Sonja A. Rasmussen, M.D., Anne Drapkin Lyerly, M.D., and Denise J. Jamieson, M.D., M.P.H.
doi : 10.1056/NEJMp2027940
N Engl J Med 2020; 383:2097-2099
Mark A. Rothstein, J.D., and Kyle B. Brothers, M.D., Ph.D.
doi : 10.1056/NEJMp2024123
N Engl J Med 2020; 383:2099-2101
Mary T. Bassett, M.D., M.P.H., and Sandro Galea, M.D., Dr.P.H.
doi : 10.1056/NEJMp2026170
N Engl J Med 2020; 383:2101-2103
D. Robin Taylor, M.D., D.Sc.
doi : 10.1056/NEJMp2003459
N Engl J Med 2020; 383:2103-2105
Michael J. Mina, M.D., Ph.D., Roy Parker, Ph.D., and Daniel B. Larremore, Ph.D.
doi : 10.1056/NEJMp2025631
N Engl J Med 2020; 383:e120
Rueben C. Warren, D.D.S., Dr.P.H., M.Div., Lachlan Forrow, M.D., David Augustin Hodge, Sr., D.Min., Ph.D., and Robert D. Truog, M.D.
doi : 10.1056/NEJMp2030033
N Engl J Med 2020; 383:e121
Julio Rosenstock, M.D., Harpreet S. Bajaj, M.D., M.P.H., Andrej Jane?, M.D., Ph.D., Robert Silver, M.D., Kamilla Begtrup, M.Sc., Melissa V. Hansen, M.D., Ph.D., Ting Jia, M.D., Ph.D., and Ronald Goldenberg, M.D. for the NN1436-4383 Investigators*
doi : 10.1056/NEJMoa2022474
N Engl J Med 2020; 383:2107-2116
It is thought that a reduction in the frequency of basal insulin injections might facilitate treatment acceptance and adherence among patients with type 2 diabetes. Insulin icodec is a basal insulin analogue designed for once-weekly administration that is in development for the treatment of diabetes.
Helio P. Guimar?es, M.D., Ph.D., Renato D. Lopes, M.D., Ph.D., Pedro G.M. de Barros e Silva, M.D., Ph.D., Idelzuita L. Liporace, M.D., Roney O. Sampaio, M.D., Ph.D., Fl?vio Tarasoutchi, M.D., Ph.D., Conrado R. Hoffmann-Filho, M.D., Rodrigo de Lemos Soares Patriota, M.D., Tiago L.L. Leiria, M.D., Ph.D., Diana Lamprea, M.D., Dalton B. Precoma, M.D., Ph.D., Fernando A. Atik, M.D., Ph.D.,
doi : 10.1056/NEJMoa2029603
N Engl J Med 2020; 383:2117-2126
The effects of rivaroxaban in patients with atrial fibrillation and a bioprosthetic mitral valve remain uncertain.
James D. Chalmers, M.B., Ch.B., Ph.D., Charles S. Haworth, M.B., Ch.B., M.D., Mark L. Metersky, M.D., Michael R. Loebinger, B.M., B.Ch., Ph.D., Francesco Blasi, M.D., Ph.D., Oriol Sibila, M.D., Ph.D., Anne E. O’Donnell, M.D., Eugene J. Sullivan, M.D., Kevin C. Mange, M.D., M.S.C.E., Carlos Fernandez, M.D., M.P.H., Jun Zou, Ph.D., and Charles L. Daley, M.D. for the WILLOW Investigators*
doi : 10.1056/NEJMoa2021713
N Engl J Med 2020; 383:2127-2137
Patients with bronchiectasis have frequent exacerbations that are thought to be related to neutrophilic inflammation. The activity and quantity of neutrophil serine proteases, including neutrophil elastase, are increased in the sputum of patients with bronchiectasis at baseline and increase further during exacerbations. Brensocatib (INS1007) is an oral reversible inhibitor of dipeptidyl peptidase 1 (DPP-1), an enzyme responsible for the activation of neutrophil serine proteases.
Nicolas J. Pejovic, M.D., Ph.D., Susanna Myrnerts H??k, M.D., M.Med., Josaphat Byamugisha, M.D., Ph.D., Tobias Alfvén, M.D., Ph.D., Clare Lubulwa, M.D., M.Med., Francesco Cavallin, M.Sc., Jolly Nankunda, M.D., Ph.D., Hege Ersdal, M.D., Ph.D., Mats Blennow, M.D., Ph.D., Daniele Trevisanuto, M.D., and Thorkild Tyllesk?r, M.D., Ph.D.
doi : 10.1056/NEJMoa2005333
N Engl J Med 2020; 383:2138-2147
Face-mask ventilation is the most common resuscitation method for birth asphyxia. Ventilation with a cuffless laryngeal mask airway (LMA) has potential advantages over face-mask ventilation during neonatal resuscitation in low-income countries, but whether the use of an LMA reduces mortality and morbidity among neonates with asphyxia is unknown.
Kimber P. Richter, Ph.D., M.P.H., Lauren Clark, M.S., Jo A. Wick, Ph.D., Erica Cruvinel, Ph.D., Dianne Durham, Ph.D., Pamela Shaw, M.D., Grace H. Shih, M.D., Christie A. Befort, Ph.D., and Robert D. Simari, M.D.
doi : 10.1056/NEJMsa1916935
N Engl J Med 2020; 383:2148-2157
In 2000, a landmark study showed that women who graduated from U.S. medical schools from 1979 through 1997 were less likely than their male counterparts to be promoted to upper faculty ranks in academic medical centers. It is unclear whether these differences persist.
Yung Gonzaga, M.D., and Mayne Fontes, M.D.
doi : 10.1056/NEJMicm2003702
N Engl J Med 2020; 383:2158
Vivek Chaurasia, M.B., B.S., and Sanjeev Bhoi, M.B., B.S., M.D.
doi : 10.1056/NEJMicm2007312
N Engl J Med 2020; 383:e122
Philippe Armand, M.D., Ph.D., Allen P. Heeger, D.O., Sanjat Kanjilal, M.D., M.P.H., and Melissa Krystel-Whittemore, M.D.
doi : 10.1056/NEJMcpc2004979
N Engl J Med 2020; 383:2159-2169
Peter A. Gottlieb, M.D., and Aaron W. Michels, M.D.
doi : 10.1056/NEJMe2031596
N Engl J Med 2020; 383:2171-2172
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2034094
N Engl J Med 2020; 383:e138
Rongbin Xu, M.B., B.S., Pei Yu, M.B., B.S., Michael J. Abramson, M.B., B.S., Ph.D., Fay H. Johnston, B.M., B.S., Ph.D., Jonathan M. Samet, M.D., Michelle L. Bell, Ph.D., Andy Haines, M.B., B.S., M.D., Kristie L. Ebi, Ph.D., M.P.H., Shanshan Li, M.D., Ph.D., and Yuming Guo, M.D., Ph.D.
doi : 10.1056/NEJMsr2028985
N Engl J Med 2020; 383:2173-2181
doi : 10.1056/NEJMc2031173
N Engl J Med 2020; 383:2182-2184
doi : 10.1056/NEJMc2027653
N Engl J Med 2020; 383:2184-2185
doi : 10.1056/NEJMc2028904
N Engl J Med 2020; 383:2185-2187
doi : 10.1056/NEJMc2029828
N Engl J Med 2020; 383:2188-2190
doi : 10.1056/NEJMc2031081
N Engl J Med 2020; 383:2190-2193
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