New England Journal of Medicine




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سفارش

Delaying Pregnancy during a Public Health Crisis — Examining Public Health Recommendations for Covid-19 and Beyond

Sonja A. Rasmussen, M.D., Anne Drapkin Lyerly, M.D., and Denise J. Jamieson, M.D., M.P.H.

doi : 10.1056/NEJMp2027940

N Engl J Med 2020; 383:2097-2099

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Banning Genetic Discrimination in Life Insurance — Time to Follow Florida’s Lead

Mark A. Rothstein, J.D., and Kyle B. Brothers, M.D., Ph.D.

doi : 10.1056/NEJMp2024123

N Engl J Med 2020; 383:2099-2101

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Reparations as a Public Health Priority — A Strategy for Ending Black–White Health Disparities

Mary T. Bassett, M.D., M.P.H., and Sandro Galea, M.D., Dr.P.H.

doi : 10.1056/NEJMp2026170

N Engl J Med 2020; 383:2101-2103

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“You Are Now Entering a Guilt-free Zone”

D. Robin Taylor, M.D., D.Sc.

doi : 10.1056/NEJMp2003459

N Engl J Med 2020; 383:2103-2105

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Rethinking Covid-19 Test Sensitivity — A Strategy for Containment

Michael J. Mina, M.D., Ph.D., Roy Parker, Ph.D., and Daniel B. Larremore, Ph.D.

doi : 10.1056/NEJMp2025631

N Engl J Med 2020; 383:e120

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Trustworthiness before Trust — Covid-19 Vaccine Trials and the Black Community

Rueben C. Warren, D.D.S., Dr.P.H., M.Div., Lachlan Forrow, M.D., David Augustin Hodge, Sr., D.Min., Ph.D., and Robert D. Truog, M.D.

doi : 10.1056/NEJMp2030033

N Engl J Med 2020; 383:e121

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Once-Weekly Insulin for Type 2 Diabetes without Previous Insulin Treatment

Julio Rosenstock, M.D., Harpreet S. Bajaj, M.D., M.P.H., Andrej Jane?, M.D., Ph.D., Robert Silver, M.D., Kamilla Begtrup, M.Sc., Melissa V. Hansen, M.D., Ph.D., Ting Jia, M.D., Ph.D., and Ronald Goldenberg, M.D. for the NN1436-4383 Investigators*

doi : 10.1056/NEJMoa2022474

N Engl J Med 2020; 383:2107-2116

It is thought that a reduction in the frequency of basal insulin injections might facilitate treatment acceptance and adherence among patients with type 2 diabetes. Insulin icodec is a basal insulin analogue designed for once-weekly administration that is in development for the treatment of diabetes.

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Rivaroxaban in Patients with Atrial Fibrillation and a Bioprosthetic Mitral Valve

Helio P. Guimar?es, M.D., Ph.D., Renato D. Lopes, M.D., Ph.D., Pedro G.M. de Barros e Silva, M.D., Ph.D., Idelzuita L. Liporace, M.D., Roney O. Sampaio, M.D., Ph.D., Fl?vio Tarasoutchi, M.D., Ph.D., Conrado R. Hoffmann-Filho, M.D., Rodrigo de Lemos Soares Patriota, M.D., Tiago L.L. Leiria, M.D., Ph.D., Diana Lamprea, M.D., Dalton B. Precoma, M.D., Ph.D., Fernando A. Atik, M.D., Ph.D.,

doi : 10.1056/NEJMoa2029603

N Engl J Med 2020; 383:2117-2126

The effects of rivaroxaban in patients with atrial fibrillation and a bioprosthetic mitral valve remain uncertain.

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Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis

James D. Chalmers, M.B., Ch.B., Ph.D., Charles S. Haworth, M.B., Ch.B., M.D., Mark L. Metersky, M.D., Michael R. Loebinger, B.M., B.Ch., Ph.D., Francesco Blasi, M.D., Ph.D., Oriol Sibila, M.D., Ph.D., Anne E. O’Donnell, M.D., Eugene J. Sullivan, M.D., Kevin C. Mange, M.D., M.S.C.E., Carlos Fernandez, M.D., M.P.H., Jun Zou, Ph.D., and Charles L. Daley, M.D. for the WILLOW Investigators*

doi : 10.1056/NEJMoa2021713

N Engl J Med 2020; 383:2127-2137

Patients with bronchiectasis have frequent exacerbations that are thought to be related to neutrophilic inflammation. The activity and quantity of neutrophil serine proteases, including neutrophil elastase, are increased in the sputum of patients with bronchiectasis at baseline and increase further during exacerbations. Brensocatib (INS1007) is an oral reversible inhibitor of dipeptidyl peptidase 1 (DPP-1), an enzyme responsible for the activation of neutrophil serine proteases.

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A Randomized Trial of Laryngeal Mask Airway in Neonatal Resuscitation

Nicolas J. Pejovic, M.D., Ph.D., Susanna Myrnerts H??k, M.D., M.Med., Josaphat Byamugisha, M.D., Ph.D., Tobias Alfvén, M.D., Ph.D., Clare Lubulwa, M.D., M.Med., Francesco Cavallin, M.Sc., Jolly Nankunda, M.D., Ph.D., Hege Ersdal, M.D., Ph.D., Mats Blennow, M.D., Ph.D., Daniele Trevisanuto, M.D., and Thorkild Tyllesk?r, M.D., Ph.D.

doi : 10.1056/NEJMoa2005333

N Engl J Med 2020; 383:2138-2147

Face-mask ventilation is the most common resuscitation method for birth asphyxia. Ventilation with a cuffless laryngeal mask airway (LMA) has potential advantages over face-mask ventilation during neonatal resuscitation in low-income countries, but whether the use of an LMA reduces mortality and morbidity among neonates with asphyxia is unknown.

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Women Physicians and Promotion in Academic Medicine

Kimber P. Richter, Ph.D., M.P.H., Lauren Clark, M.S., Jo A. Wick, Ph.D., Erica Cruvinel, Ph.D., Dianne Durham, Ph.D., Pamela Shaw, M.D., Grace H. Shih, M.D., Christie A. Befort, Ph.D., and Robert D. Simari, M.D.

doi : 10.1056/NEJMsa1916935

N Engl J Med 2020; 383:2148-2157

In 2000, a landmark study showed that women who graduated from U.S. medical schools from 1979 through 1997 were less likely than their male counterparts to be promoted to upper faculty ranks in academic medical centers. It is unclear whether these differences persist.

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Blastic Plasmacytoid Dendritic-Cell Neoplasm

Yung Gonzaga, M.D., and Mayne Fontes, M.D.

doi : 10.1056/NEJMicm2003702

N Engl J Med 2020; 383:2158

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Ascaris in the Stomach

Vivek Chaurasia, M.B., B.S., and Sanjeev Bhoi, M.B., B.S., M.D.

doi : 10.1056/NEJMicm2007312

N Engl J Med 2020; 383:e122

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Case 37-2020: A 35-Year-Old Man with Lymphadenopathy and Petechiae

Philippe Armand, M.D., Ph.D., Allen P. Heeger, D.O., Sanjat Kanjilal, M.D., M.P.H., and Melissa Krystel-Whittemore, M.D.

doi : 10.1056/NEJMcpc2004979

N Engl J Med 2020; 383:2159-2169

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Advances in Diabetes Treatment — Once-Weekly Insulin

Peter A. Gottlieb, M.D., and Aaron W. Michels, M.D.

doi : 10.1056/NEJMe2031596

N Engl J Med 2020; 383:2171-2172

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Audio Interview: New Studies of Covid-19 Transmission

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2034094

N Engl J Med 2020; 383:e138

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Wildfires, Global Climate Change, and Human Health

Rongbin Xu, M.B., B.S., Pei Yu, M.B., B.S., Michael J. Abramson, M.B., B.S., Ph.D., Fay H. Johnston, B.M., B.S., Ph.D., Jonathan M. Samet, M.D., Michelle L. Bell, Ph.D., Andy Haines, M.B., B.S., M.D., Kristie L. Ebi, Ph.D., M.P.H., Shanshan Li, M.D., Ph.D., and Yuming Guo, M.D., Ph.D.

doi : 10.1056/NEJMsr2028985

N Engl J Med 2020; 383:2173-2181

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N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects

doi : 10.1056/NEJMc2031173

N Engl J Med 2020; 383:2182-2184

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Early Spread of SARS-CoV-2 in the Icelandic Population

doi : 10.1056/NEJMc2027653

N Engl J Med 2020; 383:2184-2185

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Uterine-Artery Embolization or Myomectomy for Uterine Fibroids

doi : 10.1056/NEJMc2028904

N Engl J Med 2020; 383:2185-2187

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Atypical Femur Fracture Risk versus Fragility Fracture Prevention with Bisphosphonates

doi : 10.1056/NEJMc2029828

N Engl J Med 2020; 383:2188-2190

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JAK Inhibition in the Aicardi–Goutières Syndrome

doi : 10.1056/NEJMc2031081

N Engl J Med 2020; 383:2190-2193

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