SusheelKodaliMDaRebecca T.HahnMDabMackram F.EleidMDcRobertKippermanMDdRobertSmithMDeD. ScottLimMDfWilliam A.GrayMDgAkhilNarangMDhSorin V.PislaruMDcKonstantinosKoulogiannisMDdPaulGrayburnMDeDaleFowlerMDfKatieHawthorneMDgAbdellazizDahouMDbShekhar H.DeoMBBS, PhDiPrashanthiVandrangiPhDiFlorianDeuschlMDiMichael J.MackMDeMartin B.LeonMDaTedFeldmanMDiCharles J.DavidsonMDhon behalf of theCLASP TR EFS Investigators
doi : 10.1016/j.jacc.2020.11.047
Volume 77, Issue 4, 2 February 2021, Pages 345-356
Tricuspid regurgitation (TR) is a prevalent disease with limited treatment options.
Anita W.AsgarMD, MSc
doi : 10.1016/j.jacc.2020.11.048
Volume 77, Issue 4, 2 February 2021, Pages 357-359
Ahmed A.HarhashMDabTeresa L.MayDOcChiu-HsiehHsuPhDdSachinAgarwalMDeDavid B.SederMDcMichael R.MooneyMDfNaineshPatelMDgJohnMcPhersonMDhPaulMcMullanMDiRichardRikerMDcEldarSoreideMD, PhDjKaren G.HirschMDkPascalStammetMD, PhDlAlisonDupontMDmStenRubertssonMD, PhDnHansFribergMD, PhDoNiklasNielsenMD, PhDoTanveerRabMDpKarl B.KernMDa
doi : 10.1016/j.jacc.2020.11.043
Volume 77, Issue 4, 2 February 2021, Pages 360-371
The American College of Cardiology Interventional Council published consensus-based recommendations to help identify resuscitated cardiac arrest patients with unfavorable clinical features in whom invasive procedures are unlikely to improve survival.
James P.DaubertMDaJoshua S.LeeDObSanjiv M.NarayanMD, PhDc
doi : 10.1016/j.jacc.2020.11.052
Volume 77, Issue 4, 2 February 2021, Pages 372-374
SergioLeonardiMD, MHSa?FeliceGragnanoMDbc?GretaCarraraStatdGiuseppeGargiuloMD, PhDeEnricoFrigoliMDfPascalVranckxMD, PhDgDarioDi MaioMDcVanessaSpedicatoMDbEmanueleMondaMDcLuigiFimianiMDhVincenzoFiorettiMDeFabrizioEspositoMDeMarisaAvvedimentoMDeFabioMagliuloMDeAttilioLeoneMDeSalvatoreChianeseMDeMicheleFranzeseMDeMartinaScaliseMDe…MarcoValgimigliMD, PhDbi
doi : 10.1016/j.jacc.2020.11.046
Volume 77, Issue 4, 2 February 2021, Pages 375-388
Contemporary definitions of bleeding endpoints are restricted mostly to clinically overt events. Whether hemoglobin drop per se, with or without overt bleeding, adversely affects the prognosis of patients with acute coronary syndrome (ACS) remains unclear.
OlivierBarthélémyMDaGuillaumeCaylaMD, PhDbGillesMontalescotMD, PhDa
doi : 10.1016/j.jacc.2020.11.050
Volume 77, Issue 4, 2 February 2021, Pages 389-391
PaaladineshThavendiranathanMD, SMa?TomokoNegishiMDbc?EmilySomersetMSdKazuakiNegishiMD, PhDbcMartinPenickaMD, PhDeJulieLemieuxMD, MScfSvendAakhusMD, PhDgSakikoMiyazakiMDhMitraShiraziMDiMaurizioGalderisiMD, PhDj†Thomas H.MarwickMBBS, PhD, MPHbk
doi : 10.1016/j.jacc.2020.11.020
Volume 77, Issue 4, 2 February 2021, Pages 392-401
In patients at risk of cancer therapy-related cardiac dysfunction (CTRCD), initiation of cardioprotective therapy (CPT) is constrained by the low sensitivity of ejection fraction (EF) for minor changes in left ventricular (LV) function. Global longitudinal strain (GLS) is a robust and sensitive marker of LV dysfunction, but existing observational data have been insufficient to support a routine GLS-guided strategy for CPT.
Javid J.MoslehiMDaRonald M.WittelesMDb
doi : 10.1016/j.jacc.2020.12.014
Volume 77, Issue 4, 2 February 2021, Pages 402-404
MichaelFriskPhDabChristopherLeMDabXinShenPhDab?smund T.R?eMD, PhDabYufengHouPhDabOrnellaManfraPhDabGustavo J.J.SilvaPhDabIsabellevan HoutMSccEinar S.NordenMDabdJ. MagnusAronsenMD, PhDeMartinLaasmaaPhDabEmil K.S.EspePhDabFouad A.ZoueinPhDfRegis R.LambertPhDcChristen P.DahlMD, PhDghIvarSjaastadMD, PhDabiIda G.LundePhDabSeanCoffeyMDj…William E.LouchPhDab
doi : 10.1016/j.jacc.2020.11.044
Volume 77, Issue 4, 2 February 2021, Pages 405-419
Whereas heart failure with reduced ejection fraction (HFrEF) is associated with ventricular dilation and markedly reduced systolic function, heart failure with preserved ejection fraction (HFpEF) patients exhibit concentric hypertrophy and diastolic dysfunction. Impaired cardiomyocyte Ca2+ homeostasis in HFrEF has been linked to disruption of membrane invaginations called t-tubules, but it is unknown if such changes occur in HFpEF.
Jean-SébastienHulotMD, PhDMarineLivrozetMD, PhD
doi : 10.1016/j.jacc.2020.11.051
Volume 77, Issue 4, 2 February 2021, Pages 420-422
David J.A.JenkinsMD, PhDabcdeJ. DavidSpenceMDfEdward L.GiovannucciMD, ScDgYoung-inKimMDahiRobert G.JosseMDabeReinholdViethPhDaSandhyaSahye-PudaruthMPH, RDadMelaniePaquetteMSc, RDadDarshnaPatelBAadSoniaBlanco MejiaMD, MScacdEffieViguilioukMScacdStephanie K.NishiPhD, RDacdMeaghanKavanaghMScadTomTsirakisBAdCyril W.C.KendallPhDacdjSathish C.PichikaMScakJohn L.SievenpiperMD, PhDabcde
doi : 10.1016/j.jacc.2020.09.619
Volume 77, Issue 4, 2 February 2021, Pages 423-436
This is an update of the previous 2018 systematic review and meta-analysis of vitamin and mineral supplementation on cardiovascular disease outcomes and all-cause mortality. New randomized controlled trials and meta-analyses were identified by searching the Cochrane library, Medline, and Embase, and data were analyzed using random effects models and classified by the Grading of Recommendations Assessment Development and Evaluation approach. This updated review shows similar findings to the previous report for preventive benefits from both folic acid and B vitamins for stroke and has been graded with moderate quality. No effect was seen for the commonly used multivitamins, vitamin D, calcium, and vitamin C, and an increased risk was seen with niacin (with statin) for all-cause mortality. Conclusive evidence for the benefit of supplements across different dietary backgrounds, when the nutrient is sufficient, has not been demonstrated.
Erin D.MichosMD, MHSabMiguelCainzos-AchiricaMD, MPH, PhDacAmir S.HeraviMDaLawrence J.AppelMD, MPHbd
doi : 10.1016/j.jacc.2020.09.617
Volume 77, Issue 4, 2 February 2021, Pages 437-449
Vitamin D and calcium supplements are commonly used, often together, to optimize bone health. Multiple observational studies have linked low serum 25-hydroxyvitamin D concentrations with increased cardiovascular risk. However, subsequent randomized controlled trials (RCTs) failed to demonstrate cardiovascular benefit with vitamin D supplementation. Although vitamin D supplements do not appear to be harmful for cardiovascular health, the lack of benefit in RCTs should discourage their use for this purpose, favoring optimizing vitamin D status through healthy lifestyles such as specific foods and modest sunlight exposure. Furthermore, some (but not all) observational and RCT studies of calcium supplementation have suggested potential for cardiovascular harm. Therefore, calcium supplementation should be used cautiously, striving for recommended intake of calcium predominantly from food sources. In this review, the authors examine the currently available evidence investigating whether vitamin D and calcium supplements are helpful, harmful, or neutral for cardiovascular health.
Writing Committee Members?Catherine M.OttoMD, FACC, FAHA(Co-Chair)Rick A.NishimuraMD, MACC, FAHA(Co-Chair)Robert O.BonowMD, MS, MACC, FAHABlase A.CarabelloMD, FACC, FAHAJohn P.ErwinIIIMD, FACC, FAHAFedericoGentileMD, FACCHaniJneidMD, FACC, FAHAEric V.KriegerMD, FACCMichaelMackMD, MACCChristopherMcLeodMBCHB, PhD, FAHAPatrick T.O’GaraMD, MACC, FAHA†Vera H.RigolinMD, FACC, FAHAThoralf M.SundtIIIMD, FACC, FAHAAnnemarieThompsonMDChristopherToly
doi : 10.1016/j.jacc.2020.11.035
Volume 77, Issue 4, 2 February 2021, Pages 450-500
This executive summary of the valvular heart disease guideline provides recommendations for clinicians to diagnose and manage valvular heart disease as well as supporting documentation to encourage their use.
Writing Committee Members?Catherine M.OttoMD, FACC, FAHA(Co-Chair)Rick A.NishimuraMD, MACC, FAHA(Co-Chair)Robert O.BonowMD, MS, MACC, FAHABlase A.CarabelloMD, FACC, FAHAJohn P.ErwinIIIMD, FACC, FAHAFedericoGentileMD, FACCHaniJneidMD, FACC, FAHAEric V.KriegerMD, FACCMichaelMackMD, MACCChristopherMcLeodMBCHB, PhD, FAHAPatrick T.O’GaraMD, MACC, FAHA†Vera H.RigolinMD, FACC, FAHAThoralf M.SundtIIIMD, FACC, FAHAAnnemarieThompsonMDChristopherToly
doi : 10.1016/j.jacc.2020.11.018
Volume 77, Issue 4, 2 February 2021, Pages e25-e197
SarahChuziMDaSadiya S.KhanMD, MSabEsther S.PakMDcd
doi : 10.1016/j.jacc.2020.11.067
Volume 77, Issue 4, 2 February 2021, Pages 501-505
Sarah J.GoodlinMD
doi : 10.1016/j.jacc.2020.11.072
Volume 77, Issue 4, 2 February 2021, Pages 504-505
Sung-JiParkMD, PhDSahminLeeMD, PhDSeung-AhLeeMDDae-HeeKimMD, PhDHyung-KwanKimMD, PhDGeu-RuHongMD, PhDJong-MinSongMD, PhDCheol-HyunChungMD, PhDSeung WooParkMD, PhDDuk-HyunKangMD, PhD
doi : 10.1016/j.jacc.2020.11.045
Volume 77, Issue 4, 2 February 2021, Pages 506-508
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