European Heart Journal

Although the attention of the world and the global health community specifically is deservedly focused on the COVID-19 pandemic, other determinants of health continue to have large impacts and may also interact with COVID-19. Air pollution is one crucial example. Established evidence from other respiratory viruses and emerging evidence for COVID-19 specifically indicates that air pollution alters respiratory defense mechanisms leading to worsened infection severity. Air pollution also contributes to co-morbidities that are known to worsen outcomes amongst those infected with COVID-19, and air pollution may also enhance infection transmission due to its impact on more frequent coughing. Yet despite the massive disruption of the COVID-19 pandemic, there are reasons for optimism: broad societal lockdowns have shown us a glimpse of what a future with strong air pollution measures could yield. Thus, the urgency to combat air pollution is not diminished, but instead heightened in the context of the pandemic.

خرید پکیج و مشاهده آنلاین مقاله

A call to action for new global approaches to cardiovascular disease drug solutions

Gemma A Figtree, Keith Broadfoot, Barbara Casadei, Robert Califf, Filippo Crea

doi : 10.1093/eurheartj/ehab068

European Heart Journal, Volume 42, Issue 15, 14 April 2021, Pages 1464–1475

Whilst we continue to wrestle with the immense challenge of implementing equitable access to established evidence-based treatments, substantial gaps remain in our pharmacotherapy armament for common forms of cardiovascular disease including coronary and peripheral arterial disease, heart failure, hypertension, and arrhythmia. We need to continue to invest in the development of new approaches for the discovery, rigorous assessment, and implementation of new therapies. Currently, the time and cost to progress from lead compound/product identification to the clinic, and the success rate in getting there reduces the incentive for industry to invest, despite the enormous burden of disease and potential size of market. There are tremendous opportunities with improved phenotyping of patients currently batched together in syndromic ‘buckets’. Use of advanced imaging and molecular markers may allow stratification of patients in a manner more aligned to biological mechanisms that can, in turn, be targeted by specific approaches developed using high-throughput molecular technologies. Unbiased ‘omic’ approaches enhance the possibility of discovering completely new mechanisms in such groups. Furthermore, advances in drug discovery platforms, and models to study efficacy and toxicity more relevant to the human disease, are valuable. Re-imagining the relationships among discovery, translation, evaluation, and implementation will help reverse the trend away from investment in the cardiovascular space, establishing innovative platforms and approaches across the full spectrum of therapeutic development.

خرید پکیج و مشاهده آنلاین مقاله

Validation of risk scores for ischaemic stroke in atrial fibrillation across the spectrum of kidney function

Ype de Jong, Edouard L Fu, Merel van Diepen, Marco Trevisan, Karolina Szummer

doi : 10.1093/eurheartj/ehab059

European Heart Journal, Volume 42, Issue 15, 14 April 2021, Pages 1476–1485

The increasing prevalence of ischaemic stroke (IS) can partly be explained by the likewise growing number of patients with chronic kidney disease (CKD). Risk scores have been developed to identify high-risk patients, allowing for personalized anticoagulation therapy. However, predictive performance in CKD is unclear. The aim of this study is to validate six commonly used risk scores for IS in atrial fibrillation (AF) patients across the spectrum of kidney function.

خرید پکیج و مشاهده آنلاین مقاله

Decoding stroke risk scores in atrial fibrillation: still more work to do

David Brieger, Ben Freedman

doi : 10.1093/eurheartj/ehaa1111

European Heart Journal, Volume 42, Issue 15, 14 April 2021, Pages 1486–1488

خرید پکیج و مشاهده آنلاین مقاله

Death of a child and the risk of atrial fibrillation: a nationwide cohort study in Sweden

Dang Wei, Tristan Olofsson, Hua Chen, Imre Janszky, Fang Fang

doi : 10.1093/eurheartj/ehaa1084

European Heart Journal, Volume 42, Issue 15, 14 April 2021, Pages 1489–1495

The role of psychological stress in the aetiology of atrial fibrillation (AF) is unclear. The death of a child is one of the most severe sources of stress. We aimed to investigate whether the death of a child is associated with an increased risk of AF.

خرید پکیج و مشاهده آنلاین مقاله

A broken heart after child loss

Kim G Smolderen, Matthew M Burg

doi : 10.1093/eurheartj/ehab058

European Heart Journal, Volume 42, Issue 15, 14 April 2021, Pages 1496–1498

خرید پکیج و مشاهده آنلاین مقاله

The physical activity paradox in cardiovascular disease and all-cause mortality: the contemporary Copenhagen General Population Study with 104 046 adults

Andreas Holtermann, Peter Schnohr, B?rge Gr?nne Nordestgaard, Jacob Louis Marott

doi : 10.1093/eurheartj/ehab087

European Heart Journal, Volume 42, Issue 15, 14 April 2021, Pages 1499–1511,

Leisure time physical activity associates with reduced risk of cardiovascular disease and all-cause mortality, while these relationships for occupational physical activity are unclear. We tested the hypothesis that leisure time physical activity associates with reduced major adverse cardiovascular events (MACE) and all-cause mortality risk, while occupational physical activity associates with increased risks.

خرید پکیج و مشاهده آنلاین مقاله

Prevention of cardiovascular disease: does ‘every step counts’ apply for occupational work?

Martin Halle, Melanie Heitkamp

doi : 10.1093/eurheartj/ehab105

European Heart Journal, Volume 42, Issue 15, 14 April 2021, Pages 1512–1515

خرید پکیج و مشاهده آنلاین مقاله

All-cause mortality and location of death in patients with established cardiovascular disease before, during, and after the COVID-19 lockdown: a Danish Nationwide Cohort Study

Jawad H Butt, Emil L Fosb?l, Thomas A Gerds, Charlotte Andersson, Kristian Kragholm

doi : 10.1093/eurheartj/ehab028

European Heart Journal, Volume 42, Issue 15, 14 April 2021, Pages 1516–1523

On 13 March 2020, the Danish authorities imposed extensive nationwide lockdown measures to prevent the spread of the coronavirus disease 2019 (COVID-19) and reallocated limited healthcare resources. We investigated mortality rates, overall and according to location, in patients with established cardiovascular disease before, during, and after these lockdown measures.

خرید پکیج و مشاهده آنلاین مقاله