دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Effect of Levothyroxine on Left Ventricular Ejection Fraction in Patients With Subclinical Hypothyroidism and Acute Myocardial Infarction: A Randomized Clinical Trial
Avais Jabbar, MD; Lorna Ingoe, BSc; Shahid Junejo, MD; et al.
doi : 10.1001/jama.2020.9389
JAMA. 2020;324(3):249-258.
This randomized trial evaluates the effect of levothyroxine vs placebo on left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction and subclinical hypothyroidism.
Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2
Elizabeth Whittaker, MD; Alasdair Bamford, MD; Julia Kenny, MD; et al.
doi : 10.1001/jama.2020.10369
JAMA. 2020;324(3):259-269.
This case series describes the clinical and laboratory characteristics of children hospitalized in England from March to May 2020 who met criteria for pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PIMS-TS), and compares syndrome characteristics with historical cases of Kawasaki disease (KD), KD shock syndrome, and toxic shock syndrome (TSS).
Public Attitudes Regarding Hospitals and Physicians Encouraging Donations From Grateful Patients
Reshma Jagsi, MD, DPhil; Kent A. Griffith, MS, MPH; Joseph A. Carrese, MD, MPH; et al.
doi : 10.1001/jama.2020.9442
JAMA. 2020;324(3):270-278.
This survey study assesses US public attitudes about practices used by health care institutions to encourage philanthropic donations from grateful patients.
Multisystem Inflammatory Syndrome Related to COVID-19 in Previously Healthy Children and Adolescents in New York City
Eva W. Cheung, MD; Philip Zachariah, MD, MS; Mark Gorelik, MD; et al.
doi : 10.1001/jama.2020.10374
JAMA. 2020;324(3):294-296.
This case series describes clinical characteristics, treatment, and outcomes of 17 previously healthy SARS-CoV-2–infected children and adolescents with an inflammatory phenotype overlapping with but distinct from Kawasaki disease and toxic shock syndrome admitted to a New York City hospital in late April and early May 2020.
Association Between Mode of Delivery Among Pregnant Women With COVID-19 and Maternal and Neonatal Outcomes in Spain
Oscar Martínez-Perez, MD, PhD; Manon Vouga, MD, PhD; Sara Cruz Melguizo, MD, PhD; et al.
doi : 10.1001/jama.2020.10125
JAMA. 2020;324(3):296-299.
This cohort study estimates associations between mode of delivery (vaginal vs cesarean delivery) and maternal and neonatal birth outcomes among SARS-CoV-2–infected women giving birth in Spain.
Use of Risk Evaluation and Mitigation Strategies by the US Food and Drug Administration, 2008-2019
Jenny S. Guadamuz, PhD; Dima M. Qato, PharmD, MPH, PhD; G. Caleb Alexander, MD, MS
doi : 10.1001/jama.2020.6611
JAMA. 2020;324(3):299-301.
This study uses publicly available FDA.gov data to characterize trends in the US Food and Drug Administration’s use of Risk Evaluation and Mitigation Strategy (REMS) programs between 2008 and 2019 and to describe the number and classes of medications included, the strategies deployed, and the risks the program was intended to mitigate.
The Moral Determinants of Health
Donald M. Berwick, MD, MPP
doi : 10.1001/jama.2020.11129
JAMA. 2020;324(3):225-226.
In this Viewpoint, Berwick emphasizes that moral commitment to others, expressed through working for universal health coverage, criminal justice, and housing policy reform, climate change intervention, and more, is necessary if society is to meaningfully address adverse social determinants of health and reduce health inequalities.
COVID-19 Pandemic, Unemployment, and Civil Unrest: Underlying Deep Racial and Socioeconomic Divides
Sandro Galea, MD, DrPH; Salma M. Abdalla, MBBS, MPH
doi : 10.1001/jama.2020.11132
JAMA. 2020;324(3):227-228.
This Viewpoint discusses the inequalities underlying the preferential spread of COVID-19 and of economic hardship in lower-income communities of color in the US, and sees the national protests in support of the Black Lives Matter movement as a natural consequence of those inequities and an opportunity to change the systems that create them.
Policy Solutions for Reversing the Color-blind Public Health Response to COVID-19 in the US
Marisa K. Dowling, MD, MPP; Robin L. Kelly, PhD, MA
doi : 10.1001/jama.2020.10531
JAMA. 2020;324(3):229-230.
This Viewpoint reviews proposed legislation to address health disparities the COVID-19 pandemic has exposed and calls for reform and redesign of the US health care system and society to address inequities that affect persons of color and other vulnerable groups.
Responding to the COVID-19 Pandemic: The Need for a Structurally Competent Health Care System
Jonathan M. Metzl, MD, PhD; Aletha Maybank, MD, MPH; Fernando De Maio, PhD
doi : 10.1001/jama.2020.9289
JAMA. 2020;324(3):231-232.
This Viewpoint highlights the structural drivers of disadvantage and poverty that are antecedents of health inequity in the COVID-19 pandemic and proposes proportionately structural changes to how health and medical education systems operate to advance the health of individuals, communities, and their surrounding environments.
Health Care Policy After the COVID-19 Pandemic
Victor R. Fuchs, PhD
doi : 10.1001/jama.2020.10777
JAMA. 2020;324(3):233-234.
This Viewpoint discusses the necessity and prospects for health care reform in the wake of the coronavirus disease 2019 (COVID-19) pandemic, reviewing policy options to fund universal coverage, incentivize efficiencies, and reduce political opposition to change.
Validation and Utility Testing of Clinical Prediction Models: Time to Change the Approach
Amin Adibi, MSc; Mohsen Sadatsafavi, PhD, MD; John P. A. Ioannidis, MD, DSc
doi : 10.1001/jama.2020.1230
JAMA. 2020;324(3):235-236.
In this Viewpoint, John Ioannidis and colleagues discuss the proliferation of undervalidated or unvalidated clinical prediction models (CPMs) and propose an open-source repository where risk prediction scores could be updated in real time and validated as a means to facilitate identification of best-performing and reduce creation of duplicate or unhelpful models.
Alternative Payment Models—Victims of Their Own Success?
Amol S. Navathe, MD, PhD; Connor W. Boyle, BA; Ezekiel J. Emanuel, MD, PhD
doi : 10.1001/jama.2020.4133
JAMA. 2020;324(3):237-238.
This Viewpoint examines whether alternative payment models are a success according to the lack of significant findings by individual demonstration projects on the one hand and the plateau of overall health care spending as a share of the gross domestic product (GDP) on the other.
Can Infections Cause Alzheimer Disease?
Anthony L. Komaroff, MD
doi : 10.1001/jama.2020.4085
JAMA. 2020;324(3):239-240.
This Viewpoint considers whether viral infection contributes to Alzheimer disease.
Identifying the Risks of Unproven Regenerative Medicine Therapies
Peter W. Marks, MD, PhD; Stephen Hahn, MD
doi : 10.1001/jama.2020.9375
JAMA. 2020;324(3):241-242.
This Viewpoint discusses safety concerns surrounding unproven and unregulated regenerative medicine products—typically bone marrow, fat, placental, or umbilical cord stem cells proposed as therapies—and offers guidance about how to evaluate if the therapies meet basic Food and Drug Administration requirements for investigational agents.
Do No Harm
Nitin A. Kapur, MD, MPH
doi : 10.1001/jama.2020.11241
JAMA. 2020;324(3):243-244.
In this narrative medicine essay, a primary care physician finds little solace in his medical training while caring for his 2 young daughters as a stay-at-home dad.
2020—A Year That Will Be Remembered
Howard Bauchner, MD
doi : 10.1001/jama.2020.11308
JAMA. 2020;324(3):245.
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SARS-CoV-2–Related Inflammatory Multisystem Syndrome in Children: Different or Shared Etiology and Pathophysiology as Kawasaki Disease?
Brian W. McCrindle, MD, MPH; Cedric Manlhiot, PhD
doi : 10.1001/jama.2020.10370
JAMA. 2020;324(3):246-248.
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Perioperative Cardiovascular Risk Assessment and Management for Noncardiac Surgery: A Review
Nathaniel R. Smilowitz, MD, MS; Jeffrey S. Berger, MD, MS
doi : 10.1001/jama.2020.7840
JAMA. 2020;324(3):279-290.
This narrative review summarizes evidence that addresses commonly asked questions about cardiovascular risk assessment prior to noncardiac surgery, such as the role of preoperative stress testing and medication to reduce surgical risk and the need to discontinue anticoagulants.
Medications for Primary Prevention of Breast Cancer
Yiwey Shieh, MD, MAS; Jeffrey A. Tice, MD
doi : 10.1001/jama.2020.9246
JAMA. 2020;324(3):291-292.
This JAMA Insights Clinical Update reviews indications for use of medications for primary prevention of breast cancer and the comparative effectiveness and adverse effects of selective estrogen receptor modulators (tamoxifen, raloxifene) and aromatase inhibitors (anastrozole, exemestane) for this purpose.
Latin America and Its Global Partners Toil to Procure Medical Supplies as COVID-19 Pushes the Region to Its Limit
Rita Rubin, MA; Jennifer Abbasi; Rebecca Voelker, MSJ
doi : 10.1001/jama.2020.11182
JAMA. 2020;324(3):217-219.
This Medical News article discusses Latin America’s critical shortages of medical supplies including personal protective equipment and ventilators during the coronavirus disease 2019 pandemic.
Anthony Fauci, MD, on COVID-19 Vaccines, Schools, and Larry Kramer
Jennifer Abbasi
doi : 10.1001/jama.2020.9222
JAMA. 2020;324(3):220-222.
In this Medical News article, Anthony Fauci, MD, the country’s top infectious diseases expert, discusses the latest on COVID-19 and memories of a friend from another pandemic.
HIV Antiviral Expanded for Use in Very Young Children
Mary Chris Jaklevic, MSJ
doi : 10.1001/jama.2020.12060
JAMA. 2020;324(3):224.
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Watch Your Medicine: Video Game Therapy for Children With ADHD
10.1001/jama.2020.11924
doi : Mary Chris Jaklevic, MSJ
JAMA. 2020;324(3):224.
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Second Drug Okayed for Rare Central Nervous System Disease
Mary Chris Jaklevic, MSJ
doi : 10.1001/jama.2020.12061
JAMA. 2020;324(3):224.
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Alarming Antimicrobial Resistance Trends Emerge Globally
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2020.11330
JAMA. 2020;324(3):223.
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Diverse HPV Strains Require Strategic Vaccine Use
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2020.12058
JAMA. 2020;324(3):223.
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Reducing Global Traffic Deaths With Seatbelts and Other Technology
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2020.12059
JAMA. 2020;324(3):223.
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Breast Cancer Risk–Reducing Medications
Danielle Graham, MD, MBA; Maggie L. DiNome, MD; Patricia A. Ganz, MD
doi : 10.1001/jama.2020.11784
JAMA. 2020;324(3):310.
This JAMA Patient Page describes the indications for use of medications to reduce breast cancer risk and the benefits and risks of the 2 major drug classes, SERMs (tamoxifen, raloxifene) and aromatase inhibitors (anastrozole, exemestane).
PTSD Treatments for Veterans
Paula P. Schnurr, PhD; Sonya B. Norman, PhD; Jessica L. Hamblen, PhD
doi : 10.1001/jama.2020.7548
JAMA. 2020;324(3):301.
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PTSD Treatments for Veterans—Reply
Maria M. Steenkamp, PhD; Brett T. Litz, PhD; Charles R. Marmar, MD
doi : 10.1001/jama.2020.7554
JAMA. 2020;324(3):301-302.
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Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump for Cardiogenic Shock
Hanne Berg Ravn, MD, DMSc; Ole Kristian Lerche Helgestad, MD, PhD; Jacob Eifer Møller, MD, DMSc
doi : 10.1001/jama.2020.7557
JAMA. 2020;324(3):302-303.
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Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump for Cardiogenic Shock
John A. Rizzo, PhD; Henry Dove, PhD
doi : 10.1001/jama.2020.7551
JAMA. 2020;324(3):303.
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Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump for Cardiogenic Shock—Reply
Sanket S. Dhruva, MD, MHS; Bobak J. Mortazavi, PhD; Nihar R. Desai, MD, MPH
doi : 10.1001/jama.2020.7560
JAMA. 2020;324(3):303-304.
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Calculation Error in Study of Pregnant Women With COVID-19 and Maternal and Neonatal Outcomes in Spain
David Baud, MD, PhD
doi : 10.1001/jama.2020.12267
JAMA. 2020;324(3):304-305.
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Errors in Data and Statistical Significance
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doi : 10.1001/jama.2020.12271
JAMA. 2020;324(3):305.
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