دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
-
http://medilib.ir
- ﻣﺪﺕ ﺯﻣﺎﻥ : 365 ﺭﻭﺯ
قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
The regulatory role of Korean ginseng in skin cells
LongYou1Jae YoulCho12
doi : 10.1016/j.jgr.2020.08.004
Volume 45, Issue 3, May 2021, Pages 363-370
As the largest organ in our body, the skin acts as a barrier against external stress and damages. There are various cell types of skin, such as keratinocytes, melanocytes, fibroblasts, and skin stem cells. Korean ginseng, which is one of the biggest distributions of ginseng worldwide, is processed into different products, such as functional food, cosmetics, and medical supplies. This review aims to introduce the functional role of Korean ginseng on different dermal cell types, including the impact of Korean ginseng in anti-photodamaging, anti-inflammatory, anti-oxidative, anti-melanogenic, and wound healing activities, etc. We propose that this information could form the basis of future research of ginseng-derived components in skin health.
Review of ginsenosides targeting mitochondrial function to treat multiple disorders: Current status and perspectives
QingxiaHuang12SongGao3DaqingZhao145XiangyanLi145
doi : 10.1016/j.jgr.2020.12.004
Volume 45, Issue 3, May 2021, Pages 371-379
Mitochondrial dysfunction contributes to the pathogenesis and prognosis of many common disorders, including neurodegeneration, stroke, myocardial infarction, tumor, and metabolic diseases. Ginsenosides, the major bioactive constituents of Panax ginseng (P. ginseng), have been reported to play beneficial roles in the molecular pathophysiology of these diseases by targeting mitochondrial dysfunction. In this review, we first introduce the types of ginsenosides and basic mitochondrial functions. Then, recent findings are summarized on different ginsenosides targeting mitochondria and their key signaling pathways for the treatment of multiple diseases, including neurological disorders, cancer, heart disease, hyperglycemia, and inflammation are summarized. This review may explain the common targets of ginsenosides against multiple diseases and provide new insights into the underlying mechanisms, facilitating research on the clinical application of P. ginseng.
Effect of Korean Red Ginseng on metabolic syndrome
Sang JunYoon1?Seul KiKim1?Na YoungLee1?Ye RinChoi1Hyeong SeobKim1HaripriyaGupta1Gi SooYoun1HotaikSung2Min JeaShin1Ki TaeSuk1
doi : 10.1016/j.jgr.2020.11.002
Volume 45, Issue 3, May 2021, Pages 380-389
Metabolic syndrome (MS) refers to a clustering of at least three of the following medical conditions: high blood pressure, abdominal obesity, hyperglycemia, low high-density lipoprotein level, and high serum triglycerides. MS is related to a wide range of diseases which includes obesity, diabetes, insulin resistance, cardiovascular disease, dyslipidemia, or non-alcoholic fatty liver disease. There remains an ongoing need for improved treatment strategies for MS. The most important risk factors are dietary pattern, genetics, old age, lack of exercise, disrupted biology, medication usage, and excessive alcohol consumption, but pathophysiology of MS has not been completely identified. Korean Red Ginseng (KRG) refers to steamed/dried ginseng, traditionally associated with beneficial effects such as anti-inflammation, anti-fatigue, anti-obesity, anti-oxidant, and anti-cancer effects. KRG has been often used in traditional medicine to treat multiple metabolic conditions. This paper summarizes the effects of KRG in MS and related diseases such as obesity, cardiovascular disease, insulin resistance, diabetes, dyslipidemia, or non-alcoholic fatty liver disease based on experimental research and clinical studies.
Ginseng gintonin alleviates neurological symptoms in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis through lysophosphatidic acid 1 receptor
Sung MinNam17Jong HeeChoi2Sun-HyeChoi3Hee-JungCho3Yeon-JinCho3HyewhonRhim4Hyoung-ChunKim5Ik-HyunCho2Do-GeunKim6Seung-YeolNah3
doi : 10.1016/j.jgr.2020.04.002
Volume 45, Issue 3, May 2021, Pages 390-400
We recently showed that gintonin, an active ginseng ingredient, exhibits antibrain neurodegenerative disease effects including multiple target mechanisms such as antioxidative stress and antiinflammation via the lysophosphatidic acid (LPA) receptors. Amyotrophic lateral sclerosis (ALS) is a spinal disease characterized by neurodegenerative changes in motor neurons with subsequent skeletal muscle paralysis and death. However, pathophysiological mechanisms of ALS are still elusive, and therapeutic drugs have not yet been developed. We investigate the putative alleviating effects of gintonin in ALS.
Gintonin influences the morphology and motility of adult brain neurons via LPA receptors
Do-GeunKim1Hyeon-JoongKim2Sun-HyeChoi2Sung MinNam27Hyoung-ChunKim3HyewhonRhim4Ik-HyunCho5Man HeeRhee6Seung-YeolNah2
doi : 10.1016/j.jgr.2020.06.003
Volume 45, Issue 3, May 2021, Pages 401-407
Gintonin is an exogenous ginseng-derived G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. LPA induces in vitro morphological changes and migration through neuronal LPA1 receptor. Recently, we reported that systemic administration of gintonin increases blood-brain barrier (BBB) permeability via the paracellular pathway and its binding to brain neurons. However, little is known about the influences of gintonin on in vivo neuron morphology and migration in the brain.
Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-?B and TGF-?1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling
YanGao1?DingYuan1?LiyueGai1?XuelianWu1YueShi1YuminHe1ChaoqiLiu1ChangchengZhang1GangZhou2ChengfuYuan13
doi : 10.1016/j.jgr.2020.08.005
Volume 45, Issue 3, May 2021, Pages 408-419
The decreased renal function is known to be associated with biological aging, of which the main pathological features are chronic inflammation and renal interstitial fibrosis. In previous studies, we reported that total saponins from Panax japonicus (SPJs) can availably protect acute myocardial ischemia. We proposed that SPJs might have similar protective effects for aging-associated renal interstitial fibrosis. Thus, in the present study, we evaluated the overall effect of SPJs on renal fibrosis.
The effect of ginsenosides on depression in preclinical studies: A systematic review and meta-analysis
YunnaKim123Seung-HunCho123
doi : 10.1016/j.jgr.2020.08.006
Volume 45, Issue 3, May 2021, Pages 420-432
Many ginsenosides have been shown to be efficacious for major depressive disorder (MDD), which is a highly recurrent disorder, through several preclinical studies. We aimed to review the literature assessing the antidepressant effects of ginsenosides on MDD animal models, to establish systematic scientific evidence in a rigorous manner.
Rg3-enriched Korean Red Ginseng extract inhibits blood-brain barrier disruption in an animal model of multiple sclerosis by modulating expression of NADPH oxidase 2 and 4
Min JungLee1?Jong HeeChoi1?JinheeOh12Young HyunLee12Jun-GyoIn3Byung-JoonChang4Seung-YeolNah5Ik-HyunCho126
doi : 10.1016/j.jgr.2020.09.001
Volume 45, Issue 3, May 2021, Pages 433-441
Multiple sclerosis (MS) and its animal model, the experimental autoimmune encephalomyelitis (EAE), are primarily characterized as dysfunction of the blood-brain barrier (BBB). Ginsenoside-Rg3-enriched Korean Red Ginseng extract (Rg3-KRGE) is known to exert neuroprotective, anti-inflammatory, and anti-oxidative effects on neurological disorders. However, effects of Rg3-KRGE in EAE remain unclear.
Influence of the plant growth promoting Rhizobium panacihumi on aluminum resistance in Panax ginseng
Jong-PyoKang1YueHuo2Dong-UkYang2Deok-ChunYang12
doi : 10.1016/j.jgr.2020.01.001
Volume 45, Issue 3, May 2021, Pages 442-449
Panax ginseng is an important crop in Asian countries given its pharmaceutical uses. It is usually harvested after 4–6 years of cultivation. However, various abiotic stresses have led to its quality reduction. One of the stress causes is high content of heavy metal in ginseng cultivation area. Plant growth–promoting rhizobacteria (PGPR) can play a role in healthy growth of plants. It has been considered as a new trend for supporting the growth of many crops in heavy metal occupied areas, such as Aluminum (Al).
Effect of Korean Red Ginseng through comparative analysis of cardiac gene expression in db/db mice
Young-JinJang1AdithanAravinthan1Mohammad AmjadHossain1Spandana RajendraKopalli2BumseokKim1Nam SooKim1Chang-WonKang1Jong-HoonKim1
doi : 10.1016/j.jgr.2020.06.001
Volume 45, Issue 3, May 2021, Pages 450-455
Korean Red Ginseng (KRG) is an herbal oriental medicine known to alleviate cardiovascular dysfunction. To analysis the expression of diabetic cardiac complication-associated genes in db/db mice, we studied the cardiac gene expression following KRG treatment. In result, a total of 585 genes were found to be changed in db/db mice. Among the changed expression, 245 genes were found to 2-fold upregulated, and 340 genes were 2-fold downregulated. In addition, the changed gene expressions were ameliorated by KRG. In conclusion, KRG may be possible to normalize cardiac gene expressions in db/db mice.
Korean Red Ginseng attenuates ultraviolet-mediated inflammasome activation in keratinocytes
HuijeongAhn1Byung-CheolHan12Eui-JuHong3Beum-SooAn4EunsongLee1Seung-HoLee2Geun-ShikLee1
doi : 10.1016/j.jgr.2021.02.002
Volume 45, Issue 3, May 2021, Pages 456-463
Keratinocytes form a physical barrier and act as an innate immune cell in skin. Keratinocytes secrete pro-inflammatory cytokines, such as interleukin (IL)-1?, resulting from inflammasome activation when exposed to ultraviolet (UV) irradiation. Korean Red Ginseng extracts (RGE) have been well-studied as modulators of inflammasome activation in immune cells, such as macrophages. In the study, we elucidated the role of RGE on the UV-mediated inflammasome activation in keratinocytes compared with that in macrophages.
