N. Rajan
doi : 10.1111/bjd.19534
Volume 184, Issue 1, January 2021, Pages: 1
P. Korkmaz, A. Boyvat
doi : 10.1111/bjd.19432
Volume 184, Issue 1, January 2021, Pages: 2
M. Schmitt?Egenolf
doi : 10.1111/bjd.19544
Volume 184, Issue 1, January 2021, Pages: 3-4
L.M. Hollestein, T. Nijsten
doi : 10.1111/bjd.19208
Volume 184, Issue 1, January 2021, Pages: 4
C.E. Bax, V.P. Werth
doi : 10.1111/bjd.19207
Volume 184, Issue 1, January 2021, Pages: 5-6
L. Naldi
doi : 10.1111/bjd.19190
Volume 184, Issue 1, January 2021, Pages: 6
In this issue of the BJD, Yiu et al. present risk estimates of severe infections in patients with psoriasis from the UK, based on record linkage analyses of administrative and clinical databases, during the period April 2003 to December 2016.1 People with psoriasis had a 36% increased risk of being hospitalized and a 33% increased risk of death due to infection compared with matched controls. While the risk of infection increased with active psoriasis, no further increase in risk was documented for severe psoriasis, identified by the prescription of systemic therapies. Notably, risk estimates were adjusted for important confounding factors and comorbid conditions, supporting the notion that psoriasis per se may be linked with the increased risk.
A. Reich
doi : 10.1111/bjd.19392
Volume 184, Issue 1, January 2021, Pages: 6-7
M. Ohyama
doi : 10.1111/bjd.19388
Volume 184, Issue 1, January 2021, Pages: 7-8
R.F.L. O’Shaughnessy
doi : 10.1111/bjd.19332
Volume 184, Issue 1, January 2021, Pages: 8-9
J. Cadet
doi : 10.1111/bjd.19334
Volume 184, Issue 1, January 2021, Pages: 9-10
C.C. Zouboulis
doi : 10.1111/bjd.19165
Volume 184, Issue 1, January 2021, Pages: 10-11
Drug registrations require a standardized sequence of randomized controlled trials (RCTs). In an effort to reduce certain sources of bias when testing the effectiveness of new treatments, RCTs may, to some extent, exclude patients who could jeopardize the efficacy and safety results.
D. Bessis
doi : 10.1111/bjd.19596
Volume 184, Issue 1, January 2021, Pages: 11-12
Since the beginning of the coronavirus disease 2019 (COVID?19) pandemic, strong evidence has accumulated for the key role of an inappropriate, insufficient, overactive and/or delayed type I (mainly alpha and beta) interferon response during SARS?CoV?2 infection. Most studies have concerned critically ill patients with COVID?19 and the results have been discrepant and even contradictory. This likely reflects differences in the criteria of the studies, such as timing of sampling, nature of the affected organs, severity of the disease and presence of comorbidities.
W. Boonchai
doi : 10.1111/bjd.19245
Volume 184, Issue 1, January 2021, Pages: 13
L. Nussbaum, Y.L. Chen, G.S. Ogg
doi : 10.1111/bjd.19380
Volume 184, Issue 1, January 2021, Pages: 14-24
Psoriasis is a chronic inflammatory disease with a strong genetic component that can be triggered by environmental factors. Disease pathogenesis is mainly driven by type 1 and type 17 cytokine?producing cells which, in healthy individuals, are modulated by regulatory T cells (Tregs). Tregs play a fundamental role in immune homeostasis and contribute to the prevention of autoimmune disease by suppressing immune responses. In psoriasis, Tregs are impaired in their suppressive function leading to an altered T?helper 17/Treg balance.
M.H. Junejo J. Kentley M. Rajpopat X.L. Tan M. Firouz Mohd Mustapa C.A. Harwood
doi : 10.1111/bjd.19026
Volume 184, Issue 1, January 2021, Pages: 25-33
Erosive pustular dermatosis of the scalp (EPDS) is a chronic condition characterized by erosive plaques and subsequent scarring alopecia as a result of local trauma or inflammation. A number of therapeutic approaches have been described in the literature but there is no consensus of opinion on optimal treatment of the disease.
H. Yen H. Yen C.?C. Chi
doi : 10.1111/bjd.19025
Volume 184, Issue 1, January 2021, Pages: 34-42
Psoriasis is a multisystemic inflammatory disorder that has an unclear association with cognitive dysfunction.
A. Dizdarevic W. Troensegaard A. Uldahl O. Bergendorff I. Siemund ?. Svensson A. Sonesson
doi : 10.1111/bjd.19119
Volume 184, Issue 1, January 2021, Pages: 43-49
In contact dermatitis, it is crucial to understand and remember the outcome of patch testing. Unfortunately, many patients do not remember the results of their patch tests.
R.B. Warren A. Blauvelt Y. Poulin S. Beeck M. Kelly T. Wu Z. Geng C. Paul
doi : 10.1111/bjd.19341
Volume 184, Issue 1, January 2021, Pages: 50-59
Patients with plaque psoriasis treated with biologic therapies need more efficacious, safe and convenient treatments to improve quality of life. Risankizumab and secukinumab inhibit interleukin?23 and interleukin?17A, respectively, and are effective in adult patients with moderate?to?severe plaque psoriasis but have different dosing regimens.
K. Isaksson R. Mikiver H. Eriksson J. Lapins K. Nielsen C. Ingvar J. Lyth
doi : 10.1111/bjd.19015
Volume 184, Issue 1, January 2021, Pages: 60-67
The incidence of cutaneous malignant melanoma (CMM) continues to increase in most countries worldwide and the majority are diagnosed with thin tumours (? 1 mm).
M.S.M. Persson K.E. Harman Y. Vinogradova S.M. Langan J. Hippisley?Cox K.S. Thomas S. Gran
doi : 10.1111/bjd.19022
Volume 184, Issue 1, January 2021, Pages: 68-77
A rising incidence and high mortality were found for bullous pemphigoid (BP) over a decade ago in the UK. Updated estimates of its epidemiology are required to understand the healthcare needs of an ageing population.
Z.Z.N. Yiu R. Parisi M. Lunt R.B. Warren C.E.M. Griffiths S.M. Langan D.M. Ashcroft
doi : 10.1111/bjd.19052
Volume 184, Issue 1, January 2021, Pages: 78-86
Psoriasis is associated with risk factors for serious infections, but the independent relationship between psoriasis and serious infection is as yet unclear.
J.I. Silverberg D. Lei M. Yousaf S.R. Janmohamed P.P. Vakharia R. Chopra R. Chavda S. Gabriel K.R. Patel V. Singam R. Kantor Derek Y. Hsu
doi : 10.1111/bjd.19159
Volume 184, Issue 1, January 2021, Pages: 87-95
Multiple atopic dermatitis (AD) severity scales exist, with no gold standard for use in clinical practice.
T.W. Fischer A. Bergmann N. Kruse K. Kleszczynski C. Skobowiat A.T. Slominski R. Paus
doi : 10.1111/bjd.19115
Volume 184, Issue 1, January 2021, Pages: 96-110
Human hair is highly responsive to stress, and human scalp hair follicles (HFs) contain a peripheral neuroendocrine equivalent of the systemic hypothalamic–pituitary–adrenal (HPA) stress axis. Androgenetic alopecia (AGA) is supposed to be aggravated by stress. We used corticotropin?releasing hormone (CRH), which triggers the HPA axis, to induce a stress response in human ex vivo male AGA HFs. Caffeine is known to reverse testosterone?mediated hair growth inhibition in the same hair organ culture model.
L. Yang T. Zhang C. Zhang C. Xiao X. Bai G. Wang
doi : 10.1111/bjd.19057
Volume 184, Issue 1, January 2021, Pages: 111-122
Tripartite motif?containing protein 21 (Trim21) is an E3 ubiquitin?protein ligase that plays pivotal roles in various diseases. However, its role in mediating keratinocyte inflammation, which is a hallmark of psoriasis, has not been thoroughly elucidated.
M.M. Dorr R. Guignard F.A. Auger P.J. Rochette
doi : 10.1111/bjd.19117
Volume 184, Issue 1, January 2021, Pages: 123-132
Ultraviolet radiation (UVR) is responsible for keratinocyte cancers through the induction of mutagenic cyclobutane pyrimidine dimers (CPDs). Many factors influence CPD repair in epidermal keratinocytes, and a better understanding of those factors might lead to prevention strategies against skin cancer.
A.V. Marzano G. Genovese G. Casazza C. Moltrasio P. Dapavo G. Micali R. Sirna P. Gisondi A. Patrizi V. Dini D. Bianchini L. Bianchi L. Fania F. Prignano A. Offidani L. Atzori V. Bettoli S.P. Cannav? M. Venturini M. R. Bongiorno A. Costanzo G. Fabbrocini K. Peris
doi : 10.1111/bjd.18983
Volume 184, Issue 1, January 2021, Pages: 133-140
The anti?tumour necrosis factor (TNF)?? adalimumab is the only licenced biologic for moderate?to?severe hidradenitis suppurativa (HS). No predictors of response have been identified so far.
C.M. Magro J.J. Mulvey J. Laurence S. Sanders A.N. Crowson M. Grossman J. Harp G. Nuovo
doi : 10.1111/bjd.19415
Volume 184, Issue 1, January 2021, Pages: 141-150
There are two distinctive acral manifestations of COVID?19 embodying disparate clinical phenotypes. One is perniosis occurring in mildly symptomatic patients, typically children and young adults; the second is the thrombotic retiform purpura of critically ill adults with COVID?19.
S. Rolls E. Owen C.G. Bertram J.F. Bourke D.A. Buckley M.M.U. Chowdhury S.M. Cooper S.A. Ghaffar C.M. Green T.M. Hughes G.A. Johnston C.M. Reckling D.A. Thompson S.H. Wakelin M. Wilkinson N.M. Stone
doi : 10.1111/bjd.19127
Volume 184, Issue 1, January 2021, Pages: 151-155
Allergic contact dermatitis (ACD) to cosmetics is widely reported. To ensure we are accurately diagnosing ACD, patch test series should be continually reviewed to identify relevant and emerging allergens and highlight those that are outdated. The current British Society for Cutaneous Allergy (BSCA) facial series recommends 26 allergens and was last modified in 2012.
G. Kyriakou V. Drivelou A. Glentis
doi : 10.1111/bjd.19508
Volume 184, Issue 1, January 2021, Pages: 156-157
S. Behbahani S. Malerba F.H. Samie
doi : 10.1111/bjd.19406
Volume 184, Issue 1, January 2021, Pages: 158-160
J.M. Fernandez A.M. Thompson J.S. Kirby J.L. Hsiao V.Y. Shi
doi : 10.1111/bjd.19412
Volume 184, Issue 1, January 2021, Pages: 160-162
A.D. Gloor L. Feldmeyer A. Rammlmair C. Schlapbach D. Wallach L. Borradori
doi : 10.1111/bjd.19418
Volume 184, Issue 1, January 2021, Pages: 162-164
E. Chen M. Ghannoum B.E. Elewski
doi : 10.1111/bjd.19420
Volume 184, Issue 1, January 2021, Pages: 164-165
V.S. Narayan S.E. Uitentuis M.W. Bekkenk A. Wolkerstorfer
doi : 10.1111/bjd.19422
Volume 184, Issue 1, January 2021, Pages: 165-166
V. Exposito?Serrano L. Curto?Barredo P. Aguilera Peiro S. G?mez Armayones E. Serra?Baldrich J. Spertino M. Bonfill Ort? I. Figueras Nart G. Melé?Ninot C. Baliu?Piqué A. Sala Cunill M. Labrador?Horrillo A. Guilabert Vidal N. Fern?ndez Chico A.M. Giménez?Arnau
doi : 10.1111/bjd.19425
Volume 184, Issue 1, January 2021, Pages: 167-168
V. Gupta N. Taneja H.C. Sati V. Sreenivas M. Ramam
doi : 10.1111/bjd.19424
Volume 184, Issue 1, January 2021, Pages: 168-169
F. N. Mirza S. Yumeen M. Girardi
doi : 10.1111/bjd.19426
Volume 184, Issue 1, January 2021, Pages: 170-171
R. Speeckaert J. Lambert L. Delbaere T. Lesseliers N. van Geel
doi : 10.1111/bjd.19430
Volume 184, Issue 1, January 2021, Pages: 171-173
C. C. Zouboulis T. Wild V. A. Zouboulis Y. Har?Shai
doi : 10.1111/bjd.19427
Volume 184, Issue 1, January 2021, Pages: 173-175
J.J. Pereyra?Rodriguez J. Dom?nguez?Cruz R. Ruiz?Villaverde J.F. Silvestre M. Gal?n L. Curto I. Figueras E. Serra?Baldrich J.C. Armario?Hita
doi : 10.1111/bjd.19428
Volume 184, Issue 1, January 2021, Pages: 175-176
E. Russell S. Walker T. McPherson
doi : 10.1111/bjd.19458
Volume 184, Issue 1, January 2021, Pages: 176-178
F. Long F. He J. Wang L. Wang J. Tu Z. Zhang J. Xia Z. Yin Y. Lu
doi : 10.1111/bjd.19466
Volume 184, Issue 1, January 2021, Pages: 178-180
F.J. Ferguson G. Street L. Cunningham I.R. White J.P. McFadden J. Williams
doi : 10.1111/bjd.19482
Volume 184, Issue 1, January 2021, Pages: 180-182
X.T. Lima M.A. Cueva M.B. Alora
doi : 10.1111/bjd.19492
Volume 184, Issue 1, January 2021, Pages: 182-184
A. Nuno?Gonzalez P. Martin?Carrillo K. Magaletsky M.D. Martin Rios C. Herranz Ma?as J. Artigas Almazan G. Garc?a Casasola E. Perez Castro A. Gallego Arenas A. Mayor Ibarguren M. Feito Rodr?guez B. Lozano Masdemont M. Beato E. Ruiz Bravo P. Oliver M.D. Montero Vega P. Herranz Pinto
doi : 10.1111/bjd.19564
Volume 184, Issue 1, January 2021, Pages: 184-185
J.K. Brealey S.E. Miller
doi : 10.1111/bjd.19572
Volume 184, Issue 1, January 2021, Pages: 186
I. Colmenero C. Santonja M. Alonso?Ria?o D. Andina J.L. Rodr?guez Peralto L. Requena A. Torrelo
doi : 10.1111/bjd.19595
Volume 184, Issue 1, January 2021, Pages: 186-187
J.R. Ingram A. Ahluwalia
doi : 10.1111/bjd.18525
Volume 184, Issue 1, January 2021, Pages: e1-e2
C. Ruini S. Schuh D. Hartmann L. French J. Welzel E. Sattler
doi : 10.1111/bjd.19318
Volume 184, Issue 1, January 2021, Pages: e3
A. Greig K. Aloni G. Orchard M. Shams E. Craythorne H. Fassihi
doi : 10.1111/bjd.19323
Volume 184, Issue 1, January 2021, Pages: e4
K.M. Derrick D.R. Mazori E.R. Heilman S.A. Glick
doi : 10.1111/bjd.19568
Volume 184, Issue 1, January 2021, Pages: e5
C.D. Soares A. Mosqueda?Taylor M.G.F. de Carvalho O.P. de Almeida
doi : 10.1111/bjd.19569
Volume 184, Issue 1, January 2021, Pages: e6
doi : 10.1111/bjd.19634
Volume 184, Issue 1, January 2021, Pages: e7
Psoriasis is a skin disease that manifests as itchy, scaly plaques (patches) on the skin. It is associated with both a physical and psychological burden, and affects 0.5?1% of children and 2?3% of the population worldwide.
doi : 10.1111/bjd.19635
Volume 184, Issue 1, January 2021, Pages: e8
Contact dermatitis is a type of eczema caused by contact of the skin with a particular substance in the environment. This can cause a chronic skin disease such as hand eczema and it is crucial to identify the allergy and to obtain information on where the allergen can be found. Otherwise, the eczema becomes difficult to treat and may affect a patient’s daily life and work ability. More than a quarter of the European population has been shown to have some kind of contact allergy.
doi : 10.1111/bjd.19636
Volume 184, Issue 1, January 2021, Pages: e9
Erosive pustular dermatosis of the scalp (EPDS) is a skin disease that causes non?healing wounds on the scalp. It may be more common than previously thought, as it can be misdiagnosed. EPDS usually affects older patients with lots of sun damage, and it may also be caused by injury, surgery, or certain treatments used by dermatologists, such as 5?fluorouracil cream, which is used to treat pre?cancerous lesions.
doi : 10.1111/bjd.19637
Volume 184, Issue 1, January 2021, Pages: e10
Hidradenitis suppurativa (HS) is a chronic skin disease affecting around 1% of the population and characterized by painful boil?like lumps, cysts and scarring on skin folds.
doi : 10.1111/bjd.19638
Volume 184, Issue 1, January 2021, Pages: e11
Cutaneous malignant melanoma is a type of skin cancer that you can die from. The number of patients being diagnosed with malignant melanoma of the skin is rising in most countries. About 4000 patients were diagnosed in Sweden in 2018. The risk of dying from cutaneous melanoma is very much dependent on the thickness of melanoma, a measure given by the pathologist after removing the melanoma.
doi : 10.1111/bjd.19639
Volume 184, Issue 1, January 2021, Pages: e12
Bullous pemphigoid is a distressing disease that causes blisters and itching of the skin. Our study, from England, aimed to find out how many people get bullous pemphigoid for the first time each year (incidence), how many people are living with bullous pemphigoid at any given point (prevalence), and whether people with bullous pemphigoid are more likely to die than similar people without the disease (mortality).
doi : 10.1111/bjd.19640
Volume 184, Issue 1, January 2021, Pages: e13
Psoriasis is a chronic inflammatory skin condition that is associated with (linked to) additional conditions such as diabetes and obesity (called comorbidities), which in turn are associated with an increased risk of infection. One concern people with psoriasis have is whether the psoriasis itself, rather than the comorbidities, is associated with an increased risk of getting a serious infection, which is defined as having any infection serious enough to lead to hospital admission.
doi : 10.1111/bjd.19641
Volume 184, Issue 1, January 2021, Pages: e14
Allergic contact dermatitis (ACD) is a localised form of dermatitis or eczema which occurs 48?72 hours after a substance which causes allergy (an allergen) has been in contact with the skin. It affects 20% of people. ACD to cosmetics is widely reported, with facial eczema being the main presenting complaint.
doi : 10.1111/bjd.19642
Volume 184, Issue 1, January 2021, Pages: e15
Plaque psoriasis is a common inflammatory disease that causes raised, flaky plaques or patches on the skin. An abnormal immune system can be an important cause of psoriasis. Risankizumab and secukinumab are biologic drugs that are injected under a patient’s skin to treat different parts of the immune system. Both drugs are approved in the U. S. and E. U. to treat moderate?to?severe plaque psoriasis.
doi : 10.1111/bjd.19643
Volume 184, Issue 1, January 2021, Pages: e16
Psoriasis and dementia are both common conditions. Because of how both diseases develop within the body, they might have certain shared traits, and it has been suggested that patients with psoriasis may be at greater risk of developing impaired mental function and/or dementia. This study from Taiwan examines the published research to see whether there may be evidence of such a link.
doi : 10.1111/bjd.19646
Volume 184, Issue 1, January 2021, Pages: e17
Atopic dermatitis (AD) is a common type of eczema seen in people of all ages, particularly children. It makes the skin inflamed, itchy and sore and affects many aspects of everyday life. There is a lot of research into different treatments, but it is hard to compare them because researchers use different ways to measure how severe the eczema is.
doi : 10.1111/bjd.19647
Volume 184, Issue 1, January 2021, Pages: e18
??????????, ????????????? (????) ????????????, ??? 0.5?1% ???? 2?3% ????????
doi : 10.1111/bjd.19648
Volume 184, Issue 1, January 2021, Pages: e19
????????????????????????????????????????????, ????????????????????????????, ?????????, ??????????????????????????????????????????
doi : 10.1111/bjd.19649
Volume 184, Issue 1, January 2021, Pages: e20
????????? (EPDS) ??????, ????????????????????????????, ?????????EPDS ?????????????????, ???????????????????????? (??????????? 5??????) ???
doi : 10.1111/bjd.19650
Volume 184, Issue 1, January 2021, Pages: e21
?????? (HS) ????????, ?? 1% ???????, ??????????????????????
doi : 10.1111/bjd.19651
Volume 184, Issue 1, January 2021, Pages: e22
????????????????????????/????????????????????????2018 ?, ???? 4000 ???????????????????????????????????????, ?????????????????????????????????????????????????????????, ???? 1 ??????
doi : 10.1111/bjd.19652
Volume 184, Issue 1, January 2021, Pages: e23
?????????????????, ?????????????????????????????????????????? (???) ???????????????????? (???) ?????????????????????? (???) ?
doi : 10.1111/bjd.19653
Volume 184, Issue 1, January 2021, Pages: e24
???????????????, ????????? (?????) ??????? (??) , ?????????????????????????????, ????? (??????) ????????????????????????????????????
doi : 10.1111/bjd.19654
Volume 184, Issue 1, January 2021, Pages: e25
???????? (ACD) ???????????, ???????? (???) ?????? 48?72 ??????? 20% ????????????? ACD ?????, ??????????
doi : 10.1111/bjd.19655
Volume 184, Issue 1, January 2021, Pages: e26
?????????????????, ??????????????? (??) ?????????????????????Risankizumab ???????????????????????????????????????????????, ????????????????
doi : 10.1111/bjd.19656
Volume 184, Issue 1, January 2021, Pages: e27
??????????????????????????????, ?????????????, ???????, ???????????????????/?????????????????????????????????????????
doi : 10.1111/bjd.19657
Volume 184, Issue 1, January 2021, Pages: e28
????? (AD) ??????? (?????) ??????????????????????????, ??????????????????????????, ?????????, ????????????????????????
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