic drugs or interchangeable biologics, but the details of these laws can vary.
Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 PneumoniaA Randomized Clinical Trial
Carlo Salvarani, MD; Giovanni Dolci, MD; Marco Massari, MD; et al.
doi : 10.1001/jamainternmed.2020.6615
JAMA Intern Med. 2021;181(1):24-31
Importance The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of people worldwide. Tocilizumab has shown promising results in retrospective studies in patients with COVID-19 pneumonia with a good safety profile.
Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe PneumoniaA Randomized Clinical Trial
Olivier Hermine, MD, PhD; Xavier Mariette, MD, PhD; Pierre-Louis Tharaux, MD, PhD; et al.
doi : 10.1001/jamainternmed.2020.6820
JAMA Intern Med. 2021;181(1):32-40
Importance Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common presentation of coronavirus disease 2019 (COVID-19).
Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19
Shruti Gupta, MD, MPH; Wei Wang, PhD; Salim S. Hayek, MD; et al.
doi : 10.1001/jamainternmed.2020.6252
JAMA Intern Med. 2021;181(1):41-51
Importance Therapies that improve survival in critically ill patients with coronavirus disease 2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 receptor, may counteract the inflammatory cytokine release syndrome in patients with severe COVID-19 illness.
Assessment of Availability, Clinical Testing, and US Food and Drug Administration Review of Biosimilar Biologic Products
Thomas J. Moore, AB; Morgane C. Mouslim, DVM; Jenna L. Blunt, PharmD; et al.
doi : 10.1001/jamainternmed.2020.3997
JAMA Intern Med. 2021;181(1):52-60
Importance Biosimilar biologic products were authorized in 2010, after the US Congress established an expedited pathway for approval of clinically similar versions of approved biologic products. Unlike for most small-molecule generic drugs, approval requirements for a biosimilar included animal studies and a comparative efficacy clinical trial.
Nutritional Analysis of Foods and Beverages Depicted in Top-Grossing US Movies, 1994-2018
Bradley P. Turnwald, PhD; Isaac J. Handley-Miner, BA; Natalie A. Samuels, BA; et al.
doi : 10.1001/jamainternmed.2020.5421
JAMA Intern Med. 2021;181(1):61-70
Importance Many countries now restrict advertisements for unhealthy foods. However, movies depict foods and beverages with nutritional quality that is unknown, unregulated, and underappreciated as a source of dietary influence.
Effect of Recombinant Human Granulocyte Colony–Stimulating Factor for Patients With Coronavirus Disease 2019 (COVID-19) and LymphopeniaA Randomized Clinical Trial
Lin-ling Cheng, MD; Wei-jie Guan, PhD; Chong-yang Duan, PhD; et al.
doi : 10.1001/jamainternmed.2020.5503
JAMA Intern Med. 2021;181(1):71-78
Importance Lymphopenia is common and correlates with poor clinical outcomes in patients with coronavirus disease 2019 (COVID-19).
Risk of Overcorrection in Rapid Intermittent Bolus vs Slow Continuous Infusion Therapies of Hypertonic Saline for Patients With Symptomatic HyponatremiaThe SALSA Randomized Clinical Trial
Seon Ha Baek, PhD; You Hwan Jo, PhD; Soyeon Ahn, PhD; et al.
doi : 10.1001/jamainternmed.2020.5519
JAMA Intern Med. 2021;181(1):81-92
Importance Few high-quality studies have clarified whether hypertonic saline is best administered as slow continuous infusion (SCI) therapy or rapid intermittent bolus (RIB) therapy for symptomatic severe hyponatremia.
Trends in Noninvasive and Invasive Mechanical Ventilation Among Medicare Beneficiaries at the End of Life
Donald R. Sullivan, MD, MA, MCR; Hyosin Kim, PhD; Pedro L. Gozalo, PhD; et al.
doi : 10.1001/jamainternmed.2020.5640
JAMA Intern Med. 2021;181(1):93-102
Importance End-of-life care is costly, and decedents often experience overtreatment or low-quality care. Noninvasive ventilation (NIV) may be a palliative approach to avoid invasive mechanical ventilation (IMV) among select patients who are hospitalized at the end of life.
Association of Therapies With Reduced Pain and Improved Quality of Life in Patients With FibromyalgiaA Systematic Review and Meta-analysis
Rodrigo Oliveira Mascarenhas, MSc; Mateus Bastos Souza, BAppSc; Murilo Xavier Oliveira, PhD; et al.
doi : 10.1001/jamainternmed.2020.5651
JAMA Intern Med. 2021;181(1):104-112
Importance Fibromyalgia is a chronic condition that results in a significant burden to individuals and society.
Severe COVID-19 Infections—Knowledge Gained and Remaining Questions
Lieuwe D. J. Bos, MD, PhD; Daniel Brodie, MD; Carolyn S. Calfee, MD, MAS
doi : 10.1001/jamainternmed.2020.6047
JAMA Intern Med. 2021;181(1):9-11
Time to Reassess Tocilizumab’s Role in COVID-19 Pneumonia
Jonathan B. Parr, MD, MPH
doi : 10.1001/jamainternmed.2020.6557
JAMA Intern Med. 2021;181(1):12-15
Addressing the Cost of Biologic and Specialty Drugs
Francis J. Crosson, MD
doi : 10.1001/jamainternmed.2020.3593
JAMA Intern Med. 2021;181(1):22-23
Immune Stimulation With Recombinant Human Granulocyte Colony–Stimulating Factor for Coronavirus Disease 2019 (COVID-19)—Beware of Blind Spots
Nuala J. Meyer, MD, MS; Robert B. Lindell, MD; E. John Wherry, PhD
doi : 10.1001/jamainternmed.2020.5536
JAMA Intern Med. 2021;181(1):78-80
Noninvasive Ventilation in Seriously Ill Older Adults at the End of Life—The Evidence Remains Elusive
Anand S. Iyer, MD, MSPH
doi : 10.1001/jamainternmed.2020.5648
JAMA Intern Med. 2021;181(1):102-103
Addressing Spiritual and Religious Needs in Advanced IllnessA Teachable Moment
Christian K. Alch, MD; Kristin M. Collier, MD; Raymond Y. Yeow, MD
doi : 10.1001/jamainternmed.2020.6564
JAMA Intern Med. 2021;181(1):115-116
Implications of Early Health Care Spending Reductions for Expected Spending as the COVID-19 Pandemic Evolves
J. Michael McWilliams, MD, PhD; Ali Russo, BS; Ateev Mehrotra, MD, MPH
doi : 10.1001/jamainternmed.2020.5333
JAMA Intern Med. 2021;181(1):118-120
Risk of Severe COVID-19 Among Workers and Their Household Members
Thomas M. Selden, PhD; Terceira A. Berdahl, PhD
doi : 10.1001/jamainternmed.2020.6249
JAMA Intern Med. 2021;181(1):120-122
Diaphragm Pathology in Critically Ill Patients With COVID-19 and Postmortem Findings From 3 Medical Centers
Zhonghua Shi, MD; Heder J. de Vries, MD; Alexander P. J. Vlaar, MD, PhD; et al.
doi : 10.1001/jamainternmed.2020.6278
JAMA Intern Med. 2021;181(1):122-124
Diversity and Representation of Physicians During the COVID-19 News Cycle
Alangoya Tezel, BA; Kent A. Griffith, MPH, MS; Rochelle D. Jones, MS; et al.
doi : 10.1001/jamainternmed.2020.6285
JAMA Intern Med. 2021;181(1):124-127
Outcomes of Universal COVID-19 Testing Following Detection of Incident Cases in 11 Long-term Care Facilities
Benjamin F. Bigelow, BS; Olive Tang, AB; Bryan Barshick, MSN; et al.
doi : 10.1001/jamainternmed.2020.3738
JAMA Intern Med. 2021;181(1):127-129
Association of Neighborhood Characteristics and Travel Patterns With Fatal Drug Overdoses
Elizabeth D. Nesoff, PhD, MPH; Charles C. Branas, PhD; Silvia S. Martins, MD, PhD
doi : 10.1001/jamainternmed.2020.3823
JAMA Intern Med. 2021;181(1):129-131
Assessment of COVID-19 Hospitalizations by Race/Ethnicity in 12 States
Assessment of COVID-19 Hospitalizations by Race/Ethnicity in 12 States
doi : 10.1001/jamainternmed.2020.3857
JAMA Intern Med. 2021;181(1):131-134
Disparities in Secondhand Smoke Exposure in the United StatesNational Health and Nutrition Examination Survey 2011-2018
Surendra S. Shastri, MD; Rajesh Talluri, PhD; Sanjay Shete, PhD
doi : 10.1001/jamainternmed.2020.3975
JAMA Intern Med. 2021;181(1):134-137
Syncope Due to Complete Heart Block—A Ticking Time Bomb
Cameron T. Nutt, MD; Kevin R. Bersell, MD, PhD
doi : 10.1001/jamainternmed.2020.5660
JAMA Intern Med. 2021;181(1):113-114
The Assessment of Different Diets and Mortality Fails to Address Unmeasured Confounding
Cynthia L. Gong, PharmD, PhD; Nadine K. Zawadzki, MPH; Joel W. Hay, PhD
doi : 10.1001/jamainternmed.2020.1391
JAMA Intern Med. 2021;181(1):137-138
The Assessment of Different Diets and Mortality Fails to Address Unmeasured Confounding—Reply
Zhilei Shan, MD, PhD; Frank B. Hu, MD, PhD; Qibin Qi, MD, PhD
doi : 10.1001/jamainternmed.2020.1388
JAMA Intern Med. 2021;181(1):138-139
The Uncertain Role of Corticosteroids in the Treatment of COVID-19
Theodore G. Liou, MD; Frederick R. Adler, PhD; Nathan D. Hatton, MD
doi : 10.1001/jamainternmed.2020.2438
JAMA Intern Med. 2021;181(1):139-140
The Uncertain Role of Corticosteroids in the Treatment of COVID-19
Grant B. Ellsworth, MD, MS; Marshall J. Glesby, MD, PhD; Roy M. Gulick, MD, MPH
doi : 10.1001/jamainternmed.2020.2444
JAMA Intern Med. 2021;181(1):140
The Uncertain Role of Corticosteroids in the Treatment of COVID-19—Reply
Yuanlin Song, MD; Chaomin Wu, MD; Xiaoyan Chen, MD
doi : 10.1001/jamainternmed.2020.2435
JAMA Intern Med. 2021;181(1):140-141
Inaccurate Estimates of Negotiated Reimbursement Prices for Insulin
Eric Meadows, PhD; Ryan Urgo, MPAP; Eric H. Schultz, RPh
doi : 10.1001/jamainternmed.2020.5050
JAMA Intern Med. 2021;181(1):141
Inaccurate Estimates of Negotiated Reimbursement Prices for Insulin—Reply
Amir Meiri, MD, MPH; Dennis Ross-Degnan, ScD; J. Frank Wharam, MD, MPH
doi : 10.1001/jamainternmed.2020.5047
JAMA Intern Med. 2021;181(1):141-142
Anticoagulation Therapy and Fall Reduction
Shane O’Hanlon, MB, MSc
doi : 10.1001/jamainternmed.2020.5418
JAMA Intern Med. 2021;181(1):142
Complexities and Outcomes of Advance Care Planning
Joni Gilissen, PhD; Lieve Van den Block, PhD; Lara Pivodic, PhD
doi : 10.1001/jamainternmed.2020.5539
JAMA Intern Med. 2021;181(1):142-143
Prediction Models for COVID-19 Need Further Improvements
Hong-Qiu Gu, PhD; Junfeng Wang, PhD
doi : 10.1001/jamainternmed.2020.5740
JAMA Intern Med. 2021;181(1):143-144
Corrections to Assessment of Variation in State Regulation of Generic Drug and Interchangeable Biologic Substitutions
Ameet Sarpatwari, PhD, JD
doi : 10.1001/jamainternmed.2020.6554
JAMA Intern Med. 2021;181(1):144
Coding Errors Resulting in Some US State Misclassifications
doi : 10.1001/jamainternmed.2020.7344
JAMA Intern Med. 2021;181(1):144
Error in Author Order of the Byline
doi : 10.1001/jamainternmed.2020.7772
JAMA Intern Med. 2021;181(1):144
Errors in Group Information Supplement and End Matter
doi : 10.1001/jamainternmed.2020.7810
JAMA Intern Med. 2021;181(1):144
