دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
-
http://medilib.ir
- ﻣﺪﺕ ﺯﻣﺎﻥ : 365 ﺭﻭﺯ
قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Association between perioperative fluid administration and postoperative outcomes: a 20-year systematic review and a meta-analysis of randomized goal-directed trials in major visceral/noncardiac surgery
Antonio Messina, Chiara Robba, Lorenzo Calabr?, Daniel Zambelli, Francesca Iannuzzi, Edoardo Molinari, Silvia Scarano, Denise Battaglini, Marta Baggiani, Giacomo De Mattei, Laura Saderi, Giovanni Sotgiu, Paolo Pelosi and Maurizio Cecconi
doi : 10.1186/s13054-021-03464-1
Critical Care 2021 25:43
Appropriate perioperative fluid management is of pivotal importance to reduce postoperative complications, which impact on early and long-term patient outcome. The so-called perioperative goal-directed therapy (GDT) approach aims at customizing perioperative fluid management on the individual patients’ hemodynamic response. Whether or not the overall amount of perioperative volume infused in the context of GDT could influence postoperative surgical outcomes is unclear.
The epidemiology and clinical outcomes of ventilator-associated events among 20,769 mechanically ventilated patients at intensive care units: an observational study
Qiao He, Wen Wang, Shichao Zhu, Mingqi Wang, Yan Kang, Rui Zhang, Kang Zou, Zhiyong Zong and Xin Sun
doi : 10.1186/s13054-021-03484-x
Critical Care 2021 25:44
Ventilator-associated pneumonia (VAP) is the most common hospital-acquired infection (HAI) in intensive care units (ICUs). Ventilator-associated event (VAE), a more objective definition, has replaced traditional VAP surveillance and is now widely used in the USA. However, the adoption outside the USA is limited. This study aims to describe the epidemiology and clinical outcomes of VAEs in China, based on a prospectively maintained registry.
Incidence and management of metabolic acidosis with sodium bicarbonate in the ICU: An international observational study
Tomoko Fujii, Andrew A. Udy, Alistair Nichol, Rinaldo Bellomo, Adam M. Deane, Khaled El-Khawas, Naorungroj Thummaporn, Ary Serpa Neto, Hannah Bergin, Robert Short-Burchell, Chin-Ming Chen, Kuang-Hua Cheng, Kuo-Chen Cheng, Clemente Chia, Feng-Fan Chiang, Nai-Kuan Chou
doi : 10.1186/s13054-020-03431-2
Critical Care 2021 25:45
Metabolic acidosis is a major complication of critical illness. However, its current epidemiology and its treatment with sodium bicarbonate given to correct metabolic acidosis in the ICU are poorly understood.
Utility of AI models in critical care: union of man and the machine
Amos Lal, Vitaly Herasevich and Ognjen Gajic
doi : 10.1186/s13054-021-03478-9
Critical Care 2021 25:46
Use of the lung ultrasound score in monitoring COVID-19 patients: it’s time for a reappraisal
Luigi Vetrugno, Daniele Orso, Cristian Deana, Flavio Bassi, Gianmaria Cammarota and Tiziana Bove
doi : 10.1186/s13054-021-03483-y
Critical Care 2021 25:47
Angiopoietin-2 outperforms other endothelial biomarkers associated with severe acute kidney injury in patients with severe sepsis and respiratory failure
Wen-Kuang Yu, J. Brennan McNeil, Nancy E. Wickersham, Ciara M. Shaver, Julie A. Bastarache and Lorraine B. Ware
doi : 10.1186/s13054-021-03474-z
Critical Care 2021 25:48
Endothelial dysfunction and injury is a major pathophysiologic feature of sepsis. Sepsis is also the most frequent cause of acute kidney injury (AKI) in critically ill patients. Though most studies of AKI in sepsis have focused on tubular epithelial injury, the role of endothelial dysfunction and injury is less well studied. The goal of this study was first to investigate whether endothelial dysfunction and injury biomarkers were associated with severe AKI in sepsis patients. The second goal was to determine the best performing biomarker for severe AKI and whether this biomarker was associated with severe AKI across different etiologies of sepsis and clinical outcomes.
Acute cholangitis in intensive care units: clinical, biological, microbiological spectrum and risk factors for mortality: a multicenter study
Jean-Rémi Lavillegrand, Emmanuelle Mercier-Des-Rochettes, Elodie Baron, Frédéric Pène, Damien Contou, Raphael Favory, Sébastien Préau, Arnaud Galbois, Chloé Molliere, Arnaud-Félix Miailhe, Jean Reignier, Mehran Monchi, Claire Pichereau, Sara Thietart, Thibault Vieille, Gael Piton
doi : 10.1186/s13054-021-03480-1
Critical Care 2021 25:49
Little is known on the outcome and risk factors for mortality of patients admitted in Intensive Care units (ICUs) for Acute cholangitis (AC).
Identification and characterization of neutrophil heterogeneity in sepsis
Xinxin Qi, Yao Yu, Ran Sun, Jiamin Huang, Lu Liu, Yunxi Yang, Tao Rui and Bingwei Sun
doi : 10.1186/s13054-021-03481-0
Critical Care 2021 25:50
Although the immune function of neutrophils in sepsis has been well described, the heterogeneity of neutrophils remains unclear during the process of sepsis.
Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients
Yue Zhang, Kai Han, Chunjing Du, Rui Li, Jingyuan Liu, Hui Zeng, Liuluan Zhu and Ang Li
doi : 10.1186/s13054-021-03482-z
Critical Care 2021 25:51
Thrombosis and coagulopathy are highly prevalent in critically ill patients with COVID-19 and increase the risk of death. Immunothrombosis has recently been demonstrated to contribute to the thrombotic events in COVID-19 patients with coagulopathy. As the primary components of immunothrombosis, neutrophil extracellular traps (NETs) could be induced by complement cascade components and other proinflammatory mediators. We aimed to explore the clinical roles of NETs and the regulation of complement on the NET formation in COVID-19.
Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study
Benoit Vandenbunder, Stephan Ehrmann, Michael Piagnerelli, Bertrand Sauneuf, Nicolas Serck, Thibaud Soumagne, Julien Textoris, Christophe Vinsonneau, Nadia Aissaoui, Gauthier Blonz, Giuseppe Carbutti, Romain Courcelle, Alain D’hondt, Stephane Gaudry, Julien Higny, Geoffroy Horlait
doi : 10.1186/s13054-020-03433-0
Critical Care 2021 25:52
Controversies exist on the nature of COVID-19 related acute respiratory distress syndrome (ARDS) in particular on the static compliance of the respiratory system (Crs). We aimed to analyze the association of Crs with outcome in COVID-19-associated ARDS, to ascertain its determinants and to describe its evolution at day-14.
SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review
Maria Clara Saad Menezes, Diego Vinicius Santinelli Pestana, Gustavo Rosa Gameiro, Luiz Fernando Ferraz da Silva, ?lodie Baron, Jean-Jacques Rouby and José Otavio Costa Auler Jr
doi : 10.1186/s13054-020-03399-z
Critical Care 2021 25:53
The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-based explanations for the immune response, and COVID-19-associated hypercoagulability.
Characterization of esophageal motor activity, gastroesophageal reflux, and evaluation of prokinetic effectiveness in mechanically ventilated critically ill patients: a high-resolution impedance manometry study
Karel Balihar, Jan Kotyza, Lucie Zdrhova, Jana Kozeluhova, Michal Krcma and Martin Matejovic
doi : 10.1186/s13054-021-03479-8
Critical Care 2021 25:54
Motility disorders of upper gastrointestinal tract are common in critical illness and associated with significant clinical consequences. However, detailed quantitative and qualitative analyses of esophageal motor functions are lacking. Therefore, we aimed to characterize the key features of esophageal motility functions using high-resolution impedance manometry (HRIM) and to evaluate an objective link between esophageal motor patterns, gastric emptying, and gastroesophageal reflux. We also studied the prokinetic effects of metoclopramide.
Letter on “(1,3)-?-d-Glucan-based empirical antifungal interruption in suspected invasive candidiasis: a randomized trial”
Antonios Kritikos and Frederic Lamoth
doi : 10.1186/s13054-020-03450-z
Critical Care 2021 25:55
Septic shock, noradrenaline requirements and alpha-2 agonists: Fishing in the right pond?
Auguste Dargent, Luc Quintin and Jean-Pierre Quenot
doi : 10.1186/s13054-020-03377-5
Critical Care 2021 25:56
Renal dysfunction improves risk stratification and may call for a change in the management of intermediate- and high-risk acute pulmonary embolism: results from a multicenter cohort study with external validation
Romain Chopard, David Jimenez, Guillaume Serzian, Fiona Ecarnot, Nicolas Falvo, Elsa Kalbacher, Benjamin Bonnet, Gilles Capellier, François Schiele, Laurent Bertoletti, Manuel Monreal and Nicolas Meneveau
doi : 10.1186/s13054-021-03458-z
Critical Care 2021 25:57
Renal dysfunction influences outcomes after pulmonary embolism (PE). We aimed to determine the incremental value of adding renal dysfunction, defined by estimated glomerular filtration rate (eGFR), on top of the European Society of Cardiology (ESC) prognostic model, for the prediction of 30-day mortality in acute PE patients, which in turn could lead to the optimization of acute PE management.
High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure
Ricard Mellado-Artigas, Bruno L. Ferreyro, Federico Angriman, Mar?a Hern?ndez-Sanz, Egoitz Arruti, Antoni Torres, Jes?s Villar, Laurent Brochard and Carlos Ferrando
doi : 10.1186/s13054-021-03469-w
Critical Care 2021 25:58
Whether the use of high-flow nasal oxygen in adult patients with COVID-19 associated acute respiratory failure improves clinically relevant outcomes remains unclear. We thus sought to assess the effect of high-flow nasal oxygen on ventilator-free days, compared to early initiation of invasive mechanical ventilation, on adult patients with COVID-19.
Airway Pseudomonas aeruginosa density in mechanically ventilated patients: clinical impact and relation to therapeutic efficacy of antibiotics
Yohei Migiyama, Shinya Sakata, Shinji Iyama, Kentaro Tokunaga, Koichi Saruwatari, Yusuke Tomita, Sho Saeki, Shinichiro Okamoto, Hidenori Ichiyasu and Takuro Sakagami
doi : 10.1186/s13054-021-03488-7
Critical Care 2021 25:59
The bacterial density of Pseudomonas aeruginosa is closely related to its pathogenicity. We evaluated the effect of airway P. aeruginosa density on the clinical course of mechanically ventilated patients and the therapeutic efficacy of antibiotics.
Automated detection and quantification of reverse triggering effort under mechanical ventilation
Tài Pham, Jaume Montanya, Irene Telias, Thomas Piraino, Rudys Magrans, Rémi Coudroy, L. Felipe Damiani, Ricard Mellado Artigas, Mat?as Madorno, Lluis Blanch and Laurent Brochard
doi : 10.1186/s13054-020-03387-3
Critical Care 2021 25:60
Reverse triggering (RT) is a dyssynchrony defined by a respiratory muscle contraction following a passive mechanical insufflation. It is potentially harmful for the lung and the diaphragm, but its detection is challenging. Magnitude of effort generated by RT is currently unknown. Our objective was to validate supervised methods for automatic detection of RT using only airway pressure (Paw) and flow. A secondary objective was to describe the magnitude of the efforts generated during RT.
Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study
Alice Blet, Benjamin Deniau, Karine Santos, Dirk P. T. van Lier, Feriel Azibani, Xavier Wittebole, Benjamin G. Chousterman, Etienne Gayat, Oliver Hartmann, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin, Charles Damoisel, Nicolas Deye
doi : 10.1186/s13054-021-03471-2
Critical Care 2021 25:61
Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the degradation of various cardiovascular and endorphin mediators. High levels of circulating DPP3 (cDPP3) indicate a high risk of organ dysfunction and mortality in cardiogenic shock patients.
Impact of treating iron deficiency, diagnosed according to hepcidin quantification, on outcomes after a prolonged ICU stay compared to standard care: a multicenter, randomized, single-blinded trial
Sigismond Lasocki, Pierre Asfar, Samir Jaber, Martine Ferrandiere, Thomas Kerforne, Karim Asehnoune, Philippe Montravers, Philippe Seguin, Katell Peoc’h, Soizic Gergaud, Nicolas Nagot, Thibaud Lefebvre and Sylvain Lehmann
doi : 10.1186/s13054-020-03430-3
Critical Care 2021 25:62
Anemia is a significant problem in patients on ICU. Its commonest cause, iron deficiency (ID), is difficult to diagnose in the context of inflammation. Hepcidin is a new marker of ID. We aimed to assess whether hepcidin levels would accurately guide treatment of ID in critically ill anemic patients after a prolonged ICU stay and affect the post-ICU outcomes.
Deploying unsupervised clustering analysis to derive clinical phenotypes and risk factors associated with mortality risk in 2022 critically ill patients with COVID-19 in Spain
Alejandro Rodr?guez, Manuel Ruiz-Botella, Ignacio Mart?n-Loeches, Mar?a Jimenez Herrera, Jordi Solé-Violan, Josep G?mez, Mar?a Bod?, Sandra Trefler, Elisabeth Papiol, Emili D?az, Borja Suberviola, Montserrat Vallverdu, Eric Mayor-V?zquez, Antonio Albaya Moreno, Alfonso Canabal Berlanga, Miguel S?nchez
doi : 10.1186/s13054-021-03487-8
Critical Care 2021 25:63
The identification of factors associated with Intensive Care Unit (ICU) mortality and derived clinical phenotypes in COVID-19 patients could help for a more tailored approach to clinical decision-making that improves prognostic outcomes.
Diaphragm echodensity in mechanically ventilated patients: a description of technique and outcomes
Benjamin Coiffard, Stephen Riegler, Michael C. Sklar, Martin Dres, Stefannie Vorona, W. Darlene Reid, Laurent J. Brochard, Niall D. Ferguson and Ewan C. Goligher
doi : 10.1186/s13054-021-03494-9
Critical Care 2021 25:64
Acute increases in muscle sonographic echodensity reflect muscle injury. Diaphragm echodensity has not been measured in mechanically ventilated patients. We undertook to develop a technique to characterize changes in diaphragm echodensity during mechanical ventilation and to assess whether these changes are correlated with prolonged mechanical ventilation.
The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis
Arno Téblick, Sarah Vander Perre, Lies Pauwels, Sarah Derde, Tim Van Oudenhove, Lies Langouche and Greet Van den Berghe
doi : 10.1186/s13054-021-03475-y
Critical Care 2021 25:65
Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ We hypothesized that sepsis acutely activates the hypothalamus to generate, via corticotropin-releasing hormone (CRH) and vasopressin (AVP), ACTH-induced hypercortisolemia. Thereafter, via increased availability of free cortisol, of which breakdown is reduced, feedback inhibition at the pituitary level interferes with normal processing of pro-opiomelanocortin (POMC) into ACTH, explaining the ACTH–cortisol dissociation. We further hypothesized that, in this constellation, POMC leaches into the circulation and can contribute to adrenocortical steroidogenesis.
YKL-40 as a new promising prognostic marker of severity in COVID infection
Lauranne Schoneveld, Aurélie Ladang, Monique Henket, Anne-Noëlle Frix, Etienne Cavalier and Julien Guiot
doi : 10.1186/s13054-020-03383-7
Critical Care 2021 25:66
Epinephrine’s effects on cerebrovascular and systemic hemodynamics during cardiopulmonary resuscitation: metabolic changes may limit the persistence of the effect
Romain Jouffroy and Benoît Vivien
doi : 10.1186/s13054-020-03378-4
Critical Care 2021 25:67
Case fatality ratio of COVID-19 patients requiring invasive mechanical ventilation in Mexico: an analysis of nationwide data
Silvio A. ?amendys-Silva
doi : 10.1186/s13054-021-03485-w
Critical Care 2021 25:68
Prevalence of post-intensive care syndrome among Japanese intensive care unit patients: a prospective, multicenter, observational J-PICS study
Daisuke Kawakami, Shigeki Fujitani, Takeshi Morimoto, Hisashi Dote, Mumon Takita, Akihiro Takaba, Masaaki Hino, Michitaka Nakamura, Hiromasa Irie, Tomohiro Adachi, Mami Shibata, Jun Kataoka, Akira Korenaga, Tomoya Yamashita, Tomoya Okazaki, Masatoshi Okumura
doi : 10.1186/s13054-021-03501-z
Critical Care 2021 25:69
Many studies have compared quality of life of post-intensive care syndrome (PICS) patients with age-matched population-based controls. Many studies on PICS used the 36-item Short Form (SF-36) health survey questionnaire version 2, but lack the data for SF-36 values before and after intensive care unit (ICU) admission. Thus, clinically important changes in the parameters of SF-36 are unknown. Therefore, we determined the frequency of co-occurrence of PICS impairments at 6 months after ICU admission. We also evaluated the changes in SF-36 subscales and interpreted the patients’ subjective significance of impairment.
Surge effects and survival to hospital discharge in critical care patients with COVID-19 during the early pandemic: a cohort study
Christopher R. Dale, Rachael W. Starcher, Shu Ching Chang, Ari Robicsek, Guilford Parsons, Jason D. Goldman, Andre Vovan, David Hotchkin and Tyler J. Gluckman
doi : 10.1186/s13054-021-03504-w
Critical Care 2021 25:70
The early months of the COVID-19 pandemic were fraught with much uncertainty and some resource constraint. We assessed the change in survival to hospital discharge over time for intensive care unit patients with COVID-19 during the first 3 months of the pandemic and the presence of any surge effects on patient outcomes.
Factors influencing local signs at catheter insertion site regardless of catheter-related bloodstream infections
Niccol? Buetti, Stéphane Ruckly, Jean-Christophe Lucet, Olivier Mimoz, Bertrand Souweine and Jean-François Timsit
doi : 10.1186/s13054-021-03490-z
Critical Care 2021 25:71
Epidemiology and microbiology of ventilator-associated pneumonia in COVID-19 patients: a multicenter retrospective study in 188 patients in an un-inundated French region
Gauthier Blonz, Achille Kouatchet, Nicolas Chudeau, Emmanuel Pontis, Julien Lorber, Anthony Lemeur, Lucie Planche, Jean-Baptiste Lascarrou and Gwenhael Colin
doi : 10.1186/s13054-021-03493-w
Critical Care 2021 25:72
Reduced gastric acidity, proton pump inhibitors and increased severity of COVID-19 infections
Elizabeth Price and David F. Treacher
doi : 10.1186/s13054-021-03497-6
Critical Care 2021 25:73
Markers of endothelial and epithelial pulmonary injury in mechanically ventilated COVID-19 ICU patients
Savino Spadaro, Alberto Fogagnolo, Gianluca Campo, Ottavio Zucchetti, Marco Verri, Irene Ottaviani, Tanushree Tunstall, Salvatore Grasso, Valentina Scaramuzzo, Francesco Murgolo, Elisabetta Marangoni, Francesco Vieceli Dalla Sega, Francesca Fortini, Rita Pavasini, Paola Rizzo, Roberto Ferrari
doi : 10.1186/s13054-021-03499-4
Critical Care 2021 25:74
Biomarkers can be used to detect the presence of endothelial and/or alveolar epithelial injuries in case of ARDS. Angiopoietin-2 (Ang-2), soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion protein-1 (VCAM-1), P-selectin and E-selectin are biomarkers of endothelial injury, whereas the receptor for advanced glycation end-products (RAGE) reflects alveolar epithelial injury. The aims of this study were to evaluate whether the plasma concentration of the above-mentioned biomarkers was different 1) in survivors and non-survivors of COVID-19-related ARDS and 2) in COVID-19-related and classical ARDS.
Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps
Daniele De Luca, Paola Cogo, Martin C. Kneyber, Paolo Biban, Malcolm Grace Semple, Jesus Perez-Gil, Giorgio Conti, Pierre Tissieres and Peter C. Rimensberger
doi : 10.1186/s13054-021-03489-6
Critical Care 2021 25:75
Pediatric (PARDS) and neonatal (NARDS) acute respiratory distress syndrome have different age-specific characteristics and definitions. Trials on surfactant for ARDS in children and neonates have been performed well before the PARDS and NARDS definitions and yielded conflicting results. This is mainly due to heterogeneity in study design reflecting historic lack of pathobiology knowledge. We reviewed the available clinical and preclinical data to create an expert consensus aiming to inform future research steps and advance the knowledge in this area. Eight trials investigated the use of surfactant for ARDS in children and ten in neonates, respectively. There were improvements in oxygenation (7/8 trials in children, 7/10 in neonates) and mortality (3/8 trials in children, 1/10 in neonates) improved. Trials were heterogeneous for patients’ characteristics, surfactant type and administration strategy. Key pathobiological concepts were missed in study design. Consensus with strong agreement was reached on four statements:
Role of endothelial microRNA 155 on capillary leakage in systemic inflammation
Valerie Etzrodt, Temitayo O. Idowu, Heiko Schenk, Benjamin Seeliger, Antje Prasse, Kristina Thamm, Thorben Pape, Janina Müller-Deile, Matijs van Meurs, Thomas Thum, Ankita Garg, Robert Geffers, Klaus Stahl, Samir M. Parikh, Hermann Haller and Sascha David
doi : 10.1186/s13054-021-03500-0
Critical Care 2021 25:76
Capillary leakage is a key contributor to the pathological host response to infections. The underlying mechanisms remain incompletely understood, and the role of microRNAs (MIR) has not been investigated in detail. We hypothesized that specific MIRs might be regulated directly in the endothelium thereby contributing to vascular leakage.
Drug dosing in the critically ill obese patient: a focus on medications for hemodynamic support and prophylaxis
Brian L. Erstad and Jeffrey F. Barletta
doi : 10.1186/s13054-021-03495-8
Critical Care 2021 25:77
Medications used for supportive care or prophylaxis constitute a significant portion of drug utilization in the intensive care unit. Evidence-based guidelines are available for many aspects of supportive care but drug doses listed are typically for patients with normal body habitus and not morbid obesity. Failure to account for the pharmacokinetic changes that occur with obesity can lead to an incorrect dose and treatment failure or toxicity. This paper is intended to help clinicians design initial dosing regimens in critically ill obese patients for medications commonly used for hemodynamic support or prophylaxis. A detailed literature search of medications used for supportive care or prophylaxis listed in practice guidelines was conducted with an emphasis on obesity, pharmacokinetics and dosing. Relevant manuscripts were reviewed and strategies for dosing are provided. For medications used for hemodynamic support, a similar strategy can be used as in non-obese patients. Similarly, medications for stress ulcer prophylaxis do not need to be adjusted. Anticoagulants for venous thromboembolism prophylaxis, on the other hand, require an individualized approach where higher doses are necessary.
Use and impact of high intensity treatments in patients with traumatic brain injury across Europe: a CENTER-TBI analysis
Jilske A. Huijben, Abhishek Dixit, Nino Stocchetti, Andrew I. R. Maas, Hester F. Lingsma, Mathieu van der Jagt, David Nelson, Giuseppe Citerio, Lindsay Wilson, David K. Menon and Ari Ercole
doi : 10.1186/s13054-020-03370-y
Critical Care 2021 25:78
To study variation in, and clinical impact of high Therapy Intensity Level (TIL) treatments for elevated intracranial pressure (ICP) in patients with traumatic brain injury (TBI) across European Intensive Care Units (ICUs).
Causes and timing of death in critically ill COVID-19 patients
Damien Contou, Radj Cally, Florence Sarfati, Paul Desaint, Megan Fraissé and Gaëtan Plantefève
doi : 10.1186/s13054-021-03492-x
Critical Care 2021 25:79
Helmet CPAP to treat hypoxic pneumonia outside the ICU: an observational study during the COVID-19 outbreak
Andrea Coppadoro, Annalisa Benini, Robert Fruscio, Luisa Verga, Paolo Mazzola, Giuseppe Bellelli, Marco Carbone, Giacomo Mulinacci, Alessandro Soria, Beatrice Noè, Eduardo Beck, Riccardo Di Sciacca, Davide Ippolito, Giuseppe Citerio, Maria Grazia Valsecchi, Andrea Biondi
doi : 10.1186/s13054-021-03502-y
Critical Care 2021 25:80
Respiratory failure due to COVID-19 pneumonia is associated with high mortality and may overwhelm health care systems, due to the surge of patients requiring advanced respiratory support. Shortage of intensive care unit (ICU) beds required many patients to be treated outside the ICU despite severe gas exchange impairment. Helmet is an effective interface to provide continuous positive airway pressure (CPAP) noninvasively. We report data about the usefulness of helmet CPAP during pandemic, either as treatment, a bridge to intubation or a rescue therapy for patients with care limitations (DNI).
Computed tomography assessment of PEEP-induced alveolar recruitment in patients with severe COVID-19 pneumonia
Lorenzo Ball, Chiara Robba, Lorenzo Maiello, Jacob Herrmann, Sarah E. Gerard, Yi Xin, Denise Battaglini, Iole Brunetti, Giuseppe Minetti, Sara Seitun, Antonio Vena, Daniele Roberto Giacobbe, Matteo Bassetti, Patricia R. M. Rocco, Maurizio Cereda, Lucio Castellan
doi : 10.1186/s13054-021-03477-w
Critical Care 2021 25:81
There is a paucity of data concerning the optimal ventilator management in patients with COVID-19 pneumonia; particularly, the optimal levels of positive-end expiratory pressure (PEEP) are unknown. We aimed to investigate the effects of two levels of PEEP on alveolar recruitment in critically ill patients with severe COVID-19 pneumonia.
Long-term health-related quality of life and burden of disease after intensive care: development of a patient-reported outcome measure
Johan Malmgren, Ann-Charlotte Waldenstr?m, Christian Rylander, Elias Johannesson and Stefan Lundin
doi : 10.1186/s13054-021-03496-7
Critical Care 2021 25:82
ICU survivorship includes a diverse burden of disease. Current questionnaires used for collecting information about health-related problems and their relation to quality of life lack detailed questions in several areas relevant to ICU survivors. Our aim was to construct a provisional questionnaire on health-related issues based on interviews with ICU survivors and to test if this questionnaire was able to show differences between ICU survivors and a control group.
Predicting neurological outcome after out-of-hospital cardiac arrest with cumulative information; development and internal validation of an artificial neural network algorithm
Peder Andersson, Jesper Johnsson, Ola Bj?rnsson, Tobias Cronberg, Christian Hassager, Henrik Zetterberg, Pascal Stammet, Johan Undén, Jesper Kjaergaard, Hans Friberg, Kaj Blennow, Gisela Lilja, Matt P. Wise, Josef Dankiewicz, Niklas Nielsen and Attila Frigyesi
doi : 10.1186/s13054-021-03505-9
Critical Care 2021 25:83
Prognostication of neurological outcome in patients who remain comatose after cardiac arrest resuscitation is complex. Clinical variables, as well as biomarkers of brain injury, cardiac injury, and systemic inflammation, all yield some prognostic value. We hypothesised that cumulative information obtained during the first three days of intensive care could produce a reliable model for predicting neurological outcome following out-of-hospital cardiac arrest (OHCA) using artificial neural network (ANN) with and without biomarkers.
Frailty status among older critically ill patients with severe acute kidney injury
William Beaubien-Souligny, Alan Yang, Gerald Lebovic, Ron Wald and Sean M. Bagshaw
doi : 10.1186/s13054-021-03510-y
Critical Care 2021 25:84
Frailty status among critically ill patients with acute kidney injury (AKI) is not well described despite its importance for prognostication and informed decision-making on life-sustaining therapies. In this study, we aim to describe the epidemiology of frailty in a cohort of older critically ill patients with severe AKI, the outcomes of patients with pre-existing frailty before AKI and the factors associated with a worsening frailty status among survivors.
Closed-loop circuit for reduce oxygen waste on hollow-fiber oxygenators during extracorporeal technologies
Ignazio Condello, Flavio Rimmaudo and Giuseppe Speziale
doi : 10.1186/s13054-021-03514-8
Critical Care 2021 25:85
Long-term outcome after intensive care for COVID-19: differences between men and women—a nationwide cohort study
Erik Zettersten, Lars Engerstr?m, Max Bell, Gabriella J?derling, Johan M?rtensson, Linda Block and Emma Larsson
doi : 10.1186/s13054-021-03511-x
Critical Care 2021 25:86
Questions remain about long-term outcome for COVID-19 patients in general, and differences between men and women in particular given the fact that men seem to suffer a more dramatic course of the disease. We therefore analysed outcome beyond 90 days in ICU patients with COVID-19, with special focus on differences between men and women.
Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts
Yasser Sakr, Bruno François, Jordi Solé-Violan, Katarzyna Kotfis, Ulrich Jaschinski, Angel Estella, Marc Leone, Stephan M. Jakob, Xavier Wittebole, Luis E. Fontes, Miguel de Melo Gurgel, Thais Midega, Jean-Louis Vincent and V. Marco Ranieri
doi : 10.1186/s13054-020-03455-8
Critical Care 2021 25:87
Mortality rates for patients with ARDS remain high. We assessed temporal changes in the epidemiology and management of ARDS patients requiring invasive mechanical ventilation in European ICUs. We also investigated the association between ventilatory settings and outcome in these patients.
Energy delivery guided by indirect calorimetry in critically ill patients: a systematic review and meta-analysis
Jing-Yi Duan, Wen-He Zheng, Hua Zhou, Yuan Xu and Hui-Bin Huang
doi : 10.1186/s13054-021-03508-6
Critical Care 2021 25:88
The use of indirect calorimetry (IC) is increasing due to its precision in resting energy expenditure (REE) measurement in critically ill patients. Thus, we aimed to evaluate the clinical outcomes of an IC-guided nutrition therapy compared to predictive equations strategy in such a patient population.
Effects of surgical masks on droplet dispersion under various oxygen delivery modalities
Takahiro Takazono, Kazuko Yamamoto, Ryuta Okamoto, Shimpei Morimoto, Koichi Izumikawa and Hiroshi Mukae
doi : 10.1186/s13054-021-03512-w
Critical Care 2021 25:89
