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Ocular manifestations of dermatological diseases part II: genodermatoses
Lamia S. Al Akrash MD Mohammad A. Al Semari MD Ruaa Al Harithy MD
doi : 10.1111/ijd.15173
Volume 60, Issue 2, February 2021, Pages: 133-140
Skin and eyes share a common embryological origin from the embryonic surface ectoderm. Ocular manifestations in dermatological diseases are common and have diagnostic value. At present, there are a limited number of comprehensive reviews emphasizing the ocular manifestations of dermatological diseases. More than 40 published articles about ocular findings in dermatology were reviewed.
Pityriasis in dermatology: an updated review
Laura D. Chin BSc Nikoo Parvinnejad MD, FRCPC Richard M. Haber MD, FRCPC
doi : 10.1111/ijd.15097
Volume 60, Issue 2, February 2021, Pages: 141-158
Dermatology has a very distinctive lexicon. The term pityriasis refers to several dermatologic conditions which all feature scaling of the skin. According to the Merriam?Webster dictionary, the term pityriasis was first used in print in 1684. Although the diseases beginning with the name pityriasis are of diverse causation, they do represent important dermatologic diseases, with some common and others quite rare. It is important for dermatologists to be aware and updated on all pityriasis conditions in dermatology.
Follicular mucinosis: a review
Joanna Khalil MD Mazen Kurban MD Ossama Abbas MD
doi : 10.1111/ijd.15165
Volume 60, Issue 2, February 2021, Pages: 159-165
Follicular mucinosis (FM) is an epithelial reaction pattern characterized by follicular mucin accumulation. It has been described in association with various inflammatory and neoplastic cutaneous disorders. FM is generally divided into a primary benign idiopathic form and a secondary form usually occurring in association with cutaneous lymphomas (especially mycosis fungoides), among other entities. Distinction between the two forms can be challenging as they share many overlapping features and the lack of a single diagnostic tool to differentiate between the two. Making the distinction may require evaluating and correlating the clinical, histologic, immunohistochemical, and molecular studies together. Long?term clinical follow?up also remains very important. In this review, we describe the different entities associated with FM, its pathogenesis, and possible therapeutic options.
Treatment of melasma: a review of less commonly used antioxidants
Kayla M. Babbush BS Remy A. Babbush Amor Khachemoune MD, FAAD, FACMS
doi : 10.1111/ijd.15133
Volume 60, Issue 2, February 2021, Pages: 166-173
Melasma, a common cause for seeking dermatologic care, is a chronic condition of skin hyperpigmentation. With a poorly understood pathogenesis, and no universal cure, melasma is a challenge for many dermatologists. For decades, there has been investigation into the role of oxidative stress in melasma. In this literature review, we introduce the role of oxidative stress in melasma and discuss the function of various topical and oral antioxidant therapies for patients suffering from melasma.
Slow growing nasal tumor in an adult male
Jordan Lim MB, BCh, BAO Thomas D. Samson MD Klaus Helm MD Charlene Lam MD, MPH
doi : 10.1111/ijd.15073
Volume 60, Issue 2, February 2021, Pages: 174-175
Agminate papules and nodules on left lower limb
Juan Jimenez?Cauhe MD Patricia Garcia?Abellas MD Borja Diaz?Guimaraens MD Diego Fernandez?Nieto MD Montserrat Fernandez?Guarino MD, PhD
doi : 10.1111/ijd.14875
Volume 60, Issue 2, February 2021, Pages: 176-178
Using betaxolol for the prevention of paronychia induced by epidermal growth factor receptor inhibitors: a case–control cohort study
Chun?Wei Lu MD Ting?Ya Wang MD Chi?Feng Yen MD Kang?Hua Chen RN, PhD Chiao?En Wu MD, PhD Chih?Liang Wang MD Ping?Chih Hsu MD Yueh?Fu Fang MD Shih?Hong Li MD How?Wen Ko MD, PhD Li?Chuan Tseng RN, MS Feng?Ya Shih RN Yu?Jr Lin PhD Mei?Jun Chen MS Chun?Bing Chen MD Jong?Hwei Su Pang PhD Wen?Hung Chung MD, PhD Yu?Shien Ko MD, PhD
doi : 10.1111/ijd.15099
Volume 60, Issue 2, February 2021, Pages: 179-184
High rates of posttreatment discomfort, infection, recurrence, and increased time to return to work have been noted after nail plate avulsion resulting from epidermal growth factor receptor tyrosine kinase inhibitor(EGFR?TKI)?induced paronychia, which may even interrupt the course of treatment for EGFR?TKI therapy. Thus, we conducted this study to determine how effectively a topical ??blocker, betaxolol, prevents EGFR?TKI?induced paronychia.
Disseminated intravascular coagulopathy: a complication of Stevens–Johnson syndrome/toxic epidermal necrolysis
Rokea A. el?Azhary MD, PhD Somaira Nowsheen MD, PhD Lawrence E. Gibson MD David J. DiCaudo MD
doi : 10.1111/ijd.15370
Volume 60, Issue 2, February 2021, Pages: 185-189
The purpose of this study was to retrospectively assess clinical characteristics and mortality rate of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients who developed disseminated intravascular coagulation (DIC).
Dupilumab treatment ameliorates clinical and hematological symptoms, including blood eosinophilia, in patients with atopic dermatitis
Teruo Yamauchi MD Shun Sasaki MD, PhD Eun Seon Lee MD Takayuki Tamura MD Marina Seki MD Tasuku Miwa MD Kae Kobayashi MD, PhD Yusuke Saruta MD, PhD Yuki Kitami MD, PhD Hirohiko Sueki MD, PhD Hideaki Watanabe MD, PhD
doi : 10.1111/ijd.15183
Volume 60, Issue 2, February 2021, Pages: 190-195
Atopic dermatitis (AD) is an allergic disease that affects individuals of various ages. Recently, the IL?4/13 inhibitor dupilumab has gained regulatory approval for clinical use in AD patients. Dupilumab has been reported to reduce several markers of AD, including the serum levels of thymus and activation?regulated chemokine (TARC/CCL17), blood lactate dehydrogenase (LDH), and serum total immunoglobulin E (IgE).
Reflectance confocal microscopy and its role in the follow?up of a topical treatment for lentigo maligna
Valeria Coco MD Francesca Perino MD Alessandro Di Stefani MD Simone Cappilli MD Ketty Peris MD
doi : 10.1111/ijd.15070
Volume 60, Issue 2, February 2021, Pages: 196-200
In recent years, there has been an ongoing interest in topical treatment for lentigo maligna (LM) as imiquimod 5% cream owing to the localization of this tumor and the advanced age of patients; however, the efficacy of imiquimod 5% cream is controversial, and the rate of local relapses is about 25–53%. Reflectance confocal microscopy (RCM) is a noninvasive diagnostic tool useful not only for diagnostic purpose but also for monitoring the response to the local treatment of LM. Our aim was to demonstrate the role of RCM in the follow?up of a topical treatment with imiquimod 5% cream in clinical practice.
Balanopreputial sac and urine microbiota in patients with male genital lichen sclerosus
Richard E. Watchorn MD, FRCP Ellen H. A. van den Munckhof MSc Koen D. Quint MD, PhD Joseph Eliahoo MSc DLSHTM Maurits N. C. de Koning PhD Wim G. V. Quint PhD Christopher B. Bunker MA, MD, FRCP
doi : 10.1111/ijd.15252
Volume 60, Issue 2, February 2021, Pages: 201-207
Male genital lichen sclerosus (MGLSc) is a chronic inflammatory scarring dermatosis associated with penile carcinoma. The prepuce is pivotal in its etiology. Other proposed etiological factors are the subject of dispute and include occluded urinary exposure, autoimmunity, immunodysregulation, and infectious agents.
Cutaneous adverse events in patients receiving anticancer therapy in a tertiary hospital setting: the old and the new
Hae?Jin Suh MD ?ngeles Fl?rez PhD V?ctor Sacrist?n MD ?ngeles Rodr?guez Martinez Francisca Fern?ndez PharmD Luc?a Vilanova?Trillo PhD Manuel Constenla PhD Manuel Pereiro PhD
doi : 10.1111/ijd.15081
Volume 60, Issue 2, February 2021, Pages: 208-216
Targeted therapies and immunotherapies are increasingly prescribed, but classic chemotherapy agents are still highly used in cancer treatment. Both therapies, the old and the new, are associated with cutaneous adverse events (CAEs) that can cause treatment interruptions or reduce the quality of life of patients.
Efficacy of high?dose intralesional triamcinolone for hidradenitis suppurativa
Jessica Garelik DO Kayla Babbush BS Mondana Ghias MD Steven R. Cohen MD, MPH
doi : 10.1111/ijd.15124
Volume 60, Issue 2, February 2021, Pages: 217-221
Hidradenitis suppurativa (HS) is a chronic inflammatory disorder of hair follicles characterized by recurrent, painful nodules, abscesses, and sinus tracts (“tunnels”) typically refractory to treatment. This debilitating condition results in poor quality of life due to high disease burden. Intralesional triamcinolone (ILTAC) is a standard of care for acute inflammation and drainage associated with HS; however, the optimal therapeutic dose has not been determined. We investigated the utility of high?dose ILTAC 20 mg/ml (ILTAC?20) or 40 mg/ml (ILTAC?40), for inflammatory lesions of HS.
Primary cutaneous malignancies in nonalbino and albino Africans
Okechukwu C. Okafor DAPat, FMCPath, FICS Nnaemeka T. Onyishi FMCPath
doi : 10.1111/ijd.15312
Volume 60, Issue 2, February 2021, Pages: 222-228
The pigmented skin of black Africans has been credited with reduction in risk of skin cancer. African albinos have inherited defects in skin melanin deposition, which predisposes them to ultraviolet radiation?induced cutaneous carcinogenesis. We compared the manifestation of skin cancers between albino and nonalbino Africans aiming to describe the effect of pigmentation or lack of it on the epidemiological characteristics of skin cancer in Africans.
Complement?mediated thrombogenic vasculopathy in COVID?19
Alexandra Perea Polak MD Beatriz Romero Madrid MD Paula Patricia Garc?a Oca?a MD Guillermo Lome?a Alvarez MD Leandro Mart?nez Pilar MD, PhD Elisabeth G?mez?Moyano MD, PhD
doi : 10.1111/ijd.15267
Volume 60, Issue 2, February 2021, Pages: 229-232
Novel treatment of locally advanced cutaneous squamous cell carcinoma with cemiplimab: a case report
Rachel Nelson BS Ly Luu MD Peter Silberstein MD Manasa Velagapudi MBBS Christopher Huerter MD
doi : 10.1111/ijd.15176
Volume 60, Issue 2, February 2021, Pages: 233-235
Features of oral squamous cell carcinoma in ex vivo fluorescence confocal microscopy
Veronika Shavlokhova MD, DMD Christa Flechtenmacher MD Sameena Sandhu MD, DMD Michael Vollmer MD, DMD Jürgen Hoffmann MD, DMD, PhD, FEBOMS Michael Engel MD, DMD, PhD Oliver Ristow MD, DMD, PhD Christian Freudlsperger MD, DMD, PhD, FEBOMS
doi : 10.1111/ijd.15152
Volume 60, Issue 2, February 2021, Pages: 236-240
Real?time microscopic imaging of freshly excised oral squamous cell carcinomas (OSCCs) would be potentially supportive in rapid recognition of oral malignancy and an optimal and time?saving management of patients' surgical treatment.
Allergic contact dermatitis caused by Lavandula angustifolia and cross?reaction with Citrus bergamia essential oils in an aromatherapist
Francisco J. Navarro?Trivi?o MD Paula Jadczak PhD Ricardo Ruiz?Villaverde MD
doi : 10.1111/ijd.15027
Volume 60, Issue 2, February 2021, Pages: 241-243
Mycoplasma?induced rash and mucositis with toxic epidermal necrolysis?like progression
André Cerejeira MD Patr?cia Amoedo MD Leonor Carneiro?Le?o MD Bernardo Correia MD Susana Silva MD Cl?udio Silva MD Jo?o Pacheco MD Paula Egipto MD Filomena Azevedo MD Carmen Lisboa MD, PhD
doi : 10.1111/ijd.15332
Volume 60, Issue 2, February 2021, Pages: 244-245
Annular lichen planus associated with coronavirus SARS?CoV?2 disease (COVID?19)
Borja Diaz?Guimaraens MD Miguel Dominguez?Santas MD Ana Suarez?Valle MD Diego Fernandez?Nieto MD Juan Jimenez?Cauhe MD Asunci?n Ballester MD
doi : 10.1111/ijd.15338
Volume 60, Issue 2, February 2021, Pages: 246-247
Adherence to biological therapy in dermatological patients during the COVID?19 pandemic in Western Sicily
Giovanna Tilotta MD Giuseppe Pistone MD Paolo Caruso MD Rosario Gurreri MD Elena Castelli MD Salvatrice Curiale MD Valentina Caputo MD Maria R. Bongiorno MD
doi : 10.1111/ijd.15352
Volume 60, Issue 2, February 2021, Pages: 248-249
Publication rate of clinical trials in dermatology before and during COVID?19
Melissa A. Nickles BA Jeffrey Zhao BA Mit M. Patel BS Swati P. Garg BA Vishnutheertha Kulkarni MS Joseph M. Bianco BS Peter A. Lio MD
doi : 10.1111/ijd.15355
Volume 60, Issue 2, February 2021, Pages: 250-252
COVID?19 infection under omalizumab therapy for chronic spontaneous urticaria: three cases
Erhan Ayhan MD Murat ?ztürk MD ?sa An MD Muhammed Bekç?ba?i MD
doi : 10.1111/ijd.15379
Volume 60, Issue 2, February 2021, Pages: 253-254
A comparative study of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women: the devil is in the detail
Chun?Man Lee MBBS, MRCP(UK), MSc
doi : 10.1111/ijd.15373
Volume 60, Issue 2, February 2021, Pages: 255
Concerns on comparing drugs in dermatologic treatments from different suppliers
Paula Basso Lima MD Joana Alexandria Ferreira Dias MD Daniel Cassiano MD Ana Cl?udia Cavalcante Esposito MD, MSc Ediléia Bagatin MD, PhD Luciane Donida Bartoli Miot MD, PhD Hélio Amante Miot MD, PhD
doi : 10.1111/ijd.15371
Volume 60, Issue 2, February 2021, Pages: 256-257
Kaposi’s sarcoma in Russian HIV?negative patients: a single?center case series
Natalia P. Teplyuk PhD Purim M. Ruvinova MD Vladimir A. Varshavsky PhD Alexander S. Tertychnyy PhD Anfisa A. Lepekhova PhD
doi : 10.1111/ijd.15368
Volume 60, Issue 2, February 2021, Pages: e37-e40
Cutaneous presentation of a bladder carcinoma mimicking an epidermal cyst
Lotte M. Voeten MD Monique J. Koopmans MD, PhD Lizelotte J.M.T. Weppner?Parren MD, PhD
doi : 10.1111/ijd.15364
Volume 60, Issue 2, February 2021, Pages: e40-e41
National publication productivity in dermatology: an exploratory analysis of contributing factors
Lorena Gantenbein Alexander Navarini MD, PhD Oliver Brandt MD Simon M. Mueller MD
doi : 10.1111/ijd.15351
Volume 60, Issue 2, February 2021, Pages: e41-e44
Occipital fibrosing alopecia
M Abril Martinez?Velasco MD Brandon Burroway BS Curtis Thompson MD Tatiana Silyuk MD Antonella Tosti MD
doi : 10.1111/ijd.15335
Volume 60, Issue 2, February 2021, Pages: e44-e45
Skindex?29 cutoffs in an atopic dermatitis sample
Daniela Carvalho PhD Pedro Aguiar PhD Paulo Ferrinho PhD
doi : 10.1111/ijd.15237
Volume 60, Issue 2, February 2021, Pages: e45-e47
Thymoma?associated multiorgan autoimmunity with prominent muco?cutaneous involvement: two cases and review of the literature
Mart? Pons Benavent MD Alejandro Garc?a V?zquez MD Santiago Guillén Climent MD Saray Porcar Saura MD Dolores Ram?n Quiles MD
doi : 10.1111/ijd.15199
Volume 60, Issue 2, February 2021, Pages: e47-e49
Serological screening for celiac disease using IgA?tissue transglutaminase antibody in patients with recurrent aphthous stomatitis
Luiz F. Morgado de Abreu MD Marilda A. M. Morgado de Abreu MD, PhD Vera L. Sdepanian MD, PhD Cleonice H. W. Hirata MD, PhD Dalva R. N. Pimentel MD, PhD Jan?ina C. M. Braz MD Adilson Costa MD, PhD
doi : 10.1111/ijd.15271
Volume 60, Issue 2, February 2021, Pages: e49-e51
Performance of a deep learning?based application for the diagnosis of basal cell carcinoma in Indian patients as compared to dermatologists and nondermatologists
Rashi Pangti MD Vikas Chouhan BE Jyoti Mathur PhD Sharad Kumar BE, MS Ambika Dixit MD Sanjeev Gupta MD Soniya Mahajan MD Atula Gupta MD Somesh Gupta MD
doi : 10.1111/ijd.15242
Volume 60, Issue 2, February 2021, Pages: e51-e52
Tridimensional skin imaging in aquagenic keratoderma: virtual histology by line?field confocal optical coherence tomography
Linda Tognetti MD, PhD Diletta Fiorani MD Elisa Cinotti MD, PhD Pietro Rubegni MD, PhD
doi : 10.1111/ijd.15169
Volume 60, Issue 2, February 2021, Pages: e52-e54
The first case of a collision tumor of melanotrichoblastoma and seborrheic keratosis
Haruki Mizuta MD Kenjiro Namikawa MD, PhD Akira Takahashi MD, PhD Dai Ogata MD, PhD Yusuke Muto MD Shunichi Jinnai MD Kenta Nakama MD Keita Tsutsui MD Naoya Yamazaki MD, PhD
doi : 10.1111/ijd.15042
Volume 60, Issue 2, February 2021, Pages: e54-e56
Itch and pain by lesion morphology in hidradenitis suppurativa patients
Jennifer M. Fernandez BS RD Omar H. Rizvi MS Kendra D. Marr BS Kyla N. Price BS Aleksi J. Hendricks BS Jennifer L. Hsiao MD Vivian Y. Shi MD
doi : 10.1111/ijd.15037
Volume 60, Issue 2, February 2021, Pages: e56-e59
Fibrous hamartoma of infancy with hypertrichosis: the diagnostic challenge of a rare late?onset case
Madhusmita Sethy MD Biswanath Behera MD, DNB Aparna Palit MD Ashish Kumar Nayak MD Siddhartha Dash MD Pavithra Ayyanar MD, DNB
doi : 10.1111/ijd.15259
Volume 60, Issue 2, February 2021, Pages: e59-e60
Mycoses in the elderly population: what a 16?year experience has taught us
Eleonora Cinelli MD Mariateresa Nocerino MD Angela Patr? MD Matteo Megna MD Gabriella Fabbrocini MD Lucia Gallo MD
doi : 10.1111/ijd.15126
Volume 60, Issue 2, February 2021, Pages: e60-e62
Inverse Gottron's papules in patients with dermatomyositis: an underrecognized but important sign for interstitial lung disease
Kinoko Irie MD Natsuko Matsumura MD Michiko Hoshi MD Toshiyuki Yamamoto MD, PhD
doi : 10.1111/ijd.15204
Volume 60, Issue 2, February 2021, Pages: e62-e65
Availability of prescription medications for sale without a prescription on the internet in the United States
Yumeng Li MD, MS Karsihma Desai BS Brian Morrison MD Fabrizio Galimberti MD, PhD
doi : 10.1111/ijd.15123
Volume 60, Issue 2, February 2021, Pages: e65-e66
Unilateral upper limb chronic exertional compartment syndrome associated with deep morphea in a nonathlete patient: a very rare presentation
Yasser A. Radwan MD Julia S. Lehman MD Jacob L. Sellon MD Ashima Makol MD
doi : 10.1111/ijd.15177
Volume 60, Issue 2, February 2021, Pages: e66-e68
Autosomal recessive woolly hair and hypotrichosis in two Caucasian dizygotic twins. Description of a novel biallelic mutation in the LPAR6 gene
Jennifer Piquer?Garc?a MD Ignacio Torres?Navarro MD Francisco Mart?nez?Castellano PhD Montserrat ?vole?Buselli MD, PhD
doi : 10.1111/ijd.15207
Volume 60, Issue 2, February 2021, Pages: e68-e70
Nested melanoma: when dermoscopy turns histopathology into question
Arianna Dri MD Claudio Conforti MD Enrico Zelin MD Ludovica Toffoli MD Diego Signoretto MD Alberto Zacchi MD Iris Zalaudek MD
doi : 10.1111/ijd.15218
Volume 60, Issue 2, February 2021, Pages: e70-e72
A case of linear cutaneous lupus erythematosus as an initial manifestation of systemic lupus erythematosus
Mariko Niki MD Yoshihiro Matsudate MD, PhD Kazutoshi Murao MD, PhD Yoshiaki Kubo MD, PhD
doi : 10.1111/ijd.15080
Volume 60, Issue 2, February 2021, Pages: e72-e74
Erythema nodosum leprosum successfully treated with apremilast: more effective and safer than classic treatments?
Eva Mar?a S?nchez?Mart?nez MD Francisco Javier Melgosa?Ramos MD Lya Magdalena Moneva?Léniz MD Héctor Geg?ndez?Hern?ndez MD Amelia Prats?M??ez MD Almudena Mateu?Puchades PhD
doi : 10.1111/ijd.15205
Volume 60, Issue 2, February 2021, Pages: e74-e76
Eruptive warty dyskeratomas on the trunk of a man with end?stage renal disease
Mauricio F. Jin BS Nora S. Ali MD Nahid Y. Vidal MD
doi : 10.1111/ijd.15120
Volume 60, Issue 2, February 2021, Pages: e76-e78
Prevalence of hemophagocytic lymphohistiocytosis with dermatomyositis, other rheumatic diseases, and lymphoma
Matthew F. Helm MD Kimberly F. Breglio MD, PhD Chelsey Straight MD Steven A. Maczuga MS Victor J. Marks Jr MD Galen T. Foulke MD
doi : 10.1111/ijd.15122
Volume 60, Issue 2, February 2021, Pages: e78-e79
