AbhinavSharmaMD, PhDabKenneth W.MahaffeyMDcCharles MichaelGibsonMDdKaren A.HicksMDe†Karen P.AlexanderMDfMariaAliMBBS, MBAgBernard R.ChaitmanMDhClaesHeldMDPhDiMarkHlatkyMDjWIlliam SchuylerJonesMDfRoxanaMehranMDkVenuMenonMDlFrank W.RockholdPhDfJonathanSeltzerMD, MBA, MAmErnestSpitzerMDnoMatthewWilsonRNfRenato D.LopesMD, PhDf
doi : 10.1016/j.ahj.2021.12.012
Volume 246, April 2022, Pages 93-104
Clinical events adjudication is pivotal for generating consistent and comparable evidence in clinical trials. The methodology of event adjudication is evolving, but research is needed to develop best practices and spur innovation.
EmiliaBagiellaPhDaJohn D.PuskasMDbAlan J.MoskowitzMDaAnnetine C.GelijnsPhDaJohn H.AlexanderMDcJagatNarulaPhDdPeter K.SmithMDcKelleyHutchesonMDeHelena L.ChangMSaJames S.GammieMDfAlexanderIribarneMDgMary E.MarksBSNaYuliyaVengrenyukPhDhKeisukeYasumuraMDhSamanthaRaymondMPHaBradley S.TaylorMDiOritYardenPhDjEyalOrionMDj…Daniel J.GoldsteinMDu
doi : 10.1016/j.ahj.2021.12.009
Volume 246, April 2022, Pages 12-20
HironoriHaraMDabPatrick W.SerruysMD, PhDbcNeilO'LearyPhDdChaoGaoMDbefAliciaMurrayPhDdElaineBreslinPhDdScotGargMD, PhDgChristopheBureauPhDhJohan HCReiberPhDiEmanueleBarbatoMD, PhDjAdelAminianMDkLucJanssensMDlLiesbethRosseelMDmEdouardBenitMDnGianlucaCampoMDoVincenzoGuiducciMDpGianniCasellaMDqAndreaSantarelliMDr…YoshinobuOnumaMD, PhDb
doi : 10.1016/j.ahj.2021.12.018
Volume 246, April 2022, Pages 32-43
Connie N.HessMD, MHSabWarren H.CapellMDabMichael R.BristowMD, PhDbcWolframRufMDdeMichaelSzarekPhDabfDavid A.MorrowMD, MPHgJose C.NicolauMD, PhDhChristopher A.GraybillPhDcDebraMarshallMDcJudithHsiaMDabMarc P.BonacaMD, MPHab
doi : 10.1016/j.ahj.2021.12.010
Volume 246, April 2022, Pages 136-143
Dirkvon LewinskiMDaNorbert JTripoltDr. scient. med.bHaraldSourijMDbPeter NPferschyBScbAbderrahimOulhajcdHannesAlberMDeMarianneGwechenbergerMDfMartinMartinekMDgSebastianSeidlMDgDeddoMoertlMDhMichaelNürnbergMDiFranz XaverRoithingerMDjClemensSteinwenderMDkMarkusStühlingerMDlAndreasZirlikMDaMartinBenediktMDaEwaldKolesnikMDaMarkusWallnerMDa…DanielScherrMDa
doi : 10.1016/j.ahj.2022.01.008
Volume 246, April 2022, Pages 152-160
DaanTiesMDaPaulienvan DorpMDaGabijaPundziuteMD, PhDaCarlijn M.van der AalstPhDbJan Willem C.GratamaMD, PhDcRichard L.BraamMD, PhDdDirkjanKuijpersMD, PhDeDaniël D.LubbersMD, PhDfIvo A.C.van der BiltMD, PhDgB. DaanWestenbrinkMD, PhDaMartijn J. OudeWolcherinkMSchCarine J.M.DoggenPhDhIvanaIšgumPhDiRobinNijveldtMD, PhDjHarry J.de KoningPhDbRozemarijnVliegenthartMD, PhDkMatthijsOudkerkMD, PhDlPimvan der HarstMD, PhDam
doi : 10.1016/j.ahj.2022.01.005
Volume 246, April 2022, Pages 166-177
Mandeep S.SidhuMD, MBAaRadmilaLyubarovaMDaSripalBangaloreMD, MHAbMarc P.BonacaMD, MPHc
doi : 10.1016/j.ahj.2021.12.005
Volume 246, April 2022, Pages 44-64
An acute coronary syndrome (ACS) event is associated with a high risk of recurrent ACS, stroke, and death. To ameliorate the risk of subsequent events, current guidelines for ST-segment elevation myocardial infarction and non–ST-segment elevation ACS recommend long-term management strategies for secondary prevention including risk factor modification and anti-ischemic and antiplatelet therapies. Dual antiplatelet therapy (DAPT), comprising aspirin plus a P2Y12 inhibitor, is a critical component of secondary prevention therapy following ACS. However, despite the importance of DAPT for secondary prevention after ACS, questions remain over the optimal duration of therapy. Clinical evidence is emerging that maintenance DAPT >12 months lowers the risk of recurrent ACS events; however, this benefit must be considered against any potential risks of prolonged DAPT such as bleeding. Several tools for bleeding risk assessment have shown promise; however, their limited accuracy and discriminative power necessitates further development. Assessment of patient ischemic risk should consider the complexity of the percutaneous coronary intervention (PCI) procedure, anatomic burden of coronary artery disease, and additional underlying risk factors. Consequently, identifying patients in whom the risk:benefit ratio favors prolonged DAPT may prove invaluable for clinicians in deciding which patients should continue or stop taking DAPT at 12 months after PCI, or consider P2Y12 inhibitor monotherapy as an option. This article reviews the most recent information about the risks and benefits of DAPT continued for >12 months after ACS and provides critical guidance to assist physicians in identifying patients most likely to benefit from a secondary prevention strategy with DAPT.
Kershaw V.PatelMDa*NeilKeshvaniMDb*AmbarishPandeyMD, MSCSbMuthiahVaduganathanMD, MPHcDaJuanicia N.HolmesMSdRoland A.MatsouakaPhDdeAdam D.DeVoreMD, MHSdfLarry A.AllenMD, MHSgClyde W.YancyMDhGregg C.FonarowMDi
doi : 10.1016/j.ahj.2021.12.014
Volume 246, April 2022, Pages 1-11
Angela Y.HigginsMDaAmarnath R.AnnapureddyMDabYongfeiWangMSabKarl E.MingesPhD, MSabcLavanyaBellumkondaMDaRachelLampertMDaLynda E.RosenfeldMDaDaniel L.JacobyMDaJeptha P.CurtisMDabEdward J.MillerMD, PhDaJames V.FreemanMD, MS, MPHab
doi : 10.1016/j.ahj.2021.12.011
Volume 246, April 2022, Pages 21-31
SwethaPasalaMDaLauren B.CooperMD, MHSaMitchell A.PsotkaMD, PhDaShashank S.SinhaMD, MScaChristopher R.deFilippiMDaHenryTranMDaBehnamTehraniMDaMatthewSherwoodMD, MHSaKellyEppsMDaWayneBatchelorMD, MHSaAbdulla A.DamlujiMD, PhD, MPHab
doi : 10.1016/j.ahj.2021.11.021
Volume 246, April 2022, Pages 65-73
A. MarkFendrickMDaLaurenceDjatchePharmD, MS, RPhbZulkarnainPulunganPhDcChristieTeiglandPhDcMeiYangPhDbDominikLautschPhDbRobertHilkertMDbRobertMentzMD, FACC, FAHA, FHFSAd
doi : 10.1016/j.ahj.2021.10.189
Volume 246, April 2022, Pages 74-81
TarrynTertulienMD, MScaMary B.RobertsMSbCharles B.EatonMD, MScCrystal W.CeneMD, MPHdGiselleCorbie-SmithMD, MSceJoAnn E.MansonMD, DrPHfMatthewAllisonMD, MPHgRamiNassirPhDhKhadijahBreathettMD, MSi
doi : 10.1016/j.ahj.2021.12.013
Volume 246, April 2022, Pages 82-92
KanichiOtowaMD, PhDaShunKohsakaMDbMitsuakiSawanoMD, PhDcShintaroMatsuuraMDaAkioChikataMD, PhDaMichiroMaruyamaMD, PhDaKazuoUsudaMD, PhDaTetsuWatanabeMD, PhDdHidekiIshiiMD, PhDeTetsuyaAmanoMD, PhDfMasatoNakamuraMD, PhDgYujiIkariMD, PhDh
doi : 10.1016/j.ahj.2022.01.004
Volume 246, April 2022, Pages 105-116
GiuliaDe AngelisMDa†AntonioDe LucaMDa†MarcoMerloMDaGaetanoNuciforaMDPhDbMaddalenaRossiMDaDavideStolfoMDaGiuliaBarbatiPhDcAnnamariaDe BellisMDaMarcoMasèMDaPasqualeSantangeliMDPhDdLorenzoPagnanMDeDanieleMuserMDdf††GianfrancoSinagraMDFESCa†â€
doi : 10.1016/j.ahj.2022.01.006
Volume 246, April 2022, Pages 117-124
EssaHaririMD, MSa†IbrahimKassasMDbc†Mazen AlHammoudd†BarinderHansraMDeMohammed W.AkhterMD, MScGHcfDaniel Z.FisherMDcCraig S.SmithMDcKurt G.BarringhausMDcg
doi : 10.1016/j.ahj.2021.12.015
Volume 246, April 2022, Pages 125-135
Arnaud D.KazeMD, MPHaXiangGaoMPHbSolomon K.MusaniPhDcAurelianBidulescuMD, PhDdAlain G.BertoniMD, MPHeMarwahAbdallaMD, MPHfJustin B.Echouffo-TcheuguiMD, PhDg
doi : 10.1016/j.ahj.2021.12.016
Volume 246, April 2022, Pages 144-151
BhavJainaSimar SinghBajajbJoseph AlexanderPaguioMDcJasper SethYaoMDcBruce A.CasipitMDcEdward ChristopherDeeMDdeDeepak L.BhattMD, MPHf
doi : 10.1016/j.ahj.2022.01.011
Volume 246, April 2022, Pages 161-165
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