Journal of the American College of Cardiology




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doi : 10.1016/S0735-1097(20)38151-1

Volume 77, Issue 4, 2 February 2021, Page e19

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Contents

doi : 10.1016/S0735-1097(20)38152-3

Volume 77, Issue 4, 2 February 2021, Pages e21-e25

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Feasibility Study of the Transcatheter Valve Repair System for Severe Tricuspid Regurgitation

SusheelKodaliMDaRebecca T.HahnMDabMackram F.EleidMDcRobertKippermanMDdRobertSmithMDeD. ScottLimMDfWilliam A.GrayMDgAkhilNarangMDhSorin V.PislaruMDcKonstantinosKoulogiannisMDdPaulGrayburnMDeDaleFowlerMDfKatieHawthorneMDgAbdellazizDahouMDbShekhar H.DeoMBBS, PhDiPrashanthiVandrangiPhDiFlorianDeuschlMDiMichael J.MackMDeMartin B.LeonMDaTedFeldmanMDiCharles J.DavidsonMDhon behalf of theCLASP TR EFS Investigators

doi : 10.1016/j.jacc.2020.11.047

Volume 77, Issue 4, 2 February 2021, Pages 345-356

Tricuspid regurgitation (TR) is a prevalent disease with limited treatment options.

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Transcatheter Tricuspid Valve Therapy: Zeroing in on the Target?

Anita W.AsgarMD, MSc

doi : 10.1016/j.jacc.2020.11.048

Volume 77, Issue 4, 2 February 2021, Pages 357-359

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Risk Stratification Among Survivors of Cardiac Arrest Considered for Coronary Angiography

Ahmed A.HarhashMDabTeresa L.MayDOcChiu-HsiehHsuPhDdSachinAgarwalMDeDavid B.SederMDcMichael R.MooneyMDfNaineshPatelMDgJohnMcPhersonMDhPaulMcMullanMDiRichardRikerMDcEldarSoreideMD, PhDjKaren G.HirschMDkPascalStammetMD, PhDlAlisonDupontMDmStenRubertssonMD, PhDnHansFribergMD, PhDoNiklasNielsenMD, PhDoTanveerRabMDpKarl B.KernMDa

doi : 10.1016/j.jacc.2020.11.043

Volume 77, Issue 4, 2 February 2021, Pages 360-371

The American College of Cardiology Interventional Council published consensus-based recommendations to help identify resuscitated cardiac arrest patients with unfavorable clinical features in whom invasive procedures are unlikely to improve survival.

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Prognostication for Sudden Cardiac Arrest Patients Achieving ROSC?

James P.DaubertMDaJoshua S.LeeDObSanjiv M.NarayanMD, PhDc

doi : 10.1016/j.jacc.2020.11.052

Volume 77, Issue 4, 2 February 2021, Pages 372-374

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Prognostic Implications of Declining Hemoglobin Content in Patients Hospitalized With Acute Coronary Syndromes

SergioLeonardiMD, MHSa?FeliceGragnanoMDbc?GretaCarraraStatdGiuseppeGargiuloMD, PhDeEnricoFrigoliMDfPascalVranckxMD, PhDgDarioDi MaioMDcVanessaSpedicatoMDbEmanueleMondaMDcLuigiFimianiMDhVincenzoFiorettiMDeFabrizioEspositoMDeMarisaAvvedimentoMDeFabioMagliuloMDeAttilioLeoneMDeSalvatoreChianeseMDeMicheleFranzeseMDeMartinaScaliseMDe…MarcoValgimigliMD, PhDbi

doi : 10.1016/j.jacc.2020.11.046

Volume 77, Issue 4, 2 February 2021, Pages 375-388

Contemporary definitions of bleeding endpoints are restricted mostly to clinically overt events. Whether hemoglobin drop per se, with or without overt bleeding, adversely affects the prognosis of patients with acute coronary syndrome (ACS) remains unclear.

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Should Hemoglobin Drop Be Added to Bleeding Classifications in ACS??

OlivierBarthélémyMDaGuillaumeCaylaMD, PhDbGillesMontalescotMD, PhDa

doi : 10.1016/j.jacc.2020.11.050

Volume 77, Issue 4, 2 February 2021, Pages 389-391

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Strain-Guided Management of Potentially Cardiotoxic Cancer Therapy

PaaladineshThavendiranathanMD, SMa?TomokoNegishiMDbc?EmilySomersetMSdKazuakiNegishiMD, PhDbcMartinPenickaMD, PhDeJulieLemieuxMD, MScfSvendAakhusMD, PhDgSakikoMiyazakiMDhMitraShiraziMDiMaurizioGalderisiMD, PhDj†Thomas H.MarwickMBBS, PhD, MPHbk

doi : 10.1016/j.jacc.2020.11.020

Volume 77, Issue 4, 2 February 2021, Pages 392-401

In patients at risk of cancer therapy-related cardiac dysfunction (CTRCD), initiation of cardioprotective therapy (CPT) is constrained by the low sensitivity of ejection fraction (EF) for minor changes in left ventricular (LV) function. Global longitudinal strain (GLS) is a robust and sensitive marker of LV dysfunction, but existing observational data have been insufficient to support a routine GLS-guided strategy for CPT.

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Global Longitudinal Strain in Cardio-Oncology?

Javid J.MoslehiMDaRonald M.WittelesMDb

doi : 10.1016/j.jacc.2020.12.014

Volume 77, Issue 4, 2 February 2021, Pages 402-404

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Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction

MichaelFriskPhDabChristopherLeMDabXinShenPhDab?smund T.R?eMD, PhDabYufengHouPhDabOrnellaManfraPhDabGustavo J.J.SilvaPhDabIsabellevan HoutMSccEinar S.NordenMDabdJ. MagnusAronsenMD, PhDeMartinLaasmaaPhDabEmil K.S.EspePhDabFouad A.ZoueinPhDfRegis R.LambertPhDcChristen P.DahlMD, PhDghIvarSjaastadMD, PhDabiIda G.LundePhDabSeanCoffeyMDj…William E.LouchPhDab

doi : 10.1016/j.jacc.2020.11.044

Volume 77, Issue 4, 2 February 2021, Pages 405-419

Whereas heart failure with reduced ejection fraction (HFrEF) is associated with ventricular dilation and markedly reduced systolic function, heart failure with preserved ejection fraction (HFpEF) patients exhibit concentric hypertrophy and diastolic dysfunction. Impaired cardiomyocyte Ca2+ homeostasis in HFrEF has been linked to disruption of membrane invaginations called t-tubules, but it is unknown if such changes occur in HFpEF.

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HFpEF: Should We Consider Diabetic Patients Separately?: The Cardiomyocytes Say Yes?

Jean-SébastienHulotMD, PhDMarineLivrozetMD, PhD

doi : 10.1016/j.jacc.2020.11.051

Volume 77, Issue 4, 2 February 2021, Pages 420-422

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Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar

David J.A.JenkinsMD, PhDabcdeJ. DavidSpenceMDfEdward L.GiovannucciMD, ScDgYoung-inKimMDahiRobert G.JosseMDabeReinholdViethPhDaSandhyaSahye-PudaruthMPH, RDadMelaniePaquetteMSc, RDadDarshnaPatelBAadSoniaBlanco MejiaMD, MScacdEffieViguilioukMScacdStephanie K.NishiPhD, RDacdMeaghanKavanaghMScadTomTsirakisBAdCyril W.C.KendallPhDacdjSathish C.PichikaMScakJohn L.SievenpiperMD, PhDabcde

doi : 10.1016/j.jacc.2020.09.619

Volume 77, Issue 4, 2 February 2021, Pages 423-436

This is an update of the previous 2018 systematic review and meta-analysis of vitamin and mineral supplementation on cardiovascular disease outcomes and all-cause mortality. New randomized controlled trials and meta-analyses were identified by searching the Cochrane library, Medline, and Embase, and data were analyzed using random effects models and classified by the Grading of Recommendations Assessment Development and Evaluation approach. This updated review shows similar findings to the previous report for preventive benefits from both folic acid and B vitamins for stroke and has been graded with moderate quality. No effect was seen for the commonly used multivitamins, vitamin D, calcium, and vitamin C, and an increased risk was seen with niacin (with statin) for all-cause mortality. Conclusive evidence for the benefit of supplements across different dietary backgrounds, when the nutrient is sufficient, has not been demonstrated.

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Vitamin D, Calcium Supplements, and Implications for Cardiovascular Health: JACC Focus Seminar

Erin D.MichosMD, MHSabMiguelCainzos-AchiricaMD, MPH, PhDacAmir S.HeraviMDaLawrence J.AppelMD, MPHbd

doi : 10.1016/j.jacc.2020.09.617

Volume 77, Issue 4, 2 February 2021, Pages 437-449

Vitamin D and calcium supplements are commonly used, often together, to optimize bone health. Multiple observational studies have linked low serum 25-hydroxyvitamin D concentrations with increased cardiovascular risk. However, subsequent randomized controlled trials (RCTs) failed to demonstrate cardiovascular benefit with vitamin D supplementation. Although vitamin D supplements do not appear to be harmful for cardiovascular health, the lack of benefit in RCTs should discourage their use for this purpose, favoring optimizing vitamin D status through healthy lifestyles such as specific foods and modest sunlight exposure. Furthermore, some (but not all) observational and RCT studies of calcium supplementation have suggested potential for cardiovascular harm. Therefore, calcium supplementation should be used cautiously, striving for recommended intake of calcium predominantly from food sources. In this review, the authors examine the currently available evidence investigating whether vitamin D and calcium supplements are helpful, harmful, or neutral for cardiovascular health.

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2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Writing Committee Members?Catherine M.OttoMD, FACC, FAHA(Co-Chair)Rick A.NishimuraMD, MACC, FAHA(Co-Chair)Robert O.BonowMD, MS, MACC, FAHABlase A.CarabelloMD, FACC, FAHAJohn P.ErwinIIIMD, FACC, FAHAFedericoGentileMD, FACCHaniJneidMD, FACC, FAHAEric V.KriegerMD, FACCMichaelMackMD, MACCChristopherMcLeodMBCHB, PhD, FAHAPatrick T.O’GaraMD, MACC, FAHA†Vera H.RigolinMD, FACC, FAHAThoralf M.SundtIIIMD, FACC, FAHAAnnemarieThompsonMDChristopherToly

doi : 10.1016/j.jacc.2020.11.035

Volume 77, Issue 4, 2 February 2021, Pages 450-500

This executive summary of the valvular heart disease guideline provides recommendations for clinicians to diagnose and manage valvular heart disease as well as supporting documentation to encourage their use.

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2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Writing Committee Members?Catherine M.OttoMD, FACC, FAHA(Co-Chair)Rick A.NishimuraMD, MACC, FAHA(Co-Chair)Robert O.BonowMD, MS, MACC, FAHABlase A.CarabelloMD, FACC, FAHAJohn P.ErwinIIIMD, FACC, FAHAFedericoGentileMD, FACCHaniJneidMD, FACC, FAHAEric V.KriegerMD, FACCMichaelMackMD, MACCChristopherMcLeodMBCHB, PhD, FAHAPatrick T.O’GaraMD, MACC, FAHA†Vera H.RigolinMD, FACC, FAHAThoralf M.SundtIIIMD, FACC, FAHAAnnemarieThompsonMDChristopherToly

doi : 10.1016/j.jacc.2020.11.018

Volume 77, Issue 4, 2 February 2021, Pages e25-e197

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Primary Palliative Care Education in Advanced Heart Failure and Transplantation Cardiology Fellowships

SarahChuziMDaSadiya S.KhanMD, MSabEsther S.PakMDcd

doi : 10.1016/j.jacc.2020.11.067

Volume 77, Issue 4, 2 February 2021, Pages 501-505

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RESPONSE: Comprehensive Training for Heart Failure Clinicians: The Integration of Palliative Care

Sarah J.GoodlinMD

doi : 10.1016/j.jacc.2020.11.072

Volume 77, Issue 4, 2 February 2021, Pages 504-505

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Impact of Early Surgery and Staging Classification on Survival in Asymptomatic Very Severe Aortic Stenosis

Sung-JiParkMD, PhDSahminLeeMD, PhDSeung-AhLeeMDDae-HeeKimMD, PhDHyung-KwanKimMD, PhDGeu-RuHongMD, PhDJong-MinSongMD, PhDCheol-HyunChungMD, PhDSeung WooParkMD, PhDDuk-HyunKangMD, PhD

doi : 10.1016/j.jacc.2020.11.045

Volume 77, Issue 4, 2 February 2021, Pages 506-508

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Correction

doi : 10.1016/j.jacc.2020.12.040

Volume 77, Issue 4, 2 February 2021, Page 509

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